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PoP Star Michael Jackson Dead at AGE 50 due to Ai?

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randall

unread,

Jun 26, 2009, 12:35:39 AM6/26/09

Hi,

Rumors are flying about what haPPened to Michael Jackson.

Did he die of luPus?
http://en.wikipedia.org/wiki/Systemic_lupus_erythematosus

If so, then he'll be added to this list of notable folks who did.
http://en.wikipedia.org/wiki/Systemic_lupus_erythematosus#Notable_cases

http://www.foxnews.com/story/0,2933,529122,00.html
What Caused Michael Jackson's Cardiac Arrest?

It kills more people in the U.S. each year than breast cancer, lung
cancer and HIV/AIDS combined. The condition is called sudden cardiac
arrest (SCA) – and it only takes minutes to claim a person’s life.

“Sudden cardiac arrest is a real national tragedy,” Dr. Leslie Saxon,
chief of cardiovascular medicine at the University of Southern
California, told FOXNews.com. “It’s most often due to a sudden, very
rapid heart rhythm. The heart goes so fast a person dies right away
unless they’re shocked out of it with a defibrillator.”

While it hasn’t been confirmed what caused Michael Jackson to go into
full cardiac arrest — the Los Angeles Times reported that Jackson was
not breathing when paramedics arrived at his Los Angeles home around
12:30 p.m. and sources with the Los Angeles Fire Department said he
had no pulse either.

The paramedics tried to resuscitate Jackson and took him to UCLA
Medical Center where he was later pronounced dead.

“Even CPR can only bridge a person to a defibrillation,” Saxon said.
“So the big thing about these events is they have to be witnessed. The
odds are very good if someone witnesses it and shocks them right away.
That’s why people in places such as airports and casinos have a higher
rate of survival because there are a lot of people around and a lot of
defibrillators.”

Saxon said the problem is – if the sudden cardiac arrest is not
witnessed there’s less than 1 to 2 percent survival rate outside of a
hospital.

“You only have minutes to restore good blood flow,” she said. “That’s
why you have to act early because the brain and organs cannot live
without blood flow.”

The fact is – is that it takes just 4 to 6 minutes after cardiac
arrest before a person experiences brain death and ultimately complete
death.

During sudden cardiac arrest, electrical impulses in the heart become
rapid or chaotic, which causes the heart to suddenly stop beating, the
American Heart Association said on its Web Site. It’s not the same as
a heart attack. A heart attack occurs when the blood supply to part of
the heart muscle is blocked. However, a heart attack may cause cardiac
arrest.

Other common causes include heart disease, respiratory arrest,
electrocution, drowning, choking and trauma. Cardiac arrest can also
occur without any known cause.

“Most adults who have sudden cardiac arrest — it’s their first symptom
— some people don’t even have chest pain,” Saxon said.

An adverse response to prescription drugs or illicit use of drugs can
also cause arrhythmias leading to cardiac arrest.

Brian Oxman, Jackson’s spokesperson and longtime family, hinted that
the singer may have had trouble with prescription drugs.

"This was something which I feared and something which I warned
about," Oxman told CNN. "I can tell you for sure that this is
something I warned about. Where there is smoke there is fire."

Oxman told CNN that the singer was taking drugs to deal with past
injuries, such as a broken back and broken leg, which were getting in
the way of his concert rehearsals.

Jackson was slated to kick-off a 50 concert tour starting in London
July 13th.

An autopsy on Jackson will likely take place Friday.

Was Jackson Suffering From Lupus?

In October 2007, sources close to the pop star confirmed to
FOXNews.com that he was suffering from lupus.

“Lupus is a chronic autoimmune disease where the immune system is
unable to detect foreign invaders — like viruses – in the body,” Dr.
Cynara Coomer, FOX News medical contributor and assistant professor of
surgery at Mount Sinai Medical Center told FOXNews.com. “So the body
creates autoantibodies – or antibodies that attack the body’s own
healthy cells, causing inflammation.”

The inflammation caused by lupus can affect the joints, skin, kidneys,
blood cells, heart, lungs and brain.

“Several studies have shown that this inflammatory process can occur
in the arteries of the heart leading to the formation of fatty
plaques, also known as atherosclerosis. This can result in
cardiovascular disease and may lead to heart attack,” Coomer said.

Research estimates that at least 1.5 million Americans have lupus, the
Lupus Foundation of America said on its Web site.

There are four different types of lupus, but the most common — and
serious — form is systemic lupus erythematosus.

According to the Mayo Clinic, the signs and symptoms of lupus can come
on suddenly or develop slowly over time and can include:

— Fatigue

— Fever

— Weight loss or gain

— Joint pain, stiffness and swelling

— Butterfly-shaped rash on the face that covers the cheeks and bridge
of the nose

— Skin lesions that appear or worsen with sun exposure

— Mouth sores

— Hair loss

— Anxiety

— Depression

— Memory loss

“There’s no real known cause, but the most common type of patients
afflicted are African Americans, American Indians and Asians,” Coomer
said. “Certain antibiotics or infections, stress and some medications
may lead to lupus.”

-------------

randall... gonna miss his antics and such...

randall

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Jun 27, 2009, 2:42:56 PM6/27/09

Hi,

As I can't avoid the topical du jour mush from the mediots on CNN and
Fox,
a few more prelimenary notes for speculations regarding Michaels
demise.

Was he on a one way path to his Muslim Heavenly JOY like FARRAH (Joy
in Arabic) Fawcett?

-----------

Michael Jackson "Man in the Mirror"
http://www.youtube.com/watch?v=1zpTQCQEFhg

Lyric: If you want to make the world a better place take a look at
yourself and change...

I'm starting with the man in the mirror asking if he'll change his
ways...

-----------

I guess beyond his financial autopsy, the REAL stress required for a
concurrent drug overdose perhaps, the prominent items in Michaels life
that could account for cardiopulmonary arrest in a 50 y/o, 5 Foot 11,
125 lb. male are highly speculative till the final chips droP.

And even then the untold story becomes ripe for more media fodder or
investigative journalism.

On Michael Jacksons WIKI page:
http://en.wikipedia.org/wiki/Michael_Jackson

[...]

In the mid-1980s, Michael was alleged to have lupus and vitiligo, both
being autoimmune conditions.

------

http://en.wikipedia.org/wiki/Systemic_lupus_erythematosus#Notable_cases
Diagnosed in 1986, and confirmed by his dermatologist, Dr. Arnold
Klein, who presented legal documents during court depositions.

----

Vitiligo affects about 1% of the population and if Michael had it then
thyroid disorders, pernicious anemia, decreased adrenal gland function
or a condition called alopecia areata that causes hair loss would have
presented. Possible causes include abnormal nerve cells that hinder
the body's production of pigment or an autoimmune or autotoxic
reaction in which the pigment cells are attacked.

A handy explanation for skin discoloration?

PerhaPs...

But the wikipedia page also says he was in remission.

Right.....................wish some of us psor heads did that more
frequently
then the actual cases reveal...

Other salient facts reveal, that Michael was abused as a child.

Rightly or wrongly, he can choose to HATE the abusers or himself.

A source of conflict that never stops and fuels peculiar behaviors
self destructive or creative, perhaPs?

The obama white house otoh, and democrats like nancy pelosi HATE the
electorate for not
letting them turn us in to good little socialist marxists. LOL

But that being a story for another day when their in the mirror.

And the thrilla in DC is over. LOL

Michael Jackson - Thriller ( 13 minutes )
http://www.youtube.com/watch?v=AtyJbIOZjS8

Yikes, my fingers feel like what HIS look like. LOL

Surely the PERCEIVED versus ACTUAL abuse in Michaels case created a
http://en.wikipedia.org/wiki/Body_dysmorphic_disorder
body dysmorphia similar to what anorexic's experience. Or so it
aPPears toPically anyway.
And with fasting and colon cleansing, a dangerous situation may
develoP.
http://en.wikipedia.org/wiki/Anorexia_Nervosa

That and being a walking pharmA reP...if those drugs are abused by the
abuser/abused?

OTOH drug overdoses (narcotics, benzodiazepines, sedatives) can cause
skin discoloration.

So drugs or vitiligo or both?

Or a hyperbaric chamber? Which he denied:

http://en.wikipedia.org/wiki/Michael_Jackson#1993.E2.80.9394:_Sexual_abuse_accusations_and_marriage
Jackson gave a 90-minute interview with Oprah Winfrey in February
1993, his first television interview since 1979. He grimaced when
speaking of his childhood abuse at the hands of his father; he
believed he had missed out on much of his childhood years, admitting
that he often cried from loneliness. He denied previous tabloid rumors
that he bought the bones of the Elephant Man or slept in a hyperbaric
oxygen chamber. The entertainer went on to dispel suggestions that he
bleached his skin, stating for the first time that he had vitiligo.
The interview was watched by 90 million Americans, becoming the fourth
most-viewed non-sport program in US history. It also started a public
debate on the topic of vitiligo,
<sniP>

If Michael had been abused sexually then the abused frequently become
abusers themselves.

As to drugs, Michael may have been on the list is long: Valium, Xanax,
Ativan (lorazepam) zoloft, Vicodin, Oxycontin, Versed (midazolam),
Promethazime at one time or another.

As 28 year old heath ledger died of Xanax, Valium, OxyContin,
Restoril, and Unisom.

We SHALL know SOON what Michael TOOK as well.

========

Let's LOOK at the side effects of just ONE of these drugs:

Side effects of xanax:
Dermatologic side effects have rarely included photosensitivity.
Stevens-Johnson syndrome has also been reported.

Dermatologic side effects which resulted in discontinuation of
treatment in over 5% of patients and at a greater rate than placebo
have included sweating (14.4%).

-----------

I won't do this till after the autopsy specimens have been collected
and examined further.

And I have more precise idea to base conclusions.

=======

While being excentric, rumors of extended fasting and colon cleansing
(Michaels book) techniques
rear their heads as well.

And could also very well figure in to a CV event.

================================

As only a few psoriatics in relationship to the total population die
of the autoimmune condition itself,
Michael most likely, in some fashion similar to Heath Ledger died of
deadly combo of Rx medicines.

How do you feel now that he's gone?

Michael Jackson - The Way You Make Me Feel
http://www.youtube.com/watch?v=sEU9Q8NlOiY&feature=related

randall.... like Elvis or Picasso, his estate will become FLUSH?

Message has been deleted

randall

unread,

Jun 27, 2009, 6:51:42 PM6/27/09

On Jun 27, 12:55 pm, Susan <su...@nothanks.org> wrote:
> x-no-archive: yes
>
> Susan wrote:
> > Proiomelanocortin is what produces melanin, and it's part of the
> > endocrine system. Receptor abnormalities are well studied. It also
> > triggers HPA axis function in some ways.
>
> "ACTH is synthesized from pre-pro-opiomelanocortin (pre-POMC). The
> removal of the signal peptide during translation produces the 267 amino
> acid polypeptide POMC, which undergoes a series of post-translational
> modifications such as phosphorylation and glycosylation before it is
> proteolytically cleaved by endopeptidases to yield various polypeptide
> fragments with varying physiological activity.
>
> *****These fragments include ACTH, β-lipotropin, γ-lipotropin,
> Melanocyte Stimulating Hormone (MSH) and β-endorphin. POMC, ACTH and
> β-lipotropin are secreted from corticotropes in the anterior lobe (or
> adenohypophysis) of the pituitary gland in response to the hormone
> corticotropin-releasing hormone (CRH) released by the hypothalamus. ACTH
> is also produced by cells of the immune system (T cells, B cells and
> macrophages) in response to stimuli that go along with stress (including
> CRH).****
>
> [1]"http://en.wikipedia.org/wiki/Adrenocorticotropic_hormone
>
> Susan

randall wrote:

> Vitiligo affects about 1% of the population and if Michael had it then
> thyroid disorders, pernicious anemia, decreased adrenal gland function
> or a condition called alopecia areata that causes hair loss would have
> presented. Possible causes include abnormal nerve cells that hinder
> the body's production of pigment or an autoimmune or autotoxic
> reaction in which the pigment cells are attacked.

Proiomelanocortin is what produces melanin, and it's part of the
endocrine system. Receptor abnormalities are well studied. It also
triggers HPA axis function in some ways.

OK-- 38 hits for melainin + psoria* on pubmed:
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=psoriasis%20melanin&itool=QuerySuggestion

The second one in that group (not going to make the previous mistake-
LOL)

and take the one off the TOP and get my head bit off. <w>

-------------

http://www.ncbi.nlm.nih.gov/pubmed/18393827
Cellular and molecular mechanisms involved in the action of vitamin D
analogs targeting vitiligo depigmentation.

Birlea SA, Costin GE, Norris DA.
Department of Dermatology, Fitzsimmons Campus, Aurora, Mail Stop 8127,
PO Box 6511, Aurora, CO 80045, USA.

The active metabolite of vitamin D3 - 1,25-(OH)2D3 - exerts most of
its physiological and pharmacological actions through its nuclear
receptor (VDR), regulating the transcriptional machinery of a variety
of cell types. Basic research motivated by the detection of VDR in
numerous target cells, has indicated potential therapeutic
applications of VDR ligands in osteoporosis, cancer, secondary
hyperparathyroidism and autoimmune diseases such as psoriasis,
systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes
and multiple sclerosis. In recent years vitamin D analogs,
particularly calcipotriol and tacalcitol, have been used as topical
therapeutic agents in vitiligo, an autoimmune pigmentary disorder
characterized by aberrant loss of functional melanocytes from involved
epidermis. The presence of cytotoxic T cells targeting melanocyte
antigens and imbalance of the cytokine network were described as
characteristics of the disease, eventually leading to melanocyte
damage and death. Vitamin D ligands are designed to target the local
immune response in vitiligo, acting on specific T cell activation,
mainly by inhibiting the transition of T cells from early to late G1
phase and by inhibiting the expression of several pro-inflammatory
cytokines genes, such as those encoding tumor necrosis factor alpha
(TNF-alpha) and interferon gamma (IFN-gamma). Vitamin D(3) compounds
are known to influence melanocyte maturation and differentiation and
also to up-regulate melanogenesis through pathways activated by
specific ligand receptors, such as endothelin receptor and c-kit. In
this review we summarize the complex pathogenetic rationale of vitamin
D analogs in vitiligo depigmentation. Understanding the cellular and
molecular mechanisms through which vitamin D targets the epidermal
melanin unit is of great interest for identification of new effective
therapeutic combination(s) that might induce repigmentation in
vitiligo.

PMID: 18393827

Did Michael truly want to reverse his vitiligo induced loss of melanin
and increase skin pigmentation via D3?

If he took D3 maybe he did?

What do I know?

What did his doctors know?

--------

Epidermal + melanin { 1125 hits on pubmed}

http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=epidermal+melanin&log$=activity

If I add in keyword: hpa [ i get two hits from this search]

http://www.ncbi.nlm.nih.gov/pubmed/15946990
Human hair follicles display a functional equivalent of the
hypothalamic-pituitary-adrenal axis and synthesize cortisol.

Ito N, Ito T, Kromminga A, Bettermann A, Takigawa M, Kees F, Straub
RH, Paus R.
Department of Dermatology, Hamamatsu University School of Medicine,
Hamamatsu, Japan.

The skin and its major appendages are prominent target organs and
potent sources of key players along the classical hypothalamic-
pituitary axis, such as corticotropin releasing hormone (CRH),
adrenocorticotropic hormone (ACTH), and alpha melanocyte stimulating
hormone (alpha-MSH), and even express key steroidogenic enzymes.
Therefore, it may have established local stress response systems that
resemble the hypothalamic-pituitary-adrenal (HPA) axis. However,
functional evidence that this is indeed the case in normal human skin
in situ has still been missing. We show that microdissected, organ-
cultured human scalp hair follicles respond to CRH stimulation by up-
regulating proopiomelanocortin (POMC) transcription and
immunoreactivity (IR) for ACTH and alpha-MSH, which must have been
processed from POMC. CRH, alpha-MSH, and ACTH also modulate expression
of their cognate receptors (CRH-R1, MC1-R, MC2-R). In addition, the
strongest stimulus for adrenal cortisol production, ACTH, also up-
regulates cortisol-IR in the hair follicles. Isolated human hair
follicles secrete substantial levels of cortisol into the culture
medium, and this activity is further up-regulated by CRH. CRH also
modulates important functional hair growth parameters in vitro (hair
shaft elongation, catagen induction, hair keratinocyte proliferation,
melanin production). Finally, human hair follicles display HPA axis-
like regulatory feedback systems, since the glucocorticoid receptor
agonist hydrocortisone down-regulates follicular CRH expression. Thus,
even in the absence of endocrine, neural, or vascular systemic
connections, normal human scalp hair follicles directly respond to CRH
stimulation in a strikingly similar manner to what is seen in the
classical HPA axis, including synthesis and secretion of cortisol and
activation of prototypic neuroendocrine feedback loops.

PMID: 15946990

http://www.ncbi.nlm.nih.gov/pubmed/10893429
Corticotropin releasing hormone and proopiomelanocortin involvement in
the cutaneous response to stress.

Slominski A, Wortsman J, Luger T, Paus R, Solomon S.
Department of Pathology, Loyola University Medical Center, Maywood,
Illinois, USA.

The skin is a known target organ for the proopiomelanocortin (POMC)-
derived neuropeptides alpha-melanocyte stimulating hormone (alpha-
MSH), beta-endorphin, and ACTH and also a source of these peptides.
Skin expression levels of the POMC gene and POMC/corticotropin
releasing hormone (CRH) peptides are not static but are determined by
such factors as the physiological changes associated with hair cycle
(highest in anagen phase), ultraviolet radiation (UVR) exposure,
immune cytokine release, or the presence of cutaneous pathology. Among
the cytokines, the proinflammatory interleukin-1 produces important
upregulation of cutaneous levels of POMC mRNA, POMC peptides, and MSH
receptors; UVR also stimulates expression of all the components of the
CRH/POMC system including expression of the corresponding receptors.
Molecular characterization of the cutaneous POMC gene shows mRNA forms
similar to those found in the pituitary, which are expressed together
with shorter variants. The receptors for POMC peptides expressed in
the skin are functional and include MC1, MC5 and mu-opiate, although
most predominant are those of the MC1 class recognizing MSH and ACTH.
Receptors for CRH are also present in the skin. Because expression of,
for example, the MC1 receptor is stimulated in a similar dose-
dependent manner by UVR, cytokines, MSH peptides or melanin
precursors, actions of the ligand peptides represent a stochastic
(predictable) nonspecific response to environmental/endogenous
stresses. The powerful effects of POMC peptides and probably CRH on
the skin pigmentary, immune, and adnexal systems are consistent with
stress-neutralizing activity addressed at maintaining skin integrity
to restrict disruptions of internal homeostasis. Hence, cutaneous
expression of the CRH/POMC system is highly organized, encoding
mediators and receptors similar to the hypothalamic-pituitary-adrenal
(HPA) axis. This CRH/POMC skin system appears to generate a function
analogous to the HPA axis, that in the skin is expressed as a highly
localized response which neutralizes noxious stimuli and attendant
immune reactions.

PMID: 10893429

I will study these two and need be find more to build on tomorrow. :)

> A source of conflict that never stops and fuels peculiar behaviors
> self destructive or creative, perhaPs?

<susan said previously>
I think he also clearly suffered gender dysphoria, much more likely a
function of steroid receptor abnormalities, and typically suddenly
severe with puberty and just after, when he regressed and then
transformed.

I don't buy psych theories for clearly biochemical and physiological
disorders.

So, while we was a VERY strong willed man, you discount the sexual
abuse
or stress there from, as a causal agent?

We don't live in vacuums and while Michaels genetics might have been
causal,
then why haven't the culprit genes been found? Same goes for us?

But i'm not on a pharmaceutical load of confounders in MY EQuations or
trials.

http://en.wikipedia.org/wiki/Confounding

Surely the science behind our psor genes is enough to feel/know, have
a hunch (gut or not) a causal
relationship exists.

So..

Are you saying that an exact gene that causes mutations in the HPA
looP is at the heart of all psoriatics? And lupus and his dysmorphia?

What of nurture in Michaels stressed filled life?

Was it some Heaven with a side order of hell? Or the reverse?

Michael as far as i'm concerned might be explained by psychic
vampirism.

Surely the cause of the SEXUALLY abused becoming a de novo abuser him
self?

Where does the urge come from if not the a pain of the original trauma
foisted on
an innocent Michael Jackson?

The sins of the FATHER? PerhaPs?

Nurture or NATURE?
http://www.amazon.com/Sins-Father-Eileen-Franklin/dp/0449219992

In this case Michaels dad rolled his dice (besides giving him his
genes) and
the nurture weighed in how much in the equation of his lupus and drug
abuse and pedophlia ( he paid $30M to make one case go away)?

Surely lupus in my mind would be the only genetic situation here.

And if Michael did colon cleansing and FASTing, then he might have
thought the gut was connected to his situation and feeling WELL as
well. <g>

And if the GERM or SIN of the other cast his soul adrift then drugs
might
have soothed his physical body at the expense of his LIFE?

Just a thought, till the FACTs are in.

=====================

randall....andrenals and HPA aren't personally on my radar.
Will they become second nature or Nurture?

Susan

unread,

Jun 27, 2009, 7:04:12 PM6/27/09

randall wrote:

> <susan said previously>
> I think he also clearly suffered gender dysphoria, much more likely a
> function of steroid receptor abnormalities, and typically suddenly
> severe with puberty and just after, when he regressed and then
> transformed.
>
> I don't buy psych theories for clearly biochemical and physiological
> disorders.
>
> <in reference to the abstract i pulled on the top of that search?>
>
> So, while we was a VERY strong willed man, you discount the sexual
> abuse
> or stress there from, as a causal agent?

I think it can be a trigger, but I don't believe that gender identity
disorder is caused by psych issues, but by steroid receptor issues.
These don't have to be genetic, necessarily, they can be environmental, too.

>
>
> We don't live in vacuums and while Michaels genetics might have been
> causal,
> then why haven't the culprit genes been found? Same goes for us?

I didn't say that genetics were causal at all. If there is a genetic
receptor involvement, no one is looking for it, mostly because no drug
company is involved.

> Are you saying that an exact gene that causes mutations in the HPA
> looP is at the heart of all psoriatics? And lupus and his dysmorphia?

Nope. And dysmorphia isn't another name for transgender.

>
> What of nurture in Michaels stressed filled life?

I'm sure it made everything else in his life worse.

>
> Was it some Heaven with a side order of hell? Or the reverse?

>
> Michael as far as i'm concerned might be explained by psychic
> vampirism.
>
> Surely the cause of the SEXUALLY abused becoming a de novo abuser him
> self?

Not surely, though it often happens.

>
> Where does the urge come from if not the a pain of the original trauma
> foisted on
> an innocent Michael Jackson?

Biochemistry? All of his siblings were beaten, not just him.

> Surely lupus in my mind would be the only genetic situation here.

I don't think it's genetic. I'm not even sure I believe it's an
autoimmune disorder.

>
> And if Michael did colon cleansing and FASTing, then he might have
> thought the gut was connected to his situation and feeling WELL as
> well. <g>

Michael apparently had the dietary habits of a young child poorly
supervised. Disgusting, I'm told.

Susan

randall

unread,

Jun 29, 2009, 2:32:26 AM6/29/09

On Jun 27, 4:04 pm, Susan <su...@nothanks.org> wrote:
> randall wrote:
> > <susan said previously>
> > I think he also clearly suffered gender dysphoria, much more likely a
> > function of steroid receptor abnormalities, and typically suddenly
> > severe with puberty and just after, when he regressed and then
> > transformed.
>
> > I don't buy psych theories for clearly biochemical and physiological
> > disorders.
>
> > <in reference to the abstract i pulled on the top of that search?>
>
> > So, while we was a VERY strong willed man, you discount the sexual
> > abuse
> > or stress there from, as a causal agent?
>
> I think it can be a trigger, but I don't believe that gender identity
> disorder is caused by psych issues, but by steroid receptor issues.
> These don't have to be genetic, necessarily, they can be environmental, too.
>

As I was saying with the pyshic vampire thingy.

http://en.wikipedia.org/wiki/Energy_vampire

All that prana and your mama wants to suck it up. LOL

>
>
> > We don't live in vacuums and while Michaels genetics might have been
> > causal,
> > then why haven't the culprit genes been found? Same goes for us?
>
> I didn't say that genetics were causal at all. If there is a genetic
> receptor involvement, no one is looking for it, mostly because no drug
> company is involved.

Sure they are...

Aren't they?

2794 hits for VDR on pubmed:

You can't even go to outer sPace without triPPing those VDR's. LOL

http://www.ncbi.nlm.nih.gov/pubmed/19549793
Hypergravity modulates vitamin D receptor target gene mRNA expression
in mice.

Ishizawa M, Iwasaki KI, Kato S, Makishima M.
Nihon University School of Medicine.

The possibility of pathological calcium metabolism is a critical
health concern introduced by long-term space travel. Since vitamin D
plays an important role in calcium homeostasis, we evaluated the
effects of hypergravity on the expression of genes involved in vitamin
D and calcium metabolism in ICR mice. When exposed to 2G hypergravity
for 2 days, the mRNA expression of renal 25-hydroxyvitamin D 24-
hydroxylase (Cyp24a1) was increased and that of 25-hydroxyvitamin D
1alpha-hydroxylase (Cyp27b1) was decreased. Although hypergravity
decreased food intake and increased the expression of starvation-
induced genes, the changes in Cyp24a1 and Cyp27b1 expression were not
due to starvation, suggesting that hypergravity affects these genes
directly. Hypergravity decreased plasma 1alpha,25-dihydroxyvitamin D3
levels in ICR mice, suggesting a consequence of decreased Cyp27b1 and
increased Cyp24a1 expression. While 1alpha-hydroxyvitamin D3 [1alpha
(OH)D3] treatment induced the expression of vitamin D receptor (VDR)
target genes in the kidney of 2G-exposed ICR mice to similar levels as
controls, 1alpha(OH)D3 increased the intestinal expression of Cyp24a1
in ICR mice. Hypergravity-dependent changes of Cyp24a1 and Cyp27b1
expression were diminished in mice exposed to hypergravity for 14
days, which may represent an adaptation to hypergravity stress.
Hypergravity exposure also increased Cyp24a1 expression in the kidney
of C57BL/6J mice. We examined the effects of hypergravity on VDR-null
mice and found that renal Cyp27b1 expression in VDR-null mice was
decreased by hypergravity while renal Cyp24a1 expression was not
detected in VDR-null mice. Thus, hypergravity modifies the expression
of genes involved in vitamin D metabolism. Key words: vitamin D,
vitamin D receptor, hypergravity, kidney.

PMID: 19549793

Maybe this is the problem with HPS-axis?

OUr bodies THINK were in outer space on earth?

So?

It's all a gravity problem with come CYP-450 detox
monkeying up the arachidonic acid cascade.

LOL

Do we belong in outer sPace?

The race for....

>
> > Are you saying that an exact gene that causes mutations in the HPA
> > looP is at the heart of all psoriatics? And lupus and his dysmorphia?
>
> Nope. And dysmorphia isn't another name for transgender.

But suPPorts the females get more autoimmune conditions, now
that I"M thinking about it.

Do transgenders get psoriasis when they convert from
male to female upon hormone treatments?

Whats demographics in that situation?

>
>
>
> > What of nurture in Michaels stressed filled life?
>
> I'm sure it made everything else in his life worse.
>
>
>
> > Was it some Heaven with a side order of hell? Or the reverse?
>
> > Michael as far as i'm concerned might be explained by psychic
> > vampirism.
>
> > Surely the cause of the SEXUALLY abused becoming a de novo abuser him
> > self?
>
> Not surely, though it often happens.

Read the energy vampire thing... Or they call is energy something.

>
>
>
> > Where does the urge come from if not the a pain of the original trauma
> > foisted on
> > an innocent Michael Jackson?
>
> Biochemistry? All of his siblings were beaten, not just him.

And the hierarchy in families and position in regards to worth?

Michael being the baby and most talented?

Surely that dynamic may hold the key to his particular case?

>
> > Surely lupus in my mind would be the only genetic situation here.
>
> I don't think it's genetic. I'm not even sure I believe it's an
> autoimmune disorder.
>
>

So an HPA disorder is an Ai condition?

>
> > And if Michael did colon cleansing and FASTing, then he might have
> > thought the gut was connected to his situation and feeling WELL as
> > well. <g>
>
> Michael apparently had the dietary habits of a young child poorly
> supervised. Disgusting, I'm told.
>
> Susan

OK and if true then my commentary on his being a strong willed man
juxtaposed with a skewed view of his self image, may explain
his being a chich at heart. LOL

And though no estrogen he still, like me for instance has
TWO Ai conditions.

I'll wait for the media to explain it.

randall..

randall

unread,

Jul 4, 2009, 4:20:34 PM7/4/09

Hi,

HaPPy 4th all YOU PSOR HEADs with nothing better to do.

I'm going out on the BAY to Watch fireworks later. :)
But with Global Cooling we're worried the inversion layer (clouds)
might obscure the show.

Most years the sky is clear till the smoke from the show obscures the
show. LOL

If it's NOT one thing it's ANOTHER.

But look at this... it won't be there LONG,

http://sohowww.nascom.nasa.gov/sunspots/

A group of sPots....

Their BACK...

------------------

OH, and BTW, regarding the KING of PoP:

Liza Minelli made the comment "All of us who knew him well really know
what he was like," she said. "And I'm sure that now the accolades are
going, and I'm sure when the autopsy comes, all hell's going to break
loose. So, thank God we're celebrating him now."

------------

In a week we might or should REALLY know?

In respect to the family i'd bet they wait till after services to
release the autopsy report?

Until then, the media FUN under the SUN titilates till
the morning comes. Will one of those mediots
jumP the gun?

From the SUN:
http://img.thesun.co.uk/multimedia/archive/00834/jacko-280_834607j.jpg
MJ surgery rounduP:
http://www.anomalies-unlimited.com/Jackson.html

When MJ died God said he couldn't keep the plastic surgery but he was
allowed
one wish so he asked for Billy Mays to deliver a case of Mighty Putty.

---------

Lupus moves back in the PACK for leading cause of MJ's Death.

In the LEAD is:

Diprivan
http://en.wikipedia.org/wiki/Propofol

http://en.wikipedia.org/wiki/Propofol#Abuse

He must have been hard uP for sleeP.