Do HEALTH CARE MATH 101 - YOU'RE REsPonsible FOR YOU
randall
I'm positive that nearly EVERY PERSON with CROHN's can be
cleared of ALL symtoms by using the WIT KIT from www.thewholewhey.com
See:
http://www.thewholewhey.com/3601/162358.html
The wit kit isn't all that bad, but you are required to adhere to a
strict
diet for one month. And if your so inclined by adoPting that diet for
life you WILL create a GARDEN of HEALTH and EDEN inside of YOU.
I know as well as the next person the garden of eating fouls the
works. :(
And if Crohniaks can get CLEAR and psoriatics can GET CLEAR using the
wit kit,
then we ARE responsible for our OWN skin ...inside or outside.
We OWN our skin no matter the state or condition of PLAQUeS and gut
permeability.
Why?
Cause I said so. LOL
And i'm NOT even a GOV guy. LOL
But but ALL of US ARE tHE GOV.
But why NOT is a good question.
BE-cause your cutting anti-TNF mab DRUGs and big PHARMA out of the
equation
is neither here or there.
It's your choice but don't make ME pay for your lack of
responsibility.
You have to get square on the math.
If it (the wit kit) works and you work it, you WILL get WELL.
ok? WE have a genetic propensity surely but using
microbiome genomics (lacti loving flora) we can tilt the skew in our
favor.
------------------------
http://www.eurekalert.org/pub_releases/2009-12/uoa-boc121609.php
Breakthrough on causes of inflammatory bowel disease
New research by the University of Adelaide could help explain why some
people are more prone to Crohn's disease, ulcerative colitis and other
autoimmune diseases.
A critical imbalance of the regulatory cells required to control the
immune system has been revealed among people suffering inflammatory
bowel disease.
In a paper published in the Journal of Clinical Immunology this month,
Pathology researcher Dr Nicola Eastaff-Leung reveals that people
suffering Crohn's disease and ulcerative colitis have fewer numbers of
regulatory cells and more "attack" cells that cause inflammation.
"All the food that we eat is foreign to our body," Dr Eastaff-Leung
says. "In healthy people the immune system has a mechanism to tolerate
these foods and not react. But some people do not have enough of these
regulatory cells and their body overreacts and goes into attack mode.
That is where the inflammation occurs," she says.
Dr Eastaff-Leung says the results of her recently completed PhD at the
University of Adelaide could help provide a diagnostic tool for
gastrointestinal diseases, reducing the need for colonoscopies in
future.
"If we can establish that all people suffering Crohn's disease and
ulcerative colitis have an imbalance of these regulatory cells, we may
be able to develop a blood test that confirms suspected cases of these
diseases.
"The second, bigger challenge is to work out a treatment that can
restore the balance of these cells and also to find out why this
imbalance is happening in the first place."
Dr Eastaff-Leung, who has qualifications in both Pathology and Chinese
medicine, says there is evidence to show that diet and lifestyle play
a significant role in the development of gastrointestinal disease.
"Inflammatory bowel diseases and a lot of other autoimmune diseases
are common in Western cultures but are rarely found in the developing
or Third World countries.
"We need to look at our diet and also the obsession in Western
countries with cleanliness and antibacterial disinfectants, which has
gone overboard. Children need to be exposed to bacteria as they are
developing in order to build their immune system naturally," Dr
Eastaff-Leung says.
PhD supervisors Associate Professor Simon Barry, from the Discipline
of Paediatrics at the University of Adelaide, and Dr Adrian Cummins
from the Department of Gastroenterology at the Queen Elizabeth
Hospital, believe the ongoing study of regulatory immune cells could
help pinpoint the causes of a range of diseases, including multiple
sclerosis, rheumatoid arthritis, Type 1 diabetes and even asthma.
"In all autoimmune diseases, the immune system accidentally starts to
attack tissues and organs that it should normally leave alone. The
regulatory cells are obviously not doing their job and we need to
understand why," Dr Barry says.
Dr Eastaff-Leung will spend the next 12 months working with Assoc.
Prof. Barry developing a novel biomarker for these regulatory immune
cells in collaboration with Professor Heddy Zola from the Cooperative
Research Centre for Biomarker Translation.
"We are going to see if we can add a new layer of sophistication to
this research," Assoc. Prof. Barry says. "If the new biomarker is a
protein that plays an important functional role we can work on that to
restore the balance in the immune system."
More than 700,000 individuals are living with inflammatory bowel
disease in the US, UK and Australia.
<sniP>
With wit kit usase and growing out a few pounds of lacti loving flora
your TREGs or T-reg's will simply be created in the process.
=============================
Do we have to cut out the drugs from big pharma?
NO.
But let's face it, they become a crutch.
And YOU and I need to get well so we can sPring or RUN all out.
Check this out.
FAE for MS?
Yep it helps.
But why?
You don't want to die?
Yes but what's the pathways for MS and psoriasis that fAE's deal with?
sure:
www.ncbi.nlm.nih.gov/pubmed/19721818
Curr Neuropharmacol. 2009 Mar;7(1):60-4.
Fumaric Acid and its esters: an emerging treatment for multiple
sclerosis.
Moharregh-Khiabani D, Linker RA, Gold R, Stangel M.
Department of Neurology, Medical School Hannover, Carl-Neuberg-Strasse
1, D-30625 Hannover, Germany;
Fumaric acid is an intermediate product of the citric acid cycle that
is a source of intracellular energy in the form of adenosine
triphosphate (ATP). It is generated by oxidation of adenylsuccinate by
the enzyme succinate dehydrogenase and is then converted to maleate by
the enzyme fumarase. At present, fumaric acid esters (FAE) are
licensed for the treatment of psoriasis. Several lines of evidence
have demonstrated immunomodulatory effects for FAE. Clinical studies
in psoriasis showed a reduction of peripheral CD4(+)- and CD8(+)-T-
lymphocytes due to the ability of FAE to induce apoptosis. In vitro
studies with the ester dimethyl fumarate (DMF) described an inhibitory
effect on nuclear factor kappa B (NF-kappaB)-dependent transcription
of tumor necrosis factor-alpha (TNF-alpha) induced genes in human
endothelial cells. Animal studies using a model of central nervous
system demyelination, MOG-induced experimental autoimmune
encephalomyelitis (EAE), revealed a reduction of microglia and
macrophages in inflamed lesions. A phase II clinical study in
relapsing-remitting multiple sclerosis (RRMS) patients with a modified
fumaric acid ester, BG-12, showed as "proof of principle" a
significant reduction in the number of gadolinium enhancing lesions
after 24 weeks of treatment as compared to placebo. Further phase III
studies have now started to explore the long-term efficacy of FAE.
PMID: 19721818
FAE for psoriasis (136 returns - keywords: fumaric acid ester psoria*
http://www.ncbi.nlm.nih.gov/sites/entrezdb=pubmed&cmd=DetailsSearch&term=fumaric+acid+esters+psoria*&log$=activity
------------------
We know fumaric acid esters help some folks with psoriasis.
Yet the exact mechanism isn't totally clear or psor pathways for that
matter.
http://en.wikipedia.org/wiki/Dimethyl_fumarate
And some folks might make use of dichloroacetate (DCA) for cancer.
http://en.wikipedia.org/wiki/Dichloroacetic_acid
Dichloroacetic acid, often abbreviated DCA, is a chemical compound, an
acid, and an analogue of acetic acid in which two of the three
hydrogen atoms of the methyl group have been replaced by chlorine
atoms, it has the chemical formula CHCl2COOH. The salts and esters of
dichloroacetic acid are called dichloroacetates.
<sniP>
I see health watcher Terry polevoy mentioned in the last link.
So let's watch it ourselves. We must KNOW in order to ascribe
rationality to the process?
Surely.
Here's an article from colorado to get started with.
http://www.gazette.com/articles/professor-90901-drug-firm.html
Firm looks to therapies based on UCCS professor's research
WAYNE HEILMAN
THE GAZETTE
A small California company has signed licensing agreements for medical
technology developed by a local biology professor to treat cancer, HIV
and other autoimmune diseases, but any drugs or other treatments
likely are years from being available to the public.
Viral Genetics Inc. plans to seek Food and Drug Administration
approval during the first quarter to begin testing a new type of drug
that targets the response of an individual’s immune system to fight
off HIV, cancer, lupus, diabetes, rheumatoid arthritis and other
autoimmune diseases, said Haig Keledjian, the company’s president. The
drug was developed from research conducted by Karen Newell, a
University of Colorado at Colorado Springs associate biology
professor.
“We are confident that Viral Genetics has the capacity to develop
these technologies into products with significant impact,” said David
Allen, associate vice president for technology transfer at the
University of Colorado, which signed the agreement with the company.
“This agreement enables us to work towards bringing a diverse array of
drug therapies to the market, all based on technology developed by”
Newell, Keledjian said in a press release. “This is cutting-edge
science that Karen has developed.”
Viral Genetics is studying whether to seek grants from foundations and
the National Institutes for Health to pay for testing in the United
States, although the company already has conducted human trials in
China, Mexico and South Africa, Keledjian said.
The company also has signed a second license agreement to develop
cancer therapies using Newell’s research into the chemical compound
dichloroacetate that indicates the compound robs cancerous tumors of
energy they need to grow. That agreement will allow the company and
Newell to “pursue new lines of research,” which Keledjian said have
“tremendous potential to help patients with drug-resistant tumors, the
leading cause of death” from cancer.
Both technologies “are in the early stages and require proof of
concept,” said David Poticha, senior licensing manager for the
Technology Transfer Office at University of Colorado at Denver’s
Anschutz Medical Campus. “Both licenses address enormous potential
markets, but are years away from reaching the market. I believe the
science behind (autoimmune disease therapies) is remarkable, paradigm-
shifting science. We have a lot of hope that this technology can help
millions of people.”
Viral Genetics is based in Azusa, Calif., and stems from work started
in 1992 by Keledjian and Dr. Harry Zhabilov, who died in 2002. The
company’s stock still trades over the counter, even though Viral
Genetics deregistered its shares in March with the Securities and
Exchange Commission.
—
Contact the writer at 636-0234
---------
I can't find oNE abstract for Karen Newell and dichloroacetate on
pubmed.
Did find 1013 HITs for keyword: dichloroacetate [pubmed]
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=dichloroacetate&log$=activity
#5 on this list:
www.ncbi.nlm.nih.gov/pubmed/19753307
PLoS One. 2009 Sep 15;4(9):e7033.
Oxygen consumption can regulate the growth of tumors, a new
perspective on the warburg effect.
Chen Y, Cairns R, Papandreou I, Koong A, Denko NC.
Division of Radiation and Cancer Biology, Department of Radiation
Oncology, Stanford University School of Medicine, Stanford,
California, USA.
BACKGROUND: The unique metabolism of tumors was described many years
ago by Otto Warburg, who identified tumor cells with increased
glycolysis and decreased mitochondrial activity. However, "aerobic
glycolysis" generates fewer ATP per glucose molecule than
mitochondrial oxidative phosphorylation, so in terms of energy
production, it is unclear how increasing a less efficient process
provides tumors with a growth advantage. METHODS/FINDINGS: We carried
out a screen for loss of genetic elements in pancreatic tumor cells
that accelerated their growth as tumors, and identified mitochondrial
ribosomal protein L28 (MRPL28). Knockdown of MRPL28 in these cells
decreased mitochondrial activity, and increased glycolysis, but
paradoxically, decreased cellular growth in vitro. Following Warburg's
observations, this mutation causes decreased mitochondrial function,
compensatory increase in glycolysis and accelerated growth in vivo.
Likewise, knockdown of either mitochondrial ribosomal protein L12
(MRPL12) or cytochrome oxidase had a similar effect. Conversely,
expression of the mitochondrial uncoupling protein 1 (UCP1) increased
oxygen consumption and decreased tumor growth. Finally, treatment of
tumor bearing animals with dichloroacetate (DCA) increased pyruvate
consumption in the mitochondria, increased total oxygen consumption,
increased tumor hypoxia and slowed tumor growth. CONCLUSIONS: We
interpret these findings to show that non-oncogenic genetic changes
that alter mitochondrial metabolism can regulate tumor growth through
modulation of the consumption of oxygen, which appears to be a rate
limiting substrate for tumor proliferation.
PMID: 19753307
Links for DCA patents etc:
http://www.thedcasite.com/the_dca_patents.html
But this next link makes an even better DCA drug:
[...]
A new platinum compound developed by US scientists could be more
effective at fighting cancerous tumours than cisplatin, it was
revealed on Monday (7th December).
Stephen Lippard and colleagues are championing the value of
mitaplatin, which was created through a combination of cisplatin and
another compound, dichloroacetate (DCA).
The inclusion of DCA is crucial as it can selectively change the
properties of mitochondria in cancer cells, thus enhancing cisplatin's
ability to kill them.
<sniP>
===============
So?
Let's ask ourselves why autoimmune or cancer disease come about in the
first place.
While a large percentage of the time mother nature (DNA) or NURTURE
(enviroment) are involved one must recognize
the responsibility of the individual regardless.
With a health care bill looming over ALL OUR heads that shifts COSTs
and abrogates personal responsibility, in these matters, it becomes
incumbent for wisdom to prevail over
partisan politics and narrow minded hypocrisy.
WHO is the ultimate JUDGE of YOU? And will you say you gave up that
JOB to your uncle SAM or Aunt Obama?
Shall I FORCE you to stick an implant of GOOD Flora up your anus?
If it cuts cost for health care, why NOT?
Of course you can and most likely will recreate the environs necessary
to recreate your disease.
Aren't some of us simply killing time while we perform slow suicide?
When my psoriasis was upwards of 70% and plaque crust nearly 1/8 to
1/4 inch thick
i surely didn't have LONG life expectations.
But i wanted to live and be CLEAR.
So over the years i'm nearly CLEAR and if a heart attack doesn't get
me i'm on cruise control.
I avoid bad habits like the PLAGUE and foster lacti loving gut
critters to control
autoimmune Th1, Th17, Th22 subsets.
I also use NAC when necessary and resveratrol daily
(www.longevinex.com).
And at the present time i'm eating food high in Lactobacillus
Plantarum (kimchi) and
fostering these gut critters with sweet whey to insure their survival
in the ileum and
colon regions.
While this may be only palliative i'm working my way to a full blown
implant of
L. Plantarum with the kyo-dophilus formula from kyolic.
See:
http://www.thewholewhey.com/3601/162358.html
While the last week (trial) has put a halt with some clearings, my
psor levels are low
to begin with nOW and albeit a flarish time of year for falling flakes
it remains:
The SEASON for snow flakes. LOL
So on i go with this trial and the hope to clear or obtain 0% pasi by
Ferbruary 14, 2010.
With that on my radar who KNOWs?
I could start healing thousands of similar folks and also people with
some Th2 conditions to boot.
And that will provide me with a MERRY CHRISTMAS in the FUTURE.
randall.. :) I'll BE me and YOU BE yourself, so kick your ego off
the throne.