Dimethylfumarate (Fumaderm) -- TRPV4 - IMIQUIMOD - Gut Immunity ExPert - Eat NUTs - plus MORE...
randall
Dimethylfumarate alert:
http://www.rsc.org/chemistryworld/News/2010/April/27041002.asp
They say Dimethyl fumarate instead of Dimethylfumarate?
Conclusions: Collectively, these results suggest that the
neuroprotective effects of DMF may be in part functionally
attributable to the compound's ability to inhibit expression of
multiple neuroinflammatory mediators in brain of MS patients.
<sniP>
-----------
So where is biogen on OUR Dimethylfumarate (fumaderm) for the US
market?
And when can JXSTERNian low dose cocktails be made with it?
And notice that it's helPful for MS patients now?
---------
http://7thspace.com/headlines/344875/dimethylfumarate_inhibits_microglial_and_astrocytic_inflammation_by_suppressing_the_synthesis_of_nitric_oxide_il_1beta_tnf_alpha_and_il_6_in_an_in_vitro_model_of_brain_inflammation.html
Dimethylfumarate inhibits microglial and astrocytic inflammation by
suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and
IL-6 in an in-vitro model of brain inflammation
Brain inflammation plays a central role in multiple sclerosis (MS).
Dimethylfumarate (DMF), the main ingredient of an oral formulation of
fumaric acid esters with proven therapeutic efficacy in psoriasis, has
recently been found to ameliorate the course of relapsing-remitting
MS.
Glial cells are the effector cells of neuroinflammation; however,
little is known of the effect of DMF on microglia and astrocytes. The
purpose of this study was to use an established in vitro model of
brain inflammation to determine if DMF modulates the release of
neurotoxic molecules from microglia and astrocytes, thus inhibiting
glial inflammation.
[...]
Results: Pretreatment with DMF decreased synthesis of the
proinflammatory mediators iNOS, TNF-alpha, IL-1beta, and IL-6 at the
RNA level in activated microglia and astrocytes in vitro, associated
with a decrease in ERK phosphorylation in microglia.
Conclusions: Collectively, these results suggest that the
neuroprotective effects of DMF may be in part functionally
attributable to the compound's ability to inhibit expression of
multiple neuroinflammatory mediators in brain of MS patients.
-----------
And whats up with it on itchy sofas?
[...]
The doctors pointed to the small epidemic "of severe contact
dermatitis associated with newly acquired leather sofas and chairs" in
the UK and Finland since 2007.
The patients were resistant to skin creams and often required
hospitalisation due to the severity.
"Our case is of interest because of the two-year duration of the sofa
dermatitis prior to presentation."
The patient came in believing she had chronic eczema.
"It is important that dermatologists remain vigilant as patients may
present with dermatitis up to several years after first contact with
the sofas has been made," they advised.
<sniP>
------
OK, so that author saw the wiki page for Dimethyl fumarate (two
words).
http://en.wikipedia.org/wiki/Dimethyl_fumarate
Dimethyl fumarate is the methyl ester of fumaric acid.
http://en.wikipedia.org/wiki/Dimethyl_fumarate#Uses
Dimethyl fumarate is used to treat psoriasis.[2]. It is a lipophilic,
highly mobile molecule in human tissue. However, as an α,β-unsaturated
ester, dimethyl fumarate reacts rapidly with the detoxifying agent
glutathione by Michael addition. When administered orally, it does not
survive long enough to be absorbed into blood.[3]
Another use for dimethyl fumarate is mold inhibition, mostly for
leather products.
Tests in mouse models have been conducted with the aim of using it as
part of a specific cancer treatment.[4][5]
<sniP>
I don't care if some psor folks get a stomach ache or not.
I want my low dose fumaderm NOW. :)
Maybe i can buy some of those impregnated sofa's?
At a fire sale?
And sit on it and roll around and act like a clown?
A CLEAR CLOWN?
The thought is getting me READY freddy...
How about a trial with it?
They send me a FREE sofa and i sit on it?
LOL
Want to roll around on my leather sofa tonight?
Oh wait.... this limits me to flake babes?
Nevermind, you ROCK i'll roll. :)
================
http://www.medicalnewstoday.com/articles/188888.php
A Warm Sensor Maintains Skin Barrier
Japanese research group led by Prof. Makoto Tominaga and Dr. Takaaki
Sokabe (National Institute for Physiological Sciences: NIPS) found
that TRPV4 ion channel in skin keratinocytes is important for
formation and maintenance of barrier function to prevent dehydration.
Their finding was reported in the Journal of Biological Chemistry.
TRPV4 is one of the temperature-sensitive Ca2+-permeable channels,
namely "thermoTRPs". It is expressed in skin, acting as a warm sensor
(>27oC) to choose preferred environmental temperatures in mammals. The
research group sought the alternative function of TRPV4, since skin
keratinocytes express another thermoTRP named TRPV3, which also
functions as a warm sensor.
TRPV4 was found to interact with b-catenin, an adaptor protein between
actin filaments and E-cadherin in cell-cell junction complex. When
TRPV4 was genetically removed from keratinocytes, Ca2+-induced cell-
cell junction formation was delayed and immature, resulting in leaky
junctions. Consistently, intercellular junction-dependent skin barrier
in TRPV4-deficient mice became weak (leaky intercellular pathway)
compared to wild-type mice. Interestingly, these phenotypes were TRPV4-
specific, but not TRPV3-dependent.
Dr. Sokabe said, "TRPV4 may utilize skin temperature to provide Ca2+
for cell-cell junction complexes to reinforce their tightness. For
instance, dried skin in cold seasons or regions could be due to low
activity of TRPV4 caused by low skin temperature. Development of
chemicals modulating TRPV4 activity would be useful for barrier repair
of damaged skin."
Source:
Dr. Takaaki Sokabe
National Institute for Physiological Sciences
===============
Anti-cancer cream
http://www.medicalnewstoday.com/articles/188542.php
Meda Acquires Exclusive Rights To New Treatment Of Actinic Keratosis
Meda has acquired exclusive European rights to a new formulation of
imiquimod from Graceway Pharmaceuticals. The new formulation is 3,75%
imiquimod topical cream indicated for the treatment of actinic
keratosis (AK). This product has recently been approved in the US and
Canada.
Today, Meda markets a higher strength (5%) of imiquimod in Europe
under the trademark Aldara. In 2009, sales of Aldara were
approximately 500 MSEK.
3,75% imiquimod can be used on a significantly larger treatment area,
it is once-daily and more tolerable due to the decreased
concentration. The patent for this novel imiquimod formulation is
pending.
"We have very good experience with Aldara in Europe and we look
forward to provide AK patients with a new product with improved
tolerability that builds on the efficacy of imiquimod", says Anders
Lönner, CEO at Meda.
Graceway is continuing its development program around 3,75% imiquimod.
Meda has exclusive rights to follow-up products based on the imiquimod
substance.
In consideration for exclusive European rights for 3,75% imiquimod,
Meda will pay Graceway an undisclosed up-front and a single digit
royalty on net sales. No milestones payments will be due for 3,75%
imiquimod.
About imiquimod and actinic keratosis
Imiquimod is an immunomodulating agent that activates the body's own
immune defenses through the skin. Actinic keratosis is a common pre-
cancerous lesion that often develops on skin frequently exposed to the
sun. It should be treated as it cannot be predicted which AKs will
develop into a more serious forms of skin cancer. AK occurs in more
than 30 million people in Europe and only a small percentage of
patients have been properly treated.
Source
MEDA AB
================
http://www.medicalnewstoday.com/articles/188471.php
[...]
Digestive Advantage Lactose Intolerance. It contains the combination
of a probiotic strain of Bacillus coagulans and lactase enzyme
<sniP>
==============
This guy was in la jolla?
Oh man. I missed him?
But not now brown cow, go to new york and visit?
OK..
Then i can visit with Krueger and Mucida?
Go already.
http://newswire.rockefeller.edu/?page=engine&id=1070
New faculty member seeks secrets of intestinal immunity
Daniel Mucida, a scientist who studies the mechanisms of intestinal
immunity, has been named assistant professor and will join Rockefeller
University as head of the Laboratory of Mucosal Immunology in
September. Mucida’s appointment was the result of the university’s
fall 2009 open faculty search.
Mucida is interested in understanding how the immune system is able to
respond to pathogens without jeopardizing its tolerance to innocuous
substances, a critical balance that allows us to fend off infectious
disease without inflicting damage on our own tissues. He studies this
process in the intestines, where the body must cope with a constant
Daniel Mucida.
stream of foreign antigens from food as well as a flourishing
ecosystem of bacteria, viruses and parasites.
“The intestine is one of the best places to study immunology,” says
Mucida. “There are more lymphocytes in the intestines than there are
everywhere else in the body combined, and they must not only recognize
and clear harmful pathogens, but also maintain tolerance toward an
enormous variety of different antigens that they are exposed to every
day.”
A native of Brazil, Mucida attended the Federal University of Minas
Gerais in the Brazilian city of Belo Horizonte, graduating in 2000. It
was there that his broad childhood interest in physics, math, genetics
and marine biology evolved into a fascination with the workings of the
immune system. For his Ph.D. work he focused on tolerance in mucosal
tissues — not just those of the mouth and digestive tract, but also of
the nose and respiratory system. Working primarily in mice, he made
discoveries about how specific immune system cells — lymphocytes and T
cells — contribute to “oral tolerance,” our ability to avoid reacting
to what we ingest. He received his Ph.D. jointly from the University
of São Paulo in Brazil and New York University in 2005.
As a postdoc he has spent time at both the University of São Paulo and
the La Jolla Institute for Allergy and Immunology near San Diego,
where he has been since 2006. His work in La Jolla has focused on the
role of diet and bacteria in intestinal immunity. In 2007 he showed
that a vitamin A metabolite, retinoic acid, produced by intestinal
dendritic cells, is able to modulate the development of inflammatory
and regulatory cells. His recent studies in germ-free mice, which do
not develop a mature immune system, have shown how interactions
between bacteria and CD4 helper T cells are crucial to modulating the
cells’ inflammatory activity.
“We are very fortunate to have recruited Daniel to Rockefeller,” says
Paul Nurse, the university’s president. “His work on immunity and the
relationship between intestinal bacteria and inflammation is very
innovative and has the potential to teach us much about how we might
someday harness the power of the immune system to fight infectious
disease and prevent autoimmune conditions such as asthma.”
“Our work isn’t just about intestinal infections, food poisoning and
food allergy, but also pertains to infections that originate in other
systems,” Mucida says. “Many viruses, for instance, use the gut to
replicate and spread regardless of their point of entry. In addition,
antibodies which form in response to foreign bodies in the gut can
help the body’s immune system correctly identify threats elsewhere in
the body.”
============
Sometimes you feel like a NUT?
Sometimes you don't?
http://www.youtube.com/watch?v=YWCGxPAYn90
How could a food with coconut, magnesium rich chocolate and almonds
not be good for you?
I give.
Odd psoriasis CURE in the UK.
Get the aspirin?
http://www.telegraph.co.uk/health/healthadvice/jameslefanu/7726301/Accidental-cure-ends-50-years-of-psoriasis.html
Accidental cure ends 50 years of psoriasis
Doctor's Diary: How an 'accident' can reveal the definitive remedy for
an ailment and walnuts can lower cholestrol.
The medical division of labour within the Heath Service works, for the
most part, pretty well. The GP and hospital consultant have
complementary roles – the former providing personalised "holistic"
care and the latter the specialist knowledge to sort out complex
problems.
Still there is always the danger of falling between the two proverbial
stools when the GP, presuming the specialist has everything in hand,
does not take an active interest, to his patient's disadvantage. This
is a particular hazard for chronic conditions for which there is no
definitive cure but a host of options.
"I have suffered with psoriasis since a cricket-ball accident when
aged 14," writes a 64-year-old reader from Surrey. Since then, he has
tried the full gamut of emollients, moisturisers, coal-tar
preparations, topical steroids, the vitamin D derivative Calcipotriol
and two lots of 28 sessions of ultraviolet (UV) light therapy.
Over the years, his family doctor has not been much involved beyond
issuing repeat prescriptions, but a recent visit to his hospital
specialist had a most surprising outcome. She was keen to give him yet
another protracted session of UV light therapy but then asked almost
incidentally whether in the previous 50 years he had ever tried a
cheap and simple preparation combining a steroid cream and salicylic
acid (as found in aspirin) called Diprosalic.
http://en.wikipedia.org/wiki/Diprobase
No, he had not – but within a fortnight of two daily applications his
"peeling wallpaper" had vanished. Large areas on his thighs and
buttocks and the patches on his elbows and elsewhere "have converted
almost to a natural skin colour that is perfectly smooth".
He wondered, naturally enough, how many others like himself just
bounce along to discover almost by accident the definitive remedy for
their ailment.
The fresh walnut season has arrived to coincide with a report that
just a handful a day can usefully lower the cholesterol level – which
must be preferable to taking statins for life.
Dr Joan Sabata, of the University of California, writing in the
Archives of Internal Medicine, attributes the effects to a high
concentration of omega-3 fatty acids. This also accounts for their
supposed value as a "brain food" – whose appearance the nuts
themselves so closely resemble – in conformity with the medieval
doctrine of "signatures".
Further, as previously commented on in this column, walnuts can triple
the amount of melatonin in the blood, ensuring for a reader from
Cheshire six hours of uninterrupted sleep at night, and the further
serendipitous benefit of transforming her previous brittle nails into
powerful talons. And if that were not enough, Dr Paul Davis, also from
the University of California, reports that, at least in mice, walnuts
slow the growth of cancers of the prostate.
That is a lot of health claims for just one type of nut – posing yet
again the profound question why every type of fruit and plant should
be a unique chemical factory whose many diverse products are so
beneficial to ourselves.
This week's conundrum comes courtesy of Mrs W L of Suffolk, "an active
70-year-old woman in reasonable health", were it not that most
evenings, around 6pm, she develops burning, red-hot ears that last for
up to a couple of hours.
"The area above my ears feels swollen, and then they turn bright red
and become very painful," she writes. "At times, the pressure of my
lightweight glasses becomes unbearable." This has been going on for
over a year and "no doctor has been able to offer a solution".
James.lefanu @telegraph.co.uk
-----
Walnuts triPle up melatonin?
I can CUT back 2/3'rds of my melatonin dosage then. LOL
==================
Use this Korean Mask to unmask psoriasis?
http://www.prweb.com/releases/ElishaCoy/05/prweb4007564.htm
[...]
The natural clay used in ElishaCoy’s Herb Clay Pore Refining Mask
stimulates circulation, removes dead skin cells, absorbs dirt and
debris and draws out toxins in the skin. By incorporating the
antifungal and antibacterial benefits of Corchorus olitorius leaf
extract (Tossa Jute) damaged skin cells are healed, making the product
a helpful remedy for psoriasis, eczema and acne. “My skin looks
refreshed and the mask has a very nice scent,” said a tester.“It’s a
relaxing must-have.”
[...]
ElishaCoy products will be available through www.koreancreation.com,
an e-commerce web site starting on June, 2010. Wholesalers and
distributors please contact MZI Global Marketing at 212 366 5409
<sniP>
----------
Here's another masky thing.
http://www.sbwire.com/news/view/44910
Vivoderm Laboratories LLC (http://www.vivoderm.com), a natural and
scientific skin care company based in Southern California,
incorporates green tea in their 100% herbal facial masks and toner to
treat inflammation, wrinkles, skin sag and other signs of aging.
The Vivoderm 100% natural Anti-Aging and Anti-Acne Facial Masks are
proprietary blends of herbs unlike any other on the market, based on
the research of holistic dermatologist, Dr. H. Adhami.
[...]
Vivoderm Anti-Aging and Anti-Acne Facial Masks contain a variety of
other herbs in combination with the green tea extract, including
lavender and cumin as well as vitamins C, B6 and H. Dr. Adhami says,
“Each ingredient has been selected, based on years of research, for
its revitalizing and anti oxidant properties. Topical green tea is
also very beneficial for sensitive skin types by reducing inflammation
and irritation in the skin. Green Tea is one of our ‘star’
ingredients.”
Dr. Hsu stated in his report, “At certain concentrations, EGCG or a
mixture of the major green tea polyphenols stimulated aged
keratinocytes
<sniP>
But our psor skin cells are like not OLD at all. LOL
==============
Your mouse in the house smells your pussy cat and freaks out?
OK so why?
[...]
the protein the scientists identified belonged to the major urinary
protein (MUP) family. This was a member of the same family of proteins
the Stowers lab had previously identified as provoking male-male
aggression in mice.
I was shocked when we found another MUP, said Stowers. I thought, Weve
looked at two behaviors and were getting the same thing! That cant be
right! Yet the data was just so convincing…
To verify and extend their findings, the team moved on to analyzing
the odor emitted by cats. Working with cat saliva, the team found that
a key protein in cat saliva—Feld4, the cat version of MUP—provoked the
same fearful response from the mice and activated defensive neurons in
the mouse brain. In further experiments, the scientists showed that
predator MUPs and mouse MUPs activate different subsets of neurons in
the mouse brain.
Although I was at first hesitant that we had found the same molecule
again, evolutionarily it is actually quite exciting, said Stowers. The
order of the MUP receptors suggests that mice were first able to
detect MUPs from other species, then evolved the ability to detect
signals from other mice.
<sniP>
==============
http://www.wellnessresources.com/health/articles/quercetin_as_an_anti-cancer_nutrient/
Quercetin as an Anti-Cancer Nutrient
Saturday, May 15, 2010 - Byron Richards, CCN
Quercetin is a common flavonoid found in many fruits and plants.
Numerous studies are now being published regarding quercetin’s anti-
cancer properties. Some of these studies show how quercetin in and of
itself provides significant anti-cancer activity. A number of other
studies show how quercetin can be combined with chemo drugs to boost
their effectiveness, especially in situations of drug resistance to
treatment.
The intelligence in every cell of your body is called NF-kappaB. This
gene signal figures out how the cell will deal with stress and will
come up with new solutions if it has not previously seen the problem.
When NF-kappaB is forced to work overtime due to an unresolved problem
then its gene activity runs “hot” and is typically associated with
excessive inflammation. In situations of cancer NF-kappaB is
literally hijacked and its intelligence is used to further the
survival of cancer cells.
It is absolutely amazing that most nutrients interact differently with
cancer cells and normal cells – meaning that the nutrients tend to
enhance the health of normal cells while helping to kill cancer
cells. Believe me, this is a major advantage of nutrition. If chemo
drugs had this ability they wouldn’t be so toxic to healthy cells.
A detailed study with liver cancer cells showed that quercetin
directly turned down NF-kappaB activity, thereby interfering with the
hijacking process. Furthermore, quercetin directly turned on a
different set of gene signals that induced cell death to the cancer
cells.
Heat shock proteins are required for your cells to be able to
withstand stress. However, during the cancer hijacking then heat
shock proteins are used by the cancer cells to resist treatments as
well as to resist your body’s own anti-cancer immune system activity.
Think of heat shock proteins like the deflector shields of the Star
Trek Enterprise. A new study shows that quercetin can directly lower
this heat shock protein deflector shield in tumor cells, making them
susceptible to the immune system or other treatments.
Cigarette smoke is known to cause breast cancer. Using new gene tools
it is now possible to see how nicotine activates genes in breast
cancer cells that result in this problem. Another new study shows
that quercetin turns off the very gene signals that cigarette smoke
turns on. This is especially good news for those who are exposed to
secondary smoke.
In a just published study the combination of quercetin and a commonly
used chemo drug (Adriamycin) was able to completely eradicate
established breast cancer in an animal model – something that neither
compound could do by itself. Quercetin was able to promote a
sustained and effective immune system response against the chemo-
treated tumor.
Another recent study evaluated the ability of quercetin to help
overcome resistance to a similar chemo drug (daunorubicin) as
mentioned in the above study. In this case the researchers looked at
one of the primary methods by which cancer cells pump the drugs back
out of themselves, a reverse transport system based on something
called P-glycoprotein. In a study with pancreatic cancer cells the
researchers showed that quercetin disabled this reverse transport
system by blocking the production of P-glycoprotein, thus enabling the
chemo drug to have a much more toxic and killing effect on the cancer
cells.
Collectively, these studies show that quercetin possesses a variety of
potent anti-cancer attributes and can even be combined with chemo
drugs to help overcome resistance to drug treatment.
<sniP>
------------
keywords: psoria* AND NF-KappaB --128 hits on pubmed:
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=psoria*+AND+NF-kappaB
LPS AND NF-KappaB -- 4274 hits on pubmed:
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=LPS+AND+NF-kappaB
LPS NF-KappaB AND Quercetin -- 25 hits on pubmed:
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=LPS+AND+NF-kappaB+Quercetin
----
http://www.ncbi.nlm.nih.gov/pubmed/20417174
Arch Biochem Biophys. 2010 Apr 22. [Epub ahead of print]
Quercetin tetraacetyl derivative inhibits LPS-induced nitric oxide
synthase (iNOS) expression in J774A.1 cells.
Ortega MG, Saragusti AC, Cabrera JL, Chiabrando GA.
Farmacognosia, Departamento de Farmacia, Facultad de Ciencias
Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, 5000
Córdoba, Argentina; Instituto Multidisciplinario de Biología Vegetal
(IMBIV-CONICET), Ciudad Universitaria, 5000 Córdoba, Argentina.
Abstract
In inflammation, nitric oxide (NO) acts as a pro-inflammatory
mediator, which is synthesized by inducible nitric oxide synthase
(iNOS) in response to pro-inflammatory agents such as
lipopolysaccharide (LPS). Quercetin (Qt) has anti-inflammatory
properties through its ability to inhibits nitric oxide production and
iNOS expression in different cellular types. In the present study, we
evaluated the effect of a semi-synthetic acetyl (quercetin-3,5,7,3'-
tetraacetyl: TAQt) Qt derivative and two natural sulphated
(quercetin-3-acetyl-7,3',4'-trisulphate: ATS and quercetin-3,7,3',4'-
tetrasulphate: QTS) Qt derivatives on the LPS-induced NO production
and iNOS expression in J774A.1 cells. Our results demonstrate that
only TAQt inhibited the NO production by decreasing the iNOS mRNA and
protein levels. In addition, we showed that TAQt blocked the LPS-
induced nuclear NF-kappaB translocation by inhibiting the IkappaB-
alpha degradation. Hence, as TAQt inhibited the LPS-induced iNOS
expression and NO production, it could therefore be considered as a
potential therapeutic agent for the treatment of inflammatory diseases
related with the NO system. Copyright © 2010. Published by Elsevier
Inc.
PMID: 20417174
=================
The only times in my life when i beefed the vitamin A to really
high levels, i'd clear.
So?
Why didn't i take notice?
To, many factors you'd or i'd suspect?
http://www.physorg.com/news193319586.html
Retinoid use not associated with fracture risk
May 17, 2010 Individuals treated for acne, psoriasis or another skin
condition with vitamin A analogues (retinoids) do not appear to be at
increased risk of fracture, according to a report in the May issue of
Archives of Dermatology.
Ads by Google
Psoriasis Symptoms - Could You Be Suffering From Psoriasis? Learn More
Here. - PsoriasisLiving.com
"High doses of vitamin A as dietary intake or supplements have been
associated with adverse skeletal effects," the authors write as
background information in the article. Very high doses of vitamin A
analogues—compounds similar to vitamin A, including isoretinoin and
acitretin—may be prescribed to patients for skin conditions. These
medications have been associated with bone changes such as impaired
markers of bone reconstruction and decreased bone mineral density.
Peter Vestergaard, M.D., Ph.D., Dr.Med.Sc., and colleagues at Aarhus
University Hospital, Aarhus, Denmark, used two nationwide registers to
identify 124,655 patients with fractures during the year 2000. For
each of these patients, three persons who were the same age and sex
but had not sustained a fracture were also selected. A register of
medications purchased at pharmacies was then used to determine the use
of systemic (affecting the entire body) or topical (applied to the
skin) vitamin A analogues.
Neither topical nor systemic vitamin A analogues were associated with
the change in fracture risk at any skeletal site. There were no trends
with increasing medication dose or with longer treatment duration, nor
with either of the two types of analogues (isoretinoin or acitretin).
Even very large daily doses—14 milligrams of vitamin A analogues—were
not associated with an increased risk of fractures.
"Neither acne nor psoriasis, indications for systemic treatment with
vitamin A analogues, influenced the risk of fractures," the authors
write.
"It thus seems that vitamin A analogues are safe in terms of fractures
even at very high doses," they conclude. "Even though some studies
have reported a decreased bone mineral density with high doses of
vitamin A as retinol in dietary intake or as supplements, the decrease
may not have been of such magnitude that it altered bone biomechanical
competence."
More information: Arch Dermatol. 2010;146[5]:478-482.
---------
Should have dialed it in sooner?
You''d Think?
http://archderm.ama-assn.org/cgi/content/extract/146/5/551
Fracturing Support for the Role of Systemic Retinoid Therapy as a
Cause of Bone Demineralization
John J. DiGiovanna, MD
Arch Dermatol. 2010;146(5):551-553.
Vitamin A has been of interest to dermatologists since the 1920s, when
vitamin A deficiency in animals was associated with epithelial changes
and cancer. High doses of vitamin A were used to treat disorders of
cornification and other conditions, but the benefit was limited
because the doses required to achieve efficacy were close to those
that caused toxic effects. In addition, because vitamin A is stored in
the liver, development of toxicity limited subsequent use. Systemic
retinoid drugs were developed to harness the beneficial effects of
vitamin A with less toxicity, and thousands of different retinoids
have been synthesized. In the 1970s, early experience with the toxic
effects of systemic all-trans retinoic acid (tretinoin) for
dermatologic disorders led to the development of other retinoids as
therapeutic drugs.1 Isotretinoin, found to be highly effective for the
treatment of severe acne,2 was initially thought to be a synthetic .
http://archderm.ama-assn.org/cgi/content/abstract/146/5/478
Huh?
Who knows?
LOL
================
randall...
JRStern
wrote:
>And whats up with it on itchy sofas?
>
>[...]
>The doctors pointed to the small epidemic "of severe contact
>dermatitis associated with newly acquired leather sofas and chairs" in
>the UK and Finland since 2007.
My psoriasis first showed up shortly after I got new leather sofas
back in the 1980s, and I have wondered about it.
--
The fumaderm stuff is interesting, I had never before read of any MOA
for psoriasis.
J.