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137th Preakness from Pimilico and Finishing First or LAST in LIFE... or Long LASTING with BuckyBalls (fullerene's) -Evoo - Low Dose Alcohol- PPAR β/δ - K2 --> I'll Have Another
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randall
May 19, 2012, 5:20:14 PM5/19/12
to
hi
If you have some buckyballs hold on to them... you might wanna double
the life span of a RAT?
Or you? Or your derby, preakness horse?
Will it, or COULD it win a triPle crown? Can they detect athletes
with buckyballs in their system?
If you do the Preakness today...Pimilico Race track in Baltimore is
the place to play and RACE..
http://www.pimlico.com/
or horse AROUND?
Yep...82 degrees F and cloudy i see....
But..
Don't go gaga on alcohol:
And while I'LL have Another is the Favorite... don't be saying that
for Beer/wine/cocktails...to OFTEN...
and if psor... say NO MORE....
http://www.ncbi.nlm.nih.gov/pubmed/22594656
Expert Opin Drug Metab Toxicol. 2012 May 17.
The effects of alcohol on the metabolism and toxicology of anti-
psoriasis drugs.
Vena GA, Cassano N.
Source
University of Bari, Department of Biomedical Sciences and Human
Oncology, Unit of Dermatology and Venereology , Bari , Italy +39 080
5478920 ; +39 080 5478920 ; g.v...@dermatologia.uniba.it.
Abstract
Introduction: Alcohol has long been suspected to be a triggering and
precipitating factor of psoriasis. Alcohol misuse is common in
patients with moderate-to-severe psoriasis and appears to impair
treatment outcome. Areas covered: In this article, the authors review
the available data regarding the metabolic and toxicological
interactions between anti-psoriasis systemic drugs and ethanol and/or
alcoholic beverages. Special attention is given to the influence of
alcohol consumption on the hepatotoxic risk of some anti-psoriasis
drugs. The article was prepared using a MEDLINE literature search.
Expert opinion: The available knowledge highlights the existence of a
few significant pharmacological interactions, such as the reduced
exposure to cyclosporine by red wine, the possible increase of
cyclosporine levels following a heavy acute alcohol intake, and,
especially, the conversion of acitretin to etretinate, in the presence
of ethanol, with important implications in females of child-bearing
potential. There are limited data on the contributing role of alcohol
in the hepatotoxicity induced by some anti-psoriasis drugs and the
existing information on this topic is still controversial. However,
further investigation is needed to assess the relevance of
interactions between alcohol consumption and drug therapy for
psoriasis, under both pharmacological and toxicological perspectives.
Long-term prospective studies on large cohorts of patients are
warranted to disclose the actual significance of such potential
interactions in clinical practice.
PMID: 22594656
WE are up to 646 hits for:
alcohol + psoria* - pubmed:
http://www.ncbi.nlm.nih.gov/pubmed?term=psoria*%20alcohol
#1 of 646 is above.
OTOH a little bit of alcohol like maybe in mouth wash might be the
ticket?
If Jeanne Calment, who lived to 122 1/2 had buckyBALLS in her daily
EVOO, would she have lived to 144 or more?
What's a BuckyBALL?
Apparently it's added to your OLIVE oil.
And we know Jeanne sucked down EVOO like she ate her two pounds of
chocolate per week:
http://en.wikipedia.org/wiki/Jeanne_calment#Health_and_lifestyle
[...] Calment ascribed her longevity and relatively youthful
appearance for her age to olive oil, which she said she poured on all
her food[4] and rubbed onto her skin, as well as a diet of port wine,
and ate nearly one kilogram of chocolate every week.
<snip>
OTOH she smoked no more then two cigarettes per day and drank a glass
of port or two?
Did the cigs & low dose alcohol cause a hormetic effect?
Don't know, but may have mitichondria via endoplasmic reticulum erap1
gene ramifications? Have to check that idea.
http://en.wikipedia.org/wiki/Hormesis#Mitochondria
And Her low dose alcohol may have also turned on longevity sirtuin
(sirt1) genes or pde4 inhibitors?
http://en.wikipedia.org/wiki/Hormesis#Alcohol
[....] In 2012, researchers at UCLA found that tiny amounts (1 mM, or
0.005%) of ethanol doubled the lifespan of Caenorhabditis elegans, a
round worm frequently used in biological studies. Higher doses of 0.4%
provided no longevity benefit.
Links:
full text:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029984
or
http://www.ncbi.nlm.nih.gov/pubmed/22279556
Caenorhabditis elegans battling starvation stress: low levels of
ethanol prolong lifespan in L1 larvae.
Castro PV, Khare S, Young BD, Clarke SG.
PLoS One. 2012;7(1):e29984. Epub 2012 Jan 18.
PMID: 22279556
Free full TEXT PMC Article
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22279556/?tool=pubmed
So don't BE a typical psoriatic hOOKED on drinking to FEEL GOOD.
The Yin YANG high and LOW are to extreme... to handle... DUH!
Same...
With any drugs, LSD, Mushrooms, peyote, ibogaine, kykeon, ergot on
rye, one must be extremely cautious.
see:
caveats on usage of dangerous substances:
http://en.wikipedia.org/wiki/File:HarmCausedByDrugsTable.jpg
DANGER WILL Robinson! LoL
You might expand your mind behind the wombuverse and perverse the
inverse to the crocodile.
And becareful of O2, Nitric Oxide and cGMP release and the blue pill
(viagra) in terms of:
http://en.wikipedia.org/wiki/Erotic_asphyxiation
We might have LOST Mister Kung Fu due to it:
http://en.wikipedia.org/wiki/Erotic_asphyxiation#Famous_cases
And I KNOW ONE of you.... with a penchant for.... oh.. nevermind you
know who you ARE... LOL
OTOH maybe the skin would clear... or you might not care with LSD and
viagra (cGMP) and O2 deprivation (hypoxic conditions- temporary of
course or you become kung fu man with a sticky wicket? LOL) and B5,
Nicotinamide, Nitric oxide (NicOx), blocking Candidiasis in colon,
etc...
Could be a better exit then Leary, kung fu (david Carradine) and
Socrates?
Pass the hemPlock? Er, er, er, hemlock:
http://en.wikipedia.org/wiki/Conium
Conium ( /koʊˈnaɪ.əm/ or /ˈkoʊniəm/) is a genus of two species of
highly poisonous perennial herbaceous flowering plants in the family
Apiaceae, native to Europe and the Mediterranean region as Conium
maculatum, and to southern Africa as Conium chaerophylloides.
Decidedly unsuspicious?
http://upload.wikimedia.org/wikipedia/commons/b/b2/Conium.jpg
<snip>
Oh, oh, i've got some of these going off the last few days:
http://www.epies.net/images/american%20sweetheart%20best%20%20300.jpg
http://www.anniesannuals.com/signs/d%20-%20g/images/epiphyllum_king_midas_cl.jpg
Orange, reddish and very pretty...
<snip>
About that hemP... maybe for blocking omega-6 but not omega-3 and what
about ppar?
http://www.ncbi.nlm.nih.gov/pubmed/22606335
PLoS One. 2012;7(5):e37097. Epub 2012 May 14.
Skin-Targeted Inhibition of PPAR β/δ by Selective Antagonists to Treat
PPAR β/δ - Mediated Psoriasis-Like Skin Disease In Vivo.
Hack K, Reilly L, Palmer C, Read KD, Norval S, Kime R, Booth K,
Foerster J.
Source
Medical Research Institute, College of Medicine, Dentistry, and
Nursing, University of Dundee, Dundee, Scotland.
Abstract
We have previously shown that peroxisome proliferator activating
receptor ß/δ (PPAR β/δ is overexpressed in psoriasis. PPAR β/δ is not
present in adult epidermis of mice. Targeted expression of PPAR β/δ
and activation by a selective synthetic agonist is sufficient to
induce an inflammatory skin disease resembling psoriasis. Several
signalling pathways dysregulated in psoriasis are replicated in this
model, suggesting that PPAR β/δ activation contributes to psoriasis
pathogenesis. Thus, inhibition of PPAR β/δ might harbour therapeutical
potential. Since PPAR β/δ has pleiotropic functions in metabolism,
skin-targeted inhibition offer the potential of reducing systemic
adverse effects. Here, we report that three selective PPAR β/δ
antagonists, GSK0660, compound 3 h, and GSK3787 can be formulated for
topical application to the skin and that their skin concentration can
be accurately quantified using ultra-high performance liquid
chromatography (UPLC)/mass spectrometry. These antagonists show
efficacy in our transgenic mouse model in reducing psoriasis - like
changes triggered by activation of PPAR β/δ. PPAR β/δ antagonists
GSK0660 and compound 3 do not exhibit systemic drug accumulation after
prolonged application to the skin, nor do they induce inflammatory or
irritant changes. Significantly, the irreversible PPAR β/δ antagonist
(GSK3787) retains efficacy when applied topically only three times per
week which could be of practical clinical usefulness. Our data suggest
that topical inhibition of PPAR β/δ to treat psoriasis may warrant
further exploration.
PMID: 22606335
ONLY 47 hits: ppar + psoria* -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=psoria*%20ppar
188 hits - oleic + ppar -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=oleic%20ppar
#3 of 188
Mulberry extracts (the answer?)
http://www.ncbi.nlm.nih.gov/pubmed/22002411
[...] pmid: 22002411
Nope.. zero hits..LOL
http://www.ncbi.nlm.nih.gov/pubmed?term=mulberry%20psoria*
What time is it? LOL
Is it preakness ? Time?
Time to eat and slather EVOO?
And since Jeanne did a liter or more per week of EVOO, i'm guessing.
We return to something you will find hard to overdo or even get close
to consuming.
http://en.wikipedia.org/wiki/Olive_oil
http://en.wikipedia.org/wiki/Oleic_acid
http://en.wikipedia.org/wiki/Omega-9_fatty_acid
EVOO good for borborygmus
http://en.wikipedia.org/wiki/Borborygmus
http://en.wikipedia.org/wiki/Borborygmus#Diseases_and_conditions
http://tech.blorge.com/Structure:%20/2012/05/19/for-a-longer-life-take-buckyballs-in-olive-oil/
For a longer life take buckyballs in olive oilMay 19, 2012
by Susan Wilson
Yes, that may actually be the secret to a doubled lifespan if it works
as well in people as it does in rats. Of course the process is very
complicated and requires huge amounts of equipment so if it does turn
out that it works on humans like it works on rats, expect it to cost a
fortune.
According to articles in Extreme Longevity and Gizmag, buckyballs
dissolved in olive oil may just be the magic elixir that everyone has
been looking for. Scientists thought that it could have a wide variety
of positive uses. They suspected that buckyballs could have “UV and
radioprotection, antiviral, antioxidant, and anti-amyloid activities,
allergic response and angiogenesis inhibitions, immune stimulating and
antitumour effects, enhancing effect on neurite outgrowth, gene
delivery, and even hair-growing activity.” In other words, it could be
the source of improved health.
http://extremelongevity.net/2012/04/16/chronic-buckyball-administration-doubles-rat-lifespan/
http://extremelongevity.net/wp-content/uploads/C60-Fullerene.pdf
http://www.gizmag.com/diet-buckyballs-extending-lifespan/22245/
What is a buckyball and where does it get its name? Well, here’s the
answer:
C(60) fullerene is a naturally occurring molecule containing 60 carbon
atoms arranged in a sphere. It is famously known as the buckyball,
short for buckminsterfullerene, and discovered in 1985.
The experiment pointing to buckyball olive oil as a potential fountain
of youth included giving the mixture to rats to see if it had any
toxic side effects. They used three groups of rats. One was a
control group given nothing but normal food and water, the second was
given plain olive oil and the third olive oil and buckballs. The
findings surprised everyone. The control group had the shortest
lifespan of 17 to 37 months. The olive oil group’s life span increased
to 36 to 57 months and the buckyball in olive oil group lived 59 to 66
months.
Even though the olive oil group had an increased lifespan, you would
have to add the equivalent of eight tablespoons of uncooked olive oil
to your daily diet. That’s a lot of olive oil. The buckyball olive oil
had a concentration of 0.8 mg/ml of C-60 buckyballs. It was
administered in daily doses of 1.7mg/kg of body weight.
The results show that a the buckyball mixture could have applications
not just in increasing our lifespans but also in the treatment of
cancer and neuro degenerative problems. Unfortunately, rats are an
early stage of testing so who knows how many years or decades it will
take before it actually reaches human testing, the precursor to
allowing it to be prescribed or sold as a supplement or medication.
Because the mixture has not shown any negative side effects and
remarkably positive effects as far as longevity and preventive
properties, it may actually move more quickly through the testing
process than other substances. For those enduring excruciating cancer
treatments and neurological issues, it can’t come quick enough.
Be Sociable, Share!
<snip>
Their abstract:
http://www.ncbi.nlm.nih.gov/pubmed/22498298
Biomaterials. 2012 Jun;33(19):4936-46. Epub 2012 Apr 10.
The prolongation of the lifespan of rats by repeated oral
administration of [60]fullerene.
Baati T, Bourasset F, Gharbi N, Njim L, Abderrabba M, Kerkeni A,
Szwarc H, Moussa F.
Source
UMR CNRS 8612, Faculté de Pharmacie, Université Paris Sud XI, Rue J-B
Clément-F92296, Châtenay-Malabry, France; Unité Elements Trace et
Antioxydants, Laboratoire de Biophysique and Service d'anatomie et de
Cytologie Pathologiques, CHU de Médecine de Monastir, 5000, Tunisie.
Abstract
Countless studies showed that [60]fullerene (C(60)) and derivatives
could have many potential biomedical applications. However, while
several independent research groups showed that C(60) has no acute or
sub-acute toxicity in various experimental models, more than 25 years
after its discovery the in vivo fate and the chronic effects of this
fullerene remain unknown. If the potential of C(60) and derivatives in
the biomedical field have to be fulfilled these issues must be
addressed. Here we show that oral administration of C(60) dissolved in
olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight)
to rats not only does not entail chronic toxicity but it almost
doubles their lifespan. The effects of C(60)-olive oil solutions in an
experimental model of CCl(4) intoxication in rat strongly suggest that
the effect on lifespan is mainly due to the attenuation of age-
associated increases in oxidative stress. Pharmacokinetic studies show
that dissolved C(60) is absorbed by the gastro-intestinal tract and
eliminated in a few tens of hours. These results of importance in the
fields of medicine and toxicology should open the way for the many
possible -and waited for- biomedical applications of C(60) including
cancer therapy, neurodegenerative disorders, and ageing.
PMID: 22498298
http://en.wikipedia.org/wiki/Buckyball
Buckminsterfullerene (or buckyball) is a spherical fullerene molecule
with the formula C60. It is a cage-like fused-ring structure
(Truncated icosahedron) which resembles a soccer ball, made of twenty
hexagons and twelve pentagons, with a carbon atom at the vertices of
each polygon and a bond along each polygon edge.
<snip>
http://en.wikipedia.org/wiki/Buckyball#Applications
Applications
C60 molecules can encage and transport atoms and molecules (e.g.
radioactive labels) through the human body. For instance, lanthanum
carbide (LaC2), which reacts very strongly with water vapor and oxygen
and rapidly degrades in air, has been successfully protected inside
C60 molecules for more than six months.[10]
In the medical field, elements such as helium (that can be detected in
minute quantities) can be used as chemical tracers in impregnated
buckyballs. Buckminsterfullerene could also inhibit the HIV virus. The
C60 molecule could block the active site in a key enzyme in the human
immunodeficiency virus known as HIV-1 protease; this could inhibit
reproduction of the HIV virus in immune cells. Experiments suggest
that C60 incorporated with the alkali metals can possess catalytic
properties resembling those of platinum.[10]
The C60 molecule can also bind large numbers of hydrogen atoms (up to
one hydrogen for each carbon) without disrupting the structure. This
property suggests that C60 may be a better storage medium for hydrogen
than metal hydrides (currently regarded as the best material for that
purpose), and hence a key factor in the development of a new class
battery or even non-polluting automobiles based on fuel cells, lighter
and more efficient than lead-acid batteries.[10]
The optical absorption properties of C60 match solar spectrum that
favors C60-based films for photovoltaic applications. Conversion
efficiencies up to 5.7% have been reported in C60-polymer cells.[47]
<snip>
I noticed in Bob Park's WHAT's NEW a helium situation developing ...
www.bobpark.org
WHAT’S NEW Robert L. Park Friday, 18 May 2012 Washington, DC
[...] 3. HELIUM CRISIS: THE WORLD IS RUNNING OUT OF HELIUM.
Physicists, it must be acknowledged, have a certain reverence for
"helium,"
the second element in the periodic table, without which the 20th
century
revolution in physics would never have taken place. There is no
substitute
and the supply is nonrenewable. Helium exists on Earth today only as
a
product of radioactive decay of heavy nuclei in the crust of our
nascent
planet. It accumulated in the same underground geologic formations
that
trap natural gas (methane). At a maximum concentration of 2.7%,
natural-gas
wells represent the only practical large-scale source of helium.
North
America has more helium than any other region of the world, but is
also by
far the biggest consumer. When it's gone, it will be gone forever –
unless
we succeed in generating power by deuterium fusion. In that case
helium may
again be abundant, but that day is a long way off. In 1925 a Federal
Helium Reserve was created in Amarillo, TX as a strategic supply of
gas for
airships. By the 1950s helium had become essential to electronics
development but huge amounts were being squandered by NASA on low
priority
tasks such as purging the fuel tanks of shuttle rockets. However,
most
members of Congress remain unaware of its use for anything other than
inflating party balloons. Over the objections of the American
Physical
Society, which urged an increase in the helium reserve, the 1996
Helium
Preservation Act ordered the Interior Department to liquidate the
Federal
Helium Reserve by 2015. What then?
<snip>
Give more license to FRACK if they cracker-jack the extra Helium to
the US Gov?
Will obama or romney comply?
Or fart out another LIE? Get them some arginine and lysine? For Bill
for sure.. LoL
OK so i'm getting preaky time... two hours and counting...
Can I'll have another do it again TODAY and then do a
http://en.wikipedia.org/wiki/Triple_Crown_of_Thoroughbred_Racing#United_States_Triple_Crowns
Got to cheer for :
http://en.wikipedia.org/wiki/I%27ll_Have_Another
Yet Zayat's Bodemeister could make a come back in the next duo?
http://en.wikipedia.org/wiki/Bodemeister
I see Zayat's TWO Motorhomes in the Stables and xyz said they've got a
h2O hookup to the laundry room for jockey's... LoL
Alright a nice shower before the race in case they WIN is in the
cards.. <G>
Good thing there isn't smell-OH-vision in our TV's... <W>
http://en.wikipedia.org/wiki/Ahmed_Zayat
Race Horses have bone problems...
How about psoriatics?
Here's a new one:
http://www.ncbi.nlm.nih.gov/pubmed/22592745
Curr Rheumatol Rep. 2012 May 17.
Altered Bone Biology in Psoriatic Arthritis.
Rahimi H, Ritchlin CT.
Source
Department of Pediatrics, Division of Rheumatology, University of
Rochester Medical Center, 601 Elmwood Avenue, Box 777, Rochester, NY,
14642, USA, homaira...@urmc.rochester.edu.
Abstract
Psoriatic arthritis (PsA) is characterized by focal bone erosions
mediated by osteoclasts at the bone-pannus junction. The bulk of
research over the past decade has centered on mechanisms that underlie
osteoclastogenesis along with new insights into osteoimmunology;
however, recent advances that focus on steps that lead to new bone
formation are beginning to emerge. New revelations about bone
formation may have direct relevance to PsA given the presence of
enthesophytes, syndesmophytes, and bony ankylosis frequently observed
in patients with this disorder. In this review, we discuss current
developments in the pathogenesis of new bone formation, novel imaging
approaches to study bone remodeling and highlight innovative
approaches to study the effect of inflammation on bone. Lastly, we
discuss promising therapies that target joint inflammation and
osteitis with the potential to mediate pathologic bone formation.
PMID: 22592745
And since Horses eat GREENS rich in vitamin K2 ... why don't WE?
Only 3 hits:
http://www.ncbi.nlm.nih.gov/pubmed?term=bone%20erosion%20vitamin%20K2
#1 of 3
http://www.ncbi.nlm.nih.gov/pubmed/20556371
Effects of vitamin K2 on cortical and cancellous bone mass, cortical
osteocyte and lacunar system, and porosity in sciatic neurectomized
rats.
Iwamoto J, Matsumoto H, Takeda T, Sato Y, Yeh JK.
Calcif Tissue Int. 2010 Sep;87(3):254-62. Epub 2010 Jun 17.
PMID: 20556371
Oh well... eat greens and miso (natto)
http://en.wikipedia.org/wiki/Nattokinase
And exercise...
I best do that now as i'm getting excited...preakness excited.
Must ....try to RELAX... or i'll come in LAST?
Baffert has won Two RACES so FAR today... will he GET the BIG ONE?
So stint for his STENT.
Without that stent he might not BE THERE TODAY... if you get my drift.
And Body would grow up in a shadow... without...
A doubt?
45 pic's on this Baltimore LINK for the Preakness
http://darkroom.baltimoresun.com/2012/05/a-preakness-primer-137-years-of-horses-hats-and-high-society/#1
pic's # 22 23... dick and pat nixon # 33 sony bono #39 ...#45 says it
ALL... LoL
randall... How FAST was that? Is this the YEAR of a new TriPle
Crown? Will SEE...Soon!
If you have some buckyballs hold on to them... you might wanna double
the life span of a RAT?
Or you? Or your derby, preakness horse?
Will it, or COULD it win a triPle crown? Can they detect athletes
with buckyballs in their system?
If you do the Preakness today...Pimilico Race track in Baltimore is
the place to play and RACE..
http://www.pimlico.com/
or horse AROUND?
Yep...82 degrees F and cloudy i see....
But..
Don't go gaga on alcohol:
And while I'LL have Another is the Favorite... don't be saying that
for Beer/wine/cocktails...to OFTEN...
and if psor... say NO MORE....
http://www.ncbi.nlm.nih.gov/pubmed/22594656
Expert Opin Drug Metab Toxicol. 2012 May 17.
The effects of alcohol on the metabolism and toxicology of anti-
psoriasis drugs.
Vena GA, Cassano N.
Source
University of Bari, Department of Biomedical Sciences and Human
Oncology, Unit of Dermatology and Venereology , Bari , Italy +39 080
5478920 ; +39 080 5478920 ; g.v...@dermatologia.uniba.it.
Abstract
Introduction: Alcohol has long been suspected to be a triggering and
precipitating factor of psoriasis. Alcohol misuse is common in
patients with moderate-to-severe psoriasis and appears to impair
treatment outcome. Areas covered: In this article, the authors review
the available data regarding the metabolic and toxicological
interactions between anti-psoriasis systemic drugs and ethanol and/or
alcoholic beverages. Special attention is given to the influence of
alcohol consumption on the hepatotoxic risk of some anti-psoriasis
drugs. The article was prepared using a MEDLINE literature search.
Expert opinion: The available knowledge highlights the existence of a
few significant pharmacological interactions, such as the reduced
exposure to cyclosporine by red wine, the possible increase of
cyclosporine levels following a heavy acute alcohol intake, and,
especially, the conversion of acitretin to etretinate, in the presence
of ethanol, with important implications in females of child-bearing
potential. There are limited data on the contributing role of alcohol
in the hepatotoxicity induced by some anti-psoriasis drugs and the
existing information on this topic is still controversial. However,
further investigation is needed to assess the relevance of
interactions between alcohol consumption and drug therapy for
psoriasis, under both pharmacological and toxicological perspectives.
Long-term prospective studies on large cohorts of patients are
warranted to disclose the actual significance of such potential
interactions in clinical practice.
PMID: 22594656
WE are up to 646 hits for:
alcohol + psoria* - pubmed:
http://www.ncbi.nlm.nih.gov/pubmed?term=psoria*%20alcohol
#1 of 646 is above.
OTOH a little bit of alcohol like maybe in mouth wash might be the
ticket?
If Jeanne Calment, who lived to 122 1/2 had buckyBALLS in her daily
EVOO, would she have lived to 144 or more?
What's a BuckyBALL?
Apparently it's added to your OLIVE oil.
And we know Jeanne sucked down EVOO like she ate her two pounds of
chocolate per week:
http://en.wikipedia.org/wiki/Jeanne_calment#Health_and_lifestyle
[...] Calment ascribed her longevity and relatively youthful
appearance for her age to olive oil, which she said she poured on all
her food[4] and rubbed onto her skin, as well as a diet of port wine,
and ate nearly one kilogram of chocolate every week.
<snip>
OTOH she smoked no more then two cigarettes per day and drank a glass
of port or two?
Did the cigs & low dose alcohol cause a hormetic effect?
Don't know, but may have mitichondria via endoplasmic reticulum erap1
gene ramifications? Have to check that idea.
http://en.wikipedia.org/wiki/Hormesis#Mitochondria
And Her low dose alcohol may have also turned on longevity sirtuin
(sirt1) genes or pde4 inhibitors?
http://en.wikipedia.org/wiki/Hormesis#Alcohol
[....] In 2012, researchers at UCLA found that tiny amounts (1 mM, or
0.005%) of ethanol doubled the lifespan of Caenorhabditis elegans, a
round worm frequently used in biological studies. Higher doses of 0.4%
provided no longevity benefit.
Links:
full text:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029984
or
http://www.ncbi.nlm.nih.gov/pubmed/22279556
Caenorhabditis elegans battling starvation stress: low levels of
ethanol prolong lifespan in L1 larvae.
Castro PV, Khare S, Young BD, Clarke SG.
PLoS One. 2012;7(1):e29984. Epub 2012 Jan 18.
PMID: 22279556
Free full TEXT PMC Article
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22279556/?tool=pubmed
So don't BE a typical psoriatic hOOKED on drinking to FEEL GOOD.
The Yin YANG high and LOW are to extreme... to handle... DUH!
Same...
With any drugs, LSD, Mushrooms, peyote, ibogaine, kykeon, ergot on
rye, one must be extremely cautious.
see:
caveats on usage of dangerous substances:
http://en.wikipedia.org/wiki/File:HarmCausedByDrugsTable.jpg
DANGER WILL Robinson! LoL
You might expand your mind behind the wombuverse and perverse the
inverse to the crocodile.
And becareful of O2, Nitric Oxide and cGMP release and the blue pill
(viagra) in terms of:
http://en.wikipedia.org/wiki/Erotic_asphyxiation
We might have LOST Mister Kung Fu due to it:
http://en.wikipedia.org/wiki/Erotic_asphyxiation#Famous_cases
And I KNOW ONE of you.... with a penchant for.... oh.. nevermind you
know who you ARE... LOL
OTOH maybe the skin would clear... or you might not care with LSD and
viagra (cGMP) and O2 deprivation (hypoxic conditions- temporary of
course or you become kung fu man with a sticky wicket? LOL) and B5,
Nicotinamide, Nitric oxide (NicOx), blocking Candidiasis in colon,
etc...
Could be a better exit then Leary, kung fu (david Carradine) and
Socrates?
Pass the hemPlock? Er, er, er, hemlock:
http://en.wikipedia.org/wiki/Conium
Conium ( /koʊˈnaɪ.əm/ or /ˈkoʊniəm/) is a genus of two species of
highly poisonous perennial herbaceous flowering plants in the family
Apiaceae, native to Europe and the Mediterranean region as Conium
maculatum, and to southern Africa as Conium chaerophylloides.
Decidedly unsuspicious?
http://upload.wikimedia.org/wikipedia/commons/b/b2/Conium.jpg
<snip>
Oh, oh, i've got some of these going off the last few days:
http://www.epies.net/images/american%20sweetheart%20best%20%20300.jpg
http://www.anniesannuals.com/signs/d%20-%20g/images/epiphyllum_king_midas_cl.jpg
Orange, reddish and very pretty...
<snip>
About that hemP... maybe for blocking omega-6 but not omega-3 and what
about ppar?
http://www.ncbi.nlm.nih.gov/pubmed/22606335
PLoS One. 2012;7(5):e37097. Epub 2012 May 14.
Skin-Targeted Inhibition of PPAR β/δ by Selective Antagonists to Treat
PPAR β/δ - Mediated Psoriasis-Like Skin Disease In Vivo.
Hack K, Reilly L, Palmer C, Read KD, Norval S, Kime R, Booth K,
Foerster J.
Source
Medical Research Institute, College of Medicine, Dentistry, and
Nursing, University of Dundee, Dundee, Scotland.
Abstract
We have previously shown that peroxisome proliferator activating
receptor ß/δ (PPAR β/δ is overexpressed in psoriasis. PPAR β/δ is not
present in adult epidermis of mice. Targeted expression of PPAR β/δ
and activation by a selective synthetic agonist is sufficient to
induce an inflammatory skin disease resembling psoriasis. Several
signalling pathways dysregulated in psoriasis are replicated in this
model, suggesting that PPAR β/δ activation contributes to psoriasis
pathogenesis. Thus, inhibition of PPAR β/δ might harbour therapeutical
potential. Since PPAR β/δ has pleiotropic functions in metabolism,
skin-targeted inhibition offer the potential of reducing systemic
adverse effects. Here, we report that three selective PPAR β/δ
antagonists, GSK0660, compound 3 h, and GSK3787 can be formulated for
topical application to the skin and that their skin concentration can
be accurately quantified using ultra-high performance liquid
chromatography (UPLC)/mass spectrometry. These antagonists show
efficacy in our transgenic mouse model in reducing psoriasis - like
changes triggered by activation of PPAR β/δ. PPAR β/δ antagonists
GSK0660 and compound 3 do not exhibit systemic drug accumulation after
prolonged application to the skin, nor do they induce inflammatory or
irritant changes. Significantly, the irreversible PPAR β/δ antagonist
(GSK3787) retains efficacy when applied topically only three times per
week which could be of practical clinical usefulness. Our data suggest
that topical inhibition of PPAR β/δ to treat psoriasis may warrant
further exploration.
PMID: 22606335
ONLY 47 hits: ppar + psoria* -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=psoria*%20ppar
188 hits - oleic + ppar -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=oleic%20ppar
#3 of 188
Mulberry extracts (the answer?)
http://www.ncbi.nlm.nih.gov/pubmed/22002411
[...] pmid: 22002411
Nope.. zero hits..LOL
http://www.ncbi.nlm.nih.gov/pubmed?term=mulberry%20psoria*
What time is it? LOL
Is it preakness ? Time?
Time to eat and slather EVOO?
And since Jeanne did a liter or more per week of EVOO, i'm guessing.
We return to something you will find hard to overdo or even get close
to consuming.
http://en.wikipedia.org/wiki/Olive_oil
http://en.wikipedia.org/wiki/Oleic_acid
http://en.wikipedia.org/wiki/Omega-9_fatty_acid
EVOO good for borborygmus
http://en.wikipedia.org/wiki/Borborygmus
http://en.wikipedia.org/wiki/Borborygmus#Diseases_and_conditions
http://tech.blorge.com/Structure:%20/2012/05/19/for-a-longer-life-take-buckyballs-in-olive-oil/
For a longer life take buckyballs in olive oilMay 19, 2012
by Susan Wilson
Yes, that may actually be the secret to a doubled lifespan if it works
as well in people as it does in rats. Of course the process is very
complicated and requires huge amounts of equipment so if it does turn
out that it works on humans like it works on rats, expect it to cost a
fortune.
According to articles in Extreme Longevity and Gizmag, buckyballs
dissolved in olive oil may just be the magic elixir that everyone has
been looking for. Scientists thought that it could have a wide variety
of positive uses. They suspected that buckyballs could have “UV and
radioprotection, antiviral, antioxidant, and anti-amyloid activities,
allergic response and angiogenesis inhibitions, immune stimulating and
antitumour effects, enhancing effect on neurite outgrowth, gene
delivery, and even hair-growing activity.” In other words, it could be
the source of improved health.
http://extremelongevity.net/2012/04/16/chronic-buckyball-administration-doubles-rat-lifespan/
http://extremelongevity.net/wp-content/uploads/C60-Fullerene.pdf
http://www.gizmag.com/diet-buckyballs-extending-lifespan/22245/
What is a buckyball and where does it get its name? Well, here’s the
answer:
C(60) fullerene is a naturally occurring molecule containing 60 carbon
atoms arranged in a sphere. It is famously known as the buckyball,
short for buckminsterfullerene, and discovered in 1985.
The experiment pointing to buckyball olive oil as a potential fountain
of youth included giving the mixture to rats to see if it had any
toxic side effects. They used three groups of rats. One was a
control group given nothing but normal food and water, the second was
given plain olive oil and the third olive oil and buckballs. The
findings surprised everyone. The control group had the shortest
lifespan of 17 to 37 months. The olive oil group’s life span increased
to 36 to 57 months and the buckyball in olive oil group lived 59 to 66
months.
Even though the olive oil group had an increased lifespan, you would
have to add the equivalent of eight tablespoons of uncooked olive oil
to your daily diet. That’s a lot of olive oil. The buckyball olive oil
had a concentration of 0.8 mg/ml of C-60 buckyballs. It was
administered in daily doses of 1.7mg/kg of body weight.
The results show that a the buckyball mixture could have applications
not just in increasing our lifespans but also in the treatment of
cancer and neuro degenerative problems. Unfortunately, rats are an
early stage of testing so who knows how many years or decades it will
take before it actually reaches human testing, the precursor to
allowing it to be prescribed or sold as a supplement or medication.
Because the mixture has not shown any negative side effects and
remarkably positive effects as far as longevity and preventive
properties, it may actually move more quickly through the testing
process than other substances. For those enduring excruciating cancer
treatments and neurological issues, it can’t come quick enough.
Be Sociable, Share!
<snip>
Their abstract:
http://www.ncbi.nlm.nih.gov/pubmed/22498298
Biomaterials. 2012 Jun;33(19):4936-46. Epub 2012 Apr 10.
The prolongation of the lifespan of rats by repeated oral
administration of [60]fullerene.
Baati T, Bourasset F, Gharbi N, Njim L, Abderrabba M, Kerkeni A,
Szwarc H, Moussa F.
Source
UMR CNRS 8612, Faculté de Pharmacie, Université Paris Sud XI, Rue J-B
Clément-F92296, Châtenay-Malabry, France; Unité Elements Trace et
Antioxydants, Laboratoire de Biophysique and Service d'anatomie et de
Cytologie Pathologiques, CHU de Médecine de Monastir, 5000, Tunisie.
Abstract
Countless studies showed that [60]fullerene (C(60)) and derivatives
could have many potential biomedical applications. However, while
several independent research groups showed that C(60) has no acute or
sub-acute toxicity in various experimental models, more than 25 years
after its discovery the in vivo fate and the chronic effects of this
fullerene remain unknown. If the potential of C(60) and derivatives in
the biomedical field have to be fulfilled these issues must be
addressed. Here we show that oral administration of C(60) dissolved in
olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight)
to rats not only does not entail chronic toxicity but it almost
doubles their lifespan. The effects of C(60)-olive oil solutions in an
experimental model of CCl(4) intoxication in rat strongly suggest that
the effect on lifespan is mainly due to the attenuation of age-
associated increases in oxidative stress. Pharmacokinetic studies show
that dissolved C(60) is absorbed by the gastro-intestinal tract and
eliminated in a few tens of hours. These results of importance in the
fields of medicine and toxicology should open the way for the many
possible -and waited for- biomedical applications of C(60) including
cancer therapy, neurodegenerative disorders, and ageing.
PMID: 22498298
http://en.wikipedia.org/wiki/Buckyball
Buckminsterfullerene (or buckyball) is a spherical fullerene molecule
with the formula C60. It is a cage-like fused-ring structure
(Truncated icosahedron) which resembles a soccer ball, made of twenty
hexagons and twelve pentagons, with a carbon atom at the vertices of
each polygon and a bond along each polygon edge.
<snip>
http://en.wikipedia.org/wiki/Buckyball#Applications
Applications
C60 molecules can encage and transport atoms and molecules (e.g.
radioactive labels) through the human body. For instance, lanthanum
carbide (LaC2), which reacts very strongly with water vapor and oxygen
and rapidly degrades in air, has been successfully protected inside
C60 molecules for more than six months.[10]
In the medical field, elements such as helium (that can be detected in
minute quantities) can be used as chemical tracers in impregnated
buckyballs. Buckminsterfullerene could also inhibit the HIV virus. The
C60 molecule could block the active site in a key enzyme in the human
immunodeficiency virus known as HIV-1 protease; this could inhibit
reproduction of the HIV virus in immune cells. Experiments suggest
that C60 incorporated with the alkali metals can possess catalytic
properties resembling those of platinum.[10]
The C60 molecule can also bind large numbers of hydrogen atoms (up to
one hydrogen for each carbon) without disrupting the structure. This
property suggests that C60 may be a better storage medium for hydrogen
than metal hydrides (currently regarded as the best material for that
purpose), and hence a key factor in the development of a new class
battery or even non-polluting automobiles based on fuel cells, lighter
and more efficient than lead-acid batteries.[10]
The optical absorption properties of C60 match solar spectrum that
favors C60-based films for photovoltaic applications. Conversion
efficiencies up to 5.7% have been reported in C60-polymer cells.[47]
<snip>
I noticed in Bob Park's WHAT's NEW a helium situation developing ...
www.bobpark.org
WHAT’S NEW Robert L. Park Friday, 18 May 2012 Washington, DC
[...] 3. HELIUM CRISIS: THE WORLD IS RUNNING OUT OF HELIUM.
Physicists, it must be acknowledged, have a certain reverence for
"helium,"
the second element in the periodic table, without which the 20th
century
revolution in physics would never have taken place. There is no
substitute
and the supply is nonrenewable. Helium exists on Earth today only as
a
product of radioactive decay of heavy nuclei in the crust of our
nascent
planet. It accumulated in the same underground geologic formations
that
trap natural gas (methane). At a maximum concentration of 2.7%,
natural-gas
wells represent the only practical large-scale source of helium.
North
America has more helium than any other region of the world, but is
also by
far the biggest consumer. When it's gone, it will be gone forever –
unless
we succeed in generating power by deuterium fusion. In that case
helium may
again be abundant, but that day is a long way off. In 1925 a Federal
Helium Reserve was created in Amarillo, TX as a strategic supply of
gas for
airships. By the 1950s helium had become essential to electronics
development but huge amounts were being squandered by NASA on low
priority
tasks such as purging the fuel tanks of shuttle rockets. However,
most
members of Congress remain unaware of its use for anything other than
inflating party balloons. Over the objections of the American
Physical
Society, which urged an increase in the helium reserve, the 1996
Helium
Preservation Act ordered the Interior Department to liquidate the
Federal
Helium Reserve by 2015. What then?
<snip>
Give more license to FRACK if they cracker-jack the extra Helium to
the US Gov?
Will obama or romney comply?
Or fart out another LIE? Get them some arginine and lysine? For Bill
for sure.. LoL
OK so i'm getting preaky time... two hours and counting...
Can I'll have another do it again TODAY and then do a
http://en.wikipedia.org/wiki/Triple_Crown_of_Thoroughbred_Racing#United_States_Triple_Crowns
Got to cheer for :
http://en.wikipedia.org/wiki/I%27ll_Have_Another
Yet Zayat's Bodemeister could make a come back in the next duo?
http://en.wikipedia.org/wiki/Bodemeister
I see Zayat's TWO Motorhomes in the Stables and xyz said they've got a
h2O hookup to the laundry room for jockey's... LoL
Alright a nice shower before the race in case they WIN is in the
cards.. <G>
Good thing there isn't smell-OH-vision in our TV's... <W>
http://en.wikipedia.org/wiki/Ahmed_Zayat
Race Horses have bone problems...
How about psoriatics?
Here's a new one:
http://www.ncbi.nlm.nih.gov/pubmed/22592745
Curr Rheumatol Rep. 2012 May 17.
Altered Bone Biology in Psoriatic Arthritis.
Rahimi H, Ritchlin CT.
Source
Department of Pediatrics, Division of Rheumatology, University of
Rochester Medical Center, 601 Elmwood Avenue, Box 777, Rochester, NY,
14642, USA, homaira...@urmc.rochester.edu.
Abstract
Psoriatic arthritis (PsA) is characterized by focal bone erosions
mediated by osteoclasts at the bone-pannus junction. The bulk of
research over the past decade has centered on mechanisms that underlie
osteoclastogenesis along with new insights into osteoimmunology;
however, recent advances that focus on steps that lead to new bone
formation are beginning to emerge. New revelations about bone
formation may have direct relevance to PsA given the presence of
enthesophytes, syndesmophytes, and bony ankylosis frequently observed
in patients with this disorder. In this review, we discuss current
developments in the pathogenesis of new bone formation, novel imaging
approaches to study bone remodeling and highlight innovative
approaches to study the effect of inflammation on bone. Lastly, we
discuss promising therapies that target joint inflammation and
osteitis with the potential to mediate pathologic bone formation.
PMID: 22592745
And since Horses eat GREENS rich in vitamin K2 ... why don't WE?
Only 3 hits:
http://www.ncbi.nlm.nih.gov/pubmed?term=bone%20erosion%20vitamin%20K2
#1 of 3
http://www.ncbi.nlm.nih.gov/pubmed/20556371
Effects of vitamin K2 on cortical and cancellous bone mass, cortical
osteocyte and lacunar system, and porosity in sciatic neurectomized
rats.
Iwamoto J, Matsumoto H, Takeda T, Sato Y, Yeh JK.
Calcif Tissue Int. 2010 Sep;87(3):254-62. Epub 2010 Jun 17.
PMID: 20556371
Oh well... eat greens and miso (natto)
http://en.wikipedia.org/wiki/Nattokinase
And exercise...
I best do that now as i'm getting excited...preakness excited.
Must ....try to RELAX... or i'll come in LAST?
Baffert has won Two RACES so FAR today... will he GET the BIG ONE?
So stint for his STENT.
Without that stent he might not BE THERE TODAY... if you get my drift.
And Body would grow up in a shadow... without...
A doubt?
45 pic's on this Baltimore LINK for the Preakness
http://darkroom.baltimoresun.com/2012/05/a-preakness-primer-137-years-of-horses-hats-and-high-society/#1
pic's # 22 23... dick and pat nixon # 33 sony bono #39 ...#45 says it
ALL... LoL
randall... How FAST was that? Is this the YEAR of a new TriPle
Crown? Will SEE...Soon!
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