Black pepper can help skin problems

[Julie Bove]

Although it does not say that it will help P, it does say that it can help
vitiligo. I find this to be interesting. I never ate black pepper as a
child and probably very little as a young adult. My parents were just not
into seasonings. But at some point I realized that I not only liked it when
coarsely and freshly ground but I REALLY liked it. So now I eat tons of it!
I have to put less in foods that I cook for my family. But if I'm making
something just for me, I put enough in there to give it a nice bite. So
perhaps this is why I no longer have the vitiligo?

http://suite101.com/article/the-top-ten-health-benefits-of-black-pepper-a193900

[randall]

> http://suite101.com/article/the-top-ten-health-benefits-of-black-pepp...


Julie,


I like where you've gone with paleodiet and now piper nigrum.

Wait? Paleodiet was skeats iirc NOW...

anyway

Thus:
http://en.wikipedia.org/wiki/Piperine

Does the metaphor fit TAOISM with WHITE SALT and Black PEPPER?


Maybe for color... and nothing more...

But does the yin yang hold TRUE?

Of course not.. LOL

Because how does white and GREEN, not to mention orange, red and PINK,
pepper fit this yin yang equation?
http://en.wikipedia.org/wiki/Black_pepper

They don't fit anything now that i'm trying to tHINK yin yangy....<w>

So is the treatment for vitiligo the same as any autoimmune condition?

I'll TRY.

seven hits: piperine + immune (zero hits for autoimmune) -pubmed
http://www.ncbi.nlm.nih.gov/pubmed/?term=piperine+immune

Hit #1 of 7 (PMID: 23531279 ) no further help for caloric restriction
with curcumin/piperine consumption.

So much for pepper and curcumin on zero food or LOW food
consumption... yikes?

What or why?


Less SODIUM and more black PEPPER?

Seems like a YeS.. but most foods we eat with black pepper are
ENHANCED flavor wise with MORE salt (sodium).

So ... ?

#2 of 7 says it does help inhibit IL-2 and IFN-γ production :

http://www.ncbi.nlm.nih.gov/pubmed/22535397
Genet Mol Res. 2012 Mar 14;11(1):617-27. doi: 10.4238/2012.March.14.5.
Piperine inhibits cytokine production by human peripheral blood
mononuclear cells.

[...] Piperine inhibited IL-2 and IFN-γ production in the PBMCs. RT-
PCR data indicated that IL-2 and IFN-γ mRNA expression in PBMCs is
suppressed by piperine. This compound significantly inhibited the
production of these two cytokines by activated PBMCs in a dose-
dependent manner. In conclusion, piperine appears to have potential as
an immunomodulatory agent for immune system suppression.
PMID: 22535397
Free full text


Let's pubmed and psor newsgroup it!


4 hits : piperine + vitiligo - pubmed
http://www.ncbi.nlm.nih.gov/pubmed/?term=vitiligo+piperine


Let the SUN SHINE and eat some black pepper on your taco? Or salad or
veggies or or or...?


#1 of 4

http://www.ncbi.nlm.nih.gov/pubmed/18284389
Br J Dermatol. 2008 May;158(5):941-50. doi: 10.1111/j.
1365-2133.2008.08464.x. Epub 2008 Feb 16.
In vivo evaluation of piperine and synthetic analogues as potential
treatments for vitiligo using a sparsely pigmented mouse model.
[...] Treatment with PIP, THP or rCHP and UVR induced a marked
pigmentation response in HRA/Skh-II mice, with clinically better
results than UVR alone. This result supports the potential use of
these compounds in treating vitiligo.
PMID: 18284389

#2 of 4

http://www.ncbi.nlm.nih.gov/pubmed/17430636
J Pharm Pharmacol. 2007 Apr;59(4):529-36.
Amides from Piper nigrum L. with dissimilar effects on melanocyte
proliferation in-vitro.
Lin Z, Liao Y, Venkatasamy R, Hider RC, Soumyanath A.

[...] Abstract
Melanocyte proliferation stimulants are of interest as potential
treatments for the depigmentary skin disorder, vitiligo. Piper nigrum
L. (Piperaceae) fruit (black pepper) water extract and its main
alkaloid, piperine (1), promote melanocyte proliferation in-vitro. A
crude chloroform extract of P. nigrum containing piperine was more
stimulatory than an equivalent concentration of the pure compound,
suggesting the presence of other active components. [...] Only those
compounds also possessing an amide group were active, although the
amino component of the amide group and chain linking it to the
methylenedioxyphenyl group can vary. P. nigrum, therefore, contains
several amides with the ability to stimulate melanocyte proliferation.
This finding supports the traditional use of P. nigrum extracts in
vitiligo and provides new lead compounds for drug development for this
disease.
PMID: 17430636

#3 of 4:

http://www.ncbi.nlm.nih.gov/pubmed/17387768
Photochem Photobiol. 2006 Nov-Dec;82(6):1541-8.
UV irradiation affects melanocyte stimulatory activity and protein
binding of piperine.

Soumyanath A, Venkatasamy R, Joshi M, Faas L, Adejuyigbe B, Drake AF,
Hider RC, Young AR.

Source
Department of Pharmacy, King's College London, Franklin-Wilkins
Building, 150 Stamford Street, London SE1 9NN, UK. soum...@ohsu.edu

Abstract
Piperine, the major alkaloid of black pepper (Piper nigrum L.;
Piperaceae), stimulates melanocyte proliferation and dendrite
formation in vitro. This property renders it a potential treatment for
the skin depigmentation disorder vitiligo. However, piperine does not
stimulate melanin synthesis in vitro, and treatments based on this
compound may therefore be more effective with concomitant exposure of
the skin to ultraviolet (UV) radiation or sunlight. The present study
investigated the effect of UVA and simulated solar radiation (SSR) on
the chemical stability of piperine, its melanocyte stimulatory effects
and its ability to bind protein and DNA. Chromatographic and
spectroscopic analysis confirmed the anticipated photoisomerization of
irradiated piperine and showed the absence of any hydrolysis to
piperinic acid. Isomerization resulted in the loss of ability to
stimulate proliferation of a mouse melanocyte cell line, and to bind
to human serum albumin. There was no evidence of DNA binding by
piperine either before or after irradiation, showing the absence of
photoadduct formation by either piperine or its geometric isomers.
This is unlike the situation with psoralens, which form DNA adducts
when administered with UVA in treating skin diseases. The present
study suggests that exposure to bright sunlight should be avoided both
during active application of piperine to the skin and in the storage
of piperine products. If UVA radiation is used with piperine in the
treatment of vitiligo, application of the compound and irradiation
should be staggered to minimize photoisomerization. This approach is
shown to effectively induce pigmentation in a sparsely pigmented mouse
strain.

PMID: 17387768



58 hits: piperine - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?hl=en&q=piperine&start=0&hl=en&


3 hits for those who miss SPELLED: peperine - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?hl=en&q=peperine&start=0&scoring=d&hl=en&


And #3 of 3 is this moron who while misspellings (peperine) makes a
TON of cents:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_thread/thread/9026fafe2e73def7/023e9e887768a94b?hl=en&lnk=gst&q=peperine#023e9e887768a94b

This moron even posted this abstract from Sept 2001:

http://www.ncbi.nlm.nih.gov/pubmed/11606014
Eur J Appl Physiol. 2001 Sep;85(5):450-6.
Dietary chloride as a possible determinant of the severity of exercise-
induced asthma.
Mickleborough TD, Gotshall RW, Kluka EM, Miller CW, Cordain L.

[...] These data suggest that both sodium and chloride contribute to
the worsening of EIA symptoms seen after consuming a normal or high
NaCl diet.
PMID: 11606014

How prescient was that to recent sodium scientific findings?

But what are they AGAIN, exactly?

Albeit Asthma being a Th2 skew the inflammation is salient to excess
sodium or not?

asthma + Th2 - 3,946 hits -pubmed
http://www.ncbi.nlm.nih.gov/pubmed/?term=asthma+th2


With Th1 - 1,749 hits -pubmed
http://www.ncbi.nlm.nih.gov/pubmed/?term=asthma+th1

261 hits with Th17 + asthma
http://www.ncbi.nlm.nih.gov/pubmed/?term=asthma+th17


OK so for me.. i'd say that less food consumption without sodium or
black pepper or curcumin is the right thing to do.

But only if i attenuate bad gut flora and raise lactic acid loving gut
flora and hit the crap in the small intestines with L. plantarum.


Now that does work for me. But even if i consume a former negative
diet and do the above i'm still clear anyway.

So much for fiddling with foods and diet.. LOL


randall...

[Julie Bove]

> #2 of 7 says it does help inhibit IL-2 and IFN-� production :

>
> http://www.ncbi.nlm.nih.gov/pubmed/22535397
> Genet Mol Res. 2012 Mar 14;11(1):617-27. doi: 10.4238/2012.March.14.5.
> Piperine inhibits cytokine production by human peripheral blood
> mononuclear cells.
>

> [...] Piperine inhibited IL-2 and IFN-� production in the PBMCs. RT-
> PCR data indicated that IL-2 and IFN-� mRNA expression in PBMCs is

Thanks! I'm not a big salt eater. I mainly only put it on popcorn, baked
potatoes, fries and green salad. I do use it in cooking. Real Salt which
is sea salt. I was gifted a large jar of mixed peppercorns but I just
prefer the black ones.

[randall]

On Apr 1, 8:23 pm, "Julie Bove" <julieb...@frontier.com> wrote:
> randall wrote:
> > On Apr 1, 3:49 am, "Julie Bove" <julieb...@frontier.com> wrote:

> > <large snip>

>
> Thanks!  I'm not a big salt eater.  I mainly only put it on popcorn, baked
> potatoes, fries and green salad.  I do use it in cooking.  Real Salt which
> is sea salt.  I was gifted a large jar of mixed peppercorns but I just
> prefer the black ones.

Julie,

I'm not either. But question what i do use now.

Have i dropped a little bit? 5-10% or so?

Maybe.

What will be the effect on any of these?

http://en.wikipedia.org/wiki/List_of_cutaneous_conditions

And what is the DDx? If multiple conditions?

http://en.wikipedia.org/wiki/Differential_diagnosis

But once again i'm really looking for trigger's first and what
can be done regarding card14 mutation if that is key for me.

Can we unMutate? Or is it due to snp machinations?

Can i balance CD4 + with MORE CD8 + and will the reverse of that help
cancer or hiv/aids?

As to YOU or other's without long term plaque you're
TO ME in that middle RANGE.

http://www.psoriasisrx.com/Plaque_Psoriasis.asp

And THUS most likely key to better understanding of the pathways,
should you respond
to diet or anything that affects my pathways also.

But where in the middle and what does it mean?

Most have no idea. And if it's DDx then it becomes even LESS CLEAR,
as
observed in the group recently.. LOL

I question someONE and say ok what's wet?

If it's pustular then how does that pathway link with plaque for
instance.

http://www.psoriasisrx.com/Pustular_Psoriasis.asp

I did have many atopic dermatitis (Th2 skew) manifestations before
early onset with plaque (Th1 skew).

http://en.wikipedia.org/wiki/Atopic_dermatitis

So what if i run in to a late onset whose main thing is SD?

Then i'm going to wonder why that person, and they could be you, onset
and then worked over it or was led to a lifetime of plaque or xyz.

Sd being
http://en.wikipedia.org/wiki/List_of_cutaneous_conditions#Psoriasis
http://www.psoriasisrx.com/Seborrhoeic_Dermatitis.asp

But is it more like or precisely like
http://www.psoriasisrx.com/Sebopsoriasis.asp

http://en.wikipedia.org/wiki/List_of_cutaneous_conditions#Seborrheic

And what does that mean in terms of a cure and with plaque in mind.

Or does it mean a lifetime of plaque and the road to Erythrodermic
Psoriasis

http://www.psoriasisrx.com/Erythrodermic_Psoriasis.asp

Certainly most people don't end up DEAD due to this one so how
serious would we be if treated to a degree that keeps us mild?

http://en.wikipedia.org/wiki/Erythroderma
Only 8% are due to having psoriasis
http://en.wikipedia.org/wiki/Erythroderma#Causes

And look at side effects as severity does increase.

What if those with severe all have EBV (Epstein Barr) and could be
MILD with
treating the EBV?

http://en.wikipedia.org/wiki/EBV_virus

Certainly seem's the road to hoe if it works.

But hoeing a cement road takes ... guts.. LOL

Or using gut flora if you're me.


anyway.. i hope MY TRIALs which have helped other's with plaque
psoriasis leads to better understandings for what i figure may one day
be a cure regardless of gene's.


randall. .. talking out my SKIN? Actions sPeak..what again?

[randall]

On Apr 2, 12:23 pm, randall <ranhu...@aol.com> wrote:
> On Apr 1, 8:23 pm, "Julie Bove" <julieb...@frontier.com> wrote:
>
> > randall wrote:
> > > On Apr 1, 3:49 am, "Julie Bove" <julieb...@frontier.com> wrote:
> > > <large snip>
>
> > Thanks!  I'm not a big salt eater.  I mainly only put it on popcorn, baked
> > potatoes, fries and green salad.  I do use it in cooking.  Real Salt which
> > is sea salt.  I was gifted a large jar of mixed peppercorns but I just
> > prefer the black ones.
>
> Julie,
>
> I'm not either. But question what i do use now.
>

<large snip>

OK.. after reading this..

I went and found some of the OLD standby stuff from this group.

This link has Pinch.com and daveW site etc.. and npf and more
http://www.dmoz.org/Health/Conditions_and_Diseases/Skin_Disorders/Psoriasis/

Went looking for deaths per year for erythroderma and found nothing..
but
used this link

http://www.rightdiagnosis.com/e/erythroderma/stats.htm

What i recall reading was 300-400 die each year due to loosing ability
to
control internal temps iirc.

But were those only psoriatic or all of these?
http://en.wikipedia.org/wiki/Erythroderma#Causes

Oh well... time will... and actions ... maybe CLEAR ...


randall.. skin topical today. slight clouds and clearings.

[Julie Bove]

I currently have a little patch of something on my right arm near the elbow.
Rough red skin. Not sure if it is P or something else. I do have a variety
of skin problems. Not really annoying or itchy and I only notice it if I
touch the roughened skin. Just putting on a moisturizer when I remember to.