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hypothalamus and NF-kB control immune and ... aging!
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JRStern
May 1, 2013, 11:58:10 PM5/1/13
to
http://www.france24.com/en/20130501-secret-longer-life-may-be-brain-study
01 May 2013 - 19H20
Secret to longer life may be in the brain: study
AFP - Scientists said Wednesday they had found a brain region that
controls physical ageing, and could target it to manipulate the
lifespan of lab mice.
The findings may be a step towards finding the holy grail of slowing
human ageing, but have yet to be tested in human subjects.
The research, published in the journal Nature, implicates the
hypothalamus -- a brain region that regulates growth, reproduction and
metabolism, in the gradual and coordinated bodily deterioration we
call ageing.
Though the brain has long been suspected of orchestrating the process,
this is the first evidence to that effect.
The team said they could speed up or slow down ageing in mice by
activating or inhibiting the brain signalling molecule NF-kB in the
hypothalamus, which in turn affects levels of a hormone called GnRH
that plays a role in the generation of neurons -- the data processing
cells of the brain.
By stimulating NF-kB, they caused a decline in GnRH which led to
impaired neurogenesis and ageing symptoms like muscle weakening, skin
atrophy, bone loss and memory impairment.
NF-kB is generally responsible for regulating the body's response to
inflammation, the New York-based team wrote.
The researchers could also slow ageing in mice by giving them the GnRH
hormone.
"Our study provided interventional strategies to slow down ageing
through targeting the hypothalamus," the study's senior author
Dongsheng Cai, professor of molecular pharmacology at the Albert
Einstein College of Medicine, told AFP by email.
"It can help to slow down ageing, which is already a big breakthrough,
as it can counteract against many ageing-related diseases," he said,
while stipulating: "I don't think ageing could be completely stopped."
Cai said he believed the mouse results would translate into humans,
"though it will need future efforts to develop safe and applicable
approaches to humans."
Commenting on the research, Harvard Medical School experts Dana
Gabuzda and Bruce Yankner said the results, if validated, may have
important implications for treatment of age-related diseases --
particularly those linked to inflammation.
"The idea also raises the intriguing possibility that hypothalamic
regulation could be therapeutically manipulated to have broad effects
on the ageing process," they wrote in Nature.
--
J.
01 May 2013 - 19H20
Secret to longer life may be in the brain: study
AFP - Scientists said Wednesday they had found a brain region that
controls physical ageing, and could target it to manipulate the
lifespan of lab mice.
The findings may be a step towards finding the holy grail of slowing
human ageing, but have yet to be tested in human subjects.
The research, published in the journal Nature, implicates the
hypothalamus -- a brain region that regulates growth, reproduction and
metabolism, in the gradual and coordinated bodily deterioration we
call ageing.
Though the brain has long been suspected of orchestrating the process,
this is the first evidence to that effect.
The team said they could speed up or slow down ageing in mice by
activating or inhibiting the brain signalling molecule NF-kB in the
hypothalamus, which in turn affects levels of a hormone called GnRH
that plays a role in the generation of neurons -- the data processing
cells of the brain.
By stimulating NF-kB, they caused a decline in GnRH which led to
impaired neurogenesis and ageing symptoms like muscle weakening, skin
atrophy, bone loss and memory impairment.
NF-kB is generally responsible for regulating the body's response to
inflammation, the New York-based team wrote.
The researchers could also slow ageing in mice by giving them the GnRH
hormone.
"Our study provided interventional strategies to slow down ageing
through targeting the hypothalamus," the study's senior author
Dongsheng Cai, professor of molecular pharmacology at the Albert
Einstein College of Medicine, told AFP by email.
"It can help to slow down ageing, which is already a big breakthrough,
as it can counteract against many ageing-related diseases," he said,
while stipulating: "I don't think ageing could be completely stopped."
Cai said he believed the mouse results would translate into humans,
"though it will need future efforts to develop safe and applicable
approaches to humans."
Commenting on the research, Harvard Medical School experts Dana
Gabuzda and Bruce Yankner said the results, if validated, may have
important implications for treatment of age-related diseases --
particularly those linked to inflammation.
"The idea also raises the intriguing possibility that hypothalamic
regulation could be therapeutically manipulated to have broad effects
on the ageing process," they wrote in Nature.
--
J.
Bohgosity BumaskiL
May 2, 2013, 5:03:51 PM5/2/13
to
-----BEGIN PGP SIGNED MESSAGE-----
Hash: SHA1
Please do not pirate web pages.
Hormones are not the fountain of youth.
Vejetarianz liv longer.
I do not want to see copy and pastes of entire web pages here. At
best they are piracy. At worst, they are also spam. This wuz not
spam, because it duz not seem to be selling anything that haz been
tested on humans, or that iz (GRAS) Generally Recognized Az Safe.
Want to know the secret to eating a lot? Here it iz: Eat a little.
That way you will live long enough to eat a lot.
- --Anthony Robbins
I appreciate that the article wuz about inflammation. The idea that
any hormone can do the entire job of life extension iz garbage. If
you want an experiment that will perform better than any hormone,
cut the protein intake of your rats in half. They will liv longer.
Want you to go further? Cut their food in half. Not only will they
be more active, your rats will liv longer.
If the life expectancy of an East Indian iz not that different from
a North American, despite our more accessible medical care, it iz
because Hindus will not eat animal products other than milk, cheez
and ghee.
Vejetarianz liv longer.
Hormones are not the fountain of youth.
Please do not pirate web pages.
_______
If you take more from the dump than you leave, then you might be a
redneck.
-----BEGIN PGP SIGNATURE-----
Version: GnuPG v2.0.17 (MingW32)
Comment: Using GnuPG with Thunderbird - http://www.enigmail.net/
iQEcBAEBAgAGBQJRgtS1AAoJEPI4YIcJ+OeMOrwH/2RnVg8GcnkBXHtVD6Qfj6qx
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=6vtZ
-----END PGP SIGNATURE-----
Hash: SHA1
Please do not pirate web pages.
Hormones are not the fountain of youth.
Vejetarianz liv longer.
I do not want to see copy and pastes of entire web pages here. At
best they are piracy. At worst, they are also spam. This wuz not
spam, because it duz not seem to be selling anything that haz been
tested on humans, or that iz (GRAS) Generally Recognized Az Safe.
Want to know the secret to eating a lot? Here it iz: Eat a little.
That way you will live long enough to eat a lot.
- --Anthony Robbins
I appreciate that the article wuz about inflammation. The idea that
any hormone can do the entire job of life extension iz garbage. If
you want an experiment that will perform better than any hormone,
cut the protein intake of your rats in half. They will liv longer.
Want you to go further? Cut their food in half. Not only will they
be more active, your rats will liv longer.
If the life expectancy of an East Indian iz not that different from
a North American, despite our more accessible medical care, it iz
because Hindus will not eat animal products other than milk, cheez
and ghee.
Vejetarianz liv longer.
Hormones are not the fountain of youth.
Please do not pirate web pages.
_______
If you take more from the dump than you leave, then you might be a
redneck.
-----BEGIN PGP SIGNATURE-----
Version: GnuPG v2.0.17 (MingW32)
Comment: Using GnuPG with Thunderbird - http://www.enigmail.net/
iQEcBAEBAgAGBQJRgtS1AAoJEPI4YIcJ+OeMOrwH/2RnVg8GcnkBXHtVD6Qfj6qx
aAzZPT4RgtsCFl/k1087I1q/vJ6pD5Rej6cBaCWDE4PMkbpkKHeILG/YGvzPKOxg
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=6vtZ
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JRStern
May 2, 2013, 10:22:49 PM5/2/13
to
On Thu, 02 May 2013 15:03:51 -0600, Bohgosity BumaskiL
<brew...@freenet.edmonton.ab.ca> wrote:
>Please do not pirate web pages.
It's already a second or third hand report, and I give the link.
<brew...@freenet.edmonton.ab.ca> wrote:
>Please do not pirate web pages.
>I appreciate that the article wuz about inflammation.
If you increase NF-kB, what *does* that do to inflamation?
Especially if you already have p.
> The idea that
>any hormone can do the entire job of life extension iz garbage.
Yet, there may be *something* to it.
Such is science.
J.
Bohgosity BumaskiL
May 3, 2013, 2:03:05 PM5/3/13
to
On 2013-05-02 8:22 PM, JRStern wrote:
> On Thu, 02 May 2013 15:03:51 -0600, Bohgosity BumaskiL
> <brew...@freenet.edmonton.ab.ca> wrote:
>
>> Please do not pirate web pages.
>
> It's already a second or third hand report, and I give the link.
>
Indirection duz not lejitimize piracy.
> On Thu, 02 May 2013 15:03:51 -0600, Bohgosity BumaskiL
> <brew...@freenet.edmonton.ab.ca> wrote:
>
>> Please do not pirate web pages.
>
> It's already a second or third hand report, and I give the link.
>
Giving the link duz not giv you a reprint license.
If you were not prepared to offer a point by point rebuttal and
thereby make that web page part of USENET, then you were not
prepared to copy the entire thing.
>
>> I appreciate that the article wuz about inflammation.
>
> Well, it was and it wasn't.
>
It wuz primarily about life extension through drugs, not my idea of
>> I appreciate that the article wuz about inflammation.
>
> Well, it was and it wasn't.
>
a subject likely to be devoid of side-effects. The only thing that
kept me from labelling this thread az off topic wuz the explicit
mention of inflammation.
>
> If you increase NF-kB, what *does* that do to inflamation?
>
I do not know. It seems to increase a growth hormone, so I am
> If you increase NF-kB, what *does* that do to inflamation?
>
inclined to _guess_ that it would make inflammation worse.
>
> Especially if you already have p.
>
>> The idea that
>> any hormone can do the entire job of life extension iz garbage.
>
> I posted it for that reason, it seems way too simple.
>
> Yet, there may be *something* to it.
>
> Such is science.
>
> J.
>
>
It iz not my kind of science. It bothers me that scientists will
> Especially if you already have p.
>
>> The idea that
>> any hormone can do the entire job of life extension iz garbage.
>
> I posted it for that reason, it seems way too simple.
>
> Yet, there may be *something* to it.
>
> Such is science.
>
> J.
>
>
take one chemical out of apples, find it to be karsinojenik, then
use that to refute the old saw that an apple a day keeps the doctor
away.
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