More Curcumin properties (cancer)
Skeats
.................Unfortunately, natural curcumin has what researchers term
"low bioavailability" -- the molecule quickly loses its anti-cancer
attributes when ingested, Shibata says. With the aim of improving the
therapeutic potential of curcumin, Shibata and his colleagues synthesized
and tested 90 variations of the molecule's structure. Two, GO-Y030 and
GO-Y031, proved to be more potent and bioavailable, than natural
curcumin.....................
rest of article at......................
http://www.sciencedaily.com/releases/2007/11/071105083732.htm
randall
http://www.sciencedaily.com/releases/2007/11/071105083732.htm
Also found in this link:
[...]
"Like curcumin, these analogues also down-regulate a number of
gene products, such as NF-kappa B, ErbB2, K-ras, that are also
implicated in breast, pancreas and lung cancers among other
diseases." <sniP>
----------------------
WE psoriatics should benefit from the downregulation of NF-Kappa B.
http://www.ncbi.nlm.nih.gov/sites/entrez?term=psoriasis%20curcumin&cmd=search&db=PubMed
&
http://www.ncbi.nlm.nih.gov/sites/entrez?term=Nf-kappa%20curcumin&cmd=search&db=PubMed
WHOOpS
Look at the first one in the last search. Keywords: NF-kappa +
curcumin
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=ShowDetailView&TermToSearch=17640567&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Role of pro-oxidants and antioxidants in the anti-inflammatory and
apoptotic effects of curcumin (diferuloylmethane).
Sandur SK, Ichikawa H, Pandey MK, Kunnumakkara AB, Sung B, Sethi G,
Aggarwal BB.
Cytokine Research Laboratory, Department of Experimental Therapeutics,
Box 143, The University of Texas M. D. Anderson Cancer Center,
Houston, TX 77030, USA.
Extensive research within the past half-century has indicated that
curcumin (diferuloylmethane), a yellow pigment in curry powder,
exhibits antioxidant, anti-inflammatory, and proapoptotic activities.
We investigated whether the anti-inflammatory and proapoptotic
activities assigned to curcumin are mediated through its prooxidant/
antioxidant mechanism. We found that TNF-mediated NF-kappaB activation
was inhibited by curcumin; and glutathione reversed the inhibition.
Similarly, suppression of TNF-induced AKT activation by curcumin was
also abrogated by glutathione. The reducing agent also counteracted
the inhibitory effects of curcumin on TNF-induced NF-kappaB-regulated
antiapoptotic (Bcl-2, Bcl-xL, IAP1), proliferative (cyclin D1), and
proinflammatory (COX-2, iNOS, and MMP-9) gene products. The
suppression of TNF-induced AP-1 activation by curcumin was also
reversed by glutathione. Also, the direct proapoptotic effects of
curcumin were inhibited by glutathione and potentiated by depletion of
intracellular glutathione by buthionine sulfoximine. Moreover,
curcumin induced the production of reactive oxygen species and
modulated intracellular GSH levels. Quenchers of hydroxyl radicals,
however, were ineffective in inhibiting curcumin-mediated NF-kappaB
suppression. Further, N-acetylcysteine partially reversed the effect
of curcumin. Based on these results we conclude that curcumin mediates
its apoptotic and anti-inflammatory activities through modulation of
the redox status of the cell.
PMID: 17640567
=========================
It's a bust. All the good done by curcumin is undone by glutathione.
No wonder we don't get the bang for the buck we expect.
But seeing that most psoriatics are low to extremely low in
glutathione
I wonder if it's further screwing up that pathway?
I posted something on it yesterday.
http://en.wikipedia.org/wiki/Glutathione
http://en.wikipedia.org/wiki/Glutathione_peroxidase
Those aren't them....
Here it is
http://en.wikipedia.org/wiki/Image:Choline_metabolism.png
For myself anyway, NAC and selenium etc, all help enough to keep
them in the program.
----------------------------------
randall.....
JXStern
wrote:
>Further to P reducing properties (allegedly)
>
>.................Unfortunately, natural curcumin has what researchers term
>"low bioavailability" -- the molecule quickly loses its anti-cancer
>attributes when ingested, Shibata says. With the aim of improving the
>therapeutic potential of curcumin, Shibata and his colleagues synthesized
>and tested 90 variations of the molecule's structure. Two, GO-Y030 and
>GO-Y031, proved to be more potent and bioavailable, than natural
>curcumin.....................
I believe it.
That's why I take it twice a day.
Maybe I should make it every four hours, like many medicines. I did
try four times a day for a while, back when, at small doses.
Fast clearing is a good thing, because you might just want your immune
system back, if you get sick. Though maybe this is a little too fast.
Which is not to say some improved molecules can't be built, I hope
they can!
I'd thought "bioavailability" was about initial absorption, and in
that regard it looks like natural curcumin is just fine.
J.
manfred
Novel Turmeric Compound Delivers Much More Curcumin to the Blood
http://www.lef.org/magazine/mag2007/oct2007_report_curcumin_01.htm
jay
Would consuming curcumin with black pepper help?
Black pepper and its pungent principle-piperine: a review of diverse
physiological effects.
Black pepper (Piper nigrum) is one of the most widely used among
spices. It is valued for its distinct biting quality attributed to the
alkaloid, piperine... Piperine has been documented to enhance the
bioavailability of a number of therapeutic drugs ...
PMID: 17987447
Skeats
"jay" <jaym...@hotmail.com> wrote in message
news:1194632447.3...@k79g2000hse.googlegroups.com...
I wouldn't mind trying both but my endoscopy showed I had some gastritis
inflammation as well as CD.
I wouldn't use them without doctor's advice.
randall
> > ...natural curcumin ... "low bioavailability"
>
> Would consuming curcumin with black pepper help?
Any and all usage of piperine (pepper extract) I find suspect for p
and all
autoimmune conditions.
While tasty
http://www.cookswares.com/discussions/peppercorns.asp
The active ingredient,
http://en.wikipedia.org/wiki/Piperine
Not only blocks a vital pathway for xenobiotic detox,
http://en.wikipedia.org/wiki/CYP3A4
But loosens the junctions in the gut and allows LPS (endotoxin) to
enter
the portal vein and tax the liver. And thereby further the
polarization
of the Th1 skew.
Here is the wiki on it::
-------------------
Piperine is the alkaloid[1] responsible for the pungency of black
pepper along with chavicine (an isomer of piperine). It has also been
used in some forms of traditional medicine and as an insecticide.
The pungency caused by capsaicin and piperine is caused by activation
of the heat and acidity sensing TRPV ion channel TRPV1 on nociceptors
(pain sensing nerve cells).
Piperine has also been found to inhibit human CYP3A4 and P-
glycoprotein, enzymes important for the metabolism and transport of
xenobiotics and metabolites.[2] In animal studies, piperine also
inhibited other enzymes important in drug metabolism.[3][4] By
inhibiting drug metabolism, piperine may increase the bioavailability
of various compounds. Notably, piperine may enhance bioavailability of
curcumin by 2000% in humans.[5]
Due to its effects on drug metabolism, piperine should be taken
cautiously (if at all) by individuals taking other medications
<snip>
---------------------------------------------------
Looks good for curcumin. But with other supplements that use piperine
or bioperin to
enhance absorption I find the same problems with Th1 skewing.
LOOKS are one thing but increased Th1 MEANs more severity of
psoriasis.
And besides the curcumin is being blocked for psoriatics in the liver
by
glutathione.
Didn't anybody read my post to this thread?
It's nearly a BUST.
>
> Black pepper and its pungent principle-piperine: a review of diverse
> physiological effects.
>
> Black pepper (Piper nigrum) is one of the most widely used among
> spices. It is valued for its distinct biting quality attributed to the
> alkaloid, piperine... Piperine has been documented to enhance the
> bioavailability of a number of therapeutic drugs ...
>
> PMID: 17987447
Thanks for the pmid.
Let's try keywords: piperine ---- in pubmed
First hit: ( most recent)
or
[...]
Piperine's bioavailability enhancing property is also partly
attributed to increased absorption as a result of its effect on the
ultrastructure of intestinal brush border. <sniP>
----------------------------------
LOOK the point is moot. Curcumin does a little, but not enough to get
excited about.
But I KNOW JX will combat me on that....
He's eating like 10 grams ++++ a day now?
randall.... at least Ferhad in Iran is my friend. LOL
jay
> > >
> > bioavailability of a number of therapeutic drugs ...
>
> inflammation as well as CD.
How did the GI determine it was CD? Did he take a biopsy of inflamed
lining? Did the biopsy show white cells, granulomas, etc? I suspected
CD due to cramps and soreness in my terminal ileum. Colonosocpy showed
non-specific ileitis but biopsy didn't indicate CD.
JXStern
>On Nov 9, 10:20 am, jay <jaym1...@hotmail.com> wrote:
>> > ...natural curcumin ... "low bioavailability"
>>
>> Would consuming curcumin with black pepper help?
>
>Any and all usage of piperine (pepper extract) I find suspect for p
>and all autoimmune conditions.
Interesting analysis.
All I can say is, I've been able to detect no benefits.
>LOOK the point is moot. Curcumin does a little, but not enough to get
>excited about.
>
>But I KNOW JX will combat me on that....
>
>He's eating like 10 grams ++++ a day now?
Gosh, who knows, it's by guess and by golly, I'm probably averaging
about eight, when I have an extra itch I'll take another gram or two,
but that's turmeric, not curcumin, do people take 8g/day of
*curcumin*, that's about a 3x factor, right?
I also have no measure of the amount of active ingredient I'm getting
out of horseradish and/or mustard, but either the different
ingredients or the additional dosage, helps on top of the turmeric.
Lack of sunshine the last week, not to mention the season, has me
extra scratchy, too. Have to sign up again at the tanning salon if
this keeps up.
I'd be really curious to see what a turmeric treatment does to some
light to moderate cases of psoriasis, instead of them first trying
topical steroids. Or heck, in addition to the topical steroids.
Though, after being on a 2g/day+ regimen for about two years now, I'm
wondering if it's not the foggy weather, but that I'm building up a
tolerance to the treatment now. That would be unfortunate. Come on,
CNTO 1275!
And where the hell did that fumaric acid ester stuff ever get off to?
Though I suppose I could fly off for a long medical vacation in
Britain or Germany or someplace (Tijuana? Mumbai? Dead Sea?), if I
really wanted to try it.
J.
Mo
take 8 G/day of turmeric with a separate 10mg of bioperine before each dose.
Itching has subsided. Scalp is only area with no benefit. Taking
inexpensive 720mg capsules after discovering no way could I do the bulk
turmeric. I wake with more energy and no aches and pains. No other meds
for arthritis at all and back playing golf. I'm using clear Aloe Vera for
moisturizer.
Skeats
You have to have an endoscopy biopsy of the stomach lining to check whether
the villii are flattened or not to confirm CD. I was quite proud of myself
as I had the endoscopy without sedation as I had nobody to take me home
afterwards. Note well: allowing students to watch makes it last longer!!
I had had a couple of tests of my lower works (barium) years ago which
didn't come up with anything at all.
The blood test had showed the CD type antibodies for which my GP had
referred me to a consultant.
Apparently after four months being glutenfree the antibodies have lessened
from 300 whatevers? to 33 so it is working for me. My doctor is very happy.
I have Dietitian and further Consultant appointments set up and I might ask
for "Dapsone" which helps clear Dermatitis Herpitiformis (the Gluten
specific rash).
Unfortunately glutenfree doesn't have any effect on the clearing of P in my
case so far. I thought it might and didn't treat it as I should have and
the P has crept back.
Only on my arms though.
Good luck in your search for help.
Skeats
rickdog
and looks at piperine enhanced curcumin:
http://www.delano.com/ReferenceArticles/curcumin-enhancement.html
A supposedly much higher bio-available form of curcumin is here:
http://www.arjunanatural.com/html/biocurcumax.htm
they claim 7 times:
http://www.thehindu.com/2006/09/05/stories/2006090501141700.htm
anyone studied Hyaluronic Acid with respect to p?
On Nov 9, 1:39 pm, randall <ranhu...@aol.com> wrote:
> On Nov 9, 10:20 am, jay <jaym1...@hotmail.com> wrote:
>
> > > ...natural curcumin ... "low bioavailability"
>
> > Would consuming curcumin with black pepper help?
>
> Any and all usage of piperine (pepper extract) I find suspect for p
> and all
> autoimmune conditions.
>
> While tastyhttp://www.cookswares.com/discussions/peppercorns.asp
>
> The active ingredient,http://en.wikipedia.org/wiki/Piperine
>
> Not only blocks a vital pathway for xenobiotic detox,http://en.wikipedia.org/wiki/CYP3A4
> But loosens the junctions in the gut and allowsLPS(endotoxin) to
> http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView...