Help - New to this - G6PD def
CyberNomaD
I am G6PD def. Are there any treatments I SHOULD AVOID? I have
looked it up....and cannot see any..but something is in my memory
about it.... (found out 17 years ago)... I have a brochure....I
downloaded...just wondered if anyone else has it..and had it interfer
with treatment or Rx..thanks.
Kim Malo
Hmmm, well the only thing that stood out to me was that there were
some antibiotics and antifungals on a list of meds to avoid
G6PDhttp://rialto.com/g6pd/table2.htm
and sometimes those categories of meds are used to treat P, including
some of the alternative meds that are antifungals and/or mild
antibiotics. And you'd probably want to be even more cautious than
most about getting into some of the immuosuppressants.
A medline search under G6PD and psoriasis
http://rialto.com/g6pd/table2.htm
turned up some interesting stuff, including the fact that some
anthralin (aka drithanol and a common psoriasis treatment in Europe)
derivatives act as inhibitors of the enzyme glucose-6-phosphate
dehydrogenase, so you might want to be very cautious there -that may
be the one you were trying to recall.
Thanks for raising the question, BTW. That was interesting reading.
It's a very good question, and one I don't think has come up here
before. The National Psoriasis Foundation page http://www.psoriais.org
site has a place to email them questions and I think it might be a
great idea for you to also visit their site and email them the
question so they can put it to some of their medical experts to see
what they say.
Kim
The Psoriasis Newsgroup Resource FAQ can be found at
http://pfaq.cjb.net
but will also be coming soon (twice a month) to a
newsgroup near you...
Randall
Hi Cyber NomaD,
you look like a perfect test bed for P theorys.......know what i mean?....
How long P? What treatments so far? How OlD are you?........... ......
Imagine if Doc Lecktor had P... I can see Clarice now serving him some
fava bean sauce (favism=G6PD no no?) with his human liver (high AA-no no
for p's) with a fine chianti (another P no no).... Poor Hannibal would have
to abstain from his favorite meals or flake away... make sure he gets
loads of grapefruit juice with his ham and eggs for breakfast.. Oh,
and loads of mashed potatoes (quayle? sp?) with gravy...
And to keep evstmgarysteve happy, never wean him from the sugar tit...
And now that is a horror flick for p's... with plenty of flare
ups....quick get the lazer beam xtrac gizmo cure... and amvie goop..
or is all this just another finger in the dike? Maybe i'll go back
and review the hygiene hypothesis and eat some dirt..or better yet 5HTP in-
stead of GHB for brain dreams with a few mg.s of melatonin for Technicolor.
randall.... nature calls....lets root for the home team...
GMan13579
>Hi Cyber NomaD,
>
> you look like a perfect test bed for P theorys.......know what i mean?....
>How long P? What treatments so far? How OlD are you?........... ......
> Imagine if Doc Lecktor had P... I can see Clarice now serving him some
>fava bean sauce (favism=G6PD no no?) with his human liver (high AA-no no
>for p's) with a fine chianti (another P no no).... Poor Hannibal would have
>to abstain from his favorite meals or flake away... make sure he gets
>loads of grapefruit juice with his ham and eggs for breakfast.. Oh,
>and loads of mashed potatoes (quayle? sp?) with gravy...
>And to keep evstmgarysteve happy, never wean him from the sugar tit...
>
>And now that is a horror flick for p's... with plenty of flare
>ups....quick get the lazer beam xtrac gizmo cure... and amvie goop..
>or is all this just another finger in the dike? Maybe i'll go back
>and review the hygiene hypothesis and eat some dirt..or better yet 5HTP in-
>stead of GHB for brain dreams with a few mg.s of melatonin for Technicolor.
>
>randall.... nature calls....lets root for the home team...
>
You feelin ok?
CyberNomaD
Randall
> Um.... anyhoooo.
>
>
Yes....?
As to your inquiry.. i feel fine... by removing high AA (arachidonic acid)
foods like liver... (a p no no) i do very well... thanks
as to your particular situation...G6PD.. i would imagine that
a lot of everyday foods would add into your angst...w/P
If you are compelled to find the very best treatment to an existing
condition.. you are in the right place...
If you wish to avoid flare ups and take personal responsibility, you
may very well find some help also..
I suggest that you take several of these words and go to deja.com and check
it out..
grapefruit juice LEF tom matthews (flavinoids)
G6PD on the web...( not much in the ng's)
peyers patches
arachidonic acid
Delta6/5 or delta 6/5 dehydrogenase (decreases 1% a year w/age) get it?
P450 cytochrome
indole-3-propionic acid
Please let me know if you are able to soothe your P...
If i were you i would take advantage of you genotype. It may
actually be worth something to all of us...
BTW.. how long have you had P? how much coverage? and your relative age of
onset and actual age... Thanks
best,
randall... maybe there is a study on dna for cyber...
Randall
Ok,
Did you do your homework yet? Lets check G6PD for the groups info...
G6PD stands for Glucose 6 Phosphate dehydrogenase. This is an
enzyme which catalyzes the conversion of Glucose 6 Phosphate to as the
starting reaction of the pentose phosphate pathway. A critical result of
this reaction pathway is the production of reduced NADP: NADPH. NADPH
is a required cofactor for a number reactions. In most tissues there are
alternate pathways for regenerating NADPH, however in red blood cells
this is the only one. THe NADPH "helps" catalyze reactions that result in,
among other things, glutathione. Glutathione is of importance especially
in red blood cells because it reduces blood born oxidants (that is it
renders reactive oxidizing species less harmful). These oxidizing
agents, if not reduced denature globulin proteins in hemoglobin
decreasing the ability of red blood cells to carry oxygen or destroying
them completely.
Clinically the result is some form of anemia. There have been over 200
variations of G6PD deficiency identified. It helps to avoid drugs and
chemicals which present oxidative challenges to the blood stream but
there are so many (including some common chemicals and foods) that
avoiding them can prove difficult. There is some interesting research
into switching on genes for gamma globulin, a globulin chain normally
produced only in the fetus that is more resistant to this, but I'm not
sure where it stands now. If you want more info let me know and I'll see
what I can dig up. David
*******************************************
I presume you know this so go ahead and see whats out there.
Its so easy.... go to www.deja.com and enter the key words in the box and
click.. read the posts that pertain and have a cyber blast.
If you are to tired from lack of NADPH i am sure you can get some help.
best,
randall...and a new link to the citric acid (krebs) for garysteve..
Randall
> ranh...@aol.com (Randall) wrote in message news:<df7e2c67.01092...@posting.google.com>...
> > CyberNomaD <cyber...@SPAMWILLKILLyayahoo.com> wrote in message news:<tufkqtovb3c6m705d...@4ax.com>...
> > > Um.... anyhoooo.
> > >
> > >
> > Yes....?
> >
> > As to your inquiry.. i feel fine... by removing high AA (arachidonic acid)
> > foods like liver... (a p no no) i do very well... thanks
could this be the defective gene? How we process AA? Sugar blocks the
action
of delta 6 desaturase and delta 5 churns out PGE 2's the evil stuff
(what cox 2
stops) (you know that slick new aspirin stuff, cox 2 quencher.. like,
why not
just not eat the wrong combo? sugar and fats or sugar and high AA
foods, like
egg yolks, pork etc) hmmm almost forgot... the sun doesn't come up the
same
for all of us... dietary fortitude can be a real paradox...
a randall- new- original... "a cox 2 paradox"... for P flares...
beware of coronal discharges...
whoops, sorry almost went into poetry... oh for those sweet rosy
posts..
sigh.."imagine all the P people living life clear"... i'm not the only
one!
> >
> > as to your particular situation...G6PD.. i would imagine that
> > a lot of everyday foods would add into your angst...w/P
> >
> > If you are compelled to find the very best treatment to an existing
> > condition.. you are in the right place...
> >
> > If you wish to avoid flare ups and take personal responsibility, you
> > may very well find some help also..
> >
> > I suggest that you take several of these words and go to deja.com and check
> > it out..
> >
> > grapefruit juice LEF tom matthews (flavinoids)
> > G6PD on the web...( not much in the ng's)
> > peyers patches
> > arachidonic acid
> > Delta6/5 or delta 6/5 dehydrogenase (decreases 1% a year w/age) get it?
correction: use delta 6/5 desaturase (sorry) do i have to find my own
mistakes?
(me talking to myself) there must be a bunch..hehe
> > P450 cytochrome
> > indole-3-propionic acid (egad- this one should throw gary a curve)
> >
> > Please let me know if you are able to soothe your P...
> > If i were you i would take advantage of you genotype. It may
> > actually be worth something to all of us....
Cyber is now out cutting a deal for his DNA and half of the net profit
from all of us... to be cured..
Or maybe his meds from G6pd cause his P and this is just me thinking
out
loud whilst suffering the web, and there is nothing here... another
dry hole.
> >
> > BTW.. how long have you had P? how much coverage? and your relative age of
> > onset and actual age... Thanks
/Still waiting...
Old cyber must be to tired to type... come home.. we want to share
your angst..
What we do best around here, besides fight over stupid things like
fire and
brimstone cures..
hmmm... like that former pres, seen charging $400 worth of merchandise
the
other day.. spend spend spend.. save america... use to be- buy war
bonds.
>
> Its so easy.... go to www.deja.com and enter the key words in the box and
> click.. read the posts that pertain and have a cyber blast.
>
> If you are to tired from lack of NADPH i am sure you can get some help.
>
> best,
> randall...and a new link to the citric acid (krebs) for garysteve..
Dear garysteve... i would have expected you to correct the above
error..
this is real sugar stuff... as to the pathways and how fats get ??? in
the bod.
So, why do the 2.?% of us have this glitch in the dna??? Or do we?
************************
from some ng post on delta 6/5 desaturase..(notice.. correction)
*******************************
as everyone knows,
omega6 fatty acids have linoleic acid which by the help of delta 6
desaturase is converted to Gamma Linoleic acid (which inhibits alpha
reductase etc) which is then converted to DGLA(dihommo gamma
linoleeic
acid) and finaly to the "good" prostaglandins,, PGE1 etc.
anyway everyone knows that insulin stimulates delta 5 desaturase which
forces DGLA to be converted to Arachidonic Acid...
Caffeine and aging, infections inhibit delta 6(the good one)..
Anyway, according to Protein Power, Alpha Linoleic acid also inhibits
Delta 6: this is truly a new one to me... does anyone have evidence of
this? this is extremely important because as the author notes, canola
oil is high in alpha linoleic acid and so it would inhibit the
formation
of gamma linoleic acid.. (which is not usually foundn in the diet
except
in ppl eating oats or borage seed oil..)
''''''''''''''''''''''
randall- notes... protein power is a book... by doctors Michael and
mary
Eades (a best seller, that many in the Med community simply pooh
pooh'ed)
The delta 6/5 desaturase studies were done in the early 90's and the
first book
that i noticed with the info was published two years later (?)
In my fuzzy remembrance it was a doctors guide to vits and mins...
(maybe)
randall... gosh i wish i got picked apart as fast as garysteve
sometimes..NOT
Randall
Now, as to your arachidonic acid lesson for the day... the first post
i found off google should be written in lay terms easily
understandable... when you see
n 3 or n 6, think omega 3 or omega 6...
I'm all for moderation, but I'm not sure the reasons you give here are
>very convincing. There's a world of difference between industrial
linseed
>oil used in paint thinner and fresh oil right from the flax seed. And
I
>can just imagine the quantities that were fed to the pigs. I wonder
>how many studies have been done to determine what happens to pigs
when
>they are
>fed (A) a teaspoon per day,
The meat will contain little arachidonic acid
>(B) a tablespoon per day, or
It contains possibly even less arachidonic acid
>(C) three tablespoons per day.
Even less arachidonic acid :-)
If the test had been done with an oil rich in n-6 compared to n-3 oil
the test would give some arachidonic acid in the meat, then more
arachidonic acid and with three spoons much more.
>I'm guessing not very many.
Right. But some has been done. What is interesting is not quantity of
oil, but the proportion btw. n-6 and n-3 acids. I know about reumatic
people who can eat freely mutton when the sheeps has just come from
the
mountains, but get very sick in spring if the mutton is a sheep that
has
been fed with n-6 rich food during winter. A big difference is the n-6
/
n-3 proportion which is very low in the autumn after the animals has
been fed wild growing grass that are rich in n-3 acids and low in n-6
acids. In spring, the proportion is normally high because the sheep
are
fed grains that mostly contain n-6 acids and thus the meat should
contain significant amounts of arachidonic acid. If these people has a
uncontrolled activity of COX-2, they get real troubles when the food
contain lots of arachidonic acid, but much less trouble if they get
lots
of n-3 acids that is competitors of the COX-2 enzyme and other enzymes
that convert arachidonic acid to signal molecules because the n-3
acids
function as inhibitors of the reactions. (It's like blocking a road
crossing with a big bus)
By the way, one test I have seen on arachidonic acid did show that
chicken fed a grainrich diet can contain more than 1 g pr 100 g meat
of
arachidonic acid. Fed a diet based mainly on grass and other greens
growing in the free and let the chicken go everywhere, the ratio of
n-6
/ n-3 has been observed down in 1:4, but when fed grain, it can reach
10:1. Some data has pointed that it should not exceed 5:1, some says
7:1
is still ok, but then cancer has not been considered. When taking into
account different illnesses that is worsened by prostaglandins
produced
uncontrolled by a constituent COX-2 (which should be induced only when
needed), the ratio should be low. Some says less than 4:1. (If it
drops
under ca. 1:1, there may be increases in bleeding time etc., risk of
brain bleeding is increased etc.)
*************
randall notes: (a no brainer)
once again.... if you love bacon and eggs.. y0u may have to go to an
extreme length to eat em... like grow your own on a high fresh grass
diet in order to limit the arachidonic acid...
and if you still don't feel like omega 6 fats are a problem for p's,
then just drink a glass of old soy bean oil with a tablespoon of sugar
each day..gloop in a few egg yolks.. this is a recipe (omega 6 fats
w/arachidonic acid plus a insulin booster) that should flare your
days/weeks /months/years..
randall...its easier to take my word...don't hit your head w/a hammer.
--------------------------------------------------------------------------------
Randall
I've gone this far.. so go to google and enter grapefruit juice and
Tom
Matthews.. (i bet we get a bonus like P-450 cytochrome as a kicker)
^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
Grapefruit juice post-translationally inhibits the action of
cytochrome
P450 3A4 (also called CYP3A4), but they are not sure which component
does it. Since this enzyme also helps to metabolize many xenobiotics
and
toxic compounds for excretion, I have decided to reduce my intake of
grapefruit and juices. A damned shame because I love them and they are
low glycemic fruit with red grapefruit even containing the valuable
lycopene!
Here is a review abstract from last August
Br J Clin Pharmacol 1998 Aug;46(2):101-10
Grapefruit juice-drug interactions.
Bailey DG, Malcolm J, Arnold O, Spence JD
Department of Medicine, London Health Sciences Centre, Ontario,
Canada.
The novel finding that grapefruit juice can markedly augment oral drug
bioavailability was based on an unexpected observation
from an interaction study between the dihydropyridine calcium channel
antagonist, felodipine, and ethanol in which grapefruit
juice was used to mask the taste of the ethanol. Subsequent
investigations showed that grapefruit juice acted by reducing
presystemic felodipine metabolism through selective post-translational
down regulation of cytochrome P450 3A4 (CYP3A4)
expression in the intestinal wall. Since the duration of effect of
grapefruit juice can last 24 h, repeated juice consumption can
result in a cumulative increase in felodipine AUC and Cmax. The high
variability of the magnitude of effect among individuals
appeared dependent upon inherent differences in enteric CYP3A4 protein
expression such that individuals with highest
baseline CYP3A4 had the highest proportional increase. At least 20
other
drugs have been assessed for an interaction with
grapefruit juice. Medications with innately low oral bioavailability
because of substantial presystemic metabolism mediated by
CYP3A4 appear affected by grapefruit juice. Clinically relevant
interactions seem likely for most dihydropyridines, terfenadine,
saquinavir, cyclosporin, midazolam, triazolam and verapamil and may
also
occur with lovastatin, cisapride and astemizole. The
importance of the interaction appears to be influenced by individual
patient susceptibility, type and amount of grapefruit juice
and administration-related factors. Although in vitro findings support
the flavonoid, naringin, or the furanocoumarin,
6',7'-dihydroxybergamottin, as being active ingredients, a recent
investigation indicated that neither of these substances made a
major contribution to grapefruit juice-drug interactions in humans.
And here is the most recent one on medline which shows that they still
do not know the full mechanism.
Clin Pharmacol Ther 1999 Mar;65(3):237-44
6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange
juice:
effects on cyclosporine disposition, enterocyte CYP3A4, and
P-glycoprotein.
Edwards DJ, Fitzsimmons ME, Schuetz EG, Yasuda K, Ducharme MP,
Warbasse
LH, Woster PM, Schuetz JD, Watkins P
College of Pharmacy and School of Medicine, Wayne State University,
Detroit, Mich, USA.
BACKGROUND: 6',7'-Dihydroxybergamottin is a furanocoumarin that
inhibits
CYP3A4 and is found in grapefruit juice and
Seville orange juice. Grapefruit juice increases the oral
bioavailability of many CYP3A4 substrates, including cyclosporine
(INN, ciclosporin), but intestinal P-glycoprotein may be a more
important determinant of cyclosporine availability.
OBJECTIVES: To evaluate the contribution of 6',7'-dihydroxybergamottin
to the effects of grapefruit juice on cyclosporine
disposition and to assess the role of CYP3A4 versus P-glycoprotein in
this interaction. METHODS: The disposition of oral
cyclosporine was compared in healthy subjects after ingestion of
water,
grapefruit juice, and Seville orange juice. Enterocyte
concentrations of CYP3A4 were measured in 2 individuals before and
after
treatment with Seville orange juice. The effect of
6',7'-dihydroxybergamottin on P-glycoprotein was assessed in vitro.
RESULTS: Area under the whole blood
concentration-time curve and peak concentration of cyclosporine were
increased by 55% and 35%, respectively, with
grapefruit juice (P < .05). Seville orange juice had no influence on
cyclosporine disposition but reduced enterocyte
concentrations of CYP3A4 by an average of 40%.
6',7'-Dihydroxybergamottin did not inhibit P-glycoprotein at
concentrations
up to 50 micromol/L. CONCLUSIONS: 6',7'-Dihydroxybergamottin is not
responsible for the effects of grapefruit juice on
cyclosporine. Because the interaction did not occur with Seville
orange
juice despite reduced enterocyte concentrations of
CYP3A4, inhibition of P-glycoprotein activity by other compounds in
grapefruit juice may be responsible. Reduced enterocyte
CYP3A4 by 6',7'-dihydroxybergamottin could be important for other
drugs
whose bioavailability is less dependent on
P-glycoprotein.
--Tom
Tom Matthews
The LIFE EXTENSION FOUNDATION - http://www.lef.org - 800-544-4440
A non-profit membership organization dedicated to the extension
of the healthy human lifespan through ground breaking research,
innovative ideas and practical methods.
LIFE EXTENSION MAGAZINE - The ultimate source for new
health and medical findings from around the world.
*************************************************
randall notes... i've only rarely found that grapefruit juice to
actually be
at the root cause of a flare up.(because i wasn't looking-duh) And it
really freaked me out as it was a full body one...never the less, i
got religion again and went back on the dietary wagon for 4-5 weeks
and cleared it all back up...
plus more...i started to question if i belonged here.. not..
An interresting, to me anyway, test would be for several people here
to
go ahead and pick up a dozen grapefruits and eat one or two a day for
several days and see if the regulation of CYP3A4 has a causative link
with any flare ups... This enzyme hangs out in the peyers patches that
are
located in the GI tract. One of my personal favorite areas to examine,
since
1982.. and no i'm not anal retentive. hehe.
Another organ, the kidney should not be overlooked. Any help out
there?
&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&
Message from the previous day..
Randall
Time to look at NADPH:
Every cell of the body contains many tiny organelles called
mitochondria (see inset, Figure 1 below). These mitochondria produce
most of the energy used by the body. Cells with a high metabolic rate
(heart muscle cells) may contain many thousands of mitochondria. Some
cells may contain only dozens.
Mitochondrial energy production is a foundation for health and
wellbeing. It is necessary for physical strength, stamina and
consciousness. Even subtle deficits in mitochondrial function can
cause weakness, fatigue and cognitive difficulties. Chemicals which
strongly interfere with mitochondrial function are known to be potent
poisons. During aging, mitochondrial function may become compromised.
Mitochondrial energy production is accomplished by two closely linked
metabolic processes. First, the citric acid cycle converts biological
fuel (carbohydrates and fatty acids) into ATP (adenosine triphosphate)
and hydrogen (in the form of NADH and FADH2) (see sidebar) for further
explanation of NADH and FADH2). Second, the electron transport chain
combines hydrogen with oxygen to generate abundant ATP in a highly
efficient and tightly controlled manner (see Figure 1 above).
Mitochondrial efficiency has been reported to be close to 70%, which
compares quite favorably with internal combustion engines (about 10%
efficient) or hydrogen-oxygen fuel cells used in spacecraft
(approximately 40% efficient). The process of generating ATP with
oxygen is called oxidative phosphorylation. This process generates
approximately ten times more ATP than the citric acid cycle alone, and
generates more ATP than any other energy-producing pathway (e.g.,
glycolysis). Oxidative phosphorylation is the primary energy process
for all aerobic organisms.
The utilization of oxygen by mitochondria is accomplished by a highly
specialized group of five protein complexes embedded in the inner
membrane of the mitochondria. Complex I accepts fuel from the citric
acid cycle in the form of NADH, which donates electrons to the chain
(see Figure 1 above). Part of the energy of this electron is used to
pump a proton (i.e., acidity) across the inner membrane, after which
the electron is passed to Complex III via coenzyme Q. Complex II
accepts electrons from FADH2 and also passes them to Complex III via
coenzyme Q. Complex III uses another part of the energy of the
electron to pump another proton across the inner mitochondrial
membrane. The electron is then passed to Complex IV via cytochrome C
where it uses most of the remaining energy to pump the third proton
across the membrane. The deenergized electron is then transferred to
oxygen to generate water.
The relative excess of protons in the intermembrane space creates a pH
and redox gradient across the inner mitochondrial membrane. The energy
of this gradient is used by Complex V to convert adenosine diphosphate
(ADP) to adenosine triphosphate (ATP), the chemical energy
“currency” of the cell. ATP can then be transported to
where work needs to be done.
Mitochondrial Aging
One interesting property of mitochondria is that they have their own
DNA (deoxyribonucleic acid), the stuff of which genes and chromosomes
are made. Mitochondrial DNA (mtDNA) is quite different from nuclear
DNA in several respects. First, it exists as a simple plasmid (a DNA
loop), and in this respect, it is more akin to bacterial DNA than the
chromosomal DNA of higher organisms. Second, mtDNA is not associated
with histones. Histones are positively charged “storage”
proteins around which nuclear DNA is wound for safekeeping (like
thread on a spool). Third, most of the complex DNA repair mechanisms
that correct damage to nuclear DNA are missing from mitochondria. All
of these features have prompted some scientists to speculate that
mitochondria are ancient remnants of primitive symbiotic bacteria.
Whether this view is correct or not, the relatively unprotected and
unrepaired mtDNA suffers more than ten times the damage that nuclear
DNA does [Miguel, 1991, 1992; Shigenaga et al., 1994]. This leads to
mitochondrial dysfunction, disruption of cellular energy production,
and accelerated cellular aging [Miguel, 1980].
Mitochondrial electron transport is not perfect. Even under ideal
conditions, some electrons “leak” from the electron
transport chain. These leaking electrons interact with oxygen to
produce superoxide radicals. With mitochondrial dysfunction, leakage
of electrons can increase significantly. The close proximity of mtDNA
to the flux of superoxide radicals (or hydroxyl radicals), and
it’s lack of protection and repair mechanisms, leads to free
radical-mediated mutations and deletions. Mitochondrial aging has been
proposed as an underlying cause of 1) free-radical stress, 2)
degenerative disease and 3) aging [Miguel, 1980, 1991, 1992, Shigenaga
et al., 1994].
Evidence is accumulating that mitochondrial dysfunction underlies many
common pathologies. Mitochondrial defects have been identified in
Parkinson’s disease, Alzheimer’s disease [Hutchin and
Cortopassi, 1995], heart disease, fatigue syndromes, numerous genetic
conditions, and nucleoside therapy for AIDS. Also, many common
nutritional deficiencies can impair mitochondrial efficiency
http://www.ceri.com/mito.htm (to see the really cool graphics)
*********************************
I get tired just thinking about the superoxide radicals... in light of
recent radicals and... (internal radiation-your own built in x-ray)
Just don't think, you can get these by just being angry. And in the
light
of recent events free radicals aren't free for you or me..
Hey ... garysteve.. are you ever gonna get a clue to my hydrogen
theory?
i am still singularly un-impressed with the ppar gamma meta-biologic
hypo in-
sulinism X thing of yours.. to many nano peptide holes ..yet, i am
still itching
for a positive denouement... have you talked with any Ligand senior
scientist?
randall .... waiting for all the facts.. hey this is only the tip.