P News
Randall
Hi,
http://www.dailycitizen.com/articles/2004/03/04/news/alin.txt
[snip] Agennix Inc., of Houston, Texas, which has been conducting
extensive research on a compound called Lactoferrin.
"Lactoferrin is a naturally occurring substance found in almost all
human secretions -- breast milk, semen, urine, sweat, tears. They
found that this substance has some very interesting properties --
antibacterial, anti-inflammatory and healing," he said. "They started
doing some testing with this on animals and discovered it had some
amazing healing properties."
Miller said the earliest human studies on Lactoferrin were done on
_psoriasis_ and asthma, "and the results were very impressive ... they
began looking for other utilizations and discovered it seemed to have
properties in helping wound healing."
[snip]
Lactoferrin must have something good in it,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14992693&dopt=Abstract
Seems to screw with the cell membrane sugars and prevent viral
binding,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14972565&dopt=Abstract
And if you fast and do a vegetarian diet,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6197838&dopt=Abstract
[snip] The improvement or impairment of signs and symptoms was related
to the lactoferrin levels in serum.
But if we have high levels of lactoferrin, whats gonna happen next?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14975505&dopt=Abstract
Although there is a general consensus that highly cationic peptides
kill bacteria primarily by injuring their membranes, an additional
hypothesis is proposed suggesting that a large variety of cationic
peptides might also render bacteria non viable by activating their
autolytic wall enzymes - muramidases (a "Trojan Horse" phenomenon),
resulting in bacteriolysis. This group of cationic peptides includes:
lysozyme, lactoferrin, neutrophil-derived permeability increasing
peptides, defensins, elastase, cathepsin G, and secretory phopholipase
A(2). In this respect, cationic peptides mimic the
bactericidal/bacteriolytic effects exerted by of beta-lactam
antibiotics. Bacteriolysis results in a massive release of the
pro-inflammatory cell-wall components, endotoxin (LPS), lipoteichoic
acid (LTA) and peptidoglycan (PPG), which if not effectively
controlled, can trigger the coagulation and complement cascades, the
release from phagocytes of inflammatory cytokines, reactive oxygen and
nitrogen species, and proteinases. Synergism (a "cross-talk") among
such agonists released following bacteriolysis, is probably the main
cause for septic shock and multiple organ failure. [snip]
Thus, a use of "cocktails" of anti-inflammatory agents might replace
the unsuccessful use of single antagonists proven in scores of
clinical trials of sepsis to by ineffective in prolonging the lives of
patients. It is enigmatic why the concept, and the publications which
support a role for cationic peptides also as potent inducers of
bacteriolysis, an arch evil and a deleterious phenomenon which
undoubtedly plays a pivotal role in the pathophysiology of
post-infectious sequelae, has been consistently disregarded.
So, if we kill the gut bug critters we release endotoxin/cytokine
cascades?
Yikes! Its an endless loop again.
http://www.jungdownunder.com/ANZSJA/uroborous%20.jpg
Can't we find something to take the garbage out?
Like lipo binding proteins? How do we uPregulate it in our bodies
naturally?
And what other clues from recent inflammatory players?
We know that VEGF is at play (vascular hyperpermeability) in
severe psoriasis,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12056961&dopt=Abstract
So, where in the hell does VEGF come from?
Some simple systemic bug (E.Coli) or what?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12925034&dopt=Abstract
Marked increase in vascular endothelial growth factor concentrations
during Escherichia coli endotoxin-induced acute inflammation in
humans.
Bacterial endotoxins can induce the synthesis and release of vascular
endothelial growth factor (VEGF), which may alter vascular
permeability and cause vascular leakage. [snip]
So, is the lactoferricin good or bad?
Its knocking out bugs,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12769736&dopt=Abstract
And can be utilized to make more efficient drugs,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14967536&dopt=Abstract
Whats being said in the groups?
http://groups.google.com/groups?hl=en&lr=&ie=ISO-8859-1&q=lactoferrin+&btnG=Google+Search&meta=
Well, medscape has the best article on it
(free subscription required),
http://www.medscape.com/viewarticle/464466
So ok! I hope that the researchers can put something to-gether
on this. It looks good for something in the Psoriasis
paradigm.
Bug what?
Lets review the company that makes it,
http://www.agennix.com/
Seeing as i wasn't breastfed, i didn't get the lactoferrin alotment
promised by that route. I did get the sterilized milk bottle routine.
Did that only make my situation more prone to Th1?
What does this site have for science info,
http://www.agennix.com/contentpages/lactoferrinscience.htm
The human lactoferrin molecule has multi-functional properties that
make it valuable as a pharmaceutical drug. It dramatically upregulates
IL-18, which has been shown to:
Induce proliferation of CD4+ / CD8+ cells and activate NK immune
cells;
Reduce angiogenesis, the growth of blood vessels, to starve tumors of
blood;
Stimulate production of GM-CSF to speed up the replacement of white
blood cells; and
Shift the cytokine profile from TH2 to TH1, favoring the development
of cell mediated immunity and protecting against allergic diseases
such as asthma.
In the past, development of products based on human lactoferrin was
hindered because its only source was human milk. Recombinant
technology developed at Baylor College of Medicine now makes producing
human lactoferrin in commercial quantities a reality. Recombinant
lactoferrin has a structure, molecular weight and other properties
identical in all material respects to native lactoferrin. It is highly
pure and can be produced in quantities sufficient for marketing as a
pharmaceutical drug. No discernible adverse effects from oral
administration of recombinant lactoferrin have been detected in animal
studies, and no lactoferrin-related serious adverse events have been
found in human clinical trials treating over 300 people.
=========================================================================
This doesn't sound good. Helps Th2 towards Th1! We psor heads are
already
Th1. What will happen good and bad if we increase lactoferrin?
Here's a pdf from Agennix on Langerhans cells and mentions their
psoriasis
research in the next to last sentence. Sorta an after thought?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8695817&dopt=Abstract
Tumor necrosis factor-alpha and FMLP receptors are functionally linked
during FMLP-stimulated activation of adherent human neutrophils.
Balazovich KJ, Suchard SJ, Remick DG, Boxer LA.
Department of Pediatrics, University of Michigan School of Medicine,
Ann Arbor, MIC, USA.
Human peripheral blood neutrophils (PMN) plated onto fibrinogen and
activated with FMLP release H2O2 and lactoferrin, a specific granule
component, with parallel kinetics. Although tumor necrosis
factor-alpha (TNF alpha) only primes PMN in suspension, it is a potent
agonist of adherent PMN. Activation of adherent PMN by FMLP (10(-7)
mol/L) stimulated detectable release of TNF alpha within 45 minutes of
stimulation, with maximal release (45.5 pg/10(6) cells) detected by 90
minutes. TNF alpha release paralleled the release of both lactoferrin
and H2O2. To determine if TNF alpha plays a role in H2O2 and
lactoferrin release, we investigated the effect of anti-TNF alpha
antibodies on FMLP-stimulated activation of adherent PMN. A
neutralizing rabbit anti-TNF alpha antibody inhibited both H2O2 and
lactoferrin release stimulated by FMLP, whereas rabbit lgG,
anti-HLA-A,B,C, anti-CD 14, and anti-interleukin-8 antibodies were
without effect. The simultaneous addition of TNF alpha (1,000 U/mL)
with anti-TNF alpha antibody reversed the inhibition seen with
anti-TNF alpha alone. Furthermore, treatment of PMN with either
actinomycin D or cylcoheximide resulted in partial (33%) inhibition of
H2O2 and lactoferrin release, suggesting that protein synthesis is
required for FMLP-mediated activation of adherent PMN. The addition of
TNF alpha to either cycloheximide or of actinomycin D-treated PMN
overcame the inhibition, indicating that the effect was specific for
TNF alpha. The addition of antibodies against either the 55-or 75-kD
TNF alpha receptors (referred to as p55 and p75, respectively)
resulted in partial (32%) inhibition of FMLP-mediated activation of
H2O2 and lactoferrin release, whereas a combination of both antibodies
reduced their release to control levels. These data indicate that both
p55 and p75 are involved in FMLP activation of adherent PMN. Taken
together, these findings indicate that the production of TNF alpha and
ligation of TNF alpha receptors are central to FMLP activation of PMN
adherent to fibrinogen.
PMID: 8695817
Oral intake of whey/lactoferrin a problem for the randall or what?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14747680&dopt=Abstract
[snip] The addition of Lf to the drinking water had no visible effect
on the immune status. Gastric intubation, single buccal doses, and
continuous doses of Lf in the diet stimulated transient systemic and
intestinal antibody responses against Lf. All of these oral modes of
Lf exposure biased mucosal and systemic T-cell responses toward
Thelper (Th)2-types and elevated IgA production by mucosal cells.
However, the less natural gastric intubation also promoted Th1-type
responses as evidenced by serum IgG(2a) antibodies and the secretion
of Th1 cytokine by mucosal and systemic T cells in vitro. Thus, one
should carefully consider the oral mode of administration for
understanding regulation of immune responses by food proteins such as
Lf.
PMID: 14747680
So, why don't we start from the earliest time possible in
this gut dilemma,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14599043&dopt=Abstract
[snip] It is now generally accepted that the microbiota of the human
gut may influence health and well-being. Lactic acid bacteria are the
most important microorganisms associated with these beneficial effects
and the elevated bifidobacterial count may be one of the greatest
advantages that breastfed infants have over infants fed with milk
formulas. Several studies relative to the selective growth stimulation
of bifidobacteria, both in vitro and in vivo, are reported in this
review. Over the years, diverse human milk components have been
identified as the specific factors able to modulate the growth of
bifidobacteria. Even if there is a certain agreement that the
bifidogenic activity of human milk may be based not on single growth
substances, but on a complex set of interacting factors, the present
state of knowledge indicates that the use of non-digestible but
fermentable carbohydrates may be an easy and reliable method to
influence the growth of lactic acid bacteria. In this context, some of
the characteristics of the major physiological effects of inulin-type
fructans, of galacto-oligosaccharides, but also of lactoferrin, a milk
whey protein fraction with purported bifidogenic activity, are briefly
examined.
PMID: 14599043
Do the eskimo's suck down milk like the european northern latitude
caucasians? Is there something to their respective evolutions missed
by the paleo researchers of some import in this lactoferrin
situation?,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12769735&dopt=Abstract
Well, if nothing else it shows that iP6 is on the right track.
Randall
Can we learn from a Pig? Arnold down on Green Acres
seemed smarter then his parents, didn't he.
Yesterday we got a lactoferrin lesson and now we
get Lactovitale the next.
http://www.mb.com.ph/WLBG200403064200.html
Former livestock feed turned human dietary supplement
By OWEN BAUTISTA
A QUEST FOR POTENT ANTIDOTE Having been introduced in the market
October last year, Lactovitale is a relatively new product that is
rapidly gaining popularity in the health food supplement industry.
What's even more amazing about this recent discovery is, it's a
Filipino invention.
"Engineer Sanchez from Cebu started with a foundation that produced
feeds for the pigs. After several usage, they noticed a significant
change in the animals health. It was when they started using it that
they began getting more out of the animals since it grows faster and
healthier than other pigs. They also noticed that the animal manure
does not smell so bad as before. It was during that time that they
took on the idea of developing something for human consumption,"
Cerezo relates.
Curiosity emanated from the theory that ill health begins in the
Colon. It is widely believed that about 90 percent of all chronic
diseases may have emanated from a disturbed or unhealthy human
gastrointestinal (GI) tract.
"Not too many people know that there is an important link between good
health and normal intestinal flora. Inside the human gut resides and
thrives a living colony of microorganisms numbering 10 times more than
all of the human cells combined. Over 400 different types of bacteria
battle to ‘colonize' the warm and moist environment of the human gut.
These microbes need the human gut and it's environment to flourish,
and the human needs these microbes to stay health," he explains.
Scientific research shows that there are two types of bacteria that
flourishes in the human gut – the good and the bad, that is. Good
health prevails when ‘good bacteria' are properly colonized in the GI
tract, while ill health is the result of too many bad bacteria.
Studies show that in order for one to stay healthy, the ration of good
to bad bacteria that must be maintained inside he body must be around
80:20.
"Once this balance is altered, the body becomes vulnerable to toxins,
and ill health sets in. This condition is known as dysbiosis and is
believed to be the major cause of more than 90 percent of illnesses
known to mankind."
AN ‘INSIDE' JOB
Clinical tests show that Lactobacillus PAFI Plantarum, which is the
active ingredient in Lactovitale, has the extraordinary ability to
inhibit the growth of certain pathogenic or ‘harmful' bacteria such as
E. Coli which is a leading cause of bloody diarrhea, P. Aeruginosa
which is a frequent cause of pneumonia and UTI, K. Pneumoniae which
causes bactermia and would infection, and the antibiotic resistant S.
Aureus which causes food poisoning.
"Laboratory tests also show that Lactobicullus PAFI Plantarum could
survive the acidic environment in the human gut and is the only
probiotic strain that cannot
be harmed by antibiotics, thereby making it implantable and extremely
beneficial to the body"
On the other hand, based on the testimonies of thousands who have
experienced this formula, this probiotic supplement when taken
properly, adequately, and religiously, had shown an extraordinary
ability to improve the health conditions of patients suffering from
dreaded illnesses such as _psoriasis_, diabetes, cancer,
kidney/liver/heart ailments, hypertension, and the like.
"By restoring the balance of the intestinal flora, thereby flushing
out toxins and inhibiting the growth of bad bacteria, Lactovitale
could help restore a healthy and efficient immune system, thereby
assisting the body in fighting off illnesses and in slowing down the
aging process."
PROBIOTICS VS. ANTIBIOTICS
The mere mention of Antibiotics would lead one to think of the wonder
drugs of the 20th century which have helped conquer many diseases that
previously resulted in death and disablement. However, recent studies
have shown its limitations. Perhaps one of the worst side effects of
using antibiotics is its indiscriminate killing of bacteria.
Probiotics does exactly the opposite.
"Probiotics are a powerful supplement that helps rebuild the balance
of good bacteria in the gastrointestinal tract and even reverse the
imbalances that may contribute to the onset of chronic conditions,"
Cerezo tells.
While a number of probiotic supplements are already being sold in
specialty stores today with a wide variety available, one could be
left guessing which one to choose.
"Clinical tests show that a particular strain of lactobacillus known
as Lactobacillus Plantarum consistently stood out from the rest for
several reasons such as its resistant to antibiotics, effectiveness
against cardiovascular diseases, and natural alternative to multiple
drugs," he cites.
Contrary to what others may immediately conclude, Lactovitale is not
an herbal drink. While its main ingredient is being extracted from
soya beans, the extract itself that is cultured into lactic and
bacteria is not an herb or an herb extract, but a living beneficial
microorganism. Fresh milk and purified water are necessary to ferment
or ‘culture' the probiotics, and molasses is needed to feed and keep
these ‘ good bacteria' alive. This is why Lactovitale is more
appropriately branded as Probiotic Health Drink and not herbal.
"Lactovitale do not claim itself as a miracle drug. It is intended as
a liquid food supplement and is registered with BFAD. It has at the
moment no approved therapeutic claims, or it has undergone BFAD
clinical test that are required to be considered as a herbal medicine
or drug. It has however passed all tests necessary to be given a
license to be manufactured as a food supplement."
He further notes, "Since Lactovitale is not a medicine, it does not
claim to cure illnesses or repair damages. What it does is to
normalize the balance of good and bad bacteria in the body, thereby
inhibiting accumulation of toxins and helping revitalize the immune
system. Once that is achieved, the chance of the human body healing
itself increases. Lactovitale cannot extend one's life. What it can do
is to help the body optimize its lifespan, and improve the quality of
life by improving one's health in relative terms. Lactovitale provides
a new ray of hope for man's unending desire for longevity and
vitality."
==========================================================================================
And i suppose these pigs taste better and fly right onto the grill
and into your mouths due to their enhanced colon gut critters?
Lactovitale, it gives your pig wings!
Ok, sorry, couldn't resist.
If you want to change the ratio of flora in your gut.
Go on a vegetarian type diet like the pagano diet then
use some proflora whey (a carbo whey as opposed to the
protein wheys that are nearly ubiquitious these days)
and see if you can grow it back. If that doesn't work
go to www.thewholewhey.com and buy the wit kit and
follow the instructions to the letter. You will have
the 80:20 ratio of flora and will be able to handle
psoriasis inflammation much much better.
If your only mild to moderate to begin with, you
should be able to stay clear for a long time,
provided you continue to use the proflora whey
supplement every day. Been my experience anyway!
So, did your psoriasis onset after streP and some
antibiotics?
That wiped out your good colon critters?
Randall
Cocktail time,
http://www.medicalposting.ca/men/article.jsp?content=20040310_094653_4520&topStory=y
Two-drug combo treats severe rheumatoid arthritis
Alefacept and methotrexate lessen joint pain and swelling
A combination of old and new drugs can help people with severely
inflamed joints due to rheumatoid arthritis.
Rheumatoid arthritis is a chronic disease in which the body's own
immune system attacks the joints and other tissues, causing redness,
pain and swelling. According to the Arthritis Society, it affects one
in 100 Canadians.
Researchers believe a new drug called alefacept offers hope for people
with a severe case of the disease. The drug works by depleting immune
system cells called memory-effector T-cells. It is also used to treat
a skin disease called psoriasis.
"Alefacept in combination with methotrexate offers new promise of
relief for rheumatoid arthritis patients suffering with their disease.
A single 12-week course of alefacept can provide sustained improvement
for up to six months," says Dr. Matthias Schneider, a professor of
medicine at the Heinrich-Heine University in Dusseldorf.
Schneider and his colleagues assessed the effectiveness of alefacept
in 36 patients with severe rheumatoid arthritis. The drug was tested
at two different doses combined with methotrexate, an older drug for
severe rheumatoid arthritis, and compared with treatment results using
methotrexate alone.
The alefacept was given intravenously once a week for 12 weeks.
Arthritis symptoms improved in 67 per cent of patients receiving
alefacept at either dose, compared with only 17 per cent of patients
on methotrexate alone.
"There were no major side-effects. Really just a little dizziness and
flushing during the infusion and that was all," Schneider says.
"What was really excellent was that we still had responses 12 weeks
after stopping the medication, so I think that is an important
finding. It is a long-lasting effect."
Alefacept can also be given as a monthly injection. Schneider says
this could be the ideal way of delivering the drug, but studies will
need to confirm this method is safe and effective.
Dr. Stanley Cohen, a clinical professor of internal medicine at the
University of Texas Southwestern Medical Center at Dallas, says the
study is good news for doctors and patients because it confirms the
role of memory-effector T-cells in rheumatoid arthritis.
"It is a good way to go. This is very promising early data."