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Otologic safety of manuka honey
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asfyso
May 19, 2012, 3:43:38 AM5/19/12
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J Otolaryngol Head Neck Surg. 2012 Apr;41 Suppl 1:S21-30.
Otologic safety of manuka honey.
Aron M, Victoria Akinpelu O, Dorion D, Daniel S.
Abstract
ABSTRACTObjective:To investigate the possible ototoxic effects of a
50% concentration of manuka honey in a chinchilla animal model.Study
Design: A prospective, controlled animal study.Setting:The Research
Institute of the Montreal Children's Hospital, McGill University
Health Centre.Subjects and Methods:Eight animals had myringotomy
incisions in both ears. One ear was randomly assigned to receive the
50% manuka honey solution. The contralateral ear received saline and
served as the control ear.Outcome Measures:Auditory brainstem evoked
responses (ABRs) were measured bilaterally for a wide range of
frequencies (between 8 and 25 kHz) before and 2 weeks after
transtympanic manuka honey and saline application. The animals were
sacrificed, and all cochleae were dissected out and processed for
light and scanning electron microscopy (SEM).Results:The measured ABR
thresholds after the application of 50% concentration of manuka honey
revealed severe ototoxicity in all honey-exposed ears. This was
accompanied by gross physical changes and histologic evidence of hair
cell toxicity on SEM and light microscopy. The control ears remained
unchanged during the period of the experiment.Conclusion:Although 50%
concentration of manuka honey is the proven concentration to have
bactericidal properties against biofilms of Pseudomonas aeruginosa and
Staphylococcus aureus, this concentration appeared to have caused
severe or intense inflammatory changes that produced facial paralysis,
vestibulotoxicity, and hearing loss.
Otologic safety of manuka honey.
Aron M, Victoria Akinpelu O, Dorion D, Daniel S.
Abstract
ABSTRACTObjective:To investigate the possible ototoxic effects of a
50% concentration of manuka honey in a chinchilla animal model.Study
Design: A prospective, controlled animal study.Setting:The Research
Institute of the Montreal Children's Hospital, McGill University
Health Centre.Subjects and Methods:Eight animals had myringotomy
incisions in both ears. One ear was randomly assigned to receive the
50% manuka honey solution. The contralateral ear received saline and
served as the control ear.Outcome Measures:Auditory brainstem evoked
responses (ABRs) were measured bilaterally for a wide range of
frequencies (between 8 and 25 kHz) before and 2 weeks after
transtympanic manuka honey and saline application. The animals were
sacrificed, and all cochleae were dissected out and processed for
light and scanning electron microscopy (SEM).Results:The measured ABR
thresholds after the application of 50% concentration of manuka honey
revealed severe ototoxicity in all honey-exposed ears. This was
accompanied by gross physical changes and histologic evidence of hair
cell toxicity on SEM and light microscopy. The control ears remained
unchanged during the period of the experiment.Conclusion:Although 50%
concentration of manuka honey is the proven concentration to have
bactericidal properties against biofilms of Pseudomonas aeruginosa and
Staphylococcus aureus, this concentration appeared to have caused
severe or intense inflammatory changes that produced facial paralysis,
vestibulotoxicity, and hearing loss.
asdfasdf
May 20, 2012, 10:51:49 PM5/20/12
to
even eat it? Sounds toxic! :)
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