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Future perspective on host-pathogen interactions during bacterial biofilm formation within the nasopharynx.
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asfyso
Feb 18, 2012, 9:30:37 AM2/18/12
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Future Microbiol. 2012 Feb;7:227-39.
Future perspective on host-pathogen interactions during bacterial
biofilm formation within the nasopharynx.
Blanchette KA, Orihuela CJ.
Source
The University of Texas Health Science Center at San Antonio,
Department of Microbiology & Immunology, 7703 Floyd Curl Drive,
MC7758, San Antonio, TX 78229-3900, USA.
Abstract
Nasopharyngeal colonization provides bacteria with a place of
residence, a platform for person-to-person transmission and for many
opportunistic pathogens it is a prerequisite event towards the
development of invasive disease. Therefore, how host factors within
the nasopharynx contribute to, inhibit or otherwise shape biofilm
formation, the primary mode of existence for colonizing bacteria, and
how biofilm bacteria subvert the acute inflammatory response that
facilitates clearance, are important topics for future microbiological
research. This review proposes the examination of host components as
bridging molecules for bacterial interactions during biofilm
formation, altered virulence determinant production and cell wall
modification as a mechanism for immunoquiescence, and the role of host
factors as signals and co-opted mechanisms for bacterial
dissemination, together providing an opportunity for disease.
PMID: 22324992 [PubMed - in process]
Future perspective on host-pathogen interactions during bacterial
biofilm formation within the nasopharynx.
Blanchette KA, Orihuela CJ.
Source
The University of Texas Health Science Center at San Antonio,
Department of Microbiology & Immunology, 7703 Floyd Curl Drive,
MC7758, San Antonio, TX 78229-3900, USA.
Abstract
Nasopharyngeal colonization provides bacteria with a place of
residence, a platform for person-to-person transmission and for many
opportunistic pathogens it is a prerequisite event towards the
development of invasive disease. Therefore, how host factors within
the nasopharynx contribute to, inhibit or otherwise shape biofilm
formation, the primary mode of existence for colonizing bacteria, and
how biofilm bacteria subvert the acute inflammatory response that
facilitates clearance, are important topics for future microbiological
research. This review proposes the examination of host components as
bridging molecules for bacterial interactions during biofilm
formation, altered virulence determinant production and cell wall
modification as a mechanism for immunoquiescence, and the role of host
factors as signals and co-opted mechanisms for bacterial
dissemination, together providing an opportunity for disease.
PMID: 22324992 [PubMed - in process]
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