Clinical and histopathologic features of biofilm-associated chronic rhinosinusitis with nasal polyps in Chinese patients

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This free article has some biofilm pictures.

Chin Med J (Engl). 2012 Mar;125(6):1104-9.
Clinical and histopathologic features of biofilm-associated chronic
rhinosinusitis with nasal polyps in Chinese patients.
Sun Y, Zhou B, Wang CS, Huang Q, Zhang Q, Han YH, Dai W, Sun YL, Fan
EZ, Li Y.
Source
Department of Otolaryngology-Head and Neck Surgery, Beijing Tong Ren
Hospital, Capital Medical University, Beijing Institute of
Otolaryngology, Key Laboratory of Otolaryngology Head and Neck
Surgery, Beijing 100730, China.
Abstract
BACKGROUND:
Biofilms have given new insights to the understanding of pathogenesis
of chronic rhinosinusitis (CRS). However, the link between biofilms
formation and local inflammatory response remains poorly defined in
CRS with nasal polys. The aim of this study was to determine the
potential association of the presence of biofilms in the nasal mucosal
tissues with clinical features in Chinese patients, which had CRS with
nasal polyps (CRSwNP).
METHODS:
A total of 19 patients with CRSwNP and 12 patients with non-CRS were
subjected to endoscopic surgery and their nasal mucosal tissue
specimens were examined histologically and by scanning electron
microscopy (SEM). Their demographic and clinical features were
recorded.
RESULTS:
Thirteen (68.4%) out of the 19 specimens from patients with CRSwNP,
but none from control patients, were positive for biofilms that
displayed typical characteristics of bacterial and fugal structures.
The presence of biofilms in the nasal mucosal tissues was associated
with significantly greater values of purulent nasal discharge and
preoperative Lund-Kennedy scores, higher levels of serum total IgE and
percentages of subjects with endoscopic surgery (ESS) history in
patients with CRSwNP, and more severe inflammation in the nasal
mucosal tissues of patients with CRSwNP.
CONCLUSION:
Our study demonstrated the presence of biofilms in the nasal mucosal
tissues of many patients, contributing to the understanding of the
pathogenic process of CRSwNP in Chinese patients.
PMID: 22613538 [PubMed - in process] Free full text