Two studies found some benefit in symptoms and mood, including efficacy
for pain, spasticity, and quality of life. Two studies found LDN safe
and well tolerated. The third didn't address those, but didn't report
negative findings either.
One study did not find significance, but did not rule out possible
effectiveness, noting other ongoing treatments might have blunted LDN
effects.
It's worth reading. The article indicates LDN is effective.
Best page on the subject I've seen yet. Someone took the anecdotal
reports seriously enough to do some science.