Iron-binding In Most Lupus Patients
ironjustice
Hydroxychloroquine Use May Be Safe in Systemic Lupus Erythematosus
"Because of its broad spectrum of benefits and safety profile,
hydroxychloroquine should be given to most patients with systemic
lupus erythematosus (SLE) during the whole course of the disease,
regardless of severity, and should be continued during pregnancy,
according to the results of a systematic review reported in the June 3
Online First issue of Annals of the Rheumatic Diseases."
---------
"Hydroxychloroquine"
The iron-binding and hydroxyl radical scavenging action of anti-
inflammatory drugs.
Xenobiotica. 1988 Apr;18(4):459-70.
Aruoma OI, Halliwell B.
Department of Biochemistry, University of London King's College,
Strand Campus, UK.
1. Hydroxyl radicals (.OH) are thought to be generated at sites
of inflammation and to contribute to tissue damage.
All anti-inflammatory drugs tested were able to scavenge .OH
generated in free solution at almost diffusion- controlled rates
(rate constants about 10(10)M-1s-1).
2. Much .OH generation in vivo occurs at specific sites, where
bound metal ions (such as Fe2+) react with H2O2 to produce
.OH that immediately attacks the site.
Only .OH scavengers that have sufficient metal-binding ability
to withdraw metal ions from this site can protect against
site-specific damage.
3. All anti-inflammatory drugs tested were able to protect against
site-specific damage by .OH in a simple model system in vitro.
Penicillamine, diclofenac sodium, piroxicam, azathioprine,
primaquine,
chloroquine and hydroxychloroquine were especially effective.
4. The ability of an anti-inflammatory drug to protect against .OH
formation in vivo depends not only on its rate constant for reaction
with .OH, but also on its metal-binding ability and on the geometry
and redox potential of any metal complex formed.
PMID: 3135672
----------------------
Anyone care to venture a guess why phlebotomy / bloodletting hasn't
even been tried in lupus when a drug that is supposed to BE .. an
**alternative** TO **bloodletting** .. IS .. now .. readily
prescribed .. ?
"Hydroxychloroquine should be the preferred alternative to phlebotomy"
Plaquenil - Plaquenil Side Effects - Plaquenil
Hydroxychloroquine has been beneficial for a high
percentage of patients with rheumatoid arthritis and lupus
erythematosus, especially chronic discoid lupus ...
---------------------------------------------------------------------------------
"Hydroxychloroquine should be the preferred alternative to phlebotomy"
Photodermatol. 1984 Dec;1(6):286-92. Links
A comparative trial of desferrioxamine and hydroxychloroquine for
treatment of porphyria cutanea tarda in alcoholic patients.Marchesi
L,
Di Padova C, Cainelli T, Reseghetti A, Di Padova F, Rovagnati P,
Cantoni L.
Forty male alcoholic patients with porphyria cutanea tarda (PCT) were
randomly assigned to 2 groups of 20. The 1st group received
desferrioxamine (30 mg/kg body weight/day for 1 week every 3 months)
whereas the latter was given hydroxychloroquine (200 mg twice/wk
orally). Alcohol abstinence was advised for all patients. Improvement
of cutaneous signs was evident after 6 months in hydroxychloroquine-
treated subjects and after 12 months in desferrioxamine-treated
subjects. At the end of the 1-year clinical trial, significant
decreases of serum iron and ferritin were found in all patients,
irrespective of the therapy. Urinary total porphyrins were reduced
significantly in both groups, but the drop was significantly more
evident in hydroxychloroquine- than in desferrioxamine-treated
subjects. After 1 year of therapy, 4 desferrioxamine-treated patients
vs 16 hydroxychloroquine-treated subjects acquired a normal urinary
porphyrin pattern. These results indicate that hydroxychloroquine is
more effective than desferrioxamine in inducing clinical and
biochemical remission of PCT. Accordingly, hydroxychloroquine should
be the preferred alternative to phlebotomy, if the latter is
contraindicated.
PMID: 6398430
-------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
ironjustice
binding <<
"Intake of meat was associated with an increased risk and that the
patients preferred fatty meat such as beef or pork"
"These results suggest that dietary and reproductive factors may be
responsible for the onset and the progression of SLE."
Female systemic lupus erythematosus in Miyagi Prefecture, Japan: a
case-control study of dietary and reproductive factors.
Tohoku J Exp Med. 1993 Mar;169(3):245-52.
Minami Y, Sasaki T, Komatsu S,
Nishikori M, Fukao A, Yoshinaga K, Hisamichi S.
Department of Public Health, Tohoku University School of Medicine,
Sendai.
To investigate risk factors of systemic lupus erythematosus (SLE) in
relation to diet and reproduction, a population-based case-control
study was conducted during the period from October 1988 to October
1989 in Miyagi Prefecture in northeastern Japan.
Included in the study were 52 female patients with the recent SLE
onset.
Two sex- and birth year-matched (+/- 2 years) controls for each
patient
were selected from the general population.
The analysis on diet showed that the frequent intake of meat was
associated with an increased risk (frequent vs. rare, relative risk
(RR)
3.36; 95% confidence interval (CI) 1.10-10.24) and that the patients
preferred fatty meat such as beef or pork.
The analysis on menstrual history revealed that menstrual
irregularity
was also associated with an increased risk (RR 3.79; 95% CI
1.43-10.01).
These results suggest that dietary and reproductive factors may be
responsible for the onset and the progression of SLE.
PMID: 8248914
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
Ken
ironjustice
You coprophagit atheists have been told my threads are NOT for you to
congregate ..
ALL you repugnant fks were told to stay off my threads ..
Homosexual atheist shteaters .. were .. specifically .. TOLD ..
Write it .. down .. shteater ..
Giiiiit .. you .. mutated atheist shteater ..
Giiiiiit .. shteater ..
Git ..
-----------
ironjustice
uroporphyrin <<
We have established .. CONCLUSIVELY .. **they** have DECIDED amongst
themselves it would be "wise" to treat EACH AND EVERY ONE WITH LUPUS
with a drug which is EXCLUSIVELY to be used INSTEAD of
**bloodletting** .. but .. bloodletting has NEVER EVEN BEEN MENTIONED
in the treatment of lupus patients .. EVER .. ever ..
Now either each and every lupus patient is .. stupid .. which is
obviously I guess .. and each and every medical person is stupid .. ?
Or .. I .. am stupid ..
This shows vitamin C .. normally .. can offset a slight buildup of
iron but WHEN the iron hits a 'certain level' the iron OVERWHELMS the
vitamin C's **ability** to OFFSET this higher iron and the body
cannot .. cope.
"Ascorbate suppresses hepatic URO accumulation at low, but not high
hepatic iron levels"
This shows when the iron gets to a 'certain point' .. BOOM ..
"Was not observed until a high hepatic iron threshold was exceeded"
It shows it can be controlled by targeting the iron with diet and / or
DIRECT iron targeting.
Uroporphyrin induces an autoimmune response / autoimmune like
response.
Effect of iron and ascorbate on uroporphyria in ascorbate-requiring
mice as a model for porphyria cutanea tarda.
Gorman N, Zaharia A, Trask HS, Szakacs JG, Jacobs NJ, Jacobs JM,
Balestra D, Sinclair JF, Sinclair PR
Hepatology. 2006 Dec 22; 45(1): 187-194
Excess hepatic iron is known to enhance both porphyria cutanea tarda
(PCT) and experimental uroporphyria.
Since previous studies havesuggested a role for ascorbate (AA) in
suppressing uroporphyria inAA-requiring rats (in the absence of excess
iron), the present studyinvestigated whether AA could suppress
uroporphyria produced byexcess hepatic iron.
Hepatic URO accumulation was produced in AA-requiring Gulo(-/-) mice
by treatment with 3,3',4,4',5-pentachlorbiphenyl, an inducer of
CYP1A2, and 5-aminolevulinic acid.
Mice were administered either sufficient AA (1000 ppm) in the drinking
water to maintainnear normal hepatic AA levels or a lower intake (75
ppm) that resulted in70% lower hepatic AA levels.
The higher AA intake suppressed hepatic URO accumulation in the
absence of administered iron, but not when irondextran (300-500 mg Fe/
kg) was administered.
This effect of iron wasnot due to hepatic AA depletion since hepatic
AA content was not decreased.
The effect of iron to prevent AA suppression of hepatic URO
accumulation was not observed until a high hepatic iron threshold was
exceeded.
At both low and high AA intakes, hepatic malondialdehyde
(MDA), an indicator of oxidative stress, was increased three-fold by
high doses of iron dextran.
MDA was considerably increased even at low iron dextran doses, but
without any increase in URO accumulation.
The level of hepatic CYP1A2 was unaffected by either AA intake.
Conclusion:
In this mouse model of PCT, AA suppresses hepatic URO accumulation at
low, but not high hepatic iron levels.
These results may have implications for the management of PCT.
(HEPATOLOGY2007;45:187-194.).
------------
Effect of an oral iron chelator or iron-deficient diets on
uroporphyria in a murine model of porphyria cutanea tarda.
Hepatology. 2007 Sep 13;
Gorman N, Zaharia A, Trask HS, Szakacs JG, Jacobs NJ, Jacobs JM,
Balestra D, Sinclair JF, Sinclair PR.
Veterans Affairs Medical Center, White River Junction, VT.
Porphyria cutanea tarda is a liver disease characterized by elevated
hepatic iron and excessive production of uroporphyrin (URO).
Phlebotomy is an effective treatment that probably acts by reducing
hepatic iron.
Here we used Hfe(-/-) mice to compare the effects on
hepatic URO accumulation of two different methods of hepatic iron
depletion: iron chelation using deferiprone (L1) versus iron-
deficient diets.
Hfe(-/-) mice in a 129S6/SvEvTac background were fed 5-
aminolevulinic acid (ALA), which results in hepatic URO accumulation,
and increasing doses of L1 in the drinking water. Hepatic URO
accumulation was completely prevented at low L1 doses, which partially
depleted hepatic nonheme iron. By histological assessment, the
decrease in hepatic URO accumulation was associated with greater
depletion of iron from hepatocytes than from Kupffer cells.
The L1 treatment had no effect on levels of hepatic cytochrome P4501A2
(CYP1A2).
L1 also effectively decreased hepatic URO accumulation in
C57BL/6 Hfe(-/-) mice treated with ALA and a CYP1A2 inducer. ALA-
treated mice maintained on defined iron-deficient diets, rather than
chow diets, did not develop uroporphyria, even when the animals were
iron-supplemented either directly in the diet or by iron dextran
injection.
Conclusion:
The results suggest that dietary factors other than iron are involved
in the development of uroporphyria and that a modest depletion of
hepatocyte iron by L1 is sufficient to prevent URO accumulation.
(HEPATOLOGY 2007.).
PMID: 17854053
Happy Oyster
wrote:
>Or .. I .. am stupid ..
************************
Yes.
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ken
ironjustice
(HEPATOLOGY2007;45:187-194.).
------------
PMID: 17854053
Who loves ya.
Tom
ken
ironjustice
This is as close to a .. gauntlet .. we are going to get ..
Somebody .. somewhere .. step up ..
There's gotta be a man amongst .. ya ..
ironjustice
"Mice maintained on defined iron-deficient diets, rather than
chow diets, did not develop uroporphyria "
The whole thing is summed up by the bizarre finding above.
The researchers **accidentally** found "something in that food is
causing disease in our mice" and they switched to a chow they created
**themselves** and found this new food .. which coincidentally ..
**doesn't contain meat** .. didn't cause the disease NO MATTER HOW
MUCH IRON WAS GIVEN TO THE ANIMALS.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
, even when the animals were