Ovarian Cancer
ironjustice
spread / metastasis of the cancer.
Association between blood rheology, thrombosis and cancer
survival in patients with gynecologic malignancy.
Clin Hemorheol Microcirc. 2000;22(2):107-30.
von Tempelhoff GF, Nieman F, Heilmann L, Hommel G.
Department of Obstetrics and Gynecology,
City Hospital of Ruesselsheim, Germany.
G-F.von.T...@gmx.de
In cancer patients impaired blood rheology in the presence of
coagulation activation may reduce blood flow in the vascular
microcirculation that favors thrombosis but may also support
tumor progression and metastasis.
In 451 patients with gynecological cancer and 177 patients
with corresponding benign tumor disease preoperatively, during
adjuvant treatment, when venous thrombosis (VT) or cancer
progression was diagnosed hematocrit (micro centrifuge),
hemoglobin, leukocytes, platelets (Coulter Counter); red blood
cell (RBC) aggregation (aggr.) during stasis and low shear
conditions (MA 1, Myrenne), plasma viscosity (viscosimeter
KSPV 1 Fresenius), and fibrinogen (Multifibren Behring Dade)
were investigated.
One hundred and twelve healthy women served as controls.
Preoperatively, mean plasma viscosity (pv) was significantly
higher in cancer patients as compared to patients with the
corresponding benign tumor disease (breast cancer: n = 261;
pv = 1.32 vs. 1.27 mPa s; p = 0.023; ovarian cancer: n = 68;
pv = 1.39 vs. 1.31 mPa s; p < 0.001; endometrial cancer: n = 70;
pv = 1.37 vs. 1.25 mPa s; p < 0.001; cervical cancer: n = 52;
pv = 1.33 vs. 1.26 mPa s; p = 0.004).
RBC aggr. was significantly lower in controls compared to the
preoperative values in cancer patients but mean (median) values
(RBC aggr. stasis < 21) were within the normal range in all.
Preoperatively, plasma viscosity was a significant risk factor for
the overall survival in ovarian cancer patients (p = 0.02) and for
subsequent thrombosis in ovarian (p = 0.02) and cervical cancer
patients (p = 0.007).
In the multivariate analysis plasma viscosity was an independent
prognostic marker for the overall survival of breast cancer patients
(r = 99.45; 95% CI: 7.32-980.2; p < 0.0001).
An optimized preoperative cut-off value above 1.40 mPa s
(Log-Rank-test) was significantly associated with poor outcome in
the Kaplan-Mayer survival estimates, even in node-negative breast
cancer.
In gynecologic cancer patients the combination of an increase in
RBC aggregation and plasma viscosity impairs blood-flow-properties
and may induce hypoxia in the microcirculation that favors
thrombosis, settlement of tumor-cells and thus metastasis.
Improvement of blood fluidity and thus oxygen transfer in the
tumor-vascular-microcirculation may increase susceptibility of
systemic
anti-cancer therapy.
PMID: 10831062
----------------
Br Med J. 1915 June 19; 1(2842): 1069. PMCID: PMC2302502
Copyright notice
BLOODLETTING IN PNEUMONIA
John Haddon
BLOODLETTING IN PNEUMONIA.
Sir, Dr. Balms's communication in the Journal of June 5th, p. 970,
telling how he treats some cases of pneumonia, deserves to be
noticed.
It was the late Professor John Jughes Bennet who first advocated the
expectant treatment of pneumonia, and his book on the subject was
translated into many languages.
I acted as his resident in the clinical wards of the Edinburgh Royal
Infirmary, and , by his directions, I occasionally bled patients.
Bennet would have bled the cases Dr. Balm describes , and if the idea
is original on his part , he deserves credit.
Talking about his letter with a medical friend , he told me that he
had a patient whose nose bled profusely; he failed to stop it, and
the
late Dr. Joseph Bell was consulted he told my friend that his father
would , in such a case , have opened a vein, and that was what Dr.
Joseph Bell did.
He did not take more than two tablespoonsfuls of blood , and there
was
no more bleeding from the nose.
Our grandfathers used to be bled every spring, and I have heard
Professor Bennet tell of the row of patients waiting to be bled.
Lanquid and lazy before being bled, they felt as if their youth were
renewed by the bleeding.
I heard Sir T. Clifford Allbutt tell of having had a patient
suffering
from a pulse of very high tension, who was kept for a year by one
venesection; in these days of so-called sudden death from heart
failure or apoplexy , which I look upon as an opprobrium to the
physician, it would be well to resort to an annual bleeding aagain,
unless the profession can be converted to the views set forth in my
book which proves that food is the chief cause of disease, and
restricts the quantity , as well as changes the quality , of the
patients food.
In what has been called "idiopathic anasarca" we have a neurosis ,
due
to what the ancient physicians called plethora, which was just too
much blood, and which venesecton removed.
Such anasarca is almost universal after middle life, and I have found
it in some quite young , proving that even the youngest may be
injured
by the food they eat.
Such facts ought to encourage the study of dietetics which the
General
Medical Council would do well to make a compulsory subject of
examination for every licence to practice medicine. -- I am, etc.,
Hawick June 7th, John Haddon, M.D.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Lloyd Warner
On 22/09/09 11:51 AM, in article
ac38d41f-cb18-4d3a...@z3g2000prd.googlegroups.com,
Michael B
immune system does.
http://www.patentstorm.us/patents/6384044/description.html
Interesting that the protocol is not effective when hormone
therapies have been initiated in the case of prostate cancer
but unfortunately a lot of urologists see that as the only option.
And vegetarians get cancer, too.