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Chelation In Thrombosis

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ironjustice

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Jun 27, 2009, 10:02:40 AM6/27/09

Modification of fibrin structure as a possible cause of thrombolytic
resistance
Journal of Thrombosis and Thrombolysis
Boguslaw Lipinski1
(1) Department of Genetics and Epidemiology, Joslin Diabetes Center,
Harvard Medical School, Boston, MA 02215, USA

Published online: 24 June 2009

Abstract
This paper presents a concept according to which free radicals,
specifically
the most biologically active hydroxyl radicals, induce structural
modifications
in fibrin(ogen) molecules making them resistant to proteolytic
degradation.
Such changes are analogous to those in congeneticaly altered
fibrinogen that
give rise to plasmin resistant fibrin clots and consequently to
thrombosis.
In view of the fact that hydroxyl radicals are generated in the Fenton
reaction
in the presence of iron and/or copper ions, the use of chelating
agents to
facilitate thrombolysis is rationalized.
Moreover, the resistance of thrombi older than 3 h to proteolytic
degradation
may be abrogated by the administration of free radical scavengers,
particularly
those that can be neutralized by virtue of aromatic hydroxylation,
such as
salicylates and polyphenolic compounds.