Iron In Lupus

[ironjustice]

Relationship between iron metabolism, oxidative stress, and insulin
resistance in patients with systemic lupus erythematosus.
Lozovoy M, Simão A, Oliveira S, Iryioda T, Panis C, Cecchini R, Dichi
I.
Scand J Rheumatol. 2013 Feb 20.
Department of Clinical Analysis, University North of Paraná (UNOPAR) ,
Paraná , Brazil.

Abstract
Objective: The aim of the present study was to assess oxidative stress
and iron metabolism in systemic lupus erythematosus (SLE) patients
with and without insulin resistance (IR).
Method: This study included 236 subjects (125 controls and 111 SLE
patients). Patients with SLE were divided in two groups: with (n = 72)
or without (n = 39) IR.
Results: SLE patients with IR showed higher advanced oxidation protein
product (AOPP) levels (p = 0.030) and gamma-glutamyltransferase (GGT)
levels (p = 0.001) and lower sulfhydryl groups of proteins (p =
0.0002) and total radical-trapping antioxidant parameter (TRAP)
corrected by uric acid (UA) levels (p = 0.04) when compared to SLE
patients without IR. However, SLE patients with IR presented lower
serum 8-isoprostane (p = 0.05) and carbonyl protein levels (p = 0.04)
when compared to SLE patients without IR. Serum ferritin levels were
significantly higher in SLE patients (p = 0.0006) than in controls,
and SLE patients with IR presented higher serum ferritin levels (p =
0.01) than SLE patients without IR. Patients with SLE showed that IR
was inversely correlated to TRAP/UA (r = -0.2724, p = 0.0008) and
serum ferritin was positively correlated to AOPP (r = 0.2870, p =
0.004).
Conclusions: This study found that oxidative stress was higher in the
group of SLE patients with IR, and increased ferritin, whether caused
by the inflammatory process per se or hyperinsulinaemia, can favour
the redox process. In addition, the preset data reinforce the need to
measure oxidative stress with several methodologies with different
assumptions.

PMID:23424997


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