Autoimmune Disease

[ironjustice]

"Factors such as diet"

Twins Help Reveal Secrets of Lupus
(Ivanhoe Newswire) -- Identical twins are nearly genetically
identical, but cellular changes resulting from exposure to
environmental factors could cause disease in one sibling and not the
other.

Scientists from Spain and the United States have studied twins
discordant for the autoimmune disease lupus, mapping DNA modifications
across the genome and shedding light on genetic changes that may play
a role in the disease.

Because the genetic makeup of identical twins is nearly identical,
phenotypic traits and heritable diseases often manifest in both
siblings. However, some traits and diseases, such as autoimmune
disease, can arise in only one sibling, suggesting other factors such
as environment likely play a role in determining phenotypic
differences.

Furthermore, environmental factors such as diet and chemical exposure
can change the status of genes. Recent research has identified genetic
modifications in autoimmune diseases such as systemic lupus
erythematosus (SLE).

Researchers in this study performed the first genome-wide high-
throughput analysis of a specific genetic modification, DNA
methylation, in the context of autoimmune disease. Taking advantage of
the identical genetic background in monozygotic twins, the group
directly compared DNA methylation in healthy twins and twins
discordant for autoimmune diseases, including SLE, looking for changes
that could be related to disease in one sibling and not the other.

In the case of SLE, the group found widespread changes in DNA
methylation status at a significant number of genes. Dr. Esteban
Ballestar, senior author of the study, was quoted as saying that this
is the largest number of genes exhibiting DNA methylation changes
observed in an autoimmune disease to date, and includes genes
previously implicated in SLE pathogenesis. Importantly, Ballestar's
team found that a significant number of the modified genes are related
to multiple immune system functions and are potentially linked to SLE.

"Our study suggests that the effect of the environment or differences
in lifestyle may leave a molecular mark in key genes for immune
function that contributes to the differential onset of the disease in
twins," Ballestar was quoted as saying. Most studies of DNA
methylation and human disease have been in the context of cancer
research, Ballestar noted, and he hopes that this work will attract
more researchers to also investigate DNA methylation alterations in
autoimmune disease and other disorders for the development of
therapies.

SOURCE: Genome Research, December 21, 2009

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/4rq595

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

[Michael B]

So Zebularine would be a good drug to try for SLE?
http://www.ncbi.nlm.nih.gov/pubmed/12206775
If I had SLE, I'd be trying Low Dose Naltrexone first.

[ironjustice]

On Dec 29, 7:57 pm, Michael B <baugh...@bellsouth.net> wrote: snip <<

You've been TOLD .. shteater ..

Giiiiiit ..

"Factors such as diet"

In the case of SLE, the group found widespread changes in DNA
methylation status at a significant number of genes. Dr. Esteban
Ballestar, senior author of the study, was quoted as saying that this
is the largest number of genes exhibiting DNA methylation changes
observed in an autoimmune disease to date, and includes genes
previously implicated in SLE pathogenesis. Importantly, Ballestar's
team found that a significant number of the modified genes are
related
to multiple immune system functions and are potentially linked to
SLE.

[Michael B]

You seem to have developed a stuttering problem.
Might be because of your sexual ambivalence.
You need to get out of your mommy's basement,
get a job, leave those neighborhood children alone.

[Jan Drew]

> > Giiiiiit ..- Hide quoted text -
>
> - Show quoted text -

abuse reported.
ab...@bellsouth.net

[Ken]

On Dec 30 2009, 10:02 am, ironjustice <ironjust...@rock.com> wrote
this crap

> You've been TOLD .. shteater ..

FOAD you irrelevant POS

[ironjustice]

On Jan 11, 3:10 pm, Ken <flakey...@aol.com> wrote:snip <<

You were TOLD shteater ..

BACK to alt.shteating.atheists ..

Giiiiiit ..

[ironjustice]

On Jan 11, 2:28 pm, Michael B <baugh...@bellsouth.net> wrote: snip <<

You were TOLD shteater ..

[Ken]

Spamming Canuck Dicksucker

[ironjustice]

[ironjustice]

[Jan Drew]

Path: g2news1.google.com!postnews.google.com!
k17g2000yqh.googlegroups.com!not-for-mail
From: Ken <flakey...@aol.com>
Newsgroups:
sci.med,sci.med.nutrition,misc.health.alternative,alt.support.lupus,alt.support.chronic-
pain
Subject: Re: Worthless Ravings from the Spamming Canuck
Date: Mon, 11 Jan 2010 15:10:31 -0800 (PST)
Organization: http://groups.google.com
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Message-ID: <8d0c5141-11f7-469d-92f3-
fe4b8d...@k17g2000yqh.googlegroups.com>
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<0a872cd8-3222-4c50...@m26g2000yqb.googlegroups.com>
<593ba216-8d97-4c98...@p8g2000yqb.googlegroups.com>
NNTP-Posting-Host: 66.245.37.81
Mime-Version: 1.0
Content-Type: text/plain; charset=ISO-8859-1
Content-Transfer-Encoding: quoted-printable
X-Trace: posting.google.com 1263251431 24302 127.0.0.1 (11 Jan 2010
23:10:31 GMT)
X-Complaints-To: groups...@google.com
NNTP-Posting-Date: Mon, 11 Jan 2010 23:10:31 +0000 (UTC)
Complaints-To: groups...@google.com
Injection-Info: k17g2000yqh.googlegroups.com; posting-
host=66.245.37.81;
posting-account=fpUx3QoAAADgnytjYurcHomn0oTV40rh
User-Agent: G2/1.0
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1.1.4322; .NET CLR 2.0.50727; .NET CLR 3.0.4506.2152; .NET CLR
3.5.30729),gzip(gfe),gzip(gfe)

On Dec 30 2009, 10:02=A0am, ironjustice <ironjust...@rock.com> wrote

[ironjustice]

[ironjustice]

On Dec 29 2009, 7:51 am, ironjustice <ironjust...@rock.com> wrote:
"Factors such as diet" <<

"Intake of meat was associated with an increased risk and that the
patients preferred fatty meat such as beef or pork"
"These results suggest that dietary and reproductive factors may be
responsible for the onset and the progression of SLE."

Female systemic lupus erythematosus in Miyagi Prefecture, Japan: a
case-control study of dietary and reproductive factors.
Tohoku J Exp Med. 1993 Mar;169(3):245-52.
Minami Y, Sasaki T, Komatsu S,
Nishikori M, Fukao A, Yoshinaga K, Hisamichi S.
Department of Public Health, Tohoku University School of Medicine,
Sendai.

To investigate risk factors of systemic lupus erythematosus (SLE) in
relation to diet and reproduction, a population-based case-control
study was conducted during the period from October 1988 to October
1989 in Miyagi Prefecture in northeastern Japan.
Included in the study were 52 female patients with the recent SLE
onset.
Two sex- and birth year-matched (+/- 2 years) controls for each
patient were selected from the general population.
The analysis on diet showed that the frequent intake of meat was
associated with an increased risk (frequent vs. rare, relative risk
(RR) 3.36; 95% confidence interval (CI) 1.10-10.24) and that the
patients preferred fatty meat such as beef or pork.
The analysis on menstrual history revealed that menstrual
irregularity was also associated with an increased risk (RR 3.79;
95% CI 1.43-10.01).
These results suggest that dietary and reproductive factors may be
responsible for the onset and the progression of SLE.

PMID: 8248914

[Ken]

Spam Spam Spam

[ironjustice]

I think there are ENOUGH shteating atheists in the chronic pain
group ALREADY ..

NO MORE NEEDED .. here ..

[Ken]

sPam SPaM SpaM

[Tio Nyarlathotep]

ironjustice wrote:
> I think there are ENOUGH shteating atheists in the chronic pain
> group ALREADY ..

Did you know that Cthulhu is in hell buttfucking the blessed virgin Mary
while defecating in the beard of the holy ghost? Jesus doth lick clean
the shit off Christ's cock.

Hail Satan, Canucker! Thanks for visiting sci.med. Yall come back now,
hyear?

In Yog Sohoth,

ph'nglui mglw'nafh Cthulhu R'lyeh wgah'nagl fhtagn,
Nyarlat Hotep

[Michael B]

Isn't he going to be around for bthe next presidential race?
No need to hold out for the lesser of the evils.
After all, Rusty is not a citizen, but is a copraphagic twit.

On Jan 12, 10:35 pm, Tio Nyarlathotep <cthulhu.pht...@hotmail.com>
wrote:

[ironjustice]

No shteaters ..

Giiiiiit ..

[Ken]

Spamming Canuck Dickwadd

[ironjustice]

On Jan 13, 8:15 am, Ken <flakey...@aol.com> wrote:
snip <<

Giiiiiit .. shteater ..

[ironjustice]

"Factors such as diet"

-----------

[Ken]

SPAM

[ironjustice]

American atheist same-sex sexual predator ..

[ken]

from a Spamming Canuck Fuckhead

[ironjustice]

[Nyarlat Hotep]

ironjustice wrote:
> American atheist same-sex sexual predator ..

Are you grumpy after your grapejuice enema?

[ironjustice]

On Feb 1, 8:12 pm, Nyarlat Hotep <cthulhupht...@arkham.hotmail.com>
wrote:

Are you grumpy after your grapejuice enema? <<

ANOTHER atheist ..

Are you TOO gay guy ..

You seem to be a predator ..

[Ken]

from a spamming Canuck Dicksucker

[ironjustice]

Atheist predators congregating again ..

[Michael B]

Just a reminder of another answer
http://www.wellsphere.com/lupus-article/low-dose-naltrexone/854830

[ironjustice]

Shteaters have been told to stay off my threads ..

DOOOOO it ..

"Factors such as diet"

Twins Help Reveal Secrets of Lupus
(Ivanhoe Newswire) -- Identical twins are nearly genetically
identical, but cellular changes resulting from exposure to
environmental factors could cause disease in one sibling and not the
other.

[Michael B]

How amazing. The folks over in alt.support.diabetes have
had a long discussion about beta cells going bad because
of oxidative stress, not a single comment from "someone".

[ironjustice]

Shteater .. you've HAVE been TOLD to stay off my threads ..

DOOOOO it .. shteater ..

Giiiiiit ..