Sun Triggers Autoimmune Disease

ironjustice

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Jul 31, 2009, 9:13:52 AM7/31/09

to

This would be that porphyria cutanea Tarda .. connection .. ?
That uroporphyrin .. connection .. ?
The sun causes the uroporphyrin to be .. released .. and uroporphyrin
causes autoimmune reaction ..

"Sunlight can greatly increase the exterior symptoms of Porphyria
Cutanea Tarda"

National Institute of Environmental Health Sciences (NIEHS)
Released: Thu 30-Jul-2009, 12:00 ET

Sun Exposure May Trigger Certain Autoimmune Diseases in Women

Ultraviolet (UV) radiation from sunlight may be associated with the
development of certain autoimmune diseases, particularly in women,
according to a study by researchers at the National Institute of
Environmental Health Sciences (NIEHS), part of the National Institutes
of Health.

“This study found that women who lived in areas with higher levels of
UV exposure when they developed an autoimmune muscle disease called
myositis were more likely to develop the form known as
dermatomyositis, which weakens the muscles and causes distinctive
rashes, instead of the form called polymyositis that does not have a
rash,” said Frederick W. Miller, M.D., Ph.D., chief of the
Environmental Autoimmunity Group, Program of Clinical Research, at
NIEHS.
“Although we have not shown a direct cause and effect link between UV
exposure and this particular autoimmune disease, this study confirms
the association between UV levels and the frequency of dermatomyositis
that we found in a previous investigation,” said Miller.

The study, published in the August issue of Arthritis & Rheumatism, is
also the first to evaluate and find a possible UV radiation
association in autoimmune diseases in women.

According to Miller, women are more likely than men to develop many
autoimmune diseases, but the reasons for this have not been clear. “We
only found the association between UV exposure and dermatomyositis in
women and not in men, and it could be that inherent differences in how
women and men respond to UV radiation may play a role in the
development of certain autoimmune diseases,” said Dr. Miller. Miller
also noted that other researchers have shown that female mice develop
more skin inflammation after UV light exposure compared to male mice
and these effects may be related to the new findings in
dermatomyositis.

The study was designed to determine if there was a relationship
between the level of UV exposure at the onset of the disease and the
type of myositis and autoantibodies that people developed.
Dermatomyositis and polymyositis are the two major forms of myositis
and both are considered autoimmune diseases, in which the body's
immune system attacks muscle or skin and sometimes other tissues.
Dermatomyositis is typically accompanied by a distinctive reddish-
purple rash on the upper eyelids or over the knuckles and is often
made worse with sun exposure.

To conduct the study, the NIEHS researchers collaborated with myositis
centers across the country that had seen 380 patients who had been
diagnosed with dermatomyositis or polymyositis and determined their
autoantibodies. “Patients with autoimmune diseases make a variety of
autoantibodies that are unique to different conditions. One
autoantibody specifically associated with dermatomyositis is called
the anti-Mi-2 autoantibody and we know from our previous research that
UV radiation increases levels of the Mi-2 protein that this
autoantibody binds to,” said Miller.

In addition to finding an association between the level of UV
radiation and the proportion of women who developed dermatomyositis
compared to polymyositis, the researchers found an association between
UV levels and the proportion of women with the anti-Mi-2 autoantibody.
“More research is clearly needed to understand the potential links
between UV radiation and the development of autoimmune diseases and
autoantibodies in women,” said Miller.

“While the causes of autoimmune diseases are not known, we suspect
from emerging research that they develop after one or more
environmental exposures in genetically susceptible people,” said NIEHS
Director Linda Birnbaum, Ph.D. “This study adds UV radiation to the
growing list of environmental exposures possibly important in the
development of autoimmune diseases.”

The NIEHS supports research to understand the effects of the
environment on human health and is part of NIH. For more information
on environmental health topics, visit our Web site at http://www.niehs.nih.gov.

The National Institutes of Health (NIH) — The Nation's Medical
Research Agency — includes 27 Institutes and Centers and is a
component of the U.S. Department of Health and Human Services. It is
the primary federal agency for conducting and supporting basic,
clinical and translational medical research, and it investigates the
causes, treatments, and cures for both common and rare diseases. For
more information about NIH and its programs, visit www.nih.gov.

Reference: Love LA, Weinberg CR, McConnaughey DR, Oddis CV, Medsger
TA, Reveille JD, Arnett FC, Targoff IN, Miller FW. “Ultraviolet
Radiation Intensity Predicts the Relative Distribution of
Dermatomyositis and Anti-Mi-2 Autoantibodies in Women.” Arthritis &
Rheumatism. August, 2009.

-------------

Definition of Porphyria Cutanea Tarda | eHow.comSunlight can greatly
increase the exterior symptoms of Porphyria Cutanea Tarda. Iron
management can be granted through phlebotomy. ...
www.ehow.com/about_5033787_definition-porphyria-cutanea-tarda.html
Who loves ya.
Tom

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http://tinyurl.com/4rq595

DEAD PEOPLE WALKING
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ironjustice

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Aug 2, 2009, 4:27:14 AM8/2/09

to

On Jul 31, 6:13 am, ironjustice <ironjust...@rock.com>
wrote:autoimmune muscle disease called

myositis were more likely to develop the form known as
dermatomyositis, which weakens the muscles <<

Muscular Dystrophy And Exercise-induced Muscle Fatigue Have More In
Common Than You Might Think
ScienceDaily (Mar. 3, 2009)

http://www.sciencedaily.com/releases/2009/02/090224004346.htm

Loss of localization of the muscle-related molecule nNOS
------------

That may explain WHY vitamin E has shown to correct this dystrophin
deficiency damage.
They have shown in the mouse model vitamin E can 'standin' for the
lack of dystrophin.
This study shows vitamin E can standin for nNOS ..

---------

"Improved nNOS"

Oxidative stress and antioxidant therapy

http://www.ncbi.nlm.nih.gov/pubmed/15292117

-------------------

This relates to that PTH disease .. EXTREME fatigue which is ..
"coincidentally" .. found to be TREATED PHARMACEUTICALLY .. with .. ?

Anybody got any retention skills .. ?

Hemolysis treated with vitamin E and phosphate.
Fatigue directly related to hemolysis.

http://bloodjournal.hematologylibrary.org/cgi/reprint/8/4/336.pdf

SUMMARY
1. The action of alpha-tocopherol phosphate (aTPO4), an
anticoagulant,
on PNH hemolysis was studied by both in vitro and in vivo means.
It was found that the addition of aTPO4 to the modified Ham test
inhibited lysis of PXH erythroeytes.
During the intramuscular administration of aTPO4, the susceptibility
of the erythrocytes to lysis by fresh acidified serum progressively
decreased.
These cells, after incubation w’ith the serum, gave a positive Coombs
test.

------------------------------
So .. now .. one might wonder IF .. acetylcholine .. choline ..
phosphatidylcholine .. lecithin .. etc .. affects .. porphyria .. ?
<<

Lecithin happens to contain vitamin E and phosphate ..
------------------------

http://www.medicalnewstoday.com/articles/111618.php

"Fatigue in PNH is related directly to chronic hemolysis"

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/634q5a

Man Is A Herbivore!
http://tinyurl.com/4rq595

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

> This would be that porphyria cutanea Tarda .. connection .. ?

> on environmental health topics, visit our Web site athttp://www.niehs.nih.gov.

ironjustice

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Aug 2, 2009, 5:21:15 AM8/2/09

to

On Aug 2, 1:27 am, ironjustice <ironjust...@cool.zzn.com>
wrote:polymyositis <<

Sooo would .. ? .. this mean the tocopherol phosphate mix would be
indicated in
lupus .. too .. ?
Since one progresses from the polymyositis myasthenia lupus link .. ?
Lecithin prevents .. myasthenia .. and tocopherol phosphate / lecithin
lookalike seems to be quite the treatment for PNH .. which is linked
to polymyositis therefore to lupus myasthenia AND paroxysmal nocturnal
hemoglobinuria.
Since vitamin E is destroyed by iron and since iron is found in
abundance in those with hemoglobinuria one wonders WHY don't they
target the .. iron ..

Sounds sorta .. fishy ..
Sounds like the drug they use for lupus might be being used for some
of the above diseases .. ?
What was the drug recommended for all .. all .. lupus patients .. ?
The drug to be used after .. bloodletting .. ? .. AFTER ..
bloodletting .. ?

Soooo .. tocopherol to replace the tocopherol lost to the excess /
iron / oxidation and the inclusion of phosphates a KNOWN premiere
binder of iron and .. ? .. voila ..
Now if they would TARGET THE IRON ..
**DRUG BEING USED TELLS THEM TO**.
It evidences they MUST .. at least try .. bloodletting
BECAUSE .. ? .. standard of care tells them the drug is to be used
AFTER bloodletting has been shown not to work.
If they included this drug tocopherol phosphate WITH the iron
reduction .. ?

We would have some very happy people around ..

Imho ..

http://cme.medscape.com/viewarticle/704384?src=cmemp

Hydroxychloroquine Use May Be Safe in Systemic Lupus Erythematosus

"Because of its broad spectrum of benefits and safety profile,
hydroxychloroquine should be given to most patients with systemic
lupus erythematosus (SLE) during the whole course of the disease,
regardless of severity, and should be continued during pregnancy,
according to the results of a systematic review reported in the June
3
Online First issue of Annals of the Rheumatic Diseases."

---------

Association of paroxysmal nocturnal hemoglobinuria and polymyositis
Ann Med Interne (Paris). 1990;141(4):387-8.
Ferrari E, Taillan B, Ferrari P, Fuzibet JG, Dujardin P.
PMID: 2240952

http://www.ncbi.nlm.nih.gov/pubmed/11014960

Paroxysmal nocturnal hemoglobinuria and the risk of venous
thrombosis: review and recommendations for management of
the pregnant and nonpregnant patient.
Haemostasis. 2000 May-Jun;30(3):103-17.

CONCLUSION:
In accordance with the apparently high rate of venous
thrombosis among pregnant and nonpregnant individuals
with paroxysmal nocturnal hemoglobinuria, especially
for fatal thrombosis, we developed practical
recommendations for the prevention and treatment of
venous thromboembolic disease in these groups.
Copyright 2000 S. Karger AG, Basel

PMID: 11014960

Who loves ya.
Tom

> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk- Hide quoted text -
>
> - Show quoted text -

Ken

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Aug 2, 2009, 9:50:51 AM8/2/09

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Spamming Dickwadd

ironjustice

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Aug 2, 2009, 12:43:51 PM8/2/09

to

on environmental health topics, visit our Web site at http://www.niehs.nih.gov.

The National Institutes of Health (NIH) — The Nation's Medical
Research Agency — includes 27 Institutes and Centers and is a
component of the U.S. Department of Health and Human Services. It is
the primary federal agency for conducting and supporting basic,
clinical and translational medical research, and it investigates the
causes, treatments, and cures for both common and rare diseases. For
more information about NIH and its programs, visit www.nih.gov.

Reference: Love LA, Weinberg CR, McConnaughey DR, Oddis CV, Medsger
TA, Reveille JD, Arnett FC, Targoff IN, Miller FW. “Ultraviolet
Radiation Intensity Predicts the Relative Distribution of
Dermatomyositis and Anti-Mi-2 Autoantibodies in Women.” Arthritis &
Rheumatism. August, 2009.

-------------

Definition of Porphyria Cutanea Tarda | eHow.comSunlight can greatly
increase the exterior symptoms of Porphyria Cutanea Tarda. Iron
management can be granted through phlebotomy. ...
www.ehow.com/about_5033787_definition-porphyria-cutanea-tarda.html

Muscular Dystrophy And Exercise-induced Muscle Fatigue Have More In

http://www.sciencedaily.com/releases/2009/02/090224004346.htm

---------

"Improved nNOS"

http://www.ncbi.nlm.nih.gov/pubmed/15292117

-------------------

http://bloodjournal.hematologylibrary.org/cgi/reprint/8/4/336.pdf

http://www.medicalnewstoday.com/articles/111618.php

-------------------------------

Happy Oyster

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Aug 2, 2009, 1:52:18 PM8/2/09

to

On Sun, 2 Aug 2009 09:43:51 -0700 (PDT), ironjustice <teamt...@hotmail.com>
wrote:

>This would be

number ??? of repost of that crap?

--
"H�ret nun, was Gott der Herr *Gott verbietet,unreine Tiere zu essen
euch zu essen gibt: *(3.Buch Mose Kap. 11, 5.Buch Mose Kap.14)
Ochsen, B�ffel, Scharf und Reh, * http://www.reimbibel.de
wie es euch beliebt." (God does not even know Australia + the kangaroos...)

ironjustice

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Aug 2, 2009, 10:59:56 PM8/2/09

to

On Aug 2, 9:43 am, ironjustice <teamtan...@hotmail.com> wrote:
"Sunlight can greatly increase the exterior symptoms of Porphyria
Cutanea Tarda" <<

Complement-derived chemotactic activity is generated
in human serum containing uroporphyrin after irradiation
with 405 nm light.
Lim HW, Perez HD, Goldstein IM, Gigli I.
J Clin Invest. 1981 Apr;67(4):1072-7.
Patients with porphyrias have varying degrees of
photosensitivity, associated with elevated levels
of porphyrins in plasma, erythrocyte, urine and/or
feces.
To investigate the role of complement in the
pathogenesis of cutaneous lesions, varying amounts
of uroporphyrin were added to normal human serum
(0.1-10 microgram/ml), and the mixtures were then
exposed to 405 nm irradiation.
Such treatments result in the diminution of total
hemolytic complement activity and hemolytic titers
of C1, C4, C2, C3, and C5; furthermore, cleavage
products of C3 and C5 were detected.
Chemotactic activity for human polymorphonuclear
leukocytes was generated that was inhibitable by
incubation with anti-C5, but not with anti-C3
antisera.
No chemotactic activity was generated in Mg++-EGTA
treated serum nor in C4-deficient guinea pig serum.
These data indicate that irradiation with 405 nm
light of normal human serum containing uroporphyrin
results in activation of the complement system via
the classical pathway, and the generation of
complement (C5)-derived chemotactic activity for
human polymorphonuclear leukocytes.

PMID: 7204567

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/634q5a

Man Is A Herbivore!
http://tinyurl.com/4rq595

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

>

> on environmental health topics, visit our Web site athttp://www.niehs.nih.gov.

Peter B.

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Aug 2, 2009, 11:21:18 PM8/2/09

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"ironjustice" <ironj...@rock.com> wrote in message
news:8f3fc24d-f74f-4b92...@k13g2000prh.googlegroups.com...

>
>Sun Exposure May Trigger Certain Autoimmune Diseases in Women
>

You sure like to lie and mislead others, don't you.

Your subject conflicts with the post.

R. Paul autrey, liar, deceiver, shill & hypocrite.

"May" is a fear mongering statement and used with intent to scare the
easily frightened.

ironjustice

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Sep 2, 2009, 8:20:56 AM9/2/09

to

This would be that porphyria cutanea Tarda .. connection .. ?
That uroporphyrin .. connection .. ?
The sun causes the uroporphyrin to be .. released .. and uroporphyrin
causes autoimmune reaction ..

"Sunlight can greatly increase the exterior symptoms of Porphyria
Cutanea Tarda"