Iron Stores Predict Dialysis Death
ironjustice
Mortality in Diabetic Patients on Maintenance Hemodialysis
[Clinical Investigation]
Jenq, Chang-Chyi MD; Hsu, Ching-Wei MD; Huang, Wen-Hung MD; Chen, Kuan-
Hsing MD; Lin, Ja-Liang MD; Lin-Tan, Dan-Tzu RN
From the Department of Nephrology, Chang Gung Memorial Hospital, Lin-
Kou; Chang Gung University College of Medicine, Taiwan, Republic of
China.
Submitted June 10, 2008; accepted in revised form July 23, 2008.
Correspondence: Ja-Liang Lin, MD, Department of Nephrology and
Division of Clinical Toxicology, Chang Gung Memorial Hospital, 199,
Tung-Hwa North Road, Taipei, Taiwan, Republic of China (E-mail:
jll...@hotmail.com).
Abstract:
Background: The aim of this study was to assess the relationship
between the serum ferritin level and the 1-year outcome in diabetic
maintenance hemodialysis (MHD) patients.
Methods: The prospective clinical study enrolled 187 diabetic MHD
patients from a university hospital in Taiwan. All the patients were
divided into 3 groups according to their serum ferritin levels: group
I (<200 ng/mL; n = 71), group II (200-700 ng/mL; n = 97), and group
III (>700 ng/mL; n = 19). A total of 26 demographic, clinical, and
laboratory variables were analyzed as predictors of the 1-year
mortality.
Results: There were no significant differences between these 3 groups
except in their erythropoietin usage, hemoglobin, transferrin
saturation, and high-sensitive C-reactive protein levels. The 1-year
mortality rates were 9.2%, 11.4%, and 46.2% in groups I, II, and III,
respectively. Group I and group II patients had a lower 1-year
mortality rate than group III patients (log-rank test; χ2 = 8.807; P =
0.0112).
Conclusion: The study suggested that serum ferritin levels predict
both all-cause and infection-cause 1-year mortality in diabetic
patients on MHD. In such patients, the serum ferritin levels are
associated with both iron stores and the inflammation status.
© Copyright 2009 Southern Society for Clinical Investigation
--------------------------------------------------------------------------------
Copyright © 2009, Southern Society for Clinical Investigation. All
rights reserved.
Published by Lippincott Williams & Wilkins.
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