Iron Deposition In Calciphylaxis

[ironjustice]

Metal deposition in calcific uremic arteriolopathy
Lavanya Amuluru MDa, Whitney High MDc, Kim M. Hiatt MDb,
James Ranville PhDd, Sudhir V. Shah MDa,
Bilal Malik MDa and Sundararaman Swaminathan MDa, ,
aDivision of Nephrology, University of Arkansas for Medical Sciences,
Little Rock, Arkansas
bDepartment of Pathology and Dermatology,
University of Arkansas for Medical Sciences, Little Rock, Arkansas
cDepartment of Dermatology,
University of Colorado Health Sciences Center, Denver, Golden,
Colorado
dGeochemistry, Colorado School of Mines, Golden, Colorado
Accepted 29 January 2009. Available online 29 April 2009.

Background
Calcific uremic arteriolopathy (CUA) is an often fatal disease that
affects patients with end-stage renal disease.
Although animal studies support a role for metals in the pathogenesis
of CUA, metal accumulation in human tissue has not been previously
evaluated.

Objective
We sought to evaluate metal deposition in CUA.

Methods
Twelve histologically proven cases of CUA were identified from our
dermatopathology database.
Five skin biopsy specimens from patients with chronic kidney disease
exposed to gadolinium contrast but without CUA were used as controls.
Quantification of metals including iron, aluminum, and gadolinium in
the
lesional skin was performed using inductively coupled mass
spectrometry.

Results
Seven patients had documented exposure to gadolinium-based contrast
in the 2 years before CUA.
Three of them had concurrent nephrogenic systemic fibrosis.
Highly significant quantities of iron (P = .03) and aluminum (P = .
0002)
were detected in CUA specimens compared with controls.
Significant amounts of gadolinium were present in several CUA biopsy
specimens.

Limitations
Observational, retrospective study design and small sample size are
limitations.

Conclusion
Tissue iron and aluminum content is increased in CUA.
A significant amount of gadolinium is also present in some CUA
specimens.
Based on animal studies that strongly implicate metals in the
pathogenesis of
CUA, our data suggest that metal deposition should be considered in
the
pathogenesis of human CUA.

Key words: calcific uremic arteriolopathy; calciphylaxis; gadolinium;
metals;
nephrogenic systemic fibrosis

Abbreviations: CUA, calcific uremic arteriolopathy; NSF, nephrogenic
systemic
fibrosis; PTH, parathyroid hormone

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[me...@dude.com]

Are you trying to tell us that aluminum and gadolinium are the cause of
this disorder?

[ironjustice]

Your understanding of the article was ..

"Aluminum and gadolinium are the cause of this disorder"

Is that right .. ?

[ironjustice]

FOAD Spammer

[ironjustice]

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--------

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Predator Safety
Dedicated To The Protection Of Our Children

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