The Role of Labile Iron in Kidney Disease and Treatment with
Chelation.
Hemoglobin. 2009 Oct;33(5):378-385.
Shah SV, Rajapurkar MM.
Division of Nephrology, Department of Internal Medicine,
University of Arkansas for Medical Sciences, Little Rock, AR, USA.
There are two major forms of kidney disease: acute renal failure
[also referred to as acute kidney injury (AKI)] and chronic kidney
disease (CKD).
Acute renal failure is an abrupt loss of kidney function within
48 h, whereas CKD is a loss of kidney function greater than 3 months.
There is a large amount of experimental evidence for an increase of
labile iron in a wide variety of models of kidney disease.
Additionally, iron chelators provide protection, indicating an
important role of labile iron in these diseases.
These observations suggest that iron chelators may provide a new
modality of prevention and treatment of kidney disease.
PMID: 19821781
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