Study questions safety and effectiveness of common kidney disease
drugs
Longest placebo-controlled trial of phosphate binders conducted to
date challenges the drugs' utility
"While we continue to believe that serum, or blood, phosphorus is a
key component of the increased cardiovascular risk associated with
kidney disease, our results suggest the use of the currently approved
phosphate binding drugs does not result in substantial reductions in
serum phosphorus and may be associated with harm in this population,"
said Dr. Block. "Future clinical trials should be conducted in all
populations with adequate placebo controls and should address
alternative or complementary methods to reduce serum phosphorus," he
added.
<ironjust...@rock.com> wrote:
>Study questions safety and effectiveness of common kidney disease
>drugs
>Longest placebo-controlled trial of phosphate binders conducted to
>date challenges the drugs' utility
>"While we continue to believe that serum, or blood, phosphorus is a
>key component of the increased cardiovascular risk associated with
>kidney disease, our results suggest the use of the currently approved
>phosphate binding drugs does not result in substantial reductions in
>serum phosphorus and may be associated with harm in this population,"
>said Dr. Block. "Future clinical trials should be conducted in all
>populations with adequate placebo controls and should address
>alternative or complementary methods to reduce serum phosphorus," he
>added.
No surprises there then. Yet another example of don't believe
everything the drug companies tell our doctors. Like they care anyway!
I wonder what are "alternative or complementary methods to reduce
serum phosphorus"?
On Jul 21, 10:25 pm, Pendrag0n <nom...@thnx.com> wrote:I wonder what
are "alternative or complementary methods to reduce serum phosphorus"?
<<
Lowering phosphorus results in kidney stones .
"The risk for oxalocalcic urolithiasis increases when urinary
phosphorus inhibitors
decrease."
Minimum handling method for the analysis of phosphorous
inhibitors of urolithiasis (pyrophosphate and phytic acid)
in urine by SPE-ICP techniques.
Anal Chim Acta. 2010 Jan 25;658(2):204-8. Epub 2009 Nov 10.
Muńoz JA, López-Mesas M, Valiente M.
Grup de Tčcniques de Separació en Quķmica (GTS), UAB-Thermo Lab,
Quķmica Analķtica, Departament de Quķmica,
Universitat Autņnoma de Barcelona, 08193 Bellaterra, Spain.
Pyrophosphate (PPi) and phytic acid (IP6) are natural phosphorous
compounds with growing interest in the biomedical field due to their
ability as potential inhibitors of urolithiasis among others.
Existing methodologies for their evaluation show inconveniences
mainly associated with sample treatment, matrix interferences and
lack of resolution.
The objective of the present work is the validation of a new method
to determine both inhibitors in urine samples selectively and its
application to the diagnosis of lithiasic patients.
After urine purification by an off-line anion exchange solid phase
extraction (SPE), based in an appropriate acidic elution gradient,
the phosphorous compounds were analyzed by (31)P measurements by
inductively coupled plasma mass spectrometry (ICP-MS) in the
purified urine extracts.
Linear range and limit of detection obtained were adequate for the
analysis of the physiological amounts of the compounds in urine.
The method was successfully applied to human urine samples, resulting
in adequate accuracy and precision and allowing for the analysis of
phosphorus inhibitors of urolithiasis in urine.
The method simplicity and high sample throughput leads to a clear
alternative to current determinations of the mentioned species in
urine.
Moreover, PPi and IP6 concentrations found in patients suffering
from oxalocalcic urolithiasic were significantly lower than those
for healthy controls, supporting the fact that the risk for
oxalocalcic urolithiasis increases when urinary phosphorus inhibitors
decrease.
Thus, speciation of phosphorus inhibitors of urolithiasis in urine
of stone formers can be performed, which is of unquestionable value
in diagnostic, treatment and monitoring of urolithiasis.
> On Sat, 21 Jul 2012 13:39:14 -0700 (PDT), ironjustice
> <ironjust...@rock.com> wrote:
> >Study questions safety and effectiveness of common kidney disease
> >drugs
> >Longest placebo-controlled trial of phosphate binders conducted to
> >date challenges the drugs' utility
> >"While we continue to believe that serum, or blood, phosphorus is a
> >key component of the increased cardiovascular risk associated with
> >kidney disease, our results suggest the use of the currently approved
> >phosphate binding drugs does not result in substantial reductions in
> >serum phosphorus and may be associated with harm in this population,"
> >said Dr. Block. "Future clinical trials should be conducted in all
> >populations with adequate placebo controls and should address
> >alternative or complementary methods to reduce serum phosphorus," he
> >added.
> No surprises there then. Yet another example of don't believe
> everything the drug companies tell our doctors. Like they care anyway!
> I wonder what are "alternative or complementary methods to reduce
> serum phosphorus"?- Hide quoted text -
> On Sat, 21 Jul 2012 13:39:14 -0700 (PDT), ironjustice
> <ironjust...@rock.com> wrote:
> >Study questions safety and effectiveness of common kidney disease
> >drugs
> >Longest placebo-controlled trial of phosphate binders conducted to
> >date challenges the drugs' utility
> >"While we continue to believe that serum, or blood, phosphorus is a
> >key component of the increased cardiovascular risk associated with
> >kidney disease, our results suggest the use of the currently approved
> >phosphate binding drugs does not result in substantial reductions in
> >serum phosphorus and may be associated with harm in this population,"
> >said Dr. Block. "Future clinical trials should be conducted in all
> >populations with adequate placebo controls and should address
> >alternative or complementary methods to reduce serum phosphorus," he
> >added.
> No surprises there then. Yet another example of don't believe
> everything the drug companies tell our doctors. Like they care anyway!
> I wonder what are "alternative or complementary methods to reduce
> serum phosphorus"?
What tickles me is when ordinary folk "discover" that prescription
medications have side effects and then jump to the conclusion that
drug companies, or their doctors, or other medical professionals are
hiding things, or being dishonest, or lying.
Every medication has side effects, some minor, a few debilitating, and
even fewer fatal. Each prescription medication I've ever had has a
strip of paper warning about who shouldn't take it, and what the
medication's side effects are, some even say statistically how many
people may experience them (as 1in 100 or 1,000 or 10,000).
>> <ironjust...@rock.com> wrote:
>> >Study questions safety and effectiveness of common kidney disease
>> >drugs
>> >Longest placebo-controlled trial of phosphate binders conducted to
>> >date challenges the drugs' utility
>> >"While we continue to believe that serum, or blood, phosphorus is a
>> >key component of the increased cardiovascular risk associated with
>> >kidney disease, our results suggest the use of the currently approved
>> >phosphate binding drugs does not result in substantial reductions in
>> >serum phosphorus and may be associated with harm in this population,"
>> >said Dr. Block. "Future clinical trials should be conducted in all
>> >populations with adequate placebo controls and should address
>> >alternative or complementary methods to reduce serum phosphorus," he
>> >added.
>> No surprises there then. Yet another example of don't believe
>> everything the drug companies tell our doctors. Like they care anyway!
>> I wonder what are "alternative or complementary methods to reduce
>> serum phosphorus"?
>What tickles me is when ordinary folk "discover" that prescription
>medications have side effects and then jump to the conclusion that
>drug companies, or their doctors, or other medical professionals are
>hiding things, or being dishonest, or lying.
They are.
>Every medication has side effects, some minor, a few debilitating, and
>even fewer fatal. Each prescription medication I've ever had has a
>strip of paper warning about who shouldn't take it, and what the
>medication's side effects are, some even say statistically how many
>people may experience them (as 1in 100 or 1,000 or 10,000).
Some people are led to believe they have no choice.
> > >"While we continue to believe that serum, or blood, phosphorus is a
> > >key component of the increased cardiovascular risk associated with
> > >kidney disease, our results suggest the use of the currently approved
> > >phosphate binding drugs does not result in substantial reductions in
> > >serum phosphorus and may be associated with harm in this population,"
> > >said Dr. Block. "Future clinical trials should be conducted in all
> > >populations with adequate placebo controls and should address
> > >alternative or complementary methods to reduce serum phosphorus," he
> > >added.
> > No surprises there then. Yet another example of don't believe
> > everything the drug companies tell our doctors. Like they care anyway!
> > I wonder what are "alternative or complementary methods to reduce
> > serum phosphorus"?
> What tickles me is when ordinary folk "discover" that prescription
> medications have side effects and then jump to the conclusion that
> drug companies, or their doctors, or other medical professionals are
> hiding things, or being dishonest, or lying.
Lifestyle has no side effects.
I invite you to tell me how people vitamin D has killed.
> > > >"While we continue to believe that serum, or blood, phosphorus is a
> > > >key component of the increased cardiovascular risk associated with
> > > >kidney disease, our results suggest the use of the currently approved
> > > >phosphate binding drugs does not result in substantial reductions in
> > > >serum phosphorus and may be associated with harm in this population,"
> > > >said Dr. Block. "Future clinical trials should be conducted in all
> > > >populations with adequate placebo controls and should address
> > > >alternative or complementary methods to reduce serum phosphorus," he
> > > >added.
> > > No surprises there then. Yet another example of don't believe
> > > everything the drug companies tell our doctors. Like they care anyway!
> > > I wonder what are "alternative or complementary methods to reduce
> > > serum phosphorus"?
> > What tickles me is when ordinary folk "discover" that prescription
> > medications have side effects and then jump to the conclusion that
> > drug companies, or their doctors, or other medical professionals are
> > hiding things, or being dishonest, or lying.
> Lifestyle has no side effects.
Are you suggesting that I have implied in any of my posts that
lifestyle has no side effects?
> I invite you to tell me how people vitamin D has killed.
I have absolutely no idea, why don't you Google for it?
On Fri, 17 Aug 2012 15:53:14 -0700 (PDT), in misc.health.alternative,
John H. Gohde 'The idiot become moronic' <john.h.go...@gmail.com>
wrote:
>Lifestyle has no side effects.
Lifestyle? You do realize how stupid that sounds, because lifestyle
can be either good or bad?
>I invite you to tell me how people vitamin D has killed.
There are several published articles dealing with Vitamin D overdose
and heart disease and death.
-- Bob Officer
"It is not belief, it is curiousity. That's the big difference. Religion and belief tie us to our predecessors, foresight and curiousity tie us to our successors." Robert Templeton 1999
>> > > >"While we continue to believe that serum, or blood, phosphorus is a
>> > > >key component of the increased cardiovascular risk associated with
>> > > >kidney disease, our results suggest the use of the currently approved
>> > > >phosphate binding drugs does not result in substantial reductions in
>> > > >serum phosphorus and may be associated with harm in this population,"
>> > > >said Dr. Block. "Future clinical trials should be conducted in all
>> > > >populations with adequate placebo controls and should address
>> > > >alternative or complementary methods to reduce serum phosphorus," he
>> > > >added.
>> > > No surprises there then. Yet another example of don't believe
>> > > everything the drug companies tell our doctors. Like they care anyway!
>> > > I wonder what are "alternative or complementary methods to reduce
>> > > serum phosphorus"?
>> > What tickles me is when ordinary folk "discover" that prescription
>> > medications have side effects and then jump to the conclusion that
>> > drug companies, or their doctors, or other medical professionals are
>> > hiding things, or being dishonest, or lying.
>> Lifestyle has no side effects.
>Are you suggesting that I have implied in any of my posts that
>lifestyle has no side effects?
LOL now now.
>> I invite you to tell me how people vitamin D has killed.
>I have absolutely no idea, why don't you Google for it?
That's not very helpful is it. You seemed to be keen on helping and
now want us to help ourselves, make your mind up old bean :)
On Fri, 17 Aug 2012 20:05:58 -0700, Bob Officer <.@.> wrote:
>On Fri, 17 Aug 2012 15:53:14 -0700 (PDT), in misc.health.alternative,
>John H. Gohde 'The idiot become moronic' <john.h.go...@gmail.com>
>wrote:
>>Lifestyle has no side effects.
>Lifestyle? You do realize how stupid that sounds, because lifestyle
>can be either good or bad?
>>I invite you to tell me how people vitamin D has killed.
>There are several published articles dealing with Vitamin D overdose
>and heart disease and death.
You would struggle to find them compared to the hundreds of thousands
that have problems with statins, which is the point being made.
> >> > > >"While we continue to believe that serum, or blood, phosphorus is a
> >> > > >key component of the increased cardiovascular risk associated with
> >> > > >kidney disease, our results suggest the use of the currently approved
> >> > > >phosphate binding drugs does not result in substantial reductions in
> >> > > >serum phosphorus and may be associated with harm in this population,"
> >> > > >said Dr. Block. "Future clinical trials should be conducted in all
> >> > > >populations with adequate placebo controls and should address
> >> > > >alternative or complementary methods to reduce serum phosphorus," he
> >> > > >added.
> >> > > No surprises there then. Yet another example of don't believe
> >> > > everything the drug companies tell our doctors. Like they care anyway!
> >> > > I wonder what are "alternative or complementary methods to reduce
> >> > > serum phosphorus"?
> >> > What tickles me is when ordinary folk "discover" that prescription
> >> > medications have side effects and then jump to the conclusion that
> >> > drug companies, or their doctors, or other medical professionals are
> >> > hiding things, or being dishonest, or lying.
> >> Lifestyle has no side effects.
> >Are you suggesting that I have implied in any of my posts that
> >lifestyle has no side effects?
> LOL now now.
> >> I invite you to tell me how people vitamin D has killed.
> >I have absolutely no idea, why don't you Google for it?
> That's not very helpful is it. You seemed to be keen on helping and
> now want us to help ourselves, make your mind up old bean :)
:P I am keen on helping, but there's a big difference between helping
and hand-holding, as I'm sure you know and understand. :)
> > >> > > >"While we continue to believe that serum, or blood, phosphorus is a
> > >> > > >key component of the increased cardiovascular risk associated with
> > >> > > >kidney disease, our results suggest the use of the currently approved
> > >> > > >phosphate binding drugs does not result in substantial reductions in
> > >> > > >serum phosphorus and may be associated with harm in this population,"
> > >> > > >said Dr. Block. "Future clinical trials should be conducted in all
> > >> > > >populations with adequate placebo controls and should address
> > >> > > >alternative or complementary methods to reduce serum phosphorus," he
> > >> > > >added.
> > >> > > No surprises there then. Yet another example of don't believe
> > >> > > everything the drug companies tell our doctors. Like they care anyway!
> > >> > > I wonder what are "alternative or complementary methods to reduce
> > >> > > serum phosphorus"?
> > >> > What tickles me is when ordinary folk "discover" that prescription
> > >> > medications have side effects and then jump to the conclusion that
> > >> > drug companies, or their doctors, or other medical professionals are
> > >> > hiding things, or being dishonest, or lying.
> > >> Lifestyle has no side effects.
> > >Are you suggesting that I have implied in any of my posts that
> > >lifestyle has no side effects?
> > LOL now now.
> > >> I invite you to tell me how people vitamin D has killed.
> > >I have absolutely no idea, why don't you Google for it?
> > That's not very helpful is it. You seemed to be keen on helping and
> > now want us to help ourselves, make your mind up old bean :)
> :P I am keen on helping, but there's a big difference between helping
> and hand-holding, as I'm sure you know and understand. :)
> > > >> > > >"While we continue to believe that serum, or blood, phosphorus is a
> > > >> > > >key component of the increased cardiovascular risk associated with
> > > >> > > >kidney disease, our results suggest the use of the currently approved
> > > >> > > >phosphate binding drugs does not result in substantial reductions in
> > > >> > > >serum phosphorus and may be associated with harm in this population,"
> > > >> > > >said Dr. Block. "Future clinical trials should be conducted in all
> > > >> > > >populations with adequate placebo controls and should address
> > > >> > > >alternative or complementary methods to reduce serum phosphorus," he
> > > >> > > >added.
> > > >> > > No surprises there then. Yet another example of don't believe
> > > >> > > everything the drug companies tell our doctors. Like they care anyway!
> > > >> > > I wonder what are "alternative or complementary methods to reduce
> > > >> > > serum phosphorus"?
> > > >> > What tickles me is when ordinary folk "discover" that prescription
> > > >> > medications have side effects and then jump to the conclusion that
> > > >> > drug companies, or their doctors, or other medical professionals are
> > > >> > hiding things, or being dishonest, or lying.
> > > >> Lifestyle has no side effects.
> > > >Are you suggesting that I have implied in any of my posts that
> > > >lifestyle has no side effects?
> > > LOL now now.
> > > >> I invite you to tell me how people vitamin D has killed.
> > > >I have absolutely no idea, why don't you Google for it?
> > > That's not very helpful is it. You seemed to be keen on helping and
> > > now want us to help ourselves, make your mind up old bean :)
> > :P I am keen on helping, but there's a big difference between helping
> > and hand-holding, as I'm sure you know and understand. :)
> "I invite you to tell me how people vitamin D has killed."
> Don't know, but a number of articles concluding there is a toxic level
> which contributes to heart disease have been posted.
Most of those articles are all talking about a single study that
suggested that possibility. There are many studies out over the years
showing that there is practically no limit on the amount of Vitamin D3
an average person can take on. A person working outside in the sun
all day has taken on many tens of thousands of units of vitamin D and
it does no harm at all. Some concerned people take thousands of units
of supplements daily and are going along just fine. There may be some
folks that have an allergy or a problem of some kind with D3, but most
do not.
Lately the drug industry has ben on a kick to 'outlaw' supplements
and vitamins, so that the replacements they are making that cost more
and do less can take over and rake in more profits. They have the
billions to insert a story into the news, or to sway a study to say
mostly what they want.
An example is Lovaza which is made to replace Omega-3 fish oil. I
looked into Lovaza and found that it's mostly just the same exact fish
oil as Omega-3, but less of it. You had to take twice the amount of
Lovaza to equal Omega-3, at a higher price, with the irritation of
getting a prescription too!
They've managed to 'outlaw' supplements in the UK, but I'll let
those from there speak to it. Here in the USA there is a senator
(Dick Durbin) trying to give the FDA wide powers to make supplements
safe by taking them over and 'monitoring' them. So far they have
pushed him off, but he hasn't quit trying to attach his plan to other
bills in hopes no one will notice until too late.
Mind you, there have been 62,000 deaths from properly prescribed
drugs in one particular year, while the deaths from supplements and
vitamins was ZERO in the same year. So it becomes obvious why they
want control over the supplements.
> > >> > > >"While we continue to believe that serum, or blood, phosphorus is a
> > >> > > >key component of the increased cardiovascular risk associated with
> > >> > > >kidney disease, our results suggest the use of the currently approved
> > >> > > >phosphate binding drugs does not result in substantial reductions in
> > >> > > >serum phosphorus and may be associated with harm in this population,"
> > >> > > >said Dr. Block. "Future clinical trials should be conducted in all
> > >> > > >populations with adequate placebo controls and should address
> > >> > > >alternative or complementary methods to reduce serum phosphorus," he
> > >> > > >added.
> > >> > > No surprises there then. Yet another example of don't believe
> > >> > > everything the drug companies tell our doctors. Like they care anyway!
> > >> > > I wonder what are "alternative or complementary methods to reduce
> > >> > > serum phosphorus"?
> > >> > What tickles me is when ordinary folk "discover" that prescription
> > >> > medications have side effects and then jump to the conclusion that
> > >> > drug companies, or their doctors, or other medical professionals are
> > >> > hiding things, or being dishonest, or lying.
> > >> Lifestyle has no side effects.
> > >Are you suggesting that I have implied in any of my posts that
> > >lifestyle has no side effects?
> > LOL now now.
> > >> I invite you to tell me how people vitamin D has killed.
> > >I have absolutely no idea, why don't you Google for it?
> > That's not very helpful is it. You seemed to be keen on helping and
> > now want us to help ourselves, make your mind up old bean :)
> :P I am keen on helping, but there's a big difference between helping
> and hand-holding, as I'm sure you know and understand. :)
Perhaps it would be easier to think of it as backing up what you
say, instead of making the listener do it for you...:)
<mainframet...@yahoo.com> wrote:
>On Aug 17, 8:35 pm, "pill popper" wrote:
>> "I invite you to tell me how people vitamin D has killed."
>> Don't know, but a number of articles concluding there is a toxic level
>> which contributes to heart disease have been posted.
> Most of those articles are all talking about a single study that
>suggested that possibility. There are many studies out over the years
>showing that there is practically no limit on the amount of Vitamin D3
>an average person can take on. A person working outside in the sun
>all day has taken on many tens of thousands of units of vitamin D and
>it does no harm at all. Some concerned people take thousands of units
>of supplements daily and are going along just fine. There may be some
>folks that have an allergy or a problem of some kind with D3, but most
>do not.
> Lately the drug industry has ben on a kick to 'outlaw' supplements
>and vitamins, so that the replacements they are making that cost more
>and do less can take over and rake in more profits. They have the
>billions to insert a story into the news, or to sway a study to say
>mostly what they want.
> An example is Lovaza which is made to replace Omega-3 fish oil. I
>looked into Lovaza and found that it's mostly just the same exact fish
>oil as Omega-3, but less of it. You had to take twice the amount of
>Lovaza to equal Omega-3, at a higher price, with the irritation of
>getting a prescription too!
> They've managed to 'outlaw' supplements in the UK, but I'll let
>those from there speak to it. Here in the USA there is a senator
>(Dick Durbin) trying to give the FDA wide powers to make supplements
>safe by taking them over and 'monitoring' them. So far they have
>pushed him off, but he hasn't quit trying to attach his plan to other
>bills in hopes no one will notice until too late.
> Mind you, there have been 62,000 deaths from properly prescribed
>drugs in one particular year, while the deaths from supplements and
>vitamins was ZERO in the same year. So it becomes obvious why they
>want control over the supplements.
>Chris
Actually in the UK they have not outlawed supplements, certainly not
any I have a mind to try. Though of course this was the big fear. I
suspect it has got rid of many *cowboy* dealers, which is never a bad
thing especially when it comes to consumer protection. There is so
much junk readily available online, and much of it useless for its
intended *claimed* purpose. I suspect the US clampdown will be tougher
via the FDA.
