Expired Oxytrol & Ischemic Colitis
Dong
Is there any mechanism by which an expired Oxytrol Transdermal patch
containing Oxybutynin can promote Ischemic Colitis? One hour after
my dad used the patch (which was an expired stock given by the
Urologist), he got bloody stool (and just letting out blood) for the
next 24
hours.... until he got confined and was given colonoscopy procedure
with
the diagnosis of Ischemic Colitis. Fortunately. It resolves itself
after a
day. The patch was removed 8 hours after application. Could something
in the expired Oxybutynin or expired Transdermal patching caused
the ischemic colitis? He is 72 years old and never had any colitis
before. Thanks.
Dong
Vanny
including any supplements or herbal remedies he may be taking and look up
the drug interactions here: www.drugs.com Alternatively, take the list to
your nearest pharmacy and they will type everything into their drug
interactions database and be able to tell you whether or not the combination
would cause GI bleeding.
Even if colitis (inflammation of the colon) is not a reported side-effect of
Oxybutynin it might be a side-effect peculiar to your father and indicate
100% intolerance to the medication. On the other hand, his total GI drug
load might just be too high, especially if he smokes (or was a smoker --->
blood vessel damage) and drinks alcohol, etc. If you are in the USA and
discount the effect of drug-interaction in your father's case, the
side-effect should be reported on MedWatch
http://www.fda.gov/medwatch/how.htm This helps other patients that end up
with the same side-effect.
A PubMed search did not reveal any published incidences of Oxybutynin and GI
bleeding, and/or colitis http://www.ncbi.nlm.nih.gov/sites/entrez
Some medication, such as antibiotics, are frequently associated with with
the development of (reversible) colitis.
Vanny
"Dong" <dongp...@yahoo.com> schrieb im Newsbeitrag
news:cc8ebf07-5282-4268...@r37g2000prr.googlegroups.com...
Debs
problem because it was in a patch, on top of that it takes time for
drugs/by-products to get to the colon...
Debs
Dong
> I would also think it's unlikely that the expired drug caused the
> problem because it was in a patch, on top of that it takes time for
> drugs/by-products to get to the colon...
> Debs
>
>
>
> Vanny wrote:
> > I suggest that you ask him for a complete listing of all his medication
> > including any supplements or herbal remedies he may be taking and look up
> > the drug interactions here:www.drugs.com Alternatively, take the list to
> > your nearest pharmacy and they will type everything into their drug
> > interactions database and be able to tell you whether or not the combination
> > would cause GI bleeding.
>
> > Even if colitis (inflammation of the colon) is not a reported side-effect of
> > Oxybutynin it might be a side-effect peculiar to your father and indicate
> > 100% intolerance to the medication. On the other hand, his total GI drug
> > load might just be too high, especially if he smokes (or was a smoker --->
> > blood vessel damage) and drinks alcohol, etc. If you are in the USA and
> > discount the effect of drug-interaction in your father's case, the
> > side-effect should be reported on MedWatch
> > with the same side-effect.
>
> > A PubMed search did not reveal any published incidences of Oxybutynin and GI
>
> > Some medication, such as antibiotics, are frequently associated with with
> > the development of (reversible) colitis.
>
> > Vanny
>
> >news:cc8ebf07-5282-4268...@r37g2000prr.googlegroups.com...
>
> >>Hi,
>
> >>Is there any mechanism by which an expired Oxytrol Transdermal patch
> >>containing Oxybutynin can promote Ischemic Colitis? One hour after
> >>my dad used the patch (which was an expired stock given by the
> >>Urologist), he got bloody stool (and just letting out blood) for the
> >>next 24
> >>hours.... until he got confined and was given colonoscopy procedure
> >>with
> >>the diagnosis of Ischemic Colitis. Fortunately. It resolves itself
> >>after a
> >>day. The patch was removed 8 hours after application. Could something
> >>in the expired Oxybutynin or expired Transdermal patching caused
> >>the ischemic colitis? He is 72 years old and never had any colitis
> >>before. Thanks.
>
>
> - Show quoted text -
You or anyone knows what happens to Oxybutynin after it is expired,
like what chemical reactions occur that would turn it into another
chemical or substance?
Dong
Dong
> I suggest that you ask him for a complete listing of all his medication
> including any supplements or herbal remedies he may be taking and look up
> the drug interactions here:www.drugs.com Alternatively, take the list to
> your nearest pharmacy and they will type everything into their drug
> interactions database and be able to tell you whether or not the combination
> would cause GI bleeding.
>
> Even if colitis (inflammation of the colon) is not a reported side-effect of
> Oxybutynin it might be a side-effect peculiar to your father and indicate
> 100% intolerance to the medication. On the other hand, his total GI drug
> load might just be too high, especially if he smokes (or was a smoker --->
> blood vessel damage) and drinks alcohol, etc. If you are in the USA and
> discount the effect of drug-interaction in your father's case, the
> with the same side-effect.
Ischemic Colitis is initially problem with blood vessels that support
the colon. The inflammation is secondary. I wonder if there is any
poison that can cause ischemia of the blood vessels, or specifically
whether the expired Oxytrol (Oxybutynin patch) can become a
poison. Know the chemical composition of oxybutynin and its
chemical reactions after expiration?
Dong
>
> A PubMed search did not reveal any published incidences of Oxybutynin and GI
> bleeding, and/or colitishttp://www.ncbi.nlm.nih.gov/sites/entrez
>
> Some medication, such as antibiotics, are frequently associated with with
> the development of (reversible) colitis.
>
> Vanny
>
> "Dong" <dongpari...@yahoo.com> schrieb im Newsbeitragnews:cc8ebf07-5282-4268...@r37g2000prr.googlegroups.com...
>
>
>
> > Hi,
>
> > Is there any mechanism by which an expired Oxytrol Transdermal patch
> > containing Oxybutynin can promote Ischemic Colitis? One hour after
> > my dad used the patch (which was an expired stock given by the
> > Urologist), he got bloody stool (and just letting out blood) for the
> > next 24
> > hours.... until he got confined and was given colonoscopy procedure
> > with
> > the diagnosis of Ischemic Colitis. Fortunately. It resolves itself
> > after a
> > day. The patch was removed 8 hours after application. Could something
> > in the expired Oxybutynin or expired Transdermal patching caused
> > the ischemic colitis? He is 72 years old and never had any colitis
> > before. Thanks.
>
Rufus
> On Jan 12, 4:53 pm, "Vanny" <Vannyss2...@antispam.com> wrote:
>> I suggest that you ask him for a complete listing of all his medication
>> including any supplements or herbal remedies he may be taking and look up
>> the drug interactions here:www.drugs.com Alternatively, take the list to
>> your nearest pharmacy and they will type everything into their drug
>> interactions database and be able to tell you whether or not the combination
>> would cause GI bleeding.
>>
>> Even if colitis (inflammation of the colon) is not a reported side-effect of
>> Oxybutynin it might be a side-effect peculiar to your father and indicate
>> 100% intolerance to the medication. On the other hand, his total GI drug
>> load might just be too high, especially if he smokes (or was a smoker --->
>> blood vessel damage) and drinks alcohol, etc. If you are in the USA and
>> discount the effect of drug-interaction in your father's case, the
>> side-effect should be reported on MedWatchhttp://www.fda.gov/medwatch/how.htmThis helps other patients that end up
>> with the same side-effect.
>
> Ischemic Colitis is initially problem with blood vessels that support
> the colon. The inflammation is secondary. I wonder if there is any
> poison that can cause ischemia of the blood vessels, or specifically
> whether the expired Oxytrol (Oxybutynin patch) can become a
> poison. Know the chemical composition of oxybutynin and its
> chemical reactions after expiration?
>
> Dong
>
Goggle rocks...
http://www.google.com/search?hl=en&q=chemical+ischemia&btnG=Google+Search&aq=f&oq=
Looks like most of the research points to impact on brain
function/health though - let's try again...
http://www.google.com/search?hl=en&q=chemical+ischemia+of+colon&btnG=Search
...there we go.
--
- Rufus
Vanny
I agree with Debs, with respect to the expiration dates of medication and
Rufus with respect to chemical colitis.
There have been loose studies to test medication that has past its
use-by-date and they have been found to be perfectly alright. There is a
school of thought that suggests that pharmaceutical companies keep the
use-by-dates tight to prevent problems (being blamed that the medication was
not alright - law suits), but to also achieve higher financial turnover as
they gain when medication is thrown away.
It is likely that your father experienced chemical colitis, which was
peculiar to himself and his own medication regime/lifestyle. The average
over 65 year old is on some 4-6 different medications and a lot drink and
smoke to boot.
It says here that alcohol should be avoided
http://www.drugbank.ca/drugs/DB01062 The MSDS indicates that the substance
is stable http://129.128.185.122/drugbank2/drugs/DB01062/safety_sheets/882
However, longterm degradation products could be more toxic than the actual
drug.
A lot will depend on his other medication and his lifestyle. I can only
stress that if your father is taking multiple medications and continuing to
smoke and drink then he is more likely to experience extreme and unusual
side-effects or reactions to his medication.
If you are thinking about suing the urologist then I would forget it - he
wasn't planning on hurting your father. At the most he could only be accused
of not looking at the expiration date and as your father didn't either - in
the eyes of the law (as I as a layperson understand it) he has shared
responsibility - unless he is blind and/or suffers from a disability, which
prevents him from functioning properly mentally.
The control would be to obtain some Oxytrol patches that have not past their
use-by-date and for him to see if the patches still have the same effect.
However, I would not suggest that he does this, because it is very likely
that he will have the same reaction if he is intolerant to it.
Another argument might be that intestinal ischaemia is more common in older
folks especially if they have smoked at some time in their lives - blood
vessel damage. Older folks also generally don't drink their 2 litres of
fluid (not alcohol) a day and leave themselves wide open to vessel
thrombosis due to dehydration.
I would chalk it down to experience and include Oxybutynin in his list of
allergies/intolerances.
Vanny
"Dong" <dongp...@yahoo.com> schrieb im Newsbeitrag
news:b8b024ce-1cbe-4edd...@e1g2000pra.googlegroups.com...