Description:
Support for sufferers of irritable bowel syndrome.
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A single LGR5+ stem cell expands into replacement tissue for damaged colon
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The power of one.
Louvard D, et al. Show all Louvard D, Sigaux F, Robine S.
Sci Transl Med. 2012 Apr 18;4(130):130fs7.
Centre National de la Recherche Scientifique, Institut Curie, 75248 Paris, Cedex 05, France.
A single mouse Lgr5-positive colon stem cell can be expanded into a three-dimensional organoid that, after transplant, contributes to the... more »
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Vitamin D3 antagonizes the effects of corticosteroids in the skin
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Glucocorticoids are known to upregulate 24hydroxylase/CYP24A1, which degrades vitamin D3, and also to depress VDR expression. This paper explains how glucocorticoids are detrimental to human skin by antagonizing the actions of vitamin D3.
Interestingly in the skin, vitamin D3 has the opposite effect on fatty... more »
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Regulation of PTEN by sodium butyrate in the colonic epithelia
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I wonder if this opens up lithium as an agent in colon cancer treatment?
PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling.
Deevi R, et al. Show all Deevi R, Fatehullah A, Jagan I, Nagaraju M, Bingham V, Campbell FC.
Br J Cancer. 2011 Oct 25;105(9):1313-21. doi: 10.1038/bjc.2011.384. Epub... more »
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The anti-inflammatory actions of 5AR
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5a-Reduced glucocorticoids: a story of natural selection.
Nixon M, et al. Show all Nixon M, Upreti R, Andrew R.
J Endocrinol. 2012 Feb;212(2):111-27. Epub 2011 Sep 8.
Endocrinology, Queen's Medical Research Institute, University/British Heart Foundation Centre for Cardiovascular Science, Edinburgh EH16 4TJ,... more »
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Immunoglobulin production by tumors
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The paper is about a year old, but the implications are absolutely stunning. The recombination of genetic elements necessary for adaptive immunity is deeply tied into the development of certain tumors. No doubt this helps to explain tumor angiogenesis and innervation.
This might explain the carcinogenic/mutagenic properties of retinoids,... more »
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the butyrate/HDAC system in the regulation of miRNA processing
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The OCTN2/carnitine/PPARalpha/buty rate/HDAC system that's defective in IBD/Crohn's appears to regulate miRNA processing via HDAC1.
More on SRY and DGCR8 later.
EMBO Rep. 2012 Feb 1;13(2):142-9.
Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8.
Wada T, Kikuchi J, Furukawa Y.... more »
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The antimycobacterial function of hepcidin
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Immune Netw. 2011 Oct;11(5):245-52. Epub 2011 Oct 31.
Antimicrobial Peptides in Innate Immunity against Mycobacteria.
Shin DM, Jo EK.
Department of Microbiology and Infection Signaling Network Research Center, Chungnam National University, School of Medicine, Daejeon 301-747, Korea.
Antimicrobial peptides/proteins are ancient and naturallyoccurring... more »
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