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Byetta-weight loss and gastric bypass

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Dave

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Jan 7, 2007, 10:43:14 PM1/7/07
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I have a question about Byetta. I have been type 2 for about 15 years. I
am 200 lbs overweight, partly due to the meds, bad food choices and a bout
of depression about 1 year ago where I sat and did nothing. (bad time) I
have been taking Glipizide at each meal but I am now switching over to
Glucophage. I take about 40 units R insulin at each meal and 100mg Lantus
at night. I am on low dosages of Trileptal, Trazadone and Lamictal due to
the depression. I have just heard about Byetta from a co worker. When I
e-mailed my diabetic nurse practioner about it she replied that Byetta is
for patients who are on oral diabetes medication only and that I may need
Symlin. I don't know anything about Symlin. I am not sure if Symlin will
replace the R insulin or be added to it. I am still waiting for an
appointment with my endo to discuss it all. Is this all true or is my HMO
trying to get out of paying for the Byetta which I understand is expensive.
I must find a way to lose weight even slowly. With all the weight gaining
meds I am on I cant manage to lose even 10 pounds. I was considering gastric
bypass surgery. UCLA (will only do the surgery laproscopicly-closed
procedure) wants me to lose at least 50 pounds before I can have the
surgery. They say that its will reduce the chance of complications. ( I
carry my weight in my stomach not my tush or legs) I know about 30 people
who have had the surgery. Maybe 15% have kept enough weight off to make it
worthwhile. All of these people say its tough going surgery. Well-its tough
losing weight as well losing weight the old fashioned way so why go though
the surgery? If I could manage to lose some weight I could get back to at
least some exercise. I find it hard to exercise because I am badly winded,
my back hurts terribly when I walk. The best way I walk is in the
supermarket (catch 22 I know, I really don't need to be in the market)
holding on to the cart which helps my back pain.

I appreciate any comments or suggestions. TIA!


Ricavito

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Jan 8, 2007, 12:11:55 AM1/8/07
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Hi Dave,

I can't help you with the surgical solution question but I know others
here have researched it pretty thoroughly and will hopefully be along
shortly to give you their insight.

I take Byetta and have found it to be quite successful in decreasing my
interest in food, so that I steadily lose weight when I stay on it.
Some of us do have unpleasant side effects (nausea) to some degree, but
there are plenty of folks here who just have the pleasant one (i.e.,
the weight loss!) and I'm sure they will be around soon to give you
some encouragement (paging Loretta). In fact, I believe another poster
here reported that he had to go off Byetta because he lost too much
weight.

Byetta is expensive if you have to purchase it without insurance
(around $250/month for the max dose). I got turned down twice by
insurance (BS), but I just kept plugging away at them. I got my
employer HR rep to call them and I got the Byetta reps to call them,
and with my DBE and endo sending them info, finally they approved it.

On the Symlin question, I believe Symlin has similar effects on BG to
Byetta, but without the weight loss as a common side effect. There are
folks here on Symlin and I'm sure they will be along soon to help you.

Mainly I just wanted to say hang in there and chin up. If nothing
else, invest in the Byetta for one month (or check with your endo, as
they were giving one month's pen for free earlier this year). If it
works for you, it may help you remember what it was like not to care
about food.

As for exercise, just keep moving, doesn't matter where or how, why not
the grocery store? A body at rest wants to stay at rest, but too much
resting won't make you feel better in the long run.

Just hang in there and keep coming back here. Ignore the OT stuff and
look for the gems; there are many fine posters with lots of great info
and you will find plenty of food for thought.

Best,

Ricavito

Ricavito

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Jan 8, 2007, 12:18:53 AM1/8/07
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Well, I am replying to my own post just to add that I have no idea how
insulin and Byetta "mix" (paging Anon!). I know that if you are on
insulin or certain oral meds, you would definitely run the risk of a
hypo with Byetta. Forgive me for stating the obvious, but of course
you would want to work very closely with your medical team. Okay, I
feel better know.

Best!

Julie Bove

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Jan 8, 2007, 12:43:30 AM1/8/07
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"Dave" <phonew...@yahoo.com> wrote in message
news:m5joh.32576$Gr2....@newssvr21.news.prodigy.net...

I'm no expert on Byetta but I did overhear my Endo. tell one patient who was
on meds and insulin that he was going to prescribe it for her because her
A1c was too high. Since then I have not heard him pushing it to anybody and
he didn't mention it at all at my last visit.

As for the supermarket... I am disabled. I'm doing better now than I was
with the walking but I still have difficulty. Any store with shopping carts
I can push is a place where I know I can walk because the cart helps me keep
my balance. There was a time when I had to go to the store every day
because I could not walk up and down more than maybe 2 or 3 aisles at a
time. By the end of the week I would finally have gotten everything I
needed.

Now I can go up and down all the aisles. It took me a long time, but I
slowly get enough better to where I could do that. And I do go up and down
all the aisles whether I need to or not. I figure this is better than no
exercise at all. I don't always go to the supermarket. Sometimes it's the
drugstore. The office supply store. Or any store that I know has carts and
where I don't have to park too far from the door because otherwise I can't
get there. Yes, I know I should probably have a disabled sticker for my
vehicle. But I figure I'm not in a wheelchair. I'm no longer using the
walker and there are other people who are worse off than me. In fact if you
saw me on a good day you might not think I was disabled at all. But on a
bad day, people will ask me what is wrong with my leg or foot. They always
assume it's some injury because the rest of me looks fit.


DonnaB shallotpeel

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Jan 8, 2007, 12:51:47 AM1/8/07
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In alt.support.diabetes on Mon, 08 Jan 2007 05:43:30 GMT in Msg.#

<6Skoh.1496$GL.1262@trndny06>, "Julie Bove" <juli...@verizon.net> wrote:

> Now I can go up and down all the aisles. It took me a long time, but I
> slowly get enough better to where I could do that. And I do go up and down
> all the aisles whether I need to or not. I figure this is better than no
> exercise at all. I don't always go to the supermarket. Sometimes it's the
> drugstore. The office supply store. Or any store that I know has carts and
> where I don't have to park too far from the door because otherwise I can't
> get there. Yes, I know I should probably have a disabled sticker for my
> vehicle. But I figure I'm not in a wheelchair. I'm no longer using the
> walker and there are other people who are worse off than me. In fact if you
> saw me on a good day you might not think I was disabled at all. But on a
> bad day, people will ask me what is wrong with my leg or foot. They always
> assume it's some injury because the rest of me looks fit.

Wouldn't continuing to use the walker help with your balance as well?

--
DonnaB : ^> shallotpeel <*> Yahoo Messenger: shallotpeel

Irregular Verb Conjugation:
I have preferences. You have biases. He/She has prejudices.

Nicky

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Jan 8, 2007, 3:58:18 AM1/8/07
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On Mon, 08 Jan 2007 03:43:14 GMT, "Dave" <phonew...@yahoo.com>
wrote:

> ( I
>carry my weight in my stomach not my tush or legs)

Sometimes that means that people will lose weight low-carbing easier
than any other method?

>The best way I walk is in the
>supermarket (catch 22 I know, I really don't need to be in the market)
>holding on to the cart which helps my back pain.

Whatever lets you exercise is good.

Nicky.
T2 DX 05/2004
A1c 5.5% BMI 25 D&E
100ug Thyroxine

Andrew B. Chung, MD/PhD

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Jan 8, 2007, 6:08:33 AM1/8/07
to
Dave wrote:
> I have a question about Byetta. I have been type 2 for about 15 years. I
> am 200 lbs overweight, partly due to the meds, bad food choices and a bout
> of depression about 1 year ago where I sat and did nothing. (bad time)

Reminds me of Jolanna's difficulties:

http://groups.google.com/group/sci.med.cardiology/msg/565dcf43b835714d

The 2PD-OMER Approach now comes with a million dollar guarantee:

http://HeartMDPhD.com/wtloss.asp

You may hear about the details concerning the guarantee at the next
free public Foundation event:

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Primary online verification of the million dollars is located here:

http://MabletonGA.OurLittle.net/MillionDollars

Suggested reading:

http://groups.google.com/group/sci.med.cardiology/msg/9c44753ef8dd6341?

May GOD continue to heal our hearts with HIS living water curing our
diabetes, depression, anxiety, or panic so that we can love our
neighbors a little more and LORD Jesus Christ a whole lot more, dear
Dave whom I love unconditionally.

Prayerfully in Christ's amazing love,

Andrew <><
--
Andrew B. Chung
Cardiologist, Atlanta, Georgia, USA
http://HeartMDPhD.com/HolySpirit

As for knowing who are the very elect, these you will know by the
unconditional love they have for everyone including their enemies
(Matthew 5:44-45, 1 Corinthians 13:3, James 2:14-17).
http://HeartMDPhD.com/Love

Meanwhile, HIS brethren have been blessed:

http://MabletonGA.OurLittle.net/DreadNought

... and continue to be blessed:

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(note: Only those who are blessed by LORD GOD Almighty, Creator of
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OurLittle.net articles per a secure IP database maintained by
TheWellnessFoundation.com)

Billie

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Jan 8, 2007, 6:15:27 AM1/8/07
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"Dave" <phonew...@yahoo.com> wrote in message
news:m5joh.32576$Gr2....@newssvr21.news.prodigy.net...
: I take about 40 units R insulin at each meal and 100mg Lantus

: at night. I am on low dosages of Trileptal, Trazadone and Lamictal due to
: the depression. I have just heard about Byetta from a co worker. When I
: e-mailed my diabetic nurse practioner about it she replied that Byetta is
: for patients who are on oral diabetes medication only and that I may need
: Symlin. I don't know anything about Symlin. I am not sure if Symlin will
: replace the R insulin or be added to it.

Symlin is added prior to each meal with a mininum numer of carbs.

The Symlin helps me tremendously with control with the Prednisone I take.
Not only have I done relatively well with bg control (6.9%), but also with
weight loss. I have been sick recently, and I've not been able to be as
consistent, so I'm just now getting back on track with it. It does great
for cutting my steroid appetite which is picking up now that I am no longer
sick.


: I am still waiting for an


: appointment with my endo to discuss it all. Is this all true or is my HMO
: trying to get out of paying for the Byetta which I understand is
expensive.

Symlin is also expensive; they are sister drugs.


: I must find a way to lose weight even slowly. With all the weight gaining
: meds I am on I cant manage to lose even 10 pounds. The best way I walk

is in the
: supermarket (catch 22 I know, I really don't need to be in the market)
: holding on to the cart which helps my back pain.

I have been through the very same thing, and I urge you to have your back
checked out by your doctor. The first time I needed *basket assistance* I
had a herniated disk (not suggesting, just relating my experience of a
physiological problem needing medical attention). I have had low back pain
with sciatica since the disk, and unknowingly, the development of
Myastheynia Gravis (MG) which has included those back muscles relieved
somewhat by the *basket assistance* until the progression of the disease
beyond that point. That back pain is a nasty thing isn't it? Hope it gets
better for you. *s*

Just because I have had physiological problems does not mean that you have
one, but, again, I urge you to have your back checked out by your doctor,
and get an all clear before beginning any exercises.

Best of luck on your endeavors,
Billie

"Blessed are the flexible, for they shall not be bent out of shape."


:
:
:
: I appreciate any comments or suggestions. TIA!
:
:


rk

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Jan 8, 2007, 6:57:56 AM1/8/07
to
"Dave" <phonew...@yahoo.com> wrote in message
news:m5joh.32576$Gr2....@newssvr21.news.prodigy.net...
:I have a question about Byetta. I have been type 2 for about 15 years. I
:
:

AFAIK, Byetta is for Type 2's ONLY and Symlin is for Type 1's. They
basically
do the same thing as far as helping food digest better, but simply being on
insulin doesn't make one a T1 therefore you probably need a new diabetic
nurse and someone to give you Byetta.

Good luck,

RK, T1
Animas IR1250 pumper


Loretta Eisenberg

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Jan 8, 2007, 9:36:20 AM1/8/07
to
To me gastric bypass is a very drastic measure and since you say only 15
per cent have remained lean, it doesnt seem worth taking all those risks
.

You cannot take byetta if you are on insulin, I am on byetta and
metformin. I was also on amaryl, but I have been able to eliminate
that. I have lost twenty pounds since the middle of October. It is not
that I am dieting, it is that my appetite has decreased immensely and I
dont have the hunger I once did.

Perhaps you can ask your doctor if you could get off insulin and go on
byetta and metformin combination. I dont know about symlin but it could
be on the same order.

Loretta

--
In tribute to the United States of America and the State
of Israel, two bastions of strength in a world filled with strife and
terrorism.

TigerLily

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Jan 8, 2007, 10:58:52 AM1/8/07
to
i've read of people on this newsgroup who are on
byetta with insulin

it's an 'off label' use though

kate
--
Join us in the Diabetic-Talk Chatroom on UnderNet
/server irc.undernet.org --- /join #Diabetic-Talk
More info: http://www.diabetic-talk.org/
http://www.diabetic-talk.org/freeveggies.htm
I have no medical qualifications beyond my own
experience.
Choose your advisers carefully, because experience
can be
an expensive teacher.

"Loretta Eisenberg" <Ron...@webtv.net> wrote in
message
news:6018-45A...@storefull-3234.bay.webtv.net...

Billie

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Jan 8, 2007, 4:04:23 PM1/8/07
to
I was, then was switched to Symlin after going on the pump, and put on a six
month Symlin research. Byetta is *on label* for those on oral meds, and
Symlin is for type 1 or type 2 - for insulin users of either type.

Billie

"TigerLily" <m...@privacy.net> wrote in message
news:50f82nF...@mid.individual.net...
: i've read of people on this newsgroup who are on

: >
:
:


Paul_B

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Jan 8, 2007, 7:13:06 PM1/8/07
to
On Mon, 08 Jan 2007 03:43:14 GMT, Dave wrote:

> I have a question about Byetta. I have been type 2 for about 15 years. I
> am 200 lbs overweight, partly due to the meds, bad food choices and a bout
> of depression about 1 year ago where I sat and did nothing. (bad time) I
> have been taking Glipizide at each meal but I am now switching over to
> Glucophage. I take about 40 units R insulin at each meal and 100mg Lantus
> at night. I am on low dosages of Trileptal, Trazadone and Lamictal due to
> the depression. I have just heard about Byetta from a co worker. When I
> e-mailed my diabetic nurse practioner about it she replied that Byetta is
> for patients who are on oral diabetes medication only and that I may need
> Symlin. I don't know anything about Symlin. I am not sure if Symlin will
> replace the R insulin or be added to it. I am still waiting for an
> appointment with my endo to discuss it all. Is this all true or is my HMO
> trying to get out of paying for the Byetta which I understand is expensive.


There's definitely overlap between the two drugs. Byetta is
currently approved only for use with orals (including now the
TZD's, such as Actos), but a lot of use is happening off-label
with insulin. Byetta has the advantage of being
glucose-dependant, which means it generally won't cause hypos
because it doesn't act unless blood sugar is high, but that's not
true of the meds it can be used with. Byetta slows down the
emptying of the stomach and increases satiety, so it has great
weight-loss characteristics.

Symlin too, however, is great for weight loss. So much so that it
is being investigated for that specific use by Amylin, the maker
of both drugs. Unlike Byetta, Symlin is approved for use with
insulin. It's harder to take than Byetta, because Byetta comes in
a micro pen. Symlin's pen is due late next year.

A lot of people report that they are able to decrease dosages of
other meds. If you ask Amylin they will answer strictly by the
approved label, as they don't want to cross the FDA. But the fact
is they are in trials right now to expand the labels of these
drugs, and especially to come up with a weight-loss cocktail
therapy of two or three drugs. And there's probably nearly as
much off-label use of the drugs as there is on-label. The
diabetes blog is the best place to read the testimonies.

p.
Disclaimer: I am not a doctor and don't play one on the internet.

rk

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Jan 8, 2007, 9:28:02 PM1/8/07
to
"Paul_B" <pb_public-...@operamail.com> wrote in message
news:l7d18vmbteg5$.dlg@pbpublic.invalid...

What "Clinical Trials" is Byetta going through to be labeled for
weight loss? I was just on the Clinical Trials site checking info
on Byetta for my daughter because they DO have clinical trials
going on using Byetta and Metformin together for PCOS. There
was nothing there (in all 12 of them) anything about using it for
weight loss only. There were several references about it being
an added side effect.


--
Reisa, T1
dx-5/00 asd-7/00
Animas IR1250 pumper
Daily CHO: 150-200gm
TDD: 36-38u
Last A1C: Rising! oPPs!


rk

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Jan 8, 2007, 9:29:20 PM1/8/07
to
UG! last thing... while reading on the Symlin clinical trials
it stated that it *does* give hypos (lows) after the injection
and therefore those who have hypo unawareness shouldn't
be using it.

--
Reisa, T1
dx-5/00 asd-7/00
Animas IR1250 pumper
Daily CHO: 150-200gm
TDD: 36-38u
Last A1C: Rising! oPPs!

"Paul_B" <pb_public-...@operamail.com> wrote in message
news:l7d18vmbteg5$.dlg@pbpublic.invalid...

Billie

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Jan 8, 2007, 9:59:14 PM1/8/07
to
While I was on the six month research last year, they were very sensitive to
any lows I would have; I was to call one of them if I had a low. Symlin
does a great job of leveling out my pp..... less lows, less highs. When
without my uti, it all works really well together, but boy those infections
sure throw things off until the antibiotics kick in.

Billie

"Blessed are the flexible, for they shall not be bent out of shape."

"rk" <p_haha...@gmail.com> wrote in message
news:s-Wdnadin4WdYz_Y...@wideopenwest.com...
: UG! last thing... while reading on the Symlin clinical trials

:
:


Paul_B

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Jan 9, 2007, 7:50:06 AM1/9/07
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On Mon, 8 Jan 2007 21:29:20 -0500, rk wrote:

> UG! last thing... while reading on the Symlin clinical trials
> it stated that it *does* give hypos (lows) after the injection
> and therefore those who have hypo unawareness shouldn't
> be using it.


Symlin took a long time to be approved because of the rigidity of
the FDA's trial regimen. Because of the marriage to a legalistic
interpretation of scientifically controlled experimentation, the
dosage of insulin was not allowed to be down-titrated in the
Symlin arms of the trials. This is completely contrary to the way
the drug is used in real life. Because Symlin makes insulin use
more effective, concomitant insulin dosage must be reduced.

Thus hypos were a problem in the clinicals, and one FDA person
made it his personal quest to keep Symlin off the market, and
succeeded in delaying it for years and hobbling the launch once
it finally was approved.

My (limited) understanding is that Symlin alone cannot cause
hypos, but its use with insulin can.

p.

--

Paul_B

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Jan 9, 2007, 7:50:34 AM1/9/07
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On Mon, 8 Jan 2007 21:28:02 -0500, rk wrote:

> "Paul_B" <pb_public-...@operamail.com> wrote in message
> news:l7d18vmbteg5$.dlg@pbpublic.invalid...

>: There's definitely overlap between the two drugs. Byetta is


None that I'm aware of.

p.

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