Why T2 ?

[GysdeJongh]

<http://www.cell.com/cell-metabolism/fulltext/S1550-4131(10)00450-X>

NF-Kappa Beta, Inflammation, and Metabolic Disease

Cell Metabolism, Volume 13, Issue 1, 11-22, 5 January 2011
Copyright � 2011 Elsevier Inc. All rights reserved.
10.1016/j.cmet.2010.12.008

Authors
Rebecca G. Baker, Matthew S. Hayden, Sankar Ghosh
Summary
Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis
have been viewed historically as lipid storage disorders brought about by
overnutrition. It is now widely appreciated that chronic low-grade
inflammation plays a key role in the initiation, propagation, and
development of metabolic diseases. Consistent with its central role in
coordinating inflammatory responses, numerous recent studies have implicated
the transcription factor NF-?B in the development of such diseases, thereby
further establishing inflammation as a critical factor in their etiology and
offering hope for the development of new therapeutic approaches for their
treatment.

[Charly Coughran]

"GysdeJongh" <JonghSevenHundredElevenAtPlanet.nl> wrote in
news:519ccad0$0$9616$a826...@newsreader.readnews.com:

>
> <http://www.cell.com/cell-metabolism/fulltext/S1550-4131(10)

I had some trouble with your link. Here is another.
http://www.sciencedirect.com/science/article/pii/S1550413110004
50X

I assume your question is, "Why is type 2 included under
metabolic disorders?" Since about 80% of type 2 has long been
classified as obesity onset diabetes, it is not unusual for
papers in the field to assume that all diabetes falls under
that rubric. This allows the author to simplify the point of
view of the paper. The same thing happens with autoimmune type
1 for the same reasons.

From the introduction in the paper:

Start quote.
Metabolic syndrome encompasses a cluster of conditions that
result from nutrient excess, hyperglycemia, hyperlipidemia,
insulin resistance, obesity, and hepatic steatosis, which
together affect a quarter of Americans adults and over a
million children(Iyer et al., 2010). Metabolic diseases track
together, and obese patients are at increased risk for type 2
diabetes, while insulin-resistant patients frequently suffer
from cardiovascular diseases such as atherosclerosis.
End quote


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