Statins do the work by increasing vitamin d levels ?.Really pricey sunshine?
bigvince
after rosuvastatin treatment: a novel pleiotropic effect of statins?
Yavuz B, Ertugrul DT, Cil H, Ata N, Akin KO, Yalcin AA, Kucukazman M,
Dal K, Hokkaomeroglu MS, Yavuz BB, Tutal E.
Kecioren Teaching and Research Hospital, Department of Cardiology,
Ankara, Turkey. byav...@gmail.com
Comment in:
* Cardiovasc Drugs Ther. 2009 Aug;23(4):261-2.
OBJECTIVES: Low levels of 25-hydroxyvitamin D are associated with
higher risk of cardiovascular morbidity and mortality. Large trials
demonstrated that statins significantly decrease cardiovascular
morbidity and mortality. 7-dehydrocholesterol is the precursor of both
cholesterol and vitamin D. The aim of this study was to investigate
the possible effect of rosuvastatin on vitamin D metabolism. METHODS:
The study was performed in a prospective cohort design. The study
group consisted of 91 hyperlipidemic patients who had not been treated
with lipid lowering medications. Lipid parameters, 25 hydroxyvitamin-
D, 1,25-dihydroxyvitamin D, and bone alkaline phosphatase were
obtained at baseline and after 8 weeks of rosuvastatin treatment.
RESULTS: None of the subjects withdrew from the study because of the
adverse effects. The mean age was 59.9 +/- 12.5 years. The majority of
the patients were male (55, 60%). Seventeen patients were diabetic,
and 43 patients had systemic hypertension. There was a significant
increase in 25-hydroxyvitamin D, from mean 14.0 (range 3.7- 67) to
mean 36.3 (range 3.8 -117) ng/ml (p < 0.001), and also an increase of
1,25-dihydroxyvitamin D from mean 22.9 +/- 11.2 to 26.6 +/- 9.3 pg/dl
(p = 0.023). Bone alkaline phosphatase decreased after 8 weeks of
rosuvastatin treatment, mean 17.7 (range 2.6-214) to mean 9.5 (range
2.3-19.1) u/l (p < 0.001) rosuvastatin treatment. CONCLUSION: This
study has shown an effect of rosuvastatin on vitamin D metabolism,
with an increase in both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin
D. This may be an important pleiotropic effect whereby rosuvastatin
reduces mortality in patients with coronary artery disease. Further
studies are needed to clarify the relationship between statins and
vitamin D metabolism.
PMID: 19543962 [PubMed - indexed for MEDLINE]
Andrew B. Chung, MD/PhD
It is written in the Bible that we are to work while there is
daylight.
This illustrates how "... man does not live of bread alone but on
every word that comes out of the mouth of the LORD." (Dt 8:3, Mt 4:4,
and Lk 4:4)
Be hungrier, which truly is healthier especially for the heart:
Love in the truth,
Andrew <><
--
Andrew B. Chung, MD/PhD
Board-certified Heart Doctor
and Author of "Trust the Truth:"
http://www.amazon.com/-/e/B002G22ZWG
http://groups.google.com/group/sci.med.cardiology/msg/9642aafa0aad16eb?
Only the truth can cure the "hunger is starvation" delusion:
http://groups.google.com/group/sci.med.cardiology/msg/74281ab7d7ce78de?