Maprotiline: The Forgotten Multicyclic -

[Sal]

I tried maprotiline for a month at the maximum dose. It is very
tolerable, yet few know much about it:

(Ludiomil):

EFFICACY AND TOLERABILITY
(http://biopsychiatry.com/maprotvamitrip.htm)
"It is concluded that Maprotiline is as effective against depression
as Amitriptyline and less liable to the anticholinergic side effects.
It is, therefore, a very useful antidepressant."

UNDERUSED IN PSYCHIATRY
"MAOIs and other antidepressants, such as maprotiline, represented
less than 1% of all antidepressants used (according to our surveys)."

BEST FOR THOSE WHO RESPOND TO NORADRENALINE

Spectrofluorimetric and isotachophoretic determination of maprotiline
in human blood serum. Miroslav akrt, Electrophoresis.
Volume: 21, Issue: 14:

"Maprotiline is one of the best-studied psychoactive agents and is
considered to be the most effective specific inhibitor of
noradrenaline in the presynaptic neuron without influence of serotonin
metabolism."

[Mykstor]

<< [maprotiline]...is

considered to be the most effective specific inhibitor of
noradrenaline >>

I assume that means *reuptake* inhibitor? Who makes ludiomil? Can you get it in
the USA? I'm a desipramine responder, hence possibly a candidate.

[Sal]

If you respond to desipramine you might respond to nortriptyline too:
http://www.1drugstore-online.com/search.asp?txtsearch=nortriptyline

I believe maprotiline has been in the U.S. since 1980.