Discussions - alt.support.crohns-colitis

	~~~~~~~~~~~~~~~ BRASS KNUCKLES ~~~~~~~~~~~~~~~
	. ~~~^^^~~~ ============================== ==================== ============================== ==================== ENTER HERE: >>> [link] <<< ============================== ====================... more » By Kelli Hughes - 1:50pm - 1 new of 1 message

	~~~~~~~~~~~~~~~ CAIRN TERRIER ~~~~~~~~~~~~~~~
	. ~~~^^^~~~ ============================== ==================== ============================== ==================== ENTER HERE: >>> [link] <<< ============================== ====================... more » By Luis Pierre - 10:39am - 1 new of 1 message

	Aryl hydrocarbons cause lipid accumulation in macrophages, contribute to atherosclerosis
	Cardiovasc Res. 2009 May 1;82(2):361-70. Epub 2009 Jan 8. NPC1 repression contributes to lipid accumulation in human macrophages exposed to environmental aryl hydrocarbons. Podechard N, Le Ferrec E, Rebillard A, Fardel O, Lecureur V. Institut National de la Sante et de la Recherche Medicale U620, IFR140,... more » By Kofi - 12:41am - 1 new of 1 message

	Ethyl pyruvate inhibits HMGB1 release in colitis
	The NADH/NAD+ ratio is also pathologically perturbed in diabetes. J Leukoc Biol. 2009 Sep;86(3):633-43. Epub 2009 May 19. Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis. Dave SH, Tilstra JS, Matsuoka K, Li F, DeMarco RA, Beer-Stolz D, Sepulveda AR, Fink MP, Lotze MT, Plevy SE.... more » By Kofi - Nov 22 - 1 new of 1 message

	Statins potentiate macrophage inflammation
	Am J Trop Med Hyg. 2009 Oct;81(4):631-7 Statins fail to improve outcome in experimental cerebral malaria and potentiate Toll-like receptor-mediated cytokine production by murine macrophages. Helmers AJ, Gowda DC, Kain KC, Liles WC. Institute of Medical Science, and Division of Infectious Diseases,... more » By Kofi - Nov 22 - 1 new of 1 message

	Aryl hydrocarbon receptor suppresses TNF-alpha production in macrophages
	J Exp Med. 2009 Aug 31;206(9):2027-35. Epub 2009 Aug 24. Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses. Kimura A, Naka T, Nakahama T, Chinen I, Masuda K, Nohara K, Fujii-Kuriyama Y, Kishimoto T. Laboratory of Immune Regulation, Osaka University Graduate School of... more » By Kofi - Nov 22 - 1 new of 1 message

The aryl hydrocarbon receptor (dioxin/PCBs), herpesvirus infections and underactive macrophages

As I've posted in the IBD groups, Crohn's appears due to underachieving macrophages. There are a variety of reasons for this. Aside from the genetic ones or autoantibodies, macrophage dysfunction could be caused by viral infection or toxic exposure - and we're starting to see why these things occur hand-in-hand. To sum up my findings, the Aryl... more »

By Kofi - Nov 22 - 1 new of 1 message

	A cigarette metabolite accelerates vitamin D breakdown via the aryl hydrocarbon receptor
	No doubt this accelerated breakdown of vitamin D by smoking metabolites helps to account for the adverse effects of smoking on other conditions like Crohn's. In essence, smoking is chewing up your vitamin D stores. Toxicol Sci. 2009 May;109(1):50-8. Epub 2009 Feb 25 The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin... more » By Kofi - Nov 22 - 1 new of 1 message

	non-calcaemic Lithocholic acid acetate promotes osteoblast maturation
	Steroids. 2009 Nov;74(12):963-70. Epub 2009 Jul 29 Lithocholate--a promising non-calcaemic calcitriol surrogate for promoting human osteoblast maturation upon biomaterials. Mansell JP, Shorez D, Farrar D, Nowghani M. Department of Oral & Dental Science, University of Bristol Dental School, Lower Maudlin Street, Bristol, BS1 2LY, UK.... more » By Kofi - Nov 22 - 1 new of 1 message

	Defects in autophagy enhance IL-1beta inflammation
	Nature. 2008 Nov 13;456(7219):264-8. Epub 2008 Oct 5. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S.... more » By Kofi - Nov 21 - 1 new of 1 message