Research: Tumor necrosis factor blockers may not cause cancer after all

[zumon...@yahoo.com]

http://www.eurekalert.org/pub_releases/2006-08/jws-tnf082406.php

Tumor necrosis factor blockers may not cause cancer after all

Study finds no increased risk of lymphoma or tumors associated with
anti-TNF therapy over methotrexate use among rheumatoid arthritis
patients

Patients with rheumatoid arthritis (RA), an autoimmune, inflammatory
disease marked by progressive joint and organ damage, face a high risk
of developing cancer. Their vulnerability, especially to lymphoma and
leukemia, may be due to the nature of RA. Disease-modifying
antirheumatic drugs (DMARDs) - including tumor necrosis factor alpha
(TNFá) antagonists, a type of biologic DMARD - have also been
implicated. TNF blockers, which work by attaching to and impeding
chemical messengers behind inflammation, have had a significant impact
on the treatment of RA. They have also been linked to lymphoma among
users. In fact, reports of lymphoma prompted the Food and Drug
Administration to mandate adding a cancer risk warning to the labels of
three TNF blockers: etanercept (Enbrel), infliximab (Remicade), and
adalimumab (Humira).

Motivated by persistent concerns and inconclusive studies, researchers
at Harvard Medical School's Brigham and Women's Hospital set out to
investigate the association between treatment with TNF blockers and
occurrence of cancer in a large sample of patients with RA. Their
results, featured in the September 2006 issue of Arthritis & Rheumatism
(http://www.interscience.wiley.com/journal/arthritis), indicate that
biologic DMARD therapy poses no greater risk for cancer than therapy
with a standard prescription DMARD, methotrexate (MTX).
...

--
Luke

[NinaW]

Yaaaaaaayyyyyyyyy!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

Nina

[Golden68]

This includes REMICADE I'm sure, right?

"NinaW" <radio...@canada.com> wrote in message
news:1157077547.8...@74g2000cwt.googlegroups.com...
>
> Yaaaaaaayyyyyyyyy!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
>
> Nina
>

[zumon...@yahoo.com]

Hi Golden,

Golden68 wrote:
> This includes REMICADE I'm sure, right?

That's my take. The September issue isn't online yet so I couldn't
check the article's abstract.

I think they are combining all the TNF-a antagonists like Remicade and
Humira.

--
Luke

[Vanny]

Yes, remicade is a key treatment for rheumatoid arthritis and will
definitely have been among those tested.

I am sure that a PubMed search will bring up the scientific publication.

V.

"Golden68" <gold...@verizon.net> schrieb im Newsbeitrag
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