Iron Binding In Cancer
ironjustice
Effect of Orally Administered Bovine Lactoferrin on the
Growth of Adenomatous Colorectal Polyps in a Randomized,
Placebo-Controlled Clinical Trial
Takahiro Kozu1, Gen Iinuma2, Yasuo Ohashi5, Yutaka Saito3,
Takayuki Akasu4, Daizo Saito3, David B. Alexander7,
Masaaki Iigo7, Tadao Kakizoe6 and Hiroyuki Tsuda7
Authors' Affiliations: 1 Cancer Screening Division,
National Cancer Center,
Research Center for Cancer Prevention and Screening;
2 Diagnostic Radiology, 3 Endoscopy, and 4 Colorectal Surgery,
National Cancer Center Hospital; 5 Department of Biostatistics,
School of Health Sciences and Nursing, The University of Tokyo;
6 National Cancer Center, Tokyo, Japan; and
7 Department of Molecular Toxicology, Nagoya City University
Graduate School of Medical Sciences, Nagoya, Japan
Requests for reprints: Hiroyuki Tsuda,
Department of Molecular Toxicology,
Nagoya City University Graduate School of Medical Sciences,
1-Kawasumi, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan.
Phone: 81-52-853-8991; Fax: 81-52-853-8996;
E-mail: hts...@med.nagoya-cu.ac.jp.
---------------
Lactoferrin (LF), a secreted, iron binding glycoprotein
originally discovered as a component of milk, is found in
a variety of exocrine secretions and in the secondary granules
of polymorphonuclear leukocytes.
Animal experiments have shown that oral administration of bovine
lactoferrin (bLF) exerts anticarcinogenesis effects in the colon
and other organs of the rat.
The aim of this study was to determine whether oral bLF could
inhibit the growth of adenomatous colorectal polyps in human
patients.
A randomized, double-blind, controlled trial was conducted in 104
participants, ages 40 to 75 years, with polyps 5 mm in diameter and
likely to be adenomas.
Participants were assigned to receive placebo, 1.5-g bLF, or 3.0-g
bLF
daily for 12 months.
Target adenomatous polyps were monitored by colonoscopy.
Ingestion of 3.0-g bLF significantly retarded adenomatous polyp
growth
in participants 63 years old or younger.
Removal of adenomatous colorectal polyps is done as a preventative
measure against colorectal cancer; however, polyps can be overlooked,
and when detected, polypectomy is not always 100% effective in
eradicating
a polyp.
Our study suggests that daily intake of 3.0 g of bLF could be a
clinically
beneficial adjunct to colorectal polyp extraction.
Key Words: Lactoferrin • intestinal polyp • cancer prevention •
clinical trial
Published Online First on October 27, 2009
[Cancer Prevention Research, 10.1158/1940-6207.CAPR-08-0208]
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