Bone Repair
ironjustice
Radiographic repair in three Japanese patients with
rheumatoid arthritis treated with bucillamine.
Nanke Y, Iwatani M, Kobashigawa T,
Yago T, Yamanaka H, Kotake S.
Mod Rheumatol. 2009;19(6):681-6. Epub 2009 Aug 27.
Institute of Rheumatology, Tokyo Women's Medical University,
10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan.
y...@ior.twmu.ac.jp
Bucillamine (Bc) is a cysteine derivative with two SH groups,
and a homolog of D-penicillamine, a disease-modifying
antirheumatic drug (DMARD) widely used in Japan.
However, it remains unclear whether Bc repairs bone erosion
in patients with RA.
Here, we treated three RA patients with Bc who subsequently
showed radiographic repair of erosions and cysts.
PMID: 19711150
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Antioxidant properties of bucillamine: Possible mode of action
Dalia Mazora, , , Liya Greenberga, Dror Shamirb,
Dan Meyersteinb, c and Naomi Meyersteina
aExperimental Hematology, Department of Physiology,
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-
Sheva, Israel
bDepartment of Chemistry, Ben-Gurion University of the Negev, Beer-
Sheva, Israel
cBiological Chemistry Department, The College of Judea and Samaria,
Ariel, Israel
Received 13 August 2006. Available online 1 September 2006.
Abstract
The antioxidant properties of Bucillamine (BUC), a di-thiol
compound used for treatment of rheumatoid arthritis (RA)
and its possible mode of action, were investigated.
BUC exhibits potent antioxidant activity similar to those of
trolox and ascorbic acid.
It reduces the stable free radical diphenyl-2-picrylhydrazyl
(DPPH) with IC50 of 18.5 ± 0.1 μmol, its relative antioxidant
activity by the ferric reducing ability (FRAP) is 2.07 ± 0.01
mM and by the trolox equivalent antioxidant capacity (TEAC),
1.46 ± 0.05 mM.
However, its superoxide and apparent hydroxyl radical
scavenging activities are low (IC50 at millimolar concentrations).
We found that BUC is a strong iron (II) and copper (II) chelator.
This finding is very important since these metal ions are
significantly higher in RA patients and may be involved in
oxidative stress-induced damage.
Our study suggests that BUC is a potent antioxidant which
exerts its beneficial therapeutic activities in RA patients by
metal chelation rather than by scavenging free radical species.
Keywords: Bucillamine; Antioxidant activity; Thiols;
Reactive oxygen species; Metal chelation; Trolox
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Kevysmom
Peter B
"Kevysmom" <kevys...@gmail.com> wrote in message
news:f1427d18-6bb6-4ad2...@p8g2000yqb.googlegroups.com...
>Jesus was NOT a vegetarian
>
Nor did He have a diet plan. ;)
Jerry
> Jesus was NOT a vegetarian
He might have done better if he was.
ironjustice
STFU ..
Ken
dickhead
ironjustice
Kevysmom
P.S Jesus was NOT a vegetarian!
