Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats. de Lima MN, Presti-Torres J, Garcia VA, Guimarães MR, Scalco FS, Roesler R, Schröder N Neuropharmacology 2008 Jun 21.
Increasing evidence indicates that iron deposition in the brain might play a role in cognitive dysfunction associated with neurodegenerative disorders and aging. Previous studies have not examined whether iron- induced memory deficits can be attenuated by acute treatments with memory-enhancing agents. Phosphodiesterase type 4 (PDE4) inhibitors such as rolipram (ROL) ameliorate memory impairments in several rodent models of amnesia and have been proposed as candidate cognitive- enhancing drugs. Here we show that a single posttraining systemic injection of ROL dose-dependently attenuates the impairment of memory for novel object recognition (NOR) in rats given neonatal iron loading, a model of iron-induced cognitive impairment. Posttraining administration of ROL also recovered NOR deficits associated with aging in rats. These findings provide the first evidence that stimulation of an intracellular second messenger signaling pathway can attenuate iron-induced memory impairment, and support the view that PDE4 inhibitors might ameliorate cognitive dysfunction associated with aging and neurodegenerative disorders.
Impact of iron supplementation on cognitive functions in preschool and school-aged children: the Indian experience
Article Abstract:
Iron deficiency is a common health problem among children living in India. Approximately 60 percent of children under age three years and 44 percent between the ages of three and five years have low hemoglobin levels. In iron deficiency, the hemoglobin concentration in red blood cells is reduced, which prevents delivery of adequate amounts of oxygen to body tissues. Previous research has suggested that iron deficiency may cause children to perform poorly on cognitive or mental tests. The authors report results from four studies of iron supplementation using elemental iron in children of different ages.
On Jul 18, 9:46 am, ferr...@ironcity.com wrote: iron loading <<
What you should do is include a study which shows .. iron deficiency .. causes iron loading .. ?
Try that ..
Not .. iron .. deficiency ..
The article is about .. iron .. loading ..
Maybe you should start a thread about .. iron .. deficiency .. ?
Do you understand the difference between iron loading and iron deficiency .. ?
Do ya .. ?
One .. there is PLENTY of iron .. the other .. there isn't supposed to be ANY iron ..
You see the difference .. ?
Iron YES versus .. NO iron ..
Pretty easy to understand .. yes versus no ..
Use those well honed .. deductive skills ..
Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats. de Lima MN, Presti-Torres J, Garcia VA, Guimarães MR, Scalco FS, Roesler R, Schröder N Neuropharmacology 2008 Jun 21.
Increasing evidence indicates that iron deposition in the brain might play a role in cognitive dysfunction associated with neurodegenerative disorders and aging. Previous studies have not examined whether iron- induced memory deficits can be attenuated by acute treatments with memory-enhancing agents. Phosphodiesterase type 4 (PDE4) inhibitors such as rolipram (ROL) ameliorate memory impairments in several rodent models of amnesia and have been proposed as candidate cognitive- enhancing drugs. Here we show that a single posttraining systemic injection of ROL dose-dependently attenuates the impairment of memory for novel object recognition (NOR) in rats given neonatal iron loading, a model of iron-induced cognitive impairment. Posttraining administration of ROL also recovered NOR deficits associated with aging in rats. These findings provide the first evidence that stimulation of an intracellular second messenger signaling pathway can attenuate iron-induced memory impairment, and support the view that PDE4 inhibitors might ameliorate cognitive dysfunction associated with aging and neurodegenerative disorders.
> Impact of iron supplementation on cognitive functions in preschool and > school-aged children: the Indian experience
> Article Abstract:
> Iron deficiency is a common health problem among children living in > India. Approximately 60 percent of children under age three years and > 44 percent between the ages of three and five years have low > hemoglobin levels. In iron deficiency, the hemoglobin concentration in > red blood cells is reduced, which prevents delivery of adequate > amounts of oxygen to body tissues. Previous research has suggested > that iron deficiency may cause children to perform poorly on cognitive > or mental tests. The authors report results from four studies of iron > supplementation using elemental iron in children of different ages.
"Do you understand the difference between iron loading and iron deficiency .. ?"
Yes, and the one has been shown to correlate with the other.
Would you suggest those indian mothers and their children with cognitive problems have high iron loading? If iron causes all diseases/disorders because people eat meat, what gives with them?
India just keeps popping up again and again when it comes to wquestions of litttle or no meat intake and high levels of various diseases/disorders.
On Jul 18, 12:29 pm, ferr...@ironcity.com wrote: snip <<
The thread is iron in brain leads to neurodegeneration ..
Your deduction skills leads you to .. pregnant .. Indian .. women ..
You may think in your brain .. you have something to contribute .. but evidentally .. you .. don't ..
Find something to .. do ..
Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats. de Lima MN, Presti-Torres J, Garcia VA, Guimarães MR, Scalco FS, Roesler R, Schröder N Neuropharmacology 2008 Jun 21.
Increasing evidence indicates that iron deposition in the brain might play a role in cognitive dysfunction associated with neurodegenerative disorders and aging. Previous studies have not examined whether iron- induced memory deficits can be attenuated by acute treatments with memory-enhancing agents. Phosphodiesterase type 4 (PDE4) inhibitors such as rolipram (ROL) ameliorate memory impairments in several rodent models of amnesia and have been proposed as candidate cognitive- enhancing drugs. Here we show that a single posttraining systemic injection of ROL dose-dependently attenuates the impairment of memory for novel object recognition (NOR) in rats given neonatal iron loading, a model of iron-induced cognitive impairment. Posttraining administration of ROL also recovered NOR deficits associated with aging in rats. These findings provide the first evidence that stimulation of an intracellular second messenger signaling pathway can attenuate iron-induced memory impairment, and support the view that PDE4 inhibitors might ameliorate cognitive dysfunction associated with aging and neurodegenerative disorders.
"The thread is iron in brain leads to neurodegeneration .."
Not according to the subject line, it is about cognition and iron loading; which includes those cognition problems from low iron. Low iron is the world's number one health problem, two among many many examples provided you previously. Recall india? Little or no meat, low iron problem in children and women leading to many cognition problems, world's highest levels of diabetes and heart disease etc., a direct and specific refutation of the iron causes all diseases because people eat meat notion. Dead as a dodo.
On Jul 19, 5:18 pm, ferr...@ironcity.com wrote: Recall india? Little or no meat, low iron problem in children and women leading to many cognition problems, <<
Low iron .. ?
You mean they weren't low on anything else .. ?
They got really lucky when you think of the effects of starvation.
They could have been low in many different nutrients.
On Jul 19, 5:18 pm, ferr...@ironcity.com wrote: world's highest levels of diabetes and heart disease etc., a direct and specific refutation of the iron causes all diseases because people eat meat notion. <<
They have the highest blood iron levels of anybody. They have high diabetes. High iron is found in diabetes. What you should be doing is trying to figure out WHY they have such a high rate of iron overload and diabetes.
You won't listen to me .. so .. work at it .. boi.
Come back when you have .. dedeuced .. WHY .. "Asians have the highest blood iron levels of any race in the world" ..
Don't ya .. think .. ?
Asking a loon on the internet .. really .. using .. logic .. is kinda .. stupid.
> Not according to the subject line, it is about cognition and iron loading; > which includes those cognition problems from low iron. Low iron is the > world's number one health problem, two among many many examples provided > you previously. Recall india? Little or no meat, low iron problem in > children and women leading to many cognition problems, world's highest > levels of diabetes and heart disease etc., a direct and specific > refutation of the iron causes all diseases because people eat meat notion. > Dead as a dodo.
The iron notion is a stool with 3 legs. One says iron is the cause of all disease. Another says meat is the source of the iron. nd the last says eating meat and the iron caused all diseases is punishment from God for eating the meat.
In india we have little or no meat intake so what iron stores there are are from plant sources. They have the world's highest levels of diabetes and heart disease while at the same time children and women suffer from low iron and resulting cognition problems. Two of the leggs are broken and God cares little about such fool notions.
On Jul 20, 8:46 am, ferr...@ironcity.com wrote: snip<<
You may think in your brain .. you have something to contribute .. but evidentally .. you .. don't ..
Find something to .. do ..
Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats. de Lima MN, Presti-Torres J, Garcia VA, Guimarães MR, Scalco FS, Roesler R, Schröder N Neuropharmacology 2008 Jun 21.
Increasing evidence indicates that iron deposition in the brain might play a role in cognitive dysfunction associated with neurodegenerative disorders and aging. Previous studies have not examined whether iron- induced memory deficits can be attenuated by acute treatments with memory-enhancing agents. Phosphodiesterase type 4 (PDE4) inhibitors such as rolipram (ROL) ameliorate memory impairments in several rodent models of amnesia and have been proposed as candidate cognitive- enhancing drugs. Here we show that a single posttraining systemic injection of ROL dose-dependently attenuates the impairment of memory for novel object recognition (NOR) in rats given neonatal iron loading, a model of iron-induced cognitive impairment. Posttraining administration of ROL also recovered NOR deficits associated with aging in rats. These findings provide the first evidence that stimulation of an intracellular second messenger signaling pathway can attenuate iron-induced memory impairment, and support the view that PDE4 inhibitors might ameliorate cognitive dysfunction associated with aging and neurodegenerative disorders.
