Brain Iron and Neurodegeneration
ironjustice
Hyperphosphorylation of tau protein in superficial CNS siderosis.
Kondziella D, Zetterberg H
J Neurol Sci 2008 Jul 8.
In superficial CNS siderosis chronic subarachnoidal hemorrhage leads
to hemosiderin deposits in the subpial layers of the brain and spinal
cord.
Many years usually pass between the initial event causing chronic
bleedings and the development of cerebellar ataxia, sensory hearing
loss and various sensorimotor deficits.
The only therapeutic option is to identify and eliminate the bleeding
source.
Otherwise slow relentless decline to a bedridden state and dementia is
usually unavoidable.
However, it is not known how precisely leptomeningeal hemosiderin
deposits induce progressive neurodegeneration.
Here we present the first report of a patient with superficial CNS
siderosis in whom cerebrospinal fluid biomarkers of brain damage were
assessed.
Levels of neurofilament light protein, glial fibrillary acidic
protein, total tau protein and, most importantly, hyperphosphorylated
tau protein were increased.
The results indicate that in superficial CNS siderosis
neurodegeneration may be secondary to iron toxicity and oxidative
stress.
Similar mechanisms have been suggested for other neurodegenerative
disorders such as Alzheimer's disease.
Journal of the neurological sciences [J Neurol Sci]
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