Metal Chelators In Alzheimers

[ironjustice]

http://tinyurl.com/yjm5dck

MULTIFUNCTIONAL PRO-LIGANDS AS POTENTIAL ALZHEIMER’S DISEASE
THERAPEUTICS
by LAUREN SCOTT Hons. B.Sc.,
McMaster University, 2004
A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS
FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE FACULTY OF GRADUATE
STUDIES (Chemistry)
THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver)
July 2009 © Lauren Scott, 2009
--------------------------------------------------------------------------------

ABSTRACT
Alzheimer’s disease is the most common form of dementia, affecting
more than 24
million individuals worldwide.
Although the exact causes of disease development and progression are
unknown,
the amyloid hypothesis links the observed pathologies of elevated
metal ion
levels (Cu2+, Fe3+, Zn2+), deposition of amyloid peptide in senile
plaques,
oxidative stress and neurodegeneration in a cohesive manner.
As part of a possible intervention for this process, a series of
multifunctional
pyridinone pro-ligands were designed and synthesised.

---------------
http://www.pnas.org/content/88/15/6863.full.pdf

Proc. Nati. Acad. Sci. USA
Vol. 88, pp. 6863-6867, August 1991
Medical Sciences
Pyridinone derivatives: Specific human immunodeficiency virus
type 1 reverse transcriptase inhibitors with antiviral activity
(acquired immunodeficiency syndrome/antiviral agents/inhibition
kinetics/synergy)
MARK E. GOLDMAN*t, JACK H. NUNBERG*, JULIE A. O'BRIEN*, JULIO C.
QUINTERO*,
WILLIAM A. SCHLEIF*, KURT F. FREUND§, S. LEE GAUL§, WALFRED S. SAARI¶,
JOHN S. WAI¶,
JACOB M. HOFFMAN¶, PAUL S. ANDERSON¶, DONALD J. HUPE II, EMILIO A.
EMINII,
AND ANDREW M. STERN§
Departments of *New Lead Pharmacology, tVirus and Cell Biology,
§Biological Chemistry, and IMedicinal Chemistry, Merck S

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

[fer...@paris.com]

"Although the exact causes of disease development and progression are
unknown, the amyloid hypothesis links the observed pathologies of
elevated metal ion levels (Cu2+, Fe3+, Zn2+), deposition of amyloid
peptide in senile plaques,"

So, it is the other two metals we should be concerned about?

I heard a recent radio show where another model of the disorder suggests
that some degree of the plaques is a desired protection against
develpment of the disorder.

[ironjustice]

On Nov 25, 7:07 am, ferr...@paris.com wrote:
I heard a recent radio show where another model of the disorder
suggests
that some degree of the plaques is a desired protection against
develpment of the disorder. <<

That's very good ..

This article is about the use of metal chelating drugs to
treat disease states ..

METAL CHELATING DRUGS ..

The theme is metal chelators in diseases ..

When you see an article which supports a thesis you may have
.. you post it .. y'hear ..

http://tinyurl.com/yjm5dck

MULTIFUNCTIONAL PRO-LIGANDS AS POTENTIAL ALZHEIMER’S DISEASE
THERAPEUTICS
by LAUREN SCOTT Hons. B.Sc.,
McMaster University, 2004
A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS
FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE FACULTY OF GRADUATE
STUDIES (Chemistry)
THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver)
July 2009 © Lauren Scott, 2009

---------------------------------------------------------------------------­-----

ABSTRACT
Alzheimer’s disease is the most common form of dementia,
affecting more than 24 million individuals worldwide.

Although the exact causes of disease development and
progression are unknown, the amyloid hypothesis links
the observed pathologies of elevated metal ion levels
(Cu2+, Fe3+, Zn2+), deposition of amyloid peptide in

senile plaques, oxidative stress and neurodegeneration

[fer...@paris.com]

"Although the exact causes of disease development and progression are
unknown, the amyloid hypothesis links the observed pathologies of
elevated metal ion levels (Cu2+, Fe3+, Zn2+), deposition of amyloid
peptide in senile plaques,"

So, it is the other two metals we should be concerned about?

I heard a recent radio show where another model of the disorder suggests

that some degree of the plaques is a desired protection against
develpment of the disorder.

The response:

"That's very good ..

This article is about the use of metal chelating drugs to
treat disease states .."

Yup, and which of the 3 metals is it, if any at all?

The article was about the plaques containing them, so the radio report
was right on topic. I just ran across it again today. Sure nuff, it
says we need some level of it for normal functioning in the brain, with
the 3 metals and all it seems.

You need to learn how to think outside the box more and less connecting
dots that might not even be present.

[ironjustice]

On Nov 25, 5:17 pm, ferr...@paris.com wrote:
You need to learn how to think outside the box more and less
connecting
dots that might not even be present. <<

In other words you say .. "accept the fact your thesis may be
wrong" ..

Now why would I do that .. ?

Especially when OTHER people .. GO OUT OF THEIR WAY .. and produce a
thesis which .. coincidentally .. is EXACTLY what my thesis is .. ?

The article .. is about metal chelating drugs in disease states ..

When you see an article which supports a thesis YOU may have

.. you post it .. y'hear ..

http://tinyurl.com/yjm5dck

MULTIFUNCTIONAL PRO-LIGANDS AS POTENTIAL ALZHEIMER’S DISEASE
THERAPEUTICS
by LAUREN SCOTT Hons. B.Sc.,
McMaster University, 2004
A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS
FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in THE FACULTY OF GRADUATE
STUDIES (Chemistry)
THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver)
July 2009 © Lauren Scott, 2009
---------------------------------------------------------------------------­­-----

ABSTRACT
Alzheimer’s disease is the most common form of dementia,
affecting more than 24 million individuals worldwide.

Although the exact causes of disease development and
progression are unknown, the amyloid hypothesis links
the observed pathologies of elevated metal ion levels
(Cu2+, Fe3+, Zn2+), deposition of amyloid peptide in

[fer...@paris.com]

You need to learn how to think outside the box more and less
connecting
dots that might not even be present. <<

"In other words you say .. "accept the fact your thesis may be wrong" ..

Now why would I do that .. ?"

Several reasons. First the thesis of the article is not yours.

second as meant to support the eating meat and its iron is the cause of
* ALL * disease it fails. They clearly said the cause of the disorder
is unknown and clearly they see the 3 metals in question at those levels
as an effect not a cause.

Third the plaques in question are in the part you snipped thought by
some part of a normal brain function.

Forth, because the evidence in the real world has already dismembered
the meat and iron idea in part and in whole. That evidence provided on
request, much of it provided in your own misunderstood posts.

[ironjustice]

On Nov 27, 6:17 am, ferr...@paris.com wrote:
"In other words you say .. "accept the fact your thesis may be
wrong" ..
Now why would I do that .. ?"
Several reasons.  First the thesis of the article is not yours. <<

Iron reduction therapy for all disease .. and the thesis .. "isn't
mine" ..

You are really a whiney little btch .. aren't ya ..

I suppose the thesis is .. HERS .. eh ..

She was still in daycare .. boy ..

On Nov 27, 6:17 am, ferr...@paris.com wrote: second as meant to

support the eating meat and its iron is the cause of * ALL * disease
it fails.  <<

Take you whiney little btch self off the thread ..

NOBODY needs to here from a whiney little btch like yourself ..

NOW once again .. boy .. when you find an article which supports
ANY thesis you may have .. even if it is how a small dck is
usefull ..

YOU post it y'hear ..