Chelator Nanoparticles In Neurodegeneration
ironjustice
therapeutic agents for Alzheimer's disease.
Liu G, Men P, Perry G, Smith MA
J Nanoneurosci 2009 Jun 1; 1(1):42-55.
Alzheimer's disease (AD) is a devastating neuro-degenerative
disorder characterized by the progressive and irreversible loss
of memory followed by complete dementia.
Despite the disease's high prevalence and great economic and
social burden, an explicative etiology or viable cure is not
available.
Great effort has been made to better understand the disease's
pathogenesis, and to develop more effective therapeutic agents.
However, success is greatly hampered by the presence of the
blood-brain barrier that limits a large number of potential
therapeutics from entering the brain.
Nanoparticle-mediated drug delivery is one of the few valuable
tools for overcoming this impediment and its application as a
potential AD treatment shows promise.
In this review, the current studies on nanoparticle delivery of
chelation agents as possible therapeutics for AD are discussed
because several metals are found excessive in the AD brain and
may play a role in the disease development.
Specifically, a novel approach involving transport of iron chelation
agents into and out of the brain by nanoparticles is highlighted.
This approach may provide a safer and more effective means of
simultaneously reducing several toxic metals in the AD brain.
It may also provide insights into the mechanisms of AD
pathophysiology, and prove useful in treating other iron-associated
neurodegenerative diseases such as Friedreich's ataxia, Parkinson's
disease, Huntington's disease and Hallervorden-Spatz Syndrome.
It is important to note that the use of nanoparticle-mediated
transport
to facilitate toxicant excretion from diseased sites in the body may
advance nanoparticle technology, which is currently focused on
targeted drug delivery for disease prevention and treatment.
The application of nanoparticle-mediated drug transport in the
treatment of AD is at its very early stages of development and,
therefore, more studies are warranted.
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