Walter Plowright dies at 86; invented vaccine that eliminated serious cattle disease
Matthew Kruk
latimes.com
OBITUARY
Walter Plowright dies at 86; invented vaccine that eliminated serious
cattle disease
Plowright, a British veterinarian, is often called a hero of the 20th
century for his role in eliminating rinderpest, a virus that caused
catastrophic disaster in Africa.
By Thomas H. Maugh II
March 21, 2010
Dr. Walter Plowright, the British veterinarian often called one of the
"heroes of the 20th century" because of the massive increase in meat and
dairy products resulting from his invention of a vaccine that has almost
totally eliminated the cattle disease rinderpest, died Feb. 19 in
London. He was 86.
Most Americans have probably never heard of rinderpest, a virus in the
same family as measles that causes one of the most lethal diseases in
cattle. It never established a foothold in the Americas and was
eliminated from Europe early in the 20th century, but its introduction
to Africa in 1889 in cattle shipped from India caused what some consider
the most catastrophic natural disaster ever to affect that continent.
The virus, which strikes primarily cloven-footed animals, killed nearly
90% of cattle in sub-Saharan Africa, along with sheep, goats, buffaloes,
giraffes and wildebeests. The loss of plow animals, herds and hunting
resulted in mass starvation that killed a third of humans in Ethiopia
and two-thirds of the Masai people in Tanzania. Subsequent outbreaks
further contributed to poverty and starvation in the region.
Plowright was a young veterinary pathologist assigned to the United
Kingdom's East African Veterinary Research Organization laboratory at
Muguga, Kenya, when he and colleague R. D. Ferris began studying the
rinderpest virus in 1956. Several groups had tried without success to
develop a weakened version of the virus that could serve as a vaccine in
the way that Edward Jenner had used a weak cowpox virus to produce a
smallpox vaccine.
Plowright decided to use the relatively new technique of growing the
virus in cells in glass tubes. After passaging the virus through nearly
100 generations of cell cultures over eight years, he and Ferris
obtained a weakened version that could provoke immunity to rinderpest
but did not produce disease. The weakened virus was inexpensive to
produce and could be grown in large quantities.
The vaccine, called tissue culture rinderpest vaccine, was quickly
adopted, but cattle growers did not initially use it for long enough and
outbreaks occurred again. One such outbreak in Nigeria resulted in more
than $2 billion in losses.
In 1994, the United Nations' Food and Agriculture Organization organized
a global eradication program that trained vets and farmers to recognize
and control rinderpest and promoted widespread vaccinations. The last
major outbreak of the disease occurred in Kenya in 2001, and the FAO is
expected to declare the virus eradicated in the wild this year.
Rinderpest and smallpox will then be the only disease viruses that have
been eradicated worldwide.
The FAO has said that the cost of the rinderpest eradication campaign
was about $3 million. That investment, the agency says, has led to an
increase of $47 billion in food production in Africa and a $289-billion
increase in India.
Plowright's technique has subsequently been adopted for other viral
diseases, including African swine fever, malignant catarrhal fever and
poxviruses. In 1999, he was awarded the prestigious World Food Prize.
Walter Plowright was born July 20, 1923, in Holbeach, Lincolnshire,
England. He graduated from the Royal Veterinary College in London in
1944 and was commissioned into the Royal Army Veterinary Corps and sent
to Kenya, where he developed a lifelong love of Africa.
After the war, he returned to lecture at the veterinary college, but in
1950 joined the Colonial Veterinary Service and returned to Kenya. He
returned to England permanently in 1971 for stints at the veterinary
college and the Institute for Research on Animal Diseases in Compton,
Berkshire. Even after his retirement, he served as a consultant to many
veterinary groups.
Plowright is survived by his wife of 50 years, Dorothy.
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