Iron??? (fwd)

Tom Hennessy

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May 6, 1996, 3:00:00 AM5/6/96

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Iron removal seems to work in 'active' malaria .. too.

Who loves ya.
Tom http://www.nucleus.com/watchman
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Principal Investigators
A. Shanzer, Dept. of Organic Chemistry
Z.I. Cabantchik, Dept. of Biological Chemistry, Hebrew University of
Jerusalem

LIPOPHILIC IRON CHELATORS, TREATMENT OF MALARIA, HEMOCHROMATOSIS AND IRON
LOADING CONDITIONS

Iron sequestering compounds are also known to arrest the
growth of malaria parasites including Plasmodium falciparum and are
used as antimalarial drugs.

Tom Hennessy

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May 6, 1996, 3:00:00 AM5/6/96

to

The noose is tightening. We need .. some bloodletters.. guys.. ;)

Who loves ya.
Tom http://www.nucleus.com/watchman

==================================================

PARASITOLOGY ... Study Confirms Iron Supplements Increase Malaria
Parasite Development
________________________________________________________________

Study Confirms Iron Supplements Increase Malaria Parasite Development

Iron overload in mice increases the hepatic development of malaria
parasites.

The finding might explain why malaria was made worse in endemic
regions where iron supplementation was implemented, suggested J. Goma,
INSERM, Paris, France, and colleagues ("Iron Overload Increases
Hepatic Development of Plasmodium yoelii in Mice," Parasitology,
1996;112:165-168).

Tom Hennessy

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May 6, 1996, 3:00:00 AM5/6/96

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This tells us that in malaria cases .. which HAS.. been linked to iron
overload.. there is a substantial amount of TNF .. tumor necrosis factor.
Tumor Necrosis Factor HAS.. been linked.. to Cathexia/wasting in AIDS/HIV?
I have been trying to establish whether there is 'substantial' TNF.. in
iron overload. I 'assume'.. there is because cancer is one of the most
prevalent of the outcomes of it. Does anyone know how to check for sure?
I will keep looking to see if I can find an article which specifically
staes there is.

Who loves ya.
Tom http://www.nucleus.com/watchman

======================================
Immunology

Sheikh, N.A.; Caro, H.N.; Taverne, J.; Playfair, J.H.L.; Rademacher,
T.W. "Malaria: A Tumour Necrosis Factor Inhibitor from Parasitized
Erythrocytes." Immunology, March 1996;87(3):461-466.

According to the authors' abstract of an article published in
Immunology, "The excessive production of tumour necrosis factor (TNF)
is associated with the pathology of blood-stage malaria and
phosphatidylinositol-containing phospholipid antigens from parasitized
erythrocytes stimulate its secretion by macrophages, thus acting as
toxins. This brief report describes some properties of an inhibitor
present in lysates from erythrocytes infected with malarial parasites
that blocked the detection of recombinant TNF in an enzyme-linked
immunosorbent assay and diminished or abolished the cytotoxici ...
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_________________________________________________________________

Pediatrics

English, M.C.; Waruiru, C.; Lightowler, C.; Murphy, S.A.; Kirigha, G.;
Marsh, K. "Hyponatraemia and Dehydration in Severe Malaria." Archives
of Disease in Childhood, March 1996;74(3):201-205.

According to the authors' abstract of an article published in Archives
of Disease in Childhood, "The prevalence and hyponatraemia in malaria
were investigated. One hundred and thirty two children, 47 of whom had
cerebral malaria, were prospectively recruited and serial simple
indices of fluid and electrolyte balance and renal function monitored
during admission. In 55%, hyponatraemia (sodium (less than)135 mmol/l)
was present on admission. Hyponatraemia was pronounced (sodium less
than or equal to 130 mmol/l) in 21%, and these children gained less
weight during admission (mean weight gain ... (viewing 600 of 1698
total characters)

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Pediatrics

Sowunmi, A.; Oduola, A.M.J.; Ilesanmi, A.O.; Salako, L.A. "Open
Comparison of Artemether and Mefloquine in Uncomplicated Plasmodium
falciparum Hyperparasitaemia in Children." Annals of Tropical
Paediatrics, March 1996;16(1):5-9.

According to the authors' abstract of an article published in Annals
of Tropical Paediatrics, "The efficacy of intramuscular artemether
given for 5 days and a single oral dose of mefloquine, 25
mg/kg/body-weight, was evaluated in 84 children with uncomplicated
Plasmodium falciparum hyperparasitaemia ((greater than)5% parasitized
erythrocytes). Follow-up was for 14 days in the artemether group and
28 days in the mefloquine group. Artemether produced a significantly
higher parasite reduction at 24 hours [mean 90.6 vs 63.3%, 95%
confidence interval 10.7-43.9] and significantly shorter par ...
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