Latex And Cucumber Allergy
ironjustice
Vlaicu PC, Rusu LC, Ledesma A, Vicente M, Cuevas M, Zamorano M,
Antolín D, Alvarez E, De La Hoz B;
Journal of Investigational Allergology and Clinical Immunology (JIACI)
21 (3), 236-9 (2011)
We report the case of a 76-year-old woman who experienced dizziness,
vomiting, dyspnea, thoracic erythema, and vaginal itching within 5
minutes of eating cucumber.
She had been diagnosed 3 months earlier with papaya urticaria and
latex sensitization.
The results of skin prick tests were positive for cucumber,
watermelon, papaya, and latex and negative for melon and profilin
extracts.
ImmunoCAP for latex-specific serum immunoglobulin (Ig) E was
positive.
Cucumber-specific serum IgE was negative.
Immunoblot analysis using patient serum revealed a 30- to 32-kDa
protein band in the cucumber (peel) and papaya extracts.
Immunoblot inhibition with latex extract demonstrated inhibition of
the band in both extracts.
Immunoblot inhibition with cucumber-papaya and papaya-cucumber
revealed inhibition of the same band in the cucumber and papaya
extracts, respectively.
We present a case of IgE-mediated allergy to cucumber and papaya.
Our results strongly suggest that the allergen(s) implicated are
associated with latex sensitization. To our knowledge, this is the
first report of cucumber-latex and cucumber-papaya cross-reactivity.
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http://www.mechdir.com/press/catalog/1079/index.html
"18 percent of health care workers have some level of latex allergy"
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Iron uptake AND release by macrophages is sensitive to propranolol.
Mol Cell Biochem. 2006 Aug;288(1-2):213-7. Epub 2006 May 23.
Komarov AM, Hall JM, Chmielinska JJ, Weglicki WB.
Division of Experimental Medicine, Departments of Biochemistry &
Molecular Biology, The George Washington University Medical Center,
2300 Eye St., NW, Ross Hall, Rm. 441A, Washington, DC 20037, USA.
phy...@gwumc.edu
In this study we have tested the effects of d-propranolol (D-Pro) on
the iron uptake, iron release AND oxidative response of iron-loaded
cells in a cellular model of iron-overload using isolated rat
peritoneal macrophages incubated with iron-dextran (Fe-D).
Pretreatment of macrophages with D-Pro (5-200 microM) prior to Fe-D
exposure decreased the cellular iron content AND partially prevented
iron release from latex-activated macrophages.
Release of reactive oxygen species from activated cells was detected
by dichlorodihydrofluorescein (DCDHF, 5 microM) oxidation.
We found that loading cells with Fe-D increased their response to
latex, which was prevented by the lysosomotropic antioxidant agent D-
Pro(10 microM).
PMID: 16718379
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Excess dietary iron is the root cause for increase in childhood autism
and allergies.
Med Hypotheses. 2003 Aug;61(2):220-2.
Padhye U.
2990 River Meadows, Canton, Michigan 48188, USA.
Autism is a profoundly and poorly understood developmental disorder
that impairs a person's social and communication abilities.
I propose a hypothesis that the excessive dietary iron consumed by
today's infants is the root cause of increased cases of Autism,
allergies and other childhood diseases.
Iron is a powerful immune system modulator.
Excess iron causes hyperactive immune system.
This hyperactive immune system attacks undigested food peptides.
The chemicals released during these intense allergic reactions can
damage surrounding tissue.
Neurodegeneration is caused by combination of, oxidative stress
induced
by free iron radicals and intense immune reactions. Iron chelators
have
shown beneficial results in Autism and allergies.
Publication Types:
Review
Review, Tutorial
PMID: 12888307
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