Vitamin D Supplementation and Total Mortality
A Meta-analysis of Randomized Controlled Trials
Philippe Autier, MD; Sara Gandini, PhD
Arch Intern Med. 2007;167:1730-1737.
Background Ecological and observational studies suggest that low
vitamin D status could be associated with higher mortality from life-
threatening conditions including cancer, cardiovascular disease, and
diabetes mellitus that account for 60% to 70% of total mortality in
high-income countries. We examined the risk of dying from any cause in
subjects who participated in randomized trials testing the impact of
vitamin D supplementation (ergocalciferol [vitamin D2] or
cholecalciferol [vitamin D3]) on any health condition.
Methods The literature up to November 2006 was searched without
language restriction using the following databases: PubMed, ISI Web of
Science (Science Citation Index Expanded), EMBASE, and the Cochrane
Library.
Results We identified 18 independent randomized controlled trials,
including 57 311 participants. A total of 4777 deaths from any cause
occurred during a trial size-adjusted mean of 5.7 years. Daily doses
of vitamin D supplements varied from 300 to 2000 IU. The trial size-
adjusted mean daily vitamin D dose was 528 IU. In 9 trials, there was
a 1.4- to 5.2-fold difference in serum 25-hydroxyvitamin D between the
intervention and control groups. The summary relative risk for
mortality from any cause was 0.93 (95% confidence interval,
0.87-0.99). There was neither indication for heterogeneity nor
indication for publication biases. The summary relative risk did not
change according to the addition of calcium supplements in the
intervention. ....."
Apparently so less than 600 IU of vitamin d :much less than most
experts in this field view as optimal reduced mortality by 7 %
Thanks Vince
Nobody, but naked aborigines can depend on sunshine for their vitamin
D supply.
Another good reason to eat fatty cold-water fish and code liver oil.
On Oct 1, 7:36 am, "Mr. Natural-Health"
You can supplement cod liver oil, you know. :)
Try out your mortality rate without any vitamin D in your diet.
It appears that you have not been reading this group recently. There are
risks in cod liver oil use as it has a high content of retinol (vitamin A).
That has a detrimental effect on bone.
--
Juhana