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From: crisology <crisol...@aol.com>
Newsgroups: alt.food.vegan.science
Subject: Colon cancer from meat consumption
Date: Sat, 18 Aug 2012 09:37:16 -0700 (PDT)
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     In America, the second leading cause of death is colon cancer. Unproce=
ssed meat intake is carcinogenic through numerous mechanisms of action, suc=
h as compromised gut microbiota, obesity, excess protein, excess fat, haem =
iron intake. Most cancers can be prevented through environmental factors, p=
articularly abstaining from a diet that includes meat.
=20
     High protein/meat diets contribute to obesity. "[l]eucine-mediated mTO=
RC1-S6K1-signaling plays an important role in adipogenesis, thus increasing=
 the risk of obesity-mediated insulin resistance. (Muntoni, 2012)

     Although there are more effective diet modifications to lose weight, r=
estricting grain intake is one method that can result in some weight loss b=
ut intralumenal carcinogens are promoted when meat is not excluded from the=
 diet. When subjects consumed less than 30 g. carbohydrates/day for nine we=
eks, their feces contained 1/4 of the =91friendly=92 bacteria or probiotics=
 such as Bifidobacteria, Lactobacillus, etc., compared to the 'high carbohy=
drate dieters'. The reduced ratio of prebiotic consumption compromises gut =
health and increases susceptibility to colon cancer. (Duncan, 2007).

     Additionally, there are other cancer protective mechanisms that can be=
 obtained from plant (as opposed to meat) consumption. "Ingestion of fiber =
could modify carcinogenesis in the large bowel by a number of potential mec=
hanisms. These mechanisms include binding to bile acids, increasing fecal w=
ater and possibly diluting carcinogens" according to The National Cancer In=
stitute (2012, para 24).

     The concentrated protein ratios within meat are beyond the amounts req=
uired for normal human growth and development and may also promote accelera=
te cell proliferation (tumor growth). (Campbell, 2007; Sharma, 2007)

     Excessive fat content in meat has also been implicated in colon cancer=
 pathogenesis through production of serum hormones. LNCaP cell (Aronson, 20=
10)

     The type of iron in meat (haem) is absorbed without regulation and mea=
t consumers are prone to iron overload. =93Haem induces colonic hyperprolif=
eration and hyperplasia by inhibiting the surface to crypt signalling of fe=
edback inhibitors of proliferation=94 (O'Keefe, 2007)

                      References:=20

Aronson, W. J., Barnard, R. J., Freedland, S. J., Henning, S., Elashoff, D.=
, Jardack, P. M., Cohen, P., Heber, D., Kobayashi, N.92010 (2010). Growth i=
nhibitory effect of low fat diet on prostate cancer cells: results of a pro=
spective, randomized dietary intervention trial in men with prostate cancer=
. J Urol. 183(1):345-50. Retrieved online from: http://www.ncbi.nlm.nih.gov=
/pubmed/19914662

Campbell, T. C. (2007). Dietary protein, growth factors, and cancer. Am J C=
lin Nutr vol. 85 no. 6 1667. Retrieved online from: http://www.ajcn.org/con=
tent/85/6/1667.full

Duncan S. H. Belenguer1, A., Holtrop, G., Johnstone, A. M. Flint1, H. J. an=
d Lobley, G. E. (2007). Reduced dietary intake of carbohydrates by obese su=
bjects results in decreased concentrations of butyrate and butyrate-produci=
ng bacteria in feces. Applied and Environmental Microbiology, Vol 73, pg 10=
73-8. Retrieved online from: http://aem.asm.org/content/73/4/1073.full.pdf

Muntoni S, Mereu R, Atzori L, Mereu A, Galassi S, Corda S, Frongia P, Angiu=
s E, Pusceddu P, Contu P, Cucca F, Congia M, Muntoni S. (2012). High meat c=
onsumption is associated with type 1 diabetes mellitus in a Sardinian case-=
control study. Acta. Diabetol. Retrieved online from: http://www.ncbi.nlm.n=
ih.gov/pubmed/22391937=20

National Cancer Institute: PDQ=AE Colorectal Cancer Prevention. Bethesda, M=
D: National Cancer Institute. Retrieved online August 18, 2012 from: http:/=
/cancer.gov/cancertopics/pdq/prevention/colorectal/HealthProfessional.

O'Keefe SJ, Chung D, Mahmoud N, Sepulveda AR, Manafe M, Arch J, Adada H, va=
n der Merwe T. J Nutr. 2007 Jan;137(1 Suppl):175S-182S. Why do African Amer=
icans get more colon cancer than Native Africans? Retrieved online from: ht=
tp://www.ncbi.nlm.nih.gov/pubmed/17182822=20

Sharma, S., O'Keefe, S. J. (2007). Environmental influences on the high mor=
tality from colorectal cancer in African Americans. Postgrad Med J. 83(983)=
:583-9. Retrieved online from: http://www.ncbi.nlm.nih.gov/pubmed/17823224