White and breeding with negroes? Yer sprogs are gonna be stupid and get Alzheimers!

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Another blow for the multiculturalists!

A new gene mutation has been identified that nearly doubles
African Americans' risk for getting Alzheimer's disease,
according to a large, government-funded report out Tuesday.

The mutation in the gene ABCA7 is not the first linked to the
disease but it is a major breakthrough in research, suggesting
there could be multiple causes of Alzheimer's and therefore ways
to treat the most common form of dementia, says the report,
published Tuesday in the Journal of the American Medical
Association.

There is no effective way to prevent, cure or delay Alzheimer's,
a neurodegenerative illness that robs people of memory and other
cognitive and emotional functions. The predominant late-onset
form of Alzheimer's occurs after age 65 and is more common in
blacks than whites. The study involved almost 6,000 black
volunteers who had genetic testing; approximately 2,000 were
diagnosed with probable Alzheimer's and 4,000 were cognitively
normal.

"The first thing this tells us is there are probably many
different ways to get Alzheimer's,'' says the study's senior
author, Richard Mayeux, chair of the department of neurology at
Columbia University Medical Center, New York. "It might be like
some forms of cancer where the type of cancer you have dictates
the type of treatment you receive."

The ABCA7 gene is involved in producing cholesterol and lipids,
suggesting they may be a more important pathway in Alzheimer's
disease in blacks than in whites, the authors say. High
cholesterol and lipid levels can lead to vascular disease, heart
attacks and strokes and are more common in blacks. Treatments
that lower cholesterol and lipids may potentially be an
effective way to reduce or delay Alzheimer's in patients with
the gene variant, Mayeux says.

A variant, or mutation, is an abnormal change in the sequence of
the chemicals inside a gene. Whites with the ABCA7 mutation are
also at increased risk, but not as significantly as blacks, he
adds.

Several gene mutations have been linked with increased
Alzheimer's risk; the most significant in both whites and blacks
has been APOE-e4, says Mayeux. But the study authors say that
both ABCA7 and APOE-e4 are "major genetic risk factors" in
blacks.

"This is a major finding because it shows that blacks have an
additional risk factor compared to whites,'' says Neil
Buckholtz, director of neuroscience at the National Institute on
Aging, a branch of the National Institutes of Health. NIH funded
the study. "It's a highly significant risk that doesn't exist in
other populations. In order to find interventions, we need to
explore all the various risks."

APOE-e4 is associated with an increased number of amyloid
plaques in the brain, which form into toxic clumps that destroy
brain cells. Other processes, such as inflammation and insulin
receptivity, are also being explored as possible contributors.
ABCA7 also transports a precursor of amyloid plaques.

"We're definitely finding that there are layers to the
disease,'' says Heather Snyder, a researcher for the Alzheimer's
Association. She was not involved in this study. "We need to do
more research to find out what these targets are doing in the
brain so we can find treatments and ways of delaying the disease
from starting."

About 5 million adults in the USA have Alzheimer's, and numbers
are expected to more than triple by 2050 and cost $1.1 trillion
a year annually. About a third of the people with late-onset
Alzheimer's are 80 and older. It is the only disease among the
top 10 killers that has no effective treatments.

Snyder says the Alzheimer's Association does not recommend
people get genetic testing because the links aren't clearly
established and some people who have the gene variants do not
get the disease.

http://www.usatoday.com/story/news/nation/2013/04/09/african-
americans-alzheimers-gene/2066645/

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