Effect of Neonatal Circumcision on Pain Response During Subsequent Routine
Vaccination

Findings: Birth characteristics and infant characteristics at the time of
vaccination, including age and temperament scores, did not differ
significantly among groups.infants circumcised with placebo had higher
difference scores than uncircumcised infants for percentage facial action
(136.9 vs 77.5%), percentage cry duration (53.8 vs 24.7%), and visual
analogue scale pain scores (5.1 vs 3.1 cm). There was a significant linear
trend on all outcome measures, showing increasing pain scores from
uncircumcised infants, to those circumcised with Emla, to those circumcised
with placebo.