Androgen deprivation therapy may cause insulin resistance/diabetes

JG

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Feb 9, 2006, 4:05:25 PM2/9/06

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One would hope that selective DHT inhibition (i.e., finasteride and
dutasteride) would not induce the same effects. Has anyone who has
taken Propecia or Avodart for extended periods of time had their blood
glucose levels tested recently?

JG

Prostate cancer hormone therapy hard on the heart

By Megan Rauscher

Thu Feb 9, 11:23 AM ET

NEW YORK (Reuters Health) - Men with recurrent or advanced prostate
cancer may be put on hormone therapy to block testosterone production
in an effort to halt or slow the growth of the tumor. However, new
research shows, this may put them at increased risk for developing
insulin resistance and elevated blood sugar levels, which can affect
heart health.

These complications of what doctors call androgen-deprivation therapy
or ADT may contribute to the high rate of heart disease in men with
prostate cancer, Baltimore-based investigators report in the journal
Cancer.

Roughly half of men who develop prostate cancer die of other, unrelated
causes, explain Dr. Shehzad Basaria from Johns Hopkins University and
colleagues. Heart disease is one of the most common causes of death in
men with prostate cancer.

In a study of 53 men with prostate cancer, the researchers found that
those treated with testosterone-lowering ADT for at least one year were
more resistant to the action of insulin - the body's key
sugar-regulating hormone - and had higher glucose levels than men who
had only received local surgery and/or radiation and had normal
testosterone levels, and age-matched healthy men with normal
testosterone levels.

According to the study, 44 percent of men in the ADT group had blood
sugar levels greater than 126, which is among the criteria for the
diagnosis of diabetes. In contrast, only about 12 percent of men in the
other groups had blood sugar levels this high.

In an e-mail to Reuters Health, Basaria said: "If these observations
are confirmed in long-term prospective studies, then insulin resistance
and diabetes should be regarded as additional side effects of androgen
deprivation in these men."

In the meantime, the investigators think men with prostate cancer who
have received ADT for at least one year should be screened for high
blood sugar.

More study, they add, is needed to determine the value of anti-diabetes
drugs in men with prostate cancer.

SOURCE: Cancer, February 1, 2006.

Russ H.

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Feb 9, 2006, 5:32:54 PM2/9/06

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This is kinda serious stuff here. You would think they would have named the
drugs in the study group.What's the point in releasing the study results
without naming the drugs?

People that are doing ADT for hairloss alone deserve to know the specifics.

Ernie Primeau

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Feb 9, 2006, 8:30:21 PM2/9/06

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Suddenly the great pusher of finas and dut, razy farrel claims to be
concerned about it's effects. What an asshole. Ernie

Marcus

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Feb 9, 2006, 8:55:56 PM2/9/06

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This is nothing we don`t already know Ernie. It is something we could do
without reading on a daily basis.

"Ernie Primeau" <erni...@webtv.net> wrote in message
news:29372-43E...@storefull-3352.bay.webtv.net...
> Suddenly, I want to have sex with farrel in his asshole. Ernie
>

Pouta

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Feb 9, 2006, 10:20:41 PM2/9/06

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there might be legal considerations with regard to naming the drugs...

regardless, since there are only 2 FDA approved ADT drugs on the
market, it's hardly necessary to call them out by name

John G.

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Feb 10, 2006, 10:10:36 AM2/10/06

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this is not good...

there had been reports that fin / dut were causing irreversible,
detrimental hormonal changes in men,
and this adds to the data

Ernie Primeau

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Feb 10, 2006, 1:22:31 PM2/10/06

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crazier and crazier. Ernie

Russ H.

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Feb 10, 2006, 4:35:36 PM2/10/06

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There was an Olympian barred today because he tested postive for a possible
steroid masking agent. Turns out to be a hairloss pill.

Russ H.

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Feb 10, 2006, 4:40:13 PM2/10/06

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I've never pushed anything asshole and yes I am concerned that people may
have serious side effects from taking ADT pills. I wish they would do a
study on the effects of your method and the brain wasting it causes.Hey
wait that would mean there's only one moron in that study.

Kofi

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Feb 10, 2006, 9:16:22 PM2/10/06

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In article <1139519125.5...@z14g2000cwz.googlegroups.com>,
"JG" <Heck...@yahoo.com> wrote:

> One would hope that selective DHT inhibition (i.e., finasteride and
> dutasteride) would not induce the same effects. Has anyone who has
> taken Propecia or Avodart for extended periods of time had their blood
> glucose levels tested recently?
>

It's likely to apply to finesteride/dutasteride use but to a lesser
degree. I'd assume as much until a study said otherwise. Men with
metabolic syndrome often have lower testosterone levels and all
antiandrogens lower testosterone signaling to some extent. Of course,
too much testosterone can also cause problems for insulin use.

Baldness is a bit of a paradox when you consider how much testosterone
augments the actions of IGF-I/gh in other tissues.

Ernie Primeau

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Feb 11, 2006, 12:04:14 AM2/11/06

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crazy farrel admits he is posting as russ. What a surprise. Ernie

Ernie Primeau

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Feb 11, 2006, 12:06:28 AM2/11/06

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No paradox Kofi, we who have a deficiency of 5 -ar lose our scalp hair
when we grow body/face hair. Ernie

Ernie Primeau

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Feb 11, 2006, 12:02:57 AM2/11/06

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crazier and crazier. Ernie

Ernie Primeau

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Feb 11, 2006, 12:02:00 AM2/11/06

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Not surprising, they promise false results. Ernie

Marcus

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Feb 11, 2006, 12:23:06 AM2/11/06

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--
For a good, "Gay old time" call Ernie Primeau (727) 577-3907

"Ernie Primeau" <erni...@webtv.net> wrote in message

news:6668-43E...@storefull-3351.bay.webtv.net...
> I am still bald, which is not surprising, as my method promised false
> results. Ernie
>

Marcus

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Feb 11, 2006, 12:24:45 AM2/11/06

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"Ernie Primeau" <erni...@webtv.net> wrote in message
news:6668-43E...@storefull-3351.bay.webtv.net...

> I am crazy and admit I am grasping at straws when I falesly claim farrel
> is posting as russ. Me calling yet another person farrel, > what a
> surprise. Ernie
>

Marcus

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Feb 11, 2006, 12:26:18 AM2/11/06

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"Ernie Primeau" <erni...@webtv.net> wrote in message

news:6671-43E...@storefull-3351.bay.webtv.net...
> The paradox Kofi, is how can I, who has a deficiency of oxygen to the
> brain, continue to function, even in the limited capaicty such as I do.
> Ernie
>

Russ H.

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Feb 11, 2006, 6:24:00 AM2/11/06

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Ernie you're not in the same league as Kofi when having a scientific
discussion.Of course you're not even in the same league as as anyone with a
functional brain.

Ernie Primeau

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Feb 11, 2006, 11:36:54 AM2/11/06

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crazier and crazier. Ernie

Ernie Primeau

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Feb 11, 2006, 11:37:56 AM2/11/06

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crazy farrel is famous for accusing others of being what he is. Ernie

Nomen Nescio

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Feb 11, 2006, 6:19:10 PM2/11/06

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Farrel didn't post that. JG did.

Nomen Nescio

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Feb 11, 2006, 6:20:53 PM2/11/06

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I didn't see that post, could you link to it?

Ernie Primeau

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Feb 12, 2006, 12:28:56 AM2/12/06

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crazy farrel is addicted to lying. Ernie

Ernie Primeau

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Feb 12, 2006, 12:29:39 AM2/12/06

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No need to, we all saw it. Ernie

Marcus

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Feb 12, 2006, 5:33:17 AM2/12/06

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Ernie, when asked.. a need is clearly needed. Stop being such an
idiot,

Just confess, "I, Ernie Primeau, do not have the mental ability to post a
link".

"Ernie Primeau" <erni...@webtv.net> wrote in message

news:17043-43E...@storefull-3358.bay.webtv.net...

Ernie Primeau

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Feb 12, 2006, 11:44:38 AM2/12/06

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crazier and crazier. Ernie