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Use of polyamine analogs for hair growth

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Kofi

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Dec 20, 2009, 1:08:25 AM12/20/09
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Amino Acids. 2009 Dec 3
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Cutaneous application of alpha-methylspermidine activates the growth of
resting hair follicles in mice.
Fashe TM, Keinanen TA, Grigorenko NA, Khomutov AR, Janne J, Alhonen L,
Pietila M.
A.I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio,
University of Kuopio, P.O. Box 1627, 70211, Kuopio, Finland.

Recent studies using transgenic animals have revealed a crucial role for
polyamines in the development and the growth of skin and hair follicles.
In mammals, the growth of hair is characterized by three main cyclic
phases of transformation, including a rapid growth phase (anagen), an
apoptosis-driven regression phase (catagen) and a relatively quiescent
resting phase (telogen). The polyamine pool during the anagen phase is
higher than in telogen and catagen phases. In this study, we used
alpha-methylspermidine, a metabolically stable polyamine analog, to
artificially elevate the polyamine pool during telogen. This
manipulation was sufficient to induce hair growth in telogen phase mice
after 2 weeks of daily topical application. The application site was
characterized by typical features of anagen, such as pigmentation,
growing hair follicles, proliferation of follicular keratinocytes and
upregulation of beta-catenin. The analog penetrated the protective
epidermal layer of the skin and could be detected in dermis. The natural
polyamines were partially replaced by the analog in the application
site. However, the combined pool of natural spermidine and
alpha-methylspermidine exceeded the physiological spermidine pool in
telogen phase skin. These results highlight the role of polyamines in
hair cycle regulation and show that it is possible to control the
process of hair growth using physiologically stable polyamine analogs.

PMID: 19956989

Nomen Nescio

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Dec 20, 2009, 5:32:55 PM12/20/09
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That's exactly what I've always suspected. Very interesting.

Ernie

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Dec 20, 2009, 9:20:09 PM12/20/09
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> That's exactly what I've always suspected. Very interesting.- Hide quoted text -
>
> - Show quoted text -

Is that why commander cocksucker asshole farrel sells and promotes
useless snake oil at her www.hairlosshelp.com snake oil site. Ernie

Maier Yancov

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Dec 30, 2009, 5:27:51 PM12/30/09
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ugh, another topical -- and it would have to be applied daily...
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