Perhaps excessive MSP is lethal in some folks.
Many super wealthy tend to die off before we do, so perhaps taking
large dosages of MSP isn't all that you crack it up to be.
Abstract:
Three different doses of a combination of mefloquine-sulfadoxine-
pyrimethamine (MSP), given double-blind as a single dose to 60
children, were evaluated for efficacy and tolerance. The children, 42
boys and 18 girls aged between 5 and 15 years, received a mefloquine
dose equivalent to 1, 1.5, or 2 standard MSP (Fansimef) tablets.
Radical cure was obtained in all patients with only mild to moderate
side effects of nausea and vomiting, which were not worse in the
higher dose groups. For children living in an endemic malarious area,
a single dose of mefloquine 7.1-12.5 mg/kg, given in combination with
sulfadoxine (14.3-25.0 mg/kg) and pyrimethamine (0.7-1.3 mg/kg), is a
safe and effective treatment for uncomplicated chloroquine-resistant
Plasmodium falciparum malaria. This dose of MSP is approximately 10 mg/
kg, 20 mg/kg and 1.0 mg/kg respectively of mefloquine, sulfadoxine and
pyrimethamine, which is equivalent to a single standard tablet of
Fansimef (mefloquine, 250 mg; sulfadoxine, 500 mg; pyrimethamine, 25
mg) given to a child weighing 20-30 kg.
http://www.igenericdrugs.com/?s=MSP
MSP - MSP is a narcotic pain management agent indicated for the
relief of pain in patients who require opioid analgesics for more than
a few days. MSP interacts predominantly with the opioid mu-receptor.
These mu-binding sites are discretely distributed in the human brain,
with high densities in the posterior amygdala, hypothalamus, thalamus,
nucleus caudatus, putamen, and certain cortical areas. They are also
found on the terminal axons of primary afferents within laminae I and
II (substantia gelatinosa) of the spinal cord and in the spinal
nucleus of the trigeminal nerve. In clinical settings, MSP exerts its
principal pharmacological effect on the central nervous system and
gastrointestinal tract. Its primary actions of therapeutic value are
analgesia and sedation. MSP appears to increase the patient's
tolerance for pain and to decrease discomfort, although the presence
of the pain itself may still be recognized. In addition to analgesia,
alterations in mood, euphoria and dysphoria, and drowsiness commonly
occur. Opioids also produce respiratory depression by direct action on
brain stem respiratory centers. Oral Pain relief Adult: Initially,
5-20 mg every 4 hr (or equivalent for modified release formulations).
Start with low dose and adjust according to response.
More:
http://www.igenericdrugs.com/?s=MSP
Sounds like 120 mg/day per 100 kg adult is a maximum dosage, but
without frequent blood testing how do you know how much or little to
be taking?
Is this the same MSP as you're taking?
How many hundred mg/day are you consuming?