Progress Seen in Creating Eye Cells From Stem Cells
Lab success may someday help people with macular degeneration,
researchers say
Posted: March 24, 2011
By Alan Mozes
HealthDay Reporter
THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
of stem cell research into the world of viable treatments, scientists
have successfully fashioned adult stem cells into the kind of eye
cells that fall victim to the onset of age-related macular
degeneration, or AMD.
The work did not involve embryonic stem cells, which have been the
subject of much debate in recent years, but rather so-called "human-
induced pluripotent stem cells." The aim, according to the
researchers, was to develop a therapeutic response to the death,
caused by AMD, of retinal pigment epithelium, a cell layer that is
critical to the health of the retina's vision cells.
But the researchers, from the Georgetown University Medical Center in
Washington, D.C., stress that this was a preliminary move toward that
goal, achieved solely in a laboratory setting. They say that numerous
complex obstacles must be tackled before such newly created cells
could be transplanted into diseased eyes.
"But we have shown that we are able to generate retinal cells from
cells originally taken from a small amount of biopsied skin, that are
then induced to become stem cells," noted Nady Golestaneh, an
assistant professor in the department of biochemistry and molecular
and cellular biology at Georgetown, and a co-author of a report on the
research, published in the March 24 issue of Stem Cells. The study was
funded by the U.S. National Institutes of Health.
"The retinal cells we have generated are really functional,"
Golestaneh explained. "That means they mimic the function of native
retinal cells that play a key role in the eye for light absorption,
nutrition and receptor function."
That's important "because, if these cells die, they can induce disease
in the eye, one of which is age-related macular degeneration," she
said. "Until now, there has not been any medication that can stop this
disease. So basically these people lose their central vision, which we
need to do daily tasks like reading, driving or anything that you need
to do to be independent."
In the United States, AMD is a leading cause of vision loss among
people 60 and older.
Dr. Demetrios Vavvas, an attending physician in the retina service of
the Massachusetts Eye and Ear Infirmary and an assistant professor of
ophthalmology at Harvard Medical School, described the research
results as a "major step forward."
"But this is still very early work," Vavvas noted. "This has been
achieved only in-vitro. It is in-lab work with cell cultures. So it's
still a question how this will work in person because there are still
hurdles that need to be overcome," he added.
"For example, all of this work so far needs viruses to function as
cell carriers, and this creates problems," he explained. "So, people
are now trying to see if they can replicate this kind of lab work
without the use of viruses. That will have to happen before we can go
to human trials. And we're not there yet," Vavvas said.
"With the current know-how and technology, we're probably talking a
minimum of three to five years before we can even go to clinical
trials," he pointed out.
The researchers used a line of adult stem cells that had been a relied-
upon source for lab research. They said that the differentiation
process that prodded the stem cell stock to develop into retinal cells
equivalent to those damaged by AMD took many weeks of high-tech
culturing, but ultimately the stem cell-generated retinal cells
exhibited the same functional capacity and gene expression as
naturally occurring retinal cells, the researchers reported.
However, they cautioned that the cell line they generated also
appeared to display DNA chromosomal damage, aspects of over-expression
that prompted growth inhibition and some structural abnormalities.
Though the generated cells were deemed "viable," the researchers said
that more work would be needed to render them "safe" for treatment
purposes.
"But when we talk about the potential use of stem cells, we shouldn't
only think about transplantation," Golestaneh said. "They could also
be used as an in-vitro model to study the disease itself in the lab --
their function, their impairment, gene mutations. That would help to
generate targeted drugs to cure the disease."
That makes the cells "very valuable not only for transplantation but
also to study the mechanism of the disease and advance drug
development," Golestaneh said.
More information
The U.S. National Eye Institute has more on age-related macular
degeneration.
Isn't it great?? 3 to 5 years before they can even move to clinicals,
viruses in cells causing problems, we already now iPSC are
"unstable"...Common you morons there is clinical trial about to be
started in 3 months with already differentiated RPE
cells...unbelieavable..
On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> Progress Seen in Creating Eye Cells From Stem Cells
> Lab success may someday help people with macular degeneration,
> researchers say
> Posted: March 24, 2011
> By Alan Mozes
> HealthDay Reporter
> THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> of stem cell research into the world of viable treatments, scientists
> have successfully fashioned adult stem cells into the kind of eye
> cells that fall victim to the onset of age-related macular
> degeneration, or AMD.
> The work did not involve embryonic stem cells, which have been the
> subject of much debate in recent years, but rather so-called "human-
> induced pluripotent stem cells." The aim, according to the
> researchers, was to develop a therapeutic response to the death,
> caused by AMD, of retinal pigment epithelium, a cell layer that is
> critical to the health of the retina's vision cells.
> But the researchers, from the Georgetown University Medical Center in
> Washington, D.C., stress that this was a preliminary move toward that
> goal, achieved solely in a laboratory setting. They say that numerous
> complex obstacles must be tackled before such newly created cells
> could be transplanted into diseased eyes.
> "But we have shown that we are able to generate retinal cells from
> cells originally taken from a small amount of biopsied skin, that are
> then induced to become stem cells," noted Nady Golestaneh, an
> assistant professor in the department of biochemistry and molecular
> and cellular biology at Georgetown, and a co-author of a report on the
> research, published in the March 24 issue of Stem Cells. The study was
> funded by the U.S. National Institutes of Health.
> "The retinal cells we have generated are really functional,"
> Golestaneh explained. "That means they mimic the function of native
> retinal cells that play a key role in the eye for light absorption,
> nutrition and receptor function."
> That's important "because, if these cells die, they can induce disease
> in the eye, one of which is age-related macular degeneration," she
> said. "Until now, there has not been any medication that can stop this
> disease. So basically these people lose their central vision, which we
> need to do daily tasks like reading, driving or anything that you need
> to do to be independent."
> In the United States, AMD is a leading cause of vision loss among
> people 60 and older.
> Dr. Demetrios Vavvas, an attending physician in the retina service of
> the Massachusetts Eye and Ear Infirmary and an assistant professor of
> ophthalmology at Harvard Medical School, described the research
> results as a "major step forward."
> "But this is still very early work," Vavvas noted. "This has been
> achieved only in-vitro. It is in-lab work with cell cultures. So it's
> still a question how this will work in person because there are still
> hurdles that need to be overcome," he added.
> "For example, all of this work so far needs viruses to function as
> cell carriers, and this creates problems," he explained. "So, people
> are now trying to see if they can replicate this kind of lab work
> without the use of viruses. That will have to happen before we can go
> to human trials. And we're not there yet," Vavvas said.
> "With the current know-how and technology, we're probably talking a
> minimum of three to five years before we can even go to clinical
> trials," he pointed out.
> The researchers used a line of adult stem cells that had been a relied-
> upon source for lab research. They said that the differentiation
> process that prodded the stem cell stock to develop into retinal cells
> equivalent to those damaged by AMD took many weeks of high-tech
> culturing, but ultimately the stem cell-generated retinal cells
> exhibited the same functional capacity and gene expression as
> naturally occurring retinal cells, the researchers reported.
> However, they cautioned that the cell line they generated also
> appeared to display DNA chromosomal damage, aspects of over-expression
> that prompted growth inhibition and some structural abnormalities.
> Though the generated cells were deemed "viable," the researchers said
> that more work would be needed to render them "safe" for treatment
> purposes.
> "But when we talk about the potential use of stem cells, we shouldn't
> only think about transplantation," Golestaneh said. "They could also
> be used as an in-vitro model to study the disease itself in the lab --
> their function, their impairment, gene mutations. That would help to
> generate targeted drugs to cure the disease."
> That makes the cells "very valuable not only for transplantation but
> also to study the mechanism of the disease and advance drug
> development," Golestaneh said.
> More information
> The U.S. National Eye Institute has more on age-related macular
> degeneration.
> Isn't it great?? 3 to 5 years before they can even move to clinicals,
> viruses in cells causing problems, we already now iPSC are
> "unstable"...Common you morons there is clinical trial about to be
> started in 3 months with already differentiated RPE
> cells...unbelieavable..
> On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > Hard to believe no mention of Advanced Cell Technology...time to
> > barrage the site with hard facts folks...
> > Progress Seen in Creating Eye Cells From Stem Cells
> > Lab success may someday help people with macular degeneration,
> > researchers say
> > Posted: March 24, 2011
> > By Alan Mozes
> > HealthDay Reporter
> > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > of stem cell research into the world of viable treatments, scientists
> > have successfully fashioned adult stem cells into the kind of eye
> > cells that fall victim to the onset of age-related macular
> > degeneration, or AMD.
> > The work did not involve embryonic stem cells, which have been the
> > subject of much debate in recent years, but rather so-called "human-
> > induced pluripotent stem cells." The aim, according to the
> > researchers, was to develop a therapeutic response to the death,
> > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > critical to the health of the retina's vision cells.
> > But the researchers, from the Georgetown University Medical Center in
> > Washington, D.C., stress that this was a preliminary move toward that
> > goal, achieved solely in a laboratory setting. They say that numerous
> > complex obstacles must be tackled before such newly created cells
> > could be transplanted into diseased eyes.
> > "But we have shown that we are able to generate retinal cells from
> > cells originally taken from a small amount of biopsied skin, that are
> > then induced to become stem cells," noted Nady Golestaneh, an
> > assistant professor in the department of biochemistry and molecular
> > and cellular biology at Georgetown, and a co-author of a report on the
> > research, published in the March 24 issue of Stem Cells. The study was
> > funded by the U.S. National Institutes of Health.
> > "The retinal cells we have generated are really functional,"
> > Golestaneh explained. "That means they mimic the function of native
> > retinal cells that play a key role in the eye for light absorption,
> > nutrition and receptor function."
> > That's important "because, if these cells die, they can induce disease
> > in the eye, one of which is age-related macular degeneration," she
> > said. "Until now, there has not been any medication that can stop this
> > disease. So basically these people lose their central vision, which we
> > need to do daily tasks like reading, driving or anything that you need
> > to do to be independent."
> > In the United States, AMD is a leading cause of vision loss among
> > people 60 and older.
> > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > ophthalmology at Harvard Medical School, described the research
> > results as a "major step forward."
> > "But this is still very early work," Vavvas noted. "This has been
> > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > still a question how this will work in person because there are still
> > hurdles that need to be overcome," he added.
> > "For example, all of this work so far needs viruses to function as
> > cell carriers, and this creates problems," he explained. "So, people
> > are now trying to see if they can replicate this kind of lab work
> > without the use of viruses. That will have to happen before we can go
> > to human trials. And we're not there yet," Vavvas said.
> > "With the current know-how and technology, we're probably talking a
> > minimum of three to five years before we can even go to clinical
> > trials," he pointed out.
> > The researchers used a line of adult stem cells that had been a relied-
> > upon source for lab research. They said that the differentiation
> > process that prodded the stem cell stock to develop into retinal cells
> > equivalent to those damaged by AMD took many weeks of high-tech
> > culturing, but ultimately the stem cell-generated retinal cells
> > exhibited the same functional capacity and gene expression as
> > naturally occurring retinal cells, the researchers reported.
> > However, they cautioned that the cell line they generated also
> > appeared to display DNA chromosomal damage, aspects of over-expression
> > that prompted growth inhibition and some structural abnormalities.
> > Though the generated cells were deemed "viable," the researchers said
> > that more work would be needed to render them "safe" for treatment
> > purposes.
> > "But when we talk about the potential use of stem cells, we shouldn't
> > only think about transplantation," Golestaneh said. "They could also
> > be used as an in-vitro model to study the disease itself in the lab --
> > their function, their impairment, gene mutations. That would help to
> > generate targeted drugs to cure the disease."
> > That makes the cells "very valuable not only for transplantation but
> > also to study the mechanism of the disease and advance drug
> > development," Golestaneh said.
> > More information
> > The U.S. National Eye Institute has more on age-related macular
> > degeneration.- Hide quoted text -
Agreed Ender. Where is our PR firm? Why aren't they lining up
interviews with these magazines? Hey! Mr us-news, Guess what? We have
cells that are 5xs as effective as the nearest NIH approved lines!
Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
Blastomere! And you know what else? We don't harm the embryo! If I
had a high enough window, I would open it up and yell "We are mad as
hell, and we are not going to take it anymore!"
On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> Isn't it great?? 3 to 5 years before they can even move to clinicals,
> viruses in cells causing problems, we already now iPSC are
> "unstable"...Common you morons there is clinical trial about to be
> started in 3 months with already differentiated RPE
> cells...unbelieavable..
> On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > Hard to believe no mention of Advanced Cell Technology...time to
> > barrage the site with hard facts folks...
> > Progress Seen in Creating Eye Cells From Stem Cells
> > Lab success may someday help people with macular degeneration,
> > researchers say
> > Posted: March 24, 2011
> > By Alan Mozes
> > HealthDay Reporter
> > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > of stem cell research into the world of viable treatments, scientists
> > have successfully fashioned adult stem cells into the kind of eye
> > cells that fall victim to the onset of age-related macular
> > degeneration, or AMD.
> > The work did not involve embryonic stem cells, which have been the
> > subject of much debate in recent years, but rather so-called "human-
> > induced pluripotent stem cells." The aim, according to the
> > researchers, was to develop a therapeutic response to the death,
> > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > critical to the health of the retina's vision cells.
> > But the researchers, from the Georgetown University Medical Center in
> > Washington, D.C., stress that this was a preliminary move toward that
> > goal, achieved solely in a laboratory setting. They say that numerous
> > complex obstacles must be tackled before such newly created cells
> > could be transplanted into diseased eyes.
> > "But we have shown that we are able to generate retinal cells from
> > cells originally taken from a small amount of biopsied skin, that are
> > then induced to become stem cells," noted Nady Golestaneh, an
> > assistant professor in the department of biochemistry and molecular
> > and cellular biology at Georgetown, and a co-author of a report on the
> > research, published in the March 24 issue of Stem Cells. The study was
> > funded by the U.S. National Institutes of Health.
> > "The retinal cells we have generated are really functional,"
> > Golestaneh explained. "That means they mimic the function of native
> > retinal cells that play a key role in the eye for light absorption,
> > nutrition and receptor function."
> > That's important "because, if these cells die, they can induce disease
> > in the eye, one of which is age-related macular degeneration," she
> > said. "Until now, there has not been any medication that can stop this
> > disease. So basically these people lose their central vision, which we
> > need to do daily tasks like reading, driving or anything that you need
> > to do to be independent."
> > In the United States, AMD is a leading cause of vision loss among
> > people 60 and older.
> > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > ophthalmology at Harvard Medical School, described the research
> > results as a "major step forward."
> > "But this is still very early work," Vavvas noted. "This has been
> > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > still a question how this will work in person because there are still
> > hurdles that need to be overcome," he added.
> > "For example, all of this work so far needs viruses to function as
> > cell carriers, and this creates problems," he explained. "So, people
> > are now trying to see if they can replicate this kind of lab work
> > without the use of viruses. That will have to happen before we can go
> > to human trials. And we're not there yet," Vavvas said.
> > "With the current know-how and technology, we're probably talking a
> > minimum of three to five years before we can even go to clinical
> > trials," he pointed out.
> > The researchers used a line of adult stem cells that had been a relied-
> > upon source for lab research. They said that the differentiation
> > process that prodded the stem cell stock to develop into retinal cells
> > equivalent to those damaged by AMD took many weeks of high-tech
> > culturing, but ultimately the stem cell-generated retinal cells
> > exhibited the same functional capacity and gene expression as
> > naturally occurring retinal cells, the researchers reported.
> > However, they cautioned that the cell line they generated also
> > appeared to display DNA chromosomal damage, aspects of over-expression
> > that prompted growth inhibition and some structural abnormalities.
> > Though the generated cells were deemed "viable," the researchers said
> > that more work would be needed to render them "safe" for treatment
> > purposes.
> > "But when we talk about the potential use of stem cells, we shouldn't
> > only think about transplantation," Golestaneh said. "They could also
> > be used as an in-vitro model to study the disease itself in the lab --
> > their function, their impairment, gene mutations. That would help to
> > generate targeted drugs to cure the disease."
> > That makes the cells "very valuable not only for transplantation but
> > also to study the mechanism of the disease and advance drug
> > development," Golestaneh said.
> > More information
> > The U.S. National Eye Institute has more on age-related macular
> > degeneration.
John i hope that as we speak ACTC together with Russo working on nice
PR strategy to make us more visible in big media outlets. Could be
matched with the patient enrollment for the trials wich should be
starting in 2 weeks according Monday CC.
On Mar 24, 3:16 pm, John <vzvete...@yahoo.com> wrote:
> Agreed Ender. Where is our PR firm? Why aren't they lining up
> interviews with these magazines? Hey! Mr us-news, Guess what? We have
> cells that are 5xs as effective as the nearest NIH approved lines!
> Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> Blastomere! And you know what else? We don't harm the embryo! If I
> had a high enough window, I would open it up and yell "We are mad as
> hell, and we are not going to take it anymore!"
> On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > viruses in cells causing problems, we already now iPSC are
> > "unstable"...Common you morons there is clinical trial about to be
> > started in 3 months with already differentiated RPE
> > cells...unbelieavable..
> > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > Hard to believe no mention of Advanced Cell Technology...time to
> > > barrage the site with hard facts folks...
> > > Progress Seen in Creating Eye Cells From Stem Cells
> > > Lab success may someday help people with macular degeneration,
> > > researchers say
> > > Posted: March 24, 2011
> > > By Alan Mozes
> > > HealthDay Reporter
> > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > of stem cell research into the world of viable treatments, scientists
> > > have successfully fashioned adult stem cells into the kind of eye
> > > cells that fall victim to the onset of age-related macular
> > > degeneration, or AMD.
> > > The work did not involve embryonic stem cells, which have been the
> > > subject of much debate in recent years, but rather so-called "human-
> > > induced pluripotent stem cells." The aim, according to the
> > > researchers, was to develop a therapeutic response to the death,
> > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > critical to the health of the retina's vision cells.
> > > But the researchers, from the Georgetown University Medical Center in
> > > Washington, D.C., stress that this was a preliminary move toward that
> > > goal, achieved solely in a laboratory setting. They say that numerous
> > > complex obstacles must be tackled before such newly created cells
> > > could be transplanted into diseased eyes.
> > > "But we have shown that we are able to generate retinal cells from
> > > cells originally taken from a small amount of biopsied skin, that are
> > > then induced to become stem cells," noted Nady Golestaneh, an
> > > assistant professor in the department of biochemistry and molecular
> > > and cellular biology at Georgetown, and a co-author of a report on the
> > > research, published in the March 24 issue of Stem Cells. The study was
> > > funded by the U.S. National Institutes of Health.
> > > "The retinal cells we have generated are really functional,"
> > > Golestaneh explained. "That means they mimic the function of native
> > > retinal cells that play a key role in the eye for light absorption,
> > > nutrition and receptor function."
> > > That's important "because, if these cells die, they can induce disease
> > > in the eye, one of which is age-related macular degeneration," she
> > > said. "Until now, there has not been any medication that can stop this
> > > disease. So basically these people lose their central vision, which we
> > > need to do daily tasks like reading, driving or anything that you need
> > > to do to be independent."
> > > In the United States, AMD is a leading cause of vision loss among
> > > people 60 and older.
> > > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > > ophthalmology at Harvard Medical School, described the research
> > > results as a "major step forward."
> > > "But this is still very early work," Vavvas noted. "This has been
> > > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > > still a question how this will work in person because there are still
> > > hurdles that need to be overcome," he added.
> > > "For example, all of this work so far needs viruses to function as
> > > cell carriers, and this creates problems," he explained. "So, people
> > > are now trying to see if they can replicate this kind of lab work
> > > without the use of viruses. That will have to happen before we can go
> > > to human trials. And we're not there yet," Vavvas said.
> > > "With the current know-how and technology, we're probably talking a
> > > minimum of three to five years before we can even go to clinical
> > > trials," he pointed out.
> > > The researchers used a line of adult stem cells that had been a relied-
> > > upon source for lab research. They said that the differentiation
> > > process that prodded the stem cell stock to develop into retinal cells
> > > equivalent to those damaged by AMD took many weeks of high-tech
> > > culturing, but ultimately the stem cell-generated retinal cells
> > > exhibited the same functional capacity and gene expression as
> > > naturally occurring retinal cells, the researchers reported.
> > > However, they cautioned that the cell line they generated also
> > > appeared to display DNA chromosomal damage, aspects of over-expression
> > > that prompted growth inhibition and some structural abnormalities.
> > > Though the generated cells were deemed "viable," the researchers said
> > > that more work would be needed to render them "safe" for treatment
> > > purposes.
> > > "But when we talk about the potential use of stem cells, we shouldn't
> > > only think about transplantation," Golestaneh said. "They could also
> > > be used as an in-vitro model to study the disease itself in the lab --
> > > their function, their impairment, gene mutations. That would help to
> > > generate targeted drugs to cure the disease."
> > > That makes the cells "very valuable not only for transplantation but
> > > also to study the mechanism of the disease and advance drug
> > > development," Golestaneh said.
> > > More information
> > > The U.S. National Eye Institute has more on age-related macular
> > > degeneration.- Hide quoted text -
I hope so. It just seems like we can't do enough to get the attention
that we deserve. This posted article is a prime example of media bias.
How does this story even warrant publication? How are they even on the
radar, on the list of must have interviews? Their approach is light
years behind us.
On Mar 24, 10:20 am, Ender <Radek.Ves...@logica.com> wrote:
> John i hope that as we speak ACTC together with Russo working on nice
> PR strategy to make us more visible in big media outlets. Could be
> matched with the patient enrollment for the trials wich should be
> starting in 2 weeks according Monday CC.
> On Mar 24, 3:16 pm, John <vzvete...@yahoo.com> wrote:
> > Agreed Ender. Where is our PR firm? Why aren't they lining up
> > interviews with these magazines? Hey! Mr us-news, Guess what? We have
> > cells that are 5xs as effective as the nearest NIH approved lines!
> > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> > Blastomere! And you know what else? We don't harm the embryo! If I
> > had a high enough window, I would open it up and yell "We are mad as
> > hell, and we are not going to take it anymore!"
> > On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > > viruses in cells causing problems, we already now iPSC are
> > > "unstable"...Common you morons there is clinical trial about to be
> > > started in 3 months with already differentiated RPE
> > > cells...unbelieavable..
> > > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > > Hard to believe no mention of Advanced Cell Technology...time to
> > > > barrage the site with hard facts folks...
> > > > Progress Seen in Creating Eye Cells From Stem Cells
> > > > Lab success may someday help people with macular degeneration,
> > > > researchers say
> > > > Posted: March 24, 2011
> > > > By Alan Mozes
> > > > HealthDay Reporter
> > > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > > of stem cell research into the world of viable treatments, scientists
> > > > have successfully fashioned adult stem cells into the kind of eye
> > > > cells that fall victim to the onset of age-related macular
> > > > degeneration, or AMD.
> > > > The work did not involve embryonic stem cells, which have been the
> > > > subject of much debate in recent years, but rather so-called "human-
> > > > induced pluripotent stem cells." The aim, according to the
> > > > researchers, was to develop a therapeutic response to the death,
> > > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > > critical to the health of the retina's vision cells.
> > > > But the researchers, from the Georgetown University Medical Center in
> > > > Washington, D.C., stress that this was a preliminary move toward that
> > > > goal, achieved solely in a laboratory setting. They say that numerous
> > > > complex obstacles must be tackled before such newly created cells
> > > > could be transplanted into diseased eyes.
> > > > "But we have shown that we are able to generate retinal cells from
> > > > cells originally taken from a small amount of biopsied skin, that are
> > > > then induced to become stem cells," noted Nady Golestaneh, an
> > > > assistant professor in the department of biochemistry and molecular
> > > > and cellular biology at Georgetown, and a co-author of a report on the
> > > > research, published in the March 24 issue of Stem Cells. The study was
> > > > funded by the U.S. National Institutes of Health.
> > > > "The retinal cells we have generated are really functional,"
> > > > Golestaneh explained. "That means they mimic the function of native
> > > > retinal cells that play a key role in the eye for light absorption,
> > > > nutrition and receptor function."
> > > > That's important "because, if these cells die, they can induce disease
> > > > in the eye, one of which is age-related macular degeneration," she
> > > > said. "Until now, there has not been any medication that can stop this
> > > > disease. So basically these people lose their central vision, which we
> > > > need to do daily tasks like reading, driving or anything that you need
> > > > to do to be independent."
> > > > In the United States, AMD is a leading cause of vision loss among
> > > > people 60 and older.
> > > > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > > > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > > > ophthalmology at Harvard Medical School, described the research
> > > > results as a "major step forward."
> > > > "But this is still very early work," Vavvas noted. "This has been
> > > > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > > > still a question how this will work in person because there are still
> > > > hurdles that need to be overcome," he added.
> > > > "For example, all of this work so far needs viruses to function as
> > > > cell carriers, and this creates problems," he explained. "So, people
> > > > are now trying to see if they can replicate this kind of lab work
> > > > without the use of viruses. That will have to happen before we can go
> > > > to human trials. And we're not there yet," Vavvas said.
> > > > "With the current know-how and technology, we're probably talking a
> > > > minimum of three to five years before we can even go to clinical
> > > > trials," he pointed out.
> > > > The researchers used a line of adult stem cells that had been a relied-
> > > > upon source for lab research. They said that the differentiation
> > > > process that prodded the stem cell stock to develop into retinal cells
> > > > equivalent to those damaged by AMD took many weeks of high-tech
> > > > culturing, but ultimately the stem cell-generated retinal cells
> > > > exhibited the same functional capacity and gene expression as
> > > > naturally occurring retinal cells, the researchers reported.
> > > > However, they cautioned that the cell line they generated also
> > > > appeared to display DNA chromosomal damage, aspects of over-expression
> > > > that prompted growth inhibition and some structural abnormalities.
> > > > Though the generated cells were deemed "viable," the researchers said
> > > > that more work would be needed to render them "safe" for treatment
> > > > purposes.
> > > > "But when we talk about the potential use of stem cells, we shouldn't
> > > > only think about transplantation," Golestaneh said. "They could also
> > > > be used as an in-vitro model to study the disease itself in the lab --
> > > > their function, their impairment, gene mutations. That would help to
> > > > generate targeted drugs to cure the disease."
> > > > That makes the cells "very valuable not only for transplantation but
> > > > also to study the mechanism of the disease and advance drug
> > > > development," Golestaneh said.
> > > > More information
> > > > The U.S. National Eye Institute has more on age-related macular
> > > > degeneration.- Hide quoted text -
> I hope so. It just seems like we can't do enough to get the attention
> that we deserve. This posted article is a prime example of media bias.
> How does this story even warrant publication? How are they even on the
> radar, on the list of must have interviews? Their approach is light
> years behind us.
> On Mar 24, 10:20 am, Ender <Radek.Ves...@logica.com> wrote:
> > John i hope that as we speak ACTC together with Russo working on nice
> > PR strategy to make us more visible in big media outlets. Could be
> > matched with the patient enrollment for the trials wich should be
> > starting in 2 weeks according Monday CC.
> > On Mar 24, 3:16 pm, John <vzvete...@yahoo.com> wrote:
> > > Agreed Ender. Where is our PR firm? Why aren't they lining up
> > > interviews with these magazines? Hey! Mr us-news, Guess what? We have
> > > cells that are 5xs as effective as the nearest NIH approved lines!
> > > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> > > Blastomere! And you know what else? We don't harm the embryo! If I
> > > had a high enough window, I would open it up and yell "We are mad as
> > > hell, and we are not going to take it anymore!"
> > > On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > > > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > > > viruses in cells causing problems, we already now iPSC are
> > > > "unstable"...Common you morons there is clinical trial about to be
> > > > started in 3 months with already differentiated RPE
> > > > cells...unbelieavable..
> > > > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > > > Hard to believe no mention of Advanced Cell Technology...time to
> > > > > barrage the site with hard facts folks...
> > > > > Progress Seen in Creating Eye Cells From Stem Cells
> > > > > Lab success may someday help people with macular degeneration,
> > > > > researchers say
> > > > > Posted: March 24, 2011
> > > > > By Alan Mozes
> > > > > HealthDay Reporter
> > > > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > > > of stem cell research into the world of viable treatments, scientists
> > > > > have successfully fashioned adult stem cells into the kind of eye
> > > > > cells that fall victim to the onset of age-related macular
> > > > > degeneration, or AMD.
> > > > > The work did not involve embryonic stem cells, which have been the
> > > > > subject of much debate in recent years, but rather so-called "human-
> > > > > induced pluripotent stem cells." The aim, according to the
> > > > > researchers, was to develop a therapeutic response to the death,
> > > > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > > > critical to the health of the retina's vision cells.
> > > > > But the researchers, from the Georgetown University Medical Center in
> > > > > Washington, D.C., stress that this was a preliminary move toward that
> > > > > goal, achieved solely in a laboratory setting. They say that numerous
> > > > > complex obstacles must be tackled before such newly created cells
> > > > > could be transplanted into diseased eyes.
> > > > > "But we have shown that we are able to generate retinal cells from
> > > > > cells originally taken from a small amount of biopsied skin, that are
> > > > > then induced to become stem cells," noted Nady Golestaneh, an
> > > > > assistant professor in the department of biochemistry and molecular
> > > > > and cellular biology at Georgetown, and a co-author of a report on the
> > > > > research, published in the March 24 issue of Stem Cells. The study was
> > > > > funded by the U.S. National Institutes of Health.
> > > > > "The retinal cells we have generated are really functional,"
> > > > > Golestaneh explained. "That means they mimic the function of native
> > > > > retinal cells that play a key role in the eye for light absorption,
> > > > > nutrition and receptor function."
> > > > > That's important "because, if these cells die, they can induce disease
> > > > > in the eye, one of which is age-related macular degeneration," she
> > > > > said. "Until now, there has not been any medication that can stop this
> > > > > disease. So basically these people lose their central vision, which we
> > > > > need to do daily tasks like reading, driving or anything that you need
> > > > > to do to be independent."
> > > > > In the United States, AMD is a leading cause of vision loss among
> > > > > people 60 and older.
> > > > > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > > > > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > > > > ophthalmology at Harvard Medical School, described the research
> > > > > results as a "major step forward."
> > > > > "But this is still very early work," Vavvas noted. "This has been
> > > > > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > > > > still a question how this will work in person because there are still
> > > > > hurdles that need to be overcome," he added.
> > > > > "For example, all of this work so far needs viruses to function as
> > > > > cell carriers, and this creates problems," he explained. "So, people
> > > > > are now trying to see if they can replicate this kind of lab work
> > > > > without the use of viruses. That will have to happen before we can go
> > > > > to human trials. And we're not there yet," Vavvas said.
> > > > > "With the current know-how and technology, we're probably talking a
> > > > > minimum of three to five years before we can even go to clinical
> > > > > trials," he pointed out.
> > > > > The researchers used a line of adult stem cells that had been a relied-
> > > > > upon source for lab research. They said that the differentiation
> > > > > process that prodded the stem cell stock to develop into retinal cells
> > > > > equivalent to those damaged by AMD took many weeks of high-tech
> > > > > culturing, but ultimately the stem cell-generated retinal cells
> > > > > exhibited the same functional capacity and gene expression as
> > > > > naturally occurring retinal cells, the researchers reported.
> > > > > However, they cautioned that the cell line they generated also
> > > > > appeared to display DNA chromosomal damage, aspects of over-expression
> > > > > that prompted growth inhibition and some structural abnormalities.
> > > > > Though the generated cells were deemed "viable," the researchers said
> > > > > that more work would be needed to render them "safe" for treatment
> > > > > purposes.
> > > > > "But when we talk about the potential use of stem cells, we shouldn't
> > > > > only think about transplantation," Golestaneh said. "They could also
> > > > > be used as an in-vitro model to study the disease itself in the lab --
> > > > > their function, their impairment, gene mutations. That would help to
> > > > > generate targeted drugs to cure the disease."
> > > > > That makes the cells "very valuable not only for transplantation but
> > > > > also to study the mechanism of the disease and advance drug
> > > > > development," Golestaneh said.
> > > > > More information
> > > > > The U.S. National Eye Institute has more on age-related macular
> > > > > degeneration.- Hide quoted text -
> John i hope that as we speak ACTC together with Russo working on nice
> PR strategy to make us more visible in big media outlets. Could be
> matched with the patient enrollment for the trials wich should be
> starting in 2 weeks according Monday CC.
> On Mar 24, 3:16 pm, John <vzvete...@yahoo.com> wrote:
> > Agreed Ender. Where is our PR firm? Why aren't they lining up
> > interviews with these magazines? Hey! Mr us-news, Guess what? We have
> > cells that are 5xs as effective as the nearest NIH approved lines!
> > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> > Blastomere! And you know what else? We don't harm the embryo! If I
> > had a high enough window, I would open it up and yell "We are mad as
> > hell, and we are not going to take it anymore!"
> > On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > > viruses in cells causing problems, we already now iPSC are
> > > "unstable"...Common you morons there is clinical trial about to be
> > > started in 3 months with already differentiated RPE
> > > cells...unbelieavable..
> > > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > > Hard to believe no mention of Advanced Cell Technology...time to
> > > > barrage the site with hard facts folks...
> > > > Progress Seen in Creating Eye Cells From Stem Cells
> > > > Lab success may someday help people with macular degeneration,
> > > > researchers say
> > > > Posted: March 24, 2011
> > > > By Alan Mozes
> > > > HealthDay Reporter
> > > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > > of stem cell research into the world of viable treatments, scientists
> > > > have successfully fashioned adult stem cells into the kind of eye
> > > > cells that fall victim to the onset of age-related macular
> > > > degeneration, or AMD.
> > > > The work did not involve embryonic stem cells, which have been the
> > > > subject of much debate in recent years, but rather so-called "human-
> > > > induced pluripotent stem cells." The aim, according to the
> > > > researchers, was to develop a therapeutic response to the death,
> > > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > > critical to the health of the retina's vision cells.
> > > > But the researchers, from the Georgetown University Medical Center in
> > > > Washington, D.C., stress that this was a preliminary move toward that
> > > > goal, achieved solely in a laboratory setting. They say that numerous
> > > > complex obstacles must be tackled before such newly created cells
> > > > could be transplanted into diseased eyes.
> > > > "But we have shown that we are able to generate retinal cells from
> > > > cells originally taken from a small amount of biopsied skin, that are
> > > > then induced to become stem cells," noted Nady Golestaneh, an
> > > > assistant professor in the department of biochemistry and molecular
> > > > and cellular biology at Georgetown, and a co-author of a report on the
> > > > research, published in the March 24 issue of Stem Cells. The study was
> > > > funded by the U.S. National Institutes of Health.
> > > > "The retinal cells we have generated are really functional,"
> > > > Golestaneh explained. "That means they mimic the function of native
> > > > retinal cells that play a key role in the eye for light absorption,
> > > > nutrition and receptor function."
> > > > That's important "because, if these cells die, they can induce disease
> > > > in the eye, one of which is age-related macular degeneration," she
> > > > said. "Until now, there has not been any medication that can stop this
> > > > disease. So basically these people lose their central vision, which we
> > > > need to do daily tasks like reading, driving or anything that you need
> > > > to do to be independent."
> > > > In the United States, AMD is a leading cause of vision loss among
> > > > people 60 and older.
> > > > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > > > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > > > ophthalmology at Harvard Medical School, described the research
> > > > results as a "major step forward."
> > > > "But this is still very early work," Vavvas noted. "This has been
> > > > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > > > still a question how this will work in person because there are still
> > > > hurdles that need to be overcome," he added.
> > > > "For example, all of this work so far needs viruses to function as
> > > > cell carriers, and this creates problems," he explained. "So, people
> > > > are now trying to see if they can replicate this kind of lab work
> > > > without the use of viruses. That will have to happen before we can go
> > > > to human trials. And we're not there yet," Vavvas said.
> > > > "With the current know-how and technology, we're probably talking a
> > > > minimum of three to five years before we can even go to clinical
> > > > trials," he pointed out.
> > > > The researchers used a line of adult stem cells that had been a relied-
> > > > upon source for lab research. They said that the differentiation
> > > > process that prodded the stem cell stock to develop into retinal cells
> > > > equivalent to those damaged by AMD took many weeks of high-tech
> > > > culturing, but ultimately the stem cell-generated retinal cells
> > > > exhibited the same functional capacity and gene expression as
> > > > naturally occurring retinal cells, the researchers reported.
> > > > However, they cautioned that the cell line they generated also
> > > > appeared to display DNA chromosomal damage, aspects of over-expression
> > > > that prompted growth inhibition and some structural abnormalities.
> > > > Though the generated cells were deemed "viable," the researchers said
> > > > that more work would be needed to render them "safe" for treatment
> > > > purposes.
> > > > "But when we talk about the potential use of stem cells, we shouldn't
> > > > only think about transplantation," Golestaneh said. "They could also
> > > > be used as an in-vitro model to study the disease itself in the lab --
> > > > their function, their impairment, gene mutations. That would help to
> > > > generate targeted drugs to cure the disease."
> > > > That makes the cells "very valuable not only for transplantation but
> > > > also to study the mechanism of the disease and advance drug
> > > > development," Golestaneh said.
> > > > More information
> > > > The U.S. National Eye Institute has more on age-related macular
> > > > degeneration.- Hide quoted text -
Anyway, on the positive note this is yet another indication that RPE
cells would do what we are all expecting to do..:-)
If you think about that it's kind of "simple". You create RPE cells
and inject them into eye where they replace the dead/damaged RPE
cells, attach and voila..:-)
And that's it. I really thinking almost every day what would FDA do
with the results (results we expect)? Because just this Phase I/II
trial should with higher dosage achieve the results. One new RPE cells
are there and not causing problems what else would you need to wait
for? I'm so excited to see this work in upcomming months. GLTA
On Mar 24, 3:29 pm, John <vzvete...@yahoo.com> wrote:
> I hope so. It just seems like we can't do enough to get the attention
> that we deserve. This posted article is a prime example of media bias.
> How does this story even warrant publication? How are they even on the
> radar, on the list of must have interviews? Their approach is light
> years behind us.
> On Mar 24, 10:20 am, Ender <Radek.Ves...@logica.com> wrote:
> > John i hope that as we speak ACTC together with Russo working on nice
> > PR strategy to make us more visible in big media outlets. Could be
> > matched with the patient enrollment for the trials wich should be
> > starting in 2 weeks according Monday CC.
> > On Mar 24, 3:16 pm, John <vzvete...@yahoo.com> wrote:
> > > Agreed Ender. Where is our PR firm? Why aren't they lining up
> > > interviews with these magazines? Hey! Mr us-news, Guess what? We have
> > > cells that are 5xs as effective as the nearest NIH approved lines!
> > > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> > > Blastomere! And you know what else? We don't harm the embryo! If I
> > > had a high enough window, I would open it up and yell "We are mad as
> > > hell, and we are not going to take it anymore!"
> > > On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > > > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > > > viruses in cells causing problems, we already now iPSC are
> > > > "unstable"...Common you morons there is clinical trial about to be
> > > > started in 3 months with already differentiated RPE
> > > > cells...unbelieavable..
> > > > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > > > Hard to believe no mention of Advanced Cell Technology...time to
> > > > > barrage the site with hard facts folks...
> > > > > Progress Seen in Creating Eye Cells From Stem Cells
> > > > > Lab success may someday help people with macular degeneration,
> > > > > researchers say
> > > > > Posted: March 24, 2011
> > > > > By Alan Mozes
> > > > > HealthDay Reporter
> > > > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > > > of stem cell research into the world of viable treatments, scientists
> > > > > have successfully fashioned adult stem cells into the kind of eye
> > > > > cells that fall victim to the onset of age-related macular
> > > > > degeneration, or AMD.
> > > > > The work did not involve embryonic stem cells, which have been the
> > > > > subject of much debate in recent years, but rather so-called "human-
> > > > > induced pluripotent stem cells." The aim, according to the
> > > > > researchers, was to develop a therapeutic response to the death,
> > > > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > > > critical to the health of the retina's vision cells.
> > > > > But the researchers, from the Georgetown University Medical Center in
> > > > > Washington, D.C., stress that this was a preliminary move toward that
> > > > > goal, achieved solely in a laboratory setting. They say that numerous
> > > > > complex obstacles must be tackled before such newly created cells
> > > > > could be transplanted into diseased eyes.
> > > > > "But we have shown that we are able to generate retinal cells from
> > > > > cells originally taken from a small amount of biopsied skin, that are
> > > > > then induced to become stem cells," noted Nady Golestaneh, an
> > > > > assistant professor in the department of biochemistry and molecular
> > > > > and cellular biology at Georgetown, and a co-author of a report on the
> > > > > research, published in the March 24 issue of Stem Cells. The study was
> > > > > funded by the U.S. National Institutes of Health.
> > > > > "The retinal cells we have generated are really functional,"
> > > > > Golestaneh explained. "That means they mimic the function of native
> > > > > retinal cells that play a key role in the eye for light absorption,
> > > > > nutrition and receptor function."
> > > > > That's important "because, if these cells die, they can induce disease
> > > > > in the eye, one of which is age-related macular degeneration," she
> > > > > said. "Until now, there has not been any medication that can stop this
> > > > > disease. So basically these people lose their central vision, which we
> > > > > need to do daily tasks like reading, driving or anything that you need
> > > > > to do to be independent."
> > > > > In the United States, AMD is a leading cause of vision loss among
> > > > > people 60 and older.
> > > > > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > > > > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > > > > ophthalmology at Harvard Medical School, described the research
> > > > > results as a "major step forward."
> > > > > "But this is still very early work," Vavvas noted. "This has been
> > > > > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > > > > still a question how this will work in person because there are still
> > > > > hurdles that need to be overcome," he added.
> > > > > "For example, all of this work so far needs viruses to function as
> > > > > cell carriers, and this creates problems," he explained. "So, people
> > > > > are now trying to see if they can replicate this kind of lab work
> > > > > without the use of viruses. That will have to happen before we can go
> > > > > to human trials. And we're not there yet," Vavvas said.
> > > > > "With the current know-how and technology, we're probably talking a
> > > > > minimum of three to five years before we can even go to clinical
> > > > > trials," he pointed out.
> > > > > The researchers used a line of adult stem cells that had been a relied-
> > > > > upon source for lab research. They said that the differentiation
> > > > > process that prodded the stem cell stock to develop into retinal cells
> > > > > equivalent to those damaged by AMD took many weeks of high-tech
> > > > > culturing, but ultimately the stem cell-generated retinal cells
> > > > > exhibited the same functional capacity and gene expression as
> > > > > naturally occurring retinal cells, the researchers reported.
> > > > > However, they cautioned that the cell line they generated also
> > > > > appeared to display DNA chromosomal damage, aspects of over-expression
> > > > > that prompted growth inhibition and some structural abnormalities.
> > > > > Though the generated cells were deemed "viable," the researchers said
> > > > > that more work would be needed to render them "safe" for treatment
> > > > > purposes.
> > > > > "But when we talk about the potential use of stem cells, we shouldn't
> > > > > only think about transplantation," Golestaneh said. "They could also
> > > > > be used as an in-vitro model to study the disease itself in the lab --
> > > > > their function, their impairment, gene mutations. That would help to
> > > > > generate targeted drugs to cure the disease."
> > > > > That makes the cells "very valuable not only for transplantation but
> > > > > also to study the mechanism of the disease and advance drug
> > > > > development," Golestaneh said.
> > > > > More information
> > > > > The U.S. National Eye Institute has more on age-related macular
> > > > > degeneration.- Hide quoted text -
But Mr. fox would say " Were the embryos that you used, these
'unharmed' embryos, eventually destroyed? Even if it was not in the
process of extracting the cells, they were still destroyed, is that
not the case?" And we would say, "That is correct, but the process we
use to obtain the stem cells does not harm the embryo so in the
right...." and we would be cut off and the question reiterated... "So
the the 'embryo safe' technique that was used to extract the stem
cells was not a direct cause of the demise of the embryo, but those
embryos were still eventually destroyed, correct?" and we would say
"Well, yes. But you have to understand that... "Thank you for your
time Mr. Rabin".
We need to understand that there are a lot of people who do not think
like us. We can differentiate between what seem like huge differences
to us. To others it's still just, the embryos are eventually
destroyed. (well, until you bring in the whole process of natural
conception and childbirth and miscarriage etc...). It is becoming
clear to me that the controversy is not really about how the embryo is
destroyed. It's not even about if it is destroyed. It's about an
unwillingness to accept that the old ways are just that... old. The
old order does not want to give up that power. Therapies such as the
ones ACTC are working on are game changers that we can't even
comprehend. This technology will be besieged by the far right and the
far left, those who you think are for it and those you know never will
be. It is a society changer.
That said, we just have to do what we do. Lets not get too frustrated
when we still see that most articles are still like this 5 years from
now.
Feeed has a saying; 'Only the science will save the sheeple'. He's
right.
On Mar 24, 9:16 am, John <vzvete...@yahoo.com> wrote:
> Agreed Ender. Where is our PR firm? Why aren't they lining up
> interviews with these magazines? Hey! Mr us-news, Guess what? We have
> cells that are 5xs as effective as the nearest NIH approved lines!
> Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> Blastomere! And you know what else? We don't harm the embryo! If I
> had a high enough window, I would open it up and yell "We are mad as
> hell, and we are not going to take it anymore!"
> On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > viruses in cells causing problems, we already now iPSC are
> > "unstable"...Common you morons there is clinical trial about to be
> > started in 3 months with already differentiated RPE
> > cells...unbelieavable..
> > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > Hard to believe no mention of Advanced Cell Technology...time to
> > > barrage the site with hard facts folks...
> > > Progress Seen in Creating Eye Cells From Stem Cells
> > > Lab success may someday help people with macular degeneration,
> > > researchers say
> > > Posted: March 24, 2011
> > > By Alan Mozes
> > > HealthDay Reporter
> > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > of stem cell research into the world of viable treatments, scientists
> > > have successfully fashioned adult stem cells into the kind of eye
> > > cells that fall victim to the onset of age-related macular
> > > degeneration, or AMD.
> > > The work did not involve embryonic stem cells, which have been the
> > > subject of much debate in recent years, but rather so-called "human-
> > > induced pluripotent stem cells." The aim, according to the
> > > researchers, was to develop a therapeutic response to the death,
> > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > critical to the health of the retina's vision cells.
> > > But the researchers, from the Georgetown University Medical Center in
> > > Washington, D.C., stress that this was a preliminary move toward that
> > > goal, achieved solely in a laboratory setting. They say that numerous
> > > complex obstacles must be tackled before such newly created cells
> > > could be transplanted into diseased eyes.
> > > "But we have shown that we are able to generate retinal cells from
> > > cells originally taken from a small amount of biopsied skin, that are
> > > then induced to become stem cells," noted Nady Golestaneh, an
> > > assistant professor in the department of biochemistry and molecular
> > > and cellular biology at Georgetown, and a co-author of a report on the
> > > research, published in the March 24 issue of Stem Cells. The study was
> > > funded by the U.S. National Institutes of Health.
> > > "The retinal cells we have generated are really functional,"
> > > Golestaneh explained. "That means they mimic the function of native
> > > retinal cells that play a key role in the eye for light absorption,
> > > nutrition and receptor function."
> > > That's important "because, if these cells die, they can induce disease
> > > in the eye, one of which is age-related macular degeneration," she
> > > said. "Until now, there has not been any medication that can stop this
> > > disease. So basically these people lose their central vision, which we
> > > need to do daily tasks like reading, driving or anything that you need
> > > to do to be independent."
> > > In the United States, AMD is a leading cause of vision loss among
> > > people 60 and older.
> > > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > > ophthalmology at Harvard Medical School, described the research
> > > results as a "major step forward."
> > > "But this is still very early work," Vavvas noted. "This has been
> > > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > > still a question how this will work in person because there are still
> > > hurdles that need to be overcome," he added.
> > > "For example, all of this work so far needs viruses to function as
> > > cell carriers, and this creates problems," he explained. "So, people
> > > are now trying to see if they can replicate this kind of lab work
> > > without the use of viruses. That will have to happen before we can go
> > > to human trials. And we're not there yet," Vavvas said.
> > > "With the current know-how and technology, we're probably talking a
> > > minimum of three to five years before we can even go to clinical
> > > trials," he pointed out.
> > > The researchers used a line of adult stem cells that had been a relied-
> > > upon source for lab research. They said that the differentiation
> > > process that prodded the stem cell stock to develop into retinal cells
> > > equivalent to those damaged by AMD took many weeks of high-tech
> > > culturing, but ultimately the stem cell-generated retinal cells
> > > exhibited the same functional capacity and gene expression as
> > > naturally occurring retinal cells, the researchers reported.
> > > However, they cautioned that the cell line they generated also
> > > appeared to display DNA chromosomal damage, aspects of over-expression
> > > that prompted growth inhibition and some structural abnormalities.
> > > Though the generated cells were deemed "viable," the researchers said
> > > that more work would be needed to render them "safe" for treatment
> > > purposes.
> > > "But when we talk about the potential use of stem cells, we shouldn't
> > > only think about transplantation," Golestaneh said. "They could also
> > > be used as an in-vitro model to study the disease itself in the lab --
> > > their function, their impairment, gene mutations. That would help to
> > > generate targeted drugs to cure the disease."
> > > That makes the cells "very valuable not only for transplantation but
> > > also to study the mechanism of the disease and advance drug
> > > development," Golestaneh said.
> > > More information
> > > The U.S. National Eye Institute has more on age-related macular
> > > degeneration.
Robert I believe that too and I think the right time for begining of
media visibility is with beggining of patient enrollment. Something
like: "CNN:Patient about to be selected for hESC clinical
study"...etc..
On Mar 24, 3:33 pm, Robert Sierra <52vistav...@gmail.com> wrote:
> This guy Russo has some awesome connections in the media. I know he's
> waiting for the right moment to use those connections at CNBC.
> On Mar 24, 7:20 am, Ender <Radek.Ves...@logica.com> wrote:
> > John i hope that as we speak ACTC together with Russo working on nice
> > PR strategy to make us more visible in big media outlets. Could be
> > matched with the patient enrollment for the trials wich should be
> > starting in 2 weeks according Monday CC.
> > On Mar 24, 3:16 pm, John <vzvete...@yahoo.com> wrote:
> > > Agreed Ender. Where is our PR firm? Why aren't they lining up
> > > interviews with these magazines? Hey! Mr us-news, Guess what? We have
> > > cells that are 5xs as effective as the nearest NIH approved lines!
> > > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> > > Blastomere! And you know what else? We don't harm the embryo! If I
> > > had a high enough window, I would open it up and yell "We are mad as
> > > hell, and we are not going to take it anymore!"
> > > On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > > > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > > > viruses in cells causing problems, we already now iPSC are
> > > > "unstable"...Common you morons there is clinical trial about to be
> > > > started in 3 months with already differentiated RPE
> > > > cells...unbelieavable..
> > > > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > > > Hard to believe no mention of Advanced Cell Technology...time to
> > > > > barrage the site with hard facts folks...
> > > > > Progress Seen in Creating Eye Cells From Stem Cells
> > > > > Lab success may someday help people with macular degeneration,
> > > > > researchers say
> > > > > Posted: March 24, 2011
> > > > > By Alan Mozes
> > > > > HealthDay Reporter
> > > > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > > > of stem cell research into the world of viable treatments, scientists
> > > > > have successfully fashioned adult stem cells into the kind of eye
> > > > > cells that fall victim to the onset of age-related macular
> > > > > degeneration, or AMD.
> > > > > The work did not involve embryonic stem cells, which have been the
> > > > > subject of much debate in recent years, but rather so-called "human-
> > > > > induced pluripotent stem cells." The aim, according to the
> > > > > researchers, was to develop a therapeutic response to the death,
> > > > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > > > critical to the health of the retina's vision cells.
> > > > > But the researchers, from the Georgetown University Medical Center in
> > > > > Washington, D.C., stress that this was a preliminary move toward that
> > > > > goal, achieved solely in a laboratory setting. They say that numerous
> > > > > complex obstacles must be tackled before such newly created cells
> > > > > could be transplanted into diseased eyes.
> > > > > "But we have shown that we are able to generate retinal cells from
> > > > > cells originally taken from a small amount of biopsied skin, that are
> > > > > then induced to become stem cells," noted Nady Golestaneh, an
> > > > > assistant professor in the department of biochemistry and molecular
> > > > > and cellular biology at Georgetown, and a co-author of a report on the
> > > > > research, published in the March 24 issue of Stem Cells. The study was
> > > > > funded by the U.S. National Institutes of Health.
> > > > > "The retinal cells we have generated are really functional,"
> > > > > Golestaneh explained. "That means they mimic the function of native
> > > > > retinal cells that play a key role in the eye for light absorption,
> > > > > nutrition and receptor function."
> > > > > That's important "because, if these cells die, they can induce disease
> > > > > in the eye, one of which is age-related macular degeneration," she
> > > > > said. "Until now, there has not been any medication that can stop this
> > > > > disease. So basically these people lose their central vision, which we
> > > > > need to do daily tasks like reading, driving or anything that you need
> > > > > to do to be independent."
> > > > > In the United States, AMD is a leading cause of vision loss among
> > > > > people 60 and older.
> > > > > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > > > > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > > > > ophthalmology at Harvard Medical School, described the research
> > > > > results as a "major step forward."
> > > > > "But this is still very early work," Vavvas noted. "This has been
> > > > > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > > > > still a question how this will work in person because there are still
> > > > > hurdles that need to be overcome," he added.
> > > > > "For example, all of this work so far needs viruses to function as
> > > > > cell carriers, and this creates problems," he explained. "So, people
> > > > > are now trying to see if they can replicate this kind of lab work
> > > > > without the use of viruses. That will have to happen before we can go
> > > > > to human trials. And we're not there yet," Vavvas said.
> > > > > "With the current know-how and technology, we're probably talking a
> > > > > minimum of three to five years before we can even go to clinical
> > > > > trials," he pointed out.
> > > > > The researchers used a line of adult stem cells that had been a relied-
> > > > > upon source for lab research. They said that the differentiation
> > > > > process that prodded the stem cell stock to develop into retinal cells
> > > > > equivalent to those damaged by AMD took many weeks of high-tech
> > > > > culturing, but ultimately the stem cell-generated retinal cells
> > > > > exhibited the same functional capacity and gene expression as
> > > > > naturally occurring retinal cells, the researchers reported.
> > > > > However, they cautioned that the cell line they generated also
> > > > > appeared to display DNA chromosomal damage, aspects of over-expression
> > > > > that prompted growth inhibition and some structural abnormalities.
> > > > > Though the generated cells were deemed "viable," the researchers said
> > > > > that more work would be needed to render them "safe" for treatment
> > > > > purposes.
> > > > > "But when we talk about the potential use of stem cells, we shouldn't
> > > > > only think about transplantation," Golestaneh said. "They could also
> > > > > be used as an in-vitro model to study the disease itself in the lab --
> > > > > their function, their impairment, gene mutations. That would help to
> > > > > generate targeted drugs to cure the disease."
> > > > > That makes the cells "very valuable not only for transplantation but
> > > > > also to study the mechanism of the disease and advance drug
> > > > > development," Golestaneh said.
> > > > > More information
> > > > > The U.S. National Eye Institute has more on age-related macular
> > > > > degeneration.- Hide quoted text -
Agree with your thoughts. I think Russo will help ACTC navigate thru
these type of objections.
The fact is that the embryo from which the RPE cells we are using for
our TRIALS was destroyed. Lanza stated that ACTC could switch to a
newer hESC line where the embryo is still intact and frozen, but
making that switch will take some time. IMO, after ACTC gets the JV
money and the trials are proven to be safe & effective, ACTC will make
the switch to ramp-up manufacturing of RPE cells from a new line where
the embryo is preserved, and those RPE cells will be used for
treatments. Once this is done, ACTC will be totally clean and will be
able to shout from the rooftops that our RPE therapy is embryo safe,
and can physically point to the preserved embryo. Russo should be
able to articulate this approach to the masses at any time.
On Mar 24, 10:36 am, Toddio <toddi...@yahoo.com> wrote:
> But Mr. fox would say " Were the embryos that you used, these
> 'unharmed' embryos, eventually destroyed? Even if it was not in the
> process of extracting the cells, they were still destroyed, is that
> not the case?" And we would say, "That is correct, but the process we
> use to obtain the stem cells does not harm the embryo so in the
> right...." and we would be cut off and the question reiterated... "So
> the the 'embryo safe' technique that was used to extract the stem
> cells was not a direct cause of the demise of the embryo, but those
> embryos were still eventually destroyed, correct?" and we would say
> "Well, yes. But you have to understand that... "Thank you for your
> time Mr. Rabin".
> We need to understand that there are a lot of people who do not think
> like us. We can differentiate between what seem like huge differences
> to us. To others it's still just, the embryos are eventually
> destroyed. (well, until you bring in the whole process of natural
> conception and childbirth and miscarriage etc...). It is becoming
> clear to me that the controversy is not really about how the embryo is
> destroyed. It's not even about if it is destroyed. It's about an
> unwillingness to accept that the old ways are just that... old. The
> old order does not want to give up that power. Therapies such as the
> ones ACTC are working on are game changers that we can't even
> comprehend. This technology will be besieged by the far right and the
> far left, those who you think are for it and those you know never will
> be. It is a society changer.
> That said, we just have to do what we do. Lets not get too frustrated
> when we still see that most articles are still like this 5 years from
> now.
> Feeed has a saying; 'Only the science will save the sheeple'. He's
> right.
> On Mar 24, 9:16 am, John <vzvete...@yahoo.com> wrote:
> > Agreed Ender. Where is our PR firm? Why aren't they lining up
> > interviews with these magazines? Hey! Mr us-news, Guess what? We have
> > cells that are 5xs as effective as the nearest NIH approved lines!
> > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> > Blastomere! And you know what else? We don't harm the embryo! If I
> > had a high enough window, I would open it up and yell "We are mad as
> > hell, and we are not going to take it anymore!"
> > On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > > viruses in cells causing problems, we already now iPSC are
> > > "unstable"...Common you morons there is clinical trial about to be
> > > started in 3 months with already differentiated RPE
> > > cells...unbelieavable..
> > > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > > Hard to believe no mention of Advanced Cell Technology...time to
> > > > barrage the site with hard facts folks...
> > > > Progress Seen in Creating Eye Cells From Stem Cells
> > > > Lab success may someday help people with macular degeneration,
> > > > researchers say
> > > > Posted: March 24, 2011
> > > > By Alan Mozes
> > > > HealthDay Reporter
> > > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > > of stem cell research into the world of viable treatments, scientists
> > > > have successfully fashioned adult stem cells into the kind of eye
> > > > cells that fall victim to the onset of age-related macular
> > > > degeneration, or AMD.
> > > > The work did not involve embryonic stem cells, which have been the
> > > > subject of much debate in recent years, but rather so-called "human-
> > > > induced pluripotent stem cells." The aim, according to the
> > > > researchers, was to develop a therapeutic response to the death,
> > > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > > critical to the health of the retina's vision cells.
> > > > But the researchers, from the Georgetown University Medical Center in
> > > > Washington, D.C., stress that this was a preliminary move toward that
> > > > goal, achieved solely in a laboratory setting. They say that numerous
> > > > complex obstacles must be tackled before such newly created cells
> > > > could be transplanted into diseased eyes.
> > > > "But we have shown that we are able to generate retinal cells from
> > > > cells originally taken from a small amount of biopsied skin, that are
> > > > then induced to become stem cells," noted Nady Golestaneh, an
> > > > assistant professor in the department of biochemistry and molecular
> > > > and cellular biology at Georgetown, and a co-author of a report on the
> > > > research, published in the March 24 issue of Stem Cells. The study was
> > > > funded by the U.S. National Institutes of Health.
> > > > "The retinal cells we have generated are really functional,"
> > > > Golestaneh explained. "That means they mimic the function of native
> > > > retinal cells that play a key role in the eye for light absorption,
> > > > nutrition and receptor function."
> > > > That's important "because, if these cells die, they can induce disease
> > > > in the eye, one of which is age-related macular degeneration," she
> > > > said. "Until now, there has not been any medication that can stop this
> > > > disease. So basically these people lose their central vision, which we
> > > > need to do daily tasks like reading, driving or anything that you need
> > > > to do to be independent."
> > > > In the United States, AMD is a leading cause of vision loss among
> > > > people 60 and older.
> > > > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > > > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > > > ophthalmology at Harvard Medical School, described the research
> > > > results as a "major step forward."
> > > > "But this is still very early work," Vavvas noted. "This has been
> > > > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > > > still a question how this will work in person because there are still
> > > > hurdles that need to be overcome," he added.
> > > > "For example, all of this work so far needs viruses to function as
> > > > cell carriers, and this creates problems," he explained. "So, people
> > > > are now trying to see if they can replicate this kind of lab work
> > > > without the use of viruses. That will have to happen before we can go
> > > > to human trials. And we're not there yet," Vavvas said.
> > > > "With the current know-how and technology, we're probably talking a
> > > > minimum of three to five years before we can even go to clinical
> > > > trials," he pointed out.
> > > > The researchers used a line of adult stem cells that had been a relied-
> > > > upon source for lab research. They said that the differentiation
> > > > process that prodded the stem cell stock to develop into retinal cells
> > > > equivalent to those damaged by AMD took many weeks of high-tech
> > > > culturing, but ultimately the stem cell-generated retinal cells
> > > > exhibited the same functional capacity and gene expression as
> > > > naturally occurring retinal cells, the researchers reported.
> > > > However, they cautioned that the cell line they generated also
> > > > appeared to display DNA chromosomal damage, aspects of over-expression
> > > > that prompted growth inhibition and some structural abnormalities.
> > > > Though the generated cells were deemed "viable," the researchers said
> > > > that more work would be needed to render them "safe" for treatment
> > > > purposes.
> > > > "But when we talk about the potential use of stem cells, we shouldn't
> > > > only think about transplantation," Golestaneh said. "They could also
> > > > be used as an in-vitro model to study the disease itself in the lab --
> > > > their function, their impairment, gene mutations. That would help to
> > > > generate targeted drugs to cure the disease."
> > > > That makes the cells "very valuable not only for transplantation but
> > > > also to study the mechanism of the disease and advance drug
> > > > development," Golestaneh said.
> > > > More information
> > > > The U.S. National Eye Institute has more on age-related macular
> > > > degeneration.- Hide quoted text -
Concerning the derivation of RPE cells, it really doesn't matter
anymore. The one embryo that was used to make the stem cells that
make the RPE cells today is all that will ever be needed to make RPE
cells in the future. That's the benefit of immortality and unlimited
derivation. They won't have to touch another embryo for RPE work.
It's already done and will be the source for unlimited stem cells for
the eye in the future.
On Mar 24, 9:53 am, Jckrdu <jim.ku...@yahoo.com> wrote:
> Agree with your thoughts. I think Russo will help ACTC navigate thru
> these type of objections.
> The fact is that the embryo from which the RPE cells we are using for
> our TRIALS was destroyed. Lanza stated that ACTC could switch to a
> newer hESC line where the embryo is still intact and frozen, but
> making that switch will take some time. IMO, after ACTC gets the JV
> money and the trials are proven to be safe & effective, ACTC will make
> the switch to ramp-up manufacturing of RPE cells from a new line where
> the embryo is preserved, and those RPE cells will be used for
> treatments. Once this is done, ACTC will be totally clean and will be
> able to shout from the rooftops that our RPE therapy is embryo safe,
> and can physically point to the preserved embryo. Russo should be
> able to articulate this approach to the masses at any time.
> On Mar 24, 10:36 am, Toddio <toddi...@yahoo.com> wrote:
> > But Mr. fox would say " Were the embryos that you used, these
> > 'unharmed' embryos, eventually destroyed? Even if it was not in the
> > process of extracting the cells, they were still destroyed, is that
> > not the case?" And we would say, "That is correct, but the process we
> > use to obtain the stem cells does not harm the embryo so in the
> > right...." and we would be cut off and the question reiterated... "So
> > the the 'embryo safe' technique that was used to extract the stem
> > cells was not a direct cause of the demise of the embryo, but those
> > embryos were still eventually destroyed, correct?" and we would say
> > "Well, yes. But you have to understand that... "Thank you for your
> > time Mr. Rabin".
> > We need to understand that there are a lot of people who do not think
> > like us. We can differentiate between what seem like huge differences
> > to us. To others it's still just, the embryos are eventually
> > destroyed. (well, until you bring in the whole process of natural
> > conception and childbirth and miscarriage etc...). It is becoming
> > clear to me that the controversy is not really about how the embryo is
> > destroyed. It's not even about if it is destroyed. It's about an
> > unwillingness to accept that the old ways are just that... old. The
> > old order does not want to give up that power. Therapies such as the
> > ones ACTC are working on are game changers that we can't even
> > comprehend. This technology will be besieged by the far right and the
> > far left, those who you think are for it and those you know never will
> > be. It is a society changer.
> > That said, we just have to do what we do. Lets not get too frustrated
> > when we still see that most articles are still like this 5 years from
> > now.
> > Feeed has a saying; 'Only the science will save the sheeple'. He's
> > right.
> > On Mar 24, 9:16 am, John <vzvete...@yahoo.com> wrote:
> > > Agreed Ender. Where is our PR firm? Why aren't they lining up
> > > interviews with these magazines? Hey! Mr us-news, Guess what? We have
> > > cells that are 5xs as effective as the nearest NIH approved lines!
> > > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> > > Blastomere! And you know what else? We don't harm the embryo! If I
> > > had a high enough window, I would open it up and yell "We are mad as
> > > hell, and we are not going to take it anymore!"
> > > On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > > > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > > > viruses in cells causing problems, we already now iPSC are
> > > > "unstable"...Common you morons there is clinical trial about to be
> > > > started in 3 months with already differentiated RPE
> > > > cells...unbelieavable..
> > > > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > > > Hard to believe no mention of Advanced Cell Technology...time to
> > > > > barrage the site with hard facts folks...
> > > > > Progress Seen in Creating Eye Cells From Stem Cells
> > > > > Lab success may someday help people with macular degeneration,
> > > > > researchers say
> > > > > Posted: March 24, 2011
> > > > > By Alan Mozes
> > > > > HealthDay Reporter
> > > > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > > > of stem cell research into the world of viable treatments, scientists
> > > > > have successfully fashioned adult stem cells into the kind of eye
> > > > > cells that fall victim to the onset of age-related macular
> > > > > degeneration, or AMD.
> > > > > The work did not involve embryonic stem cells, which have been the
> > > > > subject of much debate in recent years, but rather so-called "human-
> > > > > induced pluripotent stem cells." The aim, according to the
> > > > > researchers, was to develop a therapeutic response to the death,
> > > > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > > > critical to the health of the retina's vision cells.
> > > > > But the researchers, from the Georgetown University Medical Center in
> > > > > Washington, D.C., stress that this was a preliminary move toward that
> > > > > goal, achieved solely in a laboratory setting. They say that numerous
> > > > > complex obstacles must be tackled before such newly created cells
> > > > > could be transplanted into diseased eyes.
> > > > > "But we have shown that we are able to generate retinal cells from
> > > > > cells originally taken from a small amount of biopsied skin, that are
> > > > > then induced to become stem cells," noted Nady Golestaneh, an
> > > > > assistant professor in the department of biochemistry and molecular
> > > > > and cellular biology at Georgetown, and a co-author of a report on the
> > > > > research, published in the March 24 issue of Stem Cells. The study was
> > > > > funded by the U.S. National Institutes of Health.
> > > > > "The retinal cells we have generated are really functional,"
> > > > > Golestaneh explained. "That means they mimic the function of native
> > > > > retinal cells that play a key role in the eye for light absorption,
> > > > > nutrition and receptor function."
> > > > > That's important "because, if these cells die, they can induce disease
> > > > > in the eye, one of which is age-related macular degeneration," she
> > > > > said. "Until now, there has not been any medication that can stop this
> > > > > disease. So basically these people lose their central vision, which we
> > > > > need to do daily tasks like reading, driving or anything that you need
> > > > > to do to be independent."
> > > > > In the United States, AMD is a leading cause of vision loss among
> > > > > people 60 and older.
> > > > > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > > > > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > > > > ophthalmology at Harvard Medical School, described the research
> > > > > results as a "major step forward."
> > > > > "But this is still very early work," Vavvas noted. "This has been
> > > > > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > > > > still a question how this will work in person because there are still
> > > > > hurdles that need to be overcome," he added.
> > > > > "For example, all of this work so far needs viruses to function as
> > > > > cell carriers, and this creates problems," he explained. "So, people
> > > > > are now trying to see if they can replicate this kind of lab work
> > > > > without the use of viruses. That will have to happen before we can go
> > > > > to human trials. And we're not there yet," Vavvas said.
> > > > > "With the current know-how and technology, we're probably talking a
> > > > > minimum of three to five years before we can even go to clinical
> > > > > trials," he pointed out.
> > > > > The researchers used a line of adult stem cells that had been a relied-
> > > > > upon source for lab research. They said that the differentiation
> > > > > process that prodded the stem cell stock to develop into retinal cells
> > > > > equivalent to those damaged by AMD took many weeks of high-tech
> > > > > culturing, but ultimately the stem cell-generated retinal cells
> > > > > exhibited the same functional capacity and gene expression as
> > > > > naturally occurring retinal cells, the researchers reported.
> > > > > However, they cautioned that the cell line they generated also
> > > > > appeared to display DNA chromosomal damage, aspects of over-expression
> > > > > that prompted growth inhibition and some structural abnormalities.
> > > > > Though the generated cells were deemed "viable," the researchers said
> > > > > that more work would be needed to render them "safe" for treatment
> > > > > purposes.
> > > > > "But when we talk about the potential use of stem cells, we shouldn't
> > > > > only think about transplantation," Golestaneh said. "They could also
> > > > > be used as an in-vitro model to study the disease itself in the lab --
> > > > > their function, their impairment, gene mutations. That would help to
> > > > > generate targeted drugs to cure the disease."
> > > > > That makes the cells "very valuable not only for transplantation
We can all agree on both of those points. Russo has their work cut out
for them in trying to convince those who are intent on seeing it
otherwise despite all the facts. I hope they are successful.
On Mar 24, 11:08 am, eigenman <eigenma...@gmail.com> wrote:
> Concerning the derivation of RPE cells, it really doesn't matter
> anymore. The one embryo that was used to make the stem cells that
> make the RPE cells today is all that will ever be needed to make RPE
> cells in the future. That's the benefit of immortality and unlimited
> derivation. They won't have to touch another embryo for RPE work.
> It's already done and will be the source for unlimited stem cells for
> the eye in the future.
> On Mar 24, 9:53 am, Jckrdu <jim.ku...@yahoo.com> wrote:
> > Agree with your thoughts. I think Russo will help ACTC navigate thru
> > these type of objections.
> > The fact is that the embryo from which the RPE cells we are using for
> > our TRIALS was destroyed. Lanza stated that ACTC could switch to a
> > newer hESC line where the embryo is still intact and frozen, but
> > making that switch will take some time. IMO, after ACTC gets the JV
> > money and the trials are proven to be safe & effective, ACTC will make
> > the switch to ramp-up manufacturing of RPE cells from a new line where
> > the embryo is preserved, and those RPE cells will be used for
> > treatments. Once this is done, ACTC will be totally clean and will be
> > able to shout from the rooftops that our RPE therapy is embryo safe,
> > and can physically point to the preserved embryo. Russo should be
> > able to articulate this approach to the masses at any time.
> > On Mar 24, 10:36 am, Toddio <toddi...@yahoo.com> wrote:
> > > But Mr. fox would say " Were the embryos that you used, these
> > > 'unharmed' embryos, eventually destroyed? Even if it was not in the
> > > process of extracting the cells, they were still destroyed, is that
> > > not the case?" And we would say, "That is correct, but the process we
> > > use to obtain the stem cells does not harm the embryo so in the
> > > right...." and we would be cut off and the question reiterated... "So
> > > the the 'embryo safe' technique that was used to extract the stem
> > > cells was not a direct cause of the demise of the embryo, but those
> > > embryos were still eventually destroyed, correct?" and we would say
> > > "Well, yes. But you have to understand that... "Thank you for your
> > > time Mr. Rabin".
> > > We need to understand that there are a lot of people who do not think
> > > like us. We can differentiate between what seem like huge differences
> > > to us. To others it's still just, the embryos are eventually
> > > destroyed. (well, until you bring in the whole process of natural
> > > conception and childbirth and miscarriage etc...). It is becoming
> > > clear to me that the controversy is not really about how the embryo is
> > > destroyed. It's not even about if it is destroyed. It's about an
> > > unwillingness to accept that the old ways are just that... old. The
> > > old order does not want to give up that power. Therapies such as the
> > > ones ACTC are working on are game changers that we can't even
> > > comprehend. This technology will be besieged by the far right and the
> > > far left, those who you think are for it and those you know never will
> > > be. It is a society changer.
> > > That said, we just have to do what we do. Lets not get too frustrated
> > > when we still see that most articles are still like this 5 years from
> > > now.
> > > Feeed has a saying; 'Only the science will save the sheeple'. He's
> > > right.
> > > On Mar 24, 9:16 am, John <vzvete...@yahoo.com> wrote:
> > > > Agreed Ender. Where is our PR firm? Why aren't they lining up
> > > > interviews with these magazines? Hey! Mr us-news, Guess what? We have
> > > > cells that are 5xs as effective as the nearest NIH approved lines!
> > > > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> > > > Blastomere! And you know what else? We don't harm the embryo! If I
> > > > had a high enough window, I would open it up and yell "We are mad as
> > > > hell, and we are not going to take it anymore!"
> > > > On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > > > > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > > > > viruses in cells causing problems, we already now iPSC are
> > > > > "unstable"...Common you morons there is clinical trial about to be
> > > > > started in 3 months with already differentiated RPE
> > > > > cells...unbelieavable..
> > > > > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > > > > Hard to believe no mention of Advanced Cell Technology...time to
> > > > > > barrage the site with hard facts folks...
> > > > > > Progress Seen in Creating Eye Cells From Stem Cells
> > > > > > Lab success may someday help people with macular degeneration,
> > > > > > researchers say
> > > > > > Posted: March 24, 2011
> > > > > > By Alan Mozes
> > > > > > HealthDay Reporter
> > > > > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > > > > of stem cell research into the world of viable treatments, scientists
> > > > > > have successfully fashioned adult stem cells into the kind of eye
> > > > > > cells that fall victim to the onset of age-related macular
> > > > > > degeneration, or AMD.
> > > > > > The work did not involve embryonic stem cells, which have been the
> > > > > > subject of much debate in recent years, but rather so-called "human-
> > > > > > induced pluripotent stem cells." The aim, according to the
> > > > > > researchers, was to develop a therapeutic response to the death,
> > > > > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > > > > critical to the health of the retina's vision cells.
> > > > > > But the researchers, from the Georgetown University Medical Center in
> > > > > > Washington, D.C., stress that this was a preliminary move toward that
> > > > > > goal, achieved solely in a laboratory setting. They say that numerous
> > > > > > complex obstacles must be tackled before such newly created cells
> > > > > > could be transplanted into diseased eyes.
> > > > > > "But we have shown that we are able to generate retinal cells from
> > > > > > cells originally taken from a small amount of biopsied skin, that are
> > > > > > then induced to become stem cells," noted Nady Golestaneh, an
> > > > > > assistant professor in the department of biochemistry and molecular
> > > > > > and cellular biology at Georgetown, and a co-author of a report on the
> > > > > > research, published in the March 24 issue of Stem Cells. The study was
> > > > > > funded by the U.S. National Institutes of Health.
> > > > > > "The retinal cells we have generated are really functional,"
> > > > > > Golestaneh explained. "That means they mimic the function of native
> > > > > > retinal cells that play a key role in the eye for light absorption,
> > > > > > nutrition and receptor function."
> > > > > > That's important "because, if these cells die, they can induce disease
> > > > > > in the eye, one of which is age-related macular degeneration," she
> > > > > > said. "Until now, there has not been any medication that can stop this
> > > > > > disease. So basically these people lose their central vision, which we
> > > > > > need to do daily tasks like reading, driving or anything that you need
> > > > > > to do to be independent."
> > > > > > In the United States, AMD is a leading cause of vision loss among
> > > > > > people 60 and older.
> > > > > > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > > > > > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > > > > > ophthalmology at Harvard Medical School, described the research
> > > > > > results as a "major step forward."
> > > > > > "But this is still very early work," Vavvas noted. "This has been
> > > > > > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > > > > > still a question how this will work in person because there are still
> > > > > > hurdles that need to be overcome," he added.
> > > > > > "For example, all of this work so far needs viruses to function as
> > > > > > cell carriers, and this creates problems," he explained. "So, people
> > > > > > are now trying to see if they can replicate this kind of lab work
> > > > > > without the use of viruses. That will have to happen before we can go
> > > > > > to human trials. And we're not there yet," Vavvas said.
> > > > > > "With the current know-how and technology, we're probably talking a
> > > > > > minimum of three to five years before we can even go to clinical
> > > > > > trials," he pointed out.
> > > > > > The researchers used a line of adult stem cells that had been a relied-
> > > > > > upon source for lab research. They said that the differentiation
> > > > > > process that prodded the stem cell stock to develop into retinal cells
> > > > > > equivalent to those damaged by AMD took many weeks of high-tech
> > > > > > culturing, but ultimately the stem cell-generated retinal cells
> > > > > > exhibited the same functional capacity and gene expression as
> > > > > > naturally occurring retinal cells, the researchers reported.
> > > > > > However, they cautioned that the cell line they generated also
> > > > > > appeared to display DNA chromosomal damage, aspects of over-expression
> > > > > > that prompted growth inhibition and some structural abnormalities.
> > > > > > Though the generated cells were deemed "viable," the researchers said
> > > > > > that more work
> We can all agree on both of those points. Russo has their work cut out
> for them in trying to convince those who are intent on seeing it
> otherwise despite all the facts. I hope they are successful.
> On Mar 24, 11:08 am, eigenman <eigenma...@gmail.com> wrote:
> > Concerning the derivation of RPE cells, it really doesn't matter
> > anymore. The one embryo that was used to make the stem cells that
> > make the RPE cells today is all that will ever be needed to make RPE
> > cells in the future. That's the benefit of immortality and unlimited
> > derivation. They won't have to touch another embryo for RPE work.
> > It's already done and will be the source for unlimited stem cells for
> > the eye in the future.
> > On Mar 24, 9:53 am, Jckrdu <jim.ku...@yahoo.com> wrote:
> > > Agree with your thoughts. I think Russo will help ACTC navigate thru
> > > these type of objections.
> > > The fact is that the embryo from which the RPE cells we are using for
> > > our TRIALS was destroyed. Lanza stated that ACTC could switch to a
> > > newer hESC line where the embryo is still intact and frozen, but
> > > making that switch will take some time. IMO, after ACTC gets the JV
> > > money and the trials are proven to be safe & effective, ACTC will make
> > > the switch to ramp-up manufacturing of RPE cells from a new line where
> > > the embryo is preserved, and those RPE cells will be used for
> > > treatments. Once this is done, ACTC will be totally clean and will be
> > > able to shout from the rooftops that our RPE therapy is embryo safe,
> > > and can physically point to the preserved embryo. Russo should be
> > > able to articulate this approach to the masses at any time.
> > > On Mar 24, 10:36 am, Toddio <toddi...@yahoo.com> wrote:
> > > > But Mr. fox would say " Were the embryos that you used, these
> > > > 'unharmed' embryos, eventually destroyed? Even if it was not in the
> > > > process of extracting the cells, they were still destroyed, is that
> > > > not the case?" And we would say, "That is correct, but the process we
> > > > use to obtain the stem cells does not harm the embryo so in the
> > > > right...." and we would be cut off and the question reiterated... "So
> > > > the the 'embryo safe' technique that was used to extract the stem
> > > > cells was not a direct cause of the demise of the embryo, but those
> > > > embryos were still eventually destroyed, correct?" and we would say
> > > > "Well, yes. But you have to understand that... "Thank you for your
> > > > time Mr. Rabin".
> > > > We need to understand that there are a lot of people who do not think
> > > > like us. We can differentiate between what seem like huge differences
> > > > to us. To others it's still just, the embryos are eventually
> > > > destroyed. (well, until you bring in the whole process of natural
> > > > conception and childbirth and miscarriage etc...). It is becoming
> > > > clear to me that the controversy is not really about how the embryo is
> > > > destroyed. It's not even about if it is destroyed. It's about an
> > > > unwillingness to accept that the old ways are just that... old. The
> > > > old order does not want to give up that power. Therapies such as the
> > > > ones ACTC are working on are game changers that we can't even
> > > > comprehend. This technology will be besieged by the far right and the
> > > > far left, those who you think are for it and those you know never will
> > > > be. It is a society changer.
> > > > That said, we just have to do what we do. Lets not get too frustrated
> > > > when we still see that most articles are still like this 5 years from
> > > > now.
> > > > Feeed has a saying; 'Only the science will save the sheeple'. He's
> > > > right.
> > > > On Mar 24, 9:16 am, John <vzvete...@yahoo.com> wrote:
> > > > > Agreed Ender. Where is our PR firm? Why aren't they lining up
> > > > > interviews with these magazines? Hey! Mr us-news, Guess what? We have
> > > > > cells that are 5xs as effective as the nearest NIH approved lines!
> > > > > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> > > > > Blastomere! And you know what else? We don't harm the embryo! If I
> > > > > had a high enough window, I would open it up and yell "We are mad as
> > > > > hell, and we are not going to take it anymore!"
> > > > > On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > > > > > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > > > > > viruses in cells causing problems, we already now iPSC are
> > > > > > "unstable"...Common you morons there is clinical trial about to be
> > > > > > started in 3 months with already differentiated RPE
> > > > > > cells...unbelieavable..
> > > > > > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > > > > > Hard to believe no mention of Advanced Cell Technology...time to
> > > > > > > barrage the site with hard facts folks...
> > > > > > > Progress Seen in Creating Eye Cells From Stem Cells
> > > > > > > Lab success may someday help people with macular degeneration,
> > > > > > > researchers say
> > > > > > > Posted: March 24, 2011
> > > > > > > By Alan Mozes
> > > > > > > HealthDay Reporter
> > > > > > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > > > > > of stem cell research into the world of viable treatments, scientists
> > > > > > > have successfully fashioned adult stem cells into the kind of eye
> > > > > > > cells that fall victim to the onset of age-related macular
> > > > > > > degeneration, or AMD.
> > > > > > > The work did not involve embryonic stem cells, which have been the
> > > > > > > subject of much debate in recent years, but rather so-called "human-
> > > > > > > induced pluripotent stem cells." The aim, according to the
> > > > > > > researchers, was to develop a therapeutic response to the death,
> > > > > > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > > > > > critical to the health of the retina's vision cells.
> > > > > > > But the researchers, from the Georgetown University Medical Center in
> > > > > > > Washington, D.C., stress that this was a preliminary move toward that
> > > > > > > goal, achieved solely in a laboratory setting. They say that numerous
> > > > > > > complex obstacles must be tackled before such newly created cells
> > > > > > > could be transplanted into diseased eyes.
> > > > > > > "But we have shown that we are able to generate retinal cells from
> > > > > > > cells originally taken from a small amount of biopsied skin, that are
> > > > > > > then induced to become stem cells," noted Nady Golestaneh, an
> > > > > > > assistant professor in the department of biochemistry and molecular
> > > > > > > and cellular biology at Georgetown, and a co-author of a report on the
> > > > > > > research, published in the March 24 issue of Stem Cells. The study was
> > > > > > > funded by the U.S. National Institutes of Health.
> > > > > > > "The retinal cells we have generated are really functional,"
> > > > > > > Golestaneh explained. "That means they mimic the function of native
> > > > > > > retinal cells that play a key role in the eye for light absorption,
> > > > > > > nutrition and receptor function."
> > > > > > > That's important "because, if these cells die, they can induce disease
> > > > > > > in the eye, one of which is age-related macular degeneration," she
> > > > > > > said. "Until now, there has not been any medication that can stop this
> > > > > > > disease. So basically these people lose their central vision, which we
> > > > > > > need to do daily tasks like reading, driving or anything that you need
> > > > > > > to do to be independent."
> > > > > > > In the United States, AMD is a leading cause of vision loss among
> > > > > > > people 60 and older.
> > > > > > > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > > > > > > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > > > > > > ophthalmology at Harvard Medical School, described the research
> > > > > > > results as a "major step forward."
> > > > > > > "But this is still very early work," Vavvas noted. "This has been
> > > > > > > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > > > > > > still a question how this will work in person because there are still
> > > > > > > hurdles that need to be overcome," he added.
> > > > > > > "For example, all of this work so far needs viruses to function as
> > > > > > > cell carriers, and this creates problems," he explained. "So, people
> > > > > > > are now trying to see if they can replicate this kind of lab work
> > > > > > > without the use of viruses. That will have to happen before we can go
> > > > > > > to human trials. And we're not there yet," Vavvas said.
> > > > > > > "With the current know-how and technology, we're probably talking a
> > > > > > > minimum of three to five years before we can even go to clinical
> > > > > > > trials," he pointed out.
> > > > > > > The researchers used a line of adult stem cells that had been a relied-
> > > > > > > upon source for lab research. They said that the differentiation
> > > > > > > process that prodded the stem cell stock to develop into retinal cells
> > > > > > > equivalent to those damaged by AMD took many weeks of high-tech
> > > > > > > culturing, but ultimately the stem cell-generated retinal cells
> > > > > > > exhibited the same functional capacity and gene
Perception will change once the science is validated. The blind will
not care if an unwanted embryo gave its existence of which NEVER would
have happened anyhow to heal a 100million Blind people in the world.
We send our Troops to die for Oil every fucking day, we allow 500,000
Americans to die from Smoking every year, but no no no, dont touch
those 8 cells that NOTHING can and or ever will be done to them. Dont
use them for science. HAving this conversation is like argueing with
an 8 yr about Bed time.
The Grown ups will bring the zealots kicking and screaming into the
21st century in literally months. Those that have read the detailed
animal studys know that the results happen fast/6 weeks. Mid May the
Trials start, ACT may change the World by end of Q-3.
In the interim it is important to bombard these articles with facts.
iPSC will not work for every cell in the body this fact, they dont
last as long, this is fact, this is and has been proven.They can not
be controlled yet.
feeed
Dislcosure: Raymond Lund, Ph.D., a scientific collaborator with ACT,
and considered one of the world’s foremost experts in retinal cell
physiology and vision restoration, commented, “The study results of
ACT’s RPE cells implanted in the various animal models of macular
degeneration was phenomenal. If ACT observes even a fraction of that
benefit in humans, it will be nothing short of a home run."
> Concerning the derivation of RPE cells, it really doesn't matter
> anymore. The one embryo that was used to make the stem cells that
> make the RPE cells today is all that will ever be needed to make RPE
> cells in the future. That's the benefit of immortality and unlimited
> derivation. They won't have to touch another embryo for RPE work.
> It's already done and will be the source for unlimited stem cells for
> the eye in the future.
> On Mar 24, 9:53 am, Jckrdu <jim.ku...@yahoo.com> wrote:
> > Agree with your thoughts. I think Russo will help ACTC navigate thru
> > these type of objections.
> > The fact is that the embryo from which the RPE cells we are using for
> > our TRIALS was destroyed. Lanza stated that ACTC could switch to a
> > newer hESC line where the embryo is still intact and frozen, but
> > making that switch will take some time. IMO, after ACTC gets the JV
> > money and the trials are proven to be safe & effective, ACTC will make
> > the switch to ramp-up manufacturing of RPE cells from a new line where
> > the embryo is preserved, and those RPE cells will be used for
> > treatments. Once this is done, ACTC will be totally clean and will be
> > able to shout from the rooftops that our RPE therapy is embryo safe,
> > and can physically point to the preserved embryo. Russo should be
> > able to articulate this approach to the masses at any time.
> > On Mar 24, 10:36 am, Toddio <toddi...@yahoo.com> wrote:
> > > But Mr. fox would say " Were the embryos that you used, these
> > > 'unharmed' embryos, eventually destroyed? Even if it was not in the
> > > process of extracting the cells, they were still destroyed, is that
> > > not the case?" And we would say, "That is correct, but the process we
> > > use to obtain the stem cells does not harm the embryo so in the
> > > right...." and we would be cut off and the question reiterated... "So
> > > the the 'embryo safe' technique that was used to extract the stem
> > > cells was not a direct cause of the demise of the embryo, but those
> > > embryos were still eventually destroyed, correct?" and we would say
> > > "Well, yes. But you have to understand that... "Thank you for your
> > > time Mr. Rabin".
> > > We need to understand that there are a lot of people who do not think
> > > like us. We can differentiate between what seem like huge differences
> > > to us. To others it's still just, the embryos are eventually
> > > destroyed. (well, until you bring in the whole process of natural
> > > conception and childbirth and miscarriage etc...). It is becoming
> > > clear to me that the controversy is not really about how the embryo is
> > > destroyed. It's not even about if it is destroyed. It's about an
> > > unwillingness to accept that the old ways are just that... old. The
> > > old order does not want to give up that power. Therapies such as the
> > > ones ACTC are working on are game changers that we can't even
> > > comprehend. This technology will be besieged by the far right and the
> > > far left, those who you think are for it and those you know never will
> > > be. It is a society changer.
> > > That said, we just have to do what we do. Lets not get too frustrated
> > > when we still see that most articles are still like this 5 years from
> > > now.
> > > Feeed has a saying; 'Only the science will save the sheeple'. He's
> > > right.
> > > On Mar 24, 9:16 am, John <vzvete...@yahoo.com> wrote:
> > > > Agreed Ender. Where is our PR firm? Why aren't they lining up
> > > > interviews with these magazines? Hey! Mr us-news, Guess what? We have
> > > > cells that are 5xs as effective as the nearest NIH approved lines!
> > > > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> > > > Blastomere! And you know what else? We don't harm the embryo! If I
> > > > had a high enough window, I would open it up and yell "We are mad as
> > > > hell, and we are not going to take it anymore!"
> > > > On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > > > > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > > > > viruses in cells causing problems, we already now iPSC are
> > > > > "unstable"...Common you morons there is clinical trial about to be
> > > > > started in 3 months with already differentiated RPE
> > > > > cells...unbelieavable..
> > > > > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > > > > Hard to believe no mention of Advanced Cell Technology...time to
> > > > > > barrage the site with hard facts folks...
> > > > > > Progress Seen in Creating Eye Cells From Stem Cells
> > > > > > Lab success may someday help people with macular degeneration,
> > > > > > researchers say
> > > > > > Posted: March 24, 2011
> > > > > > By Alan Mozes
> > > > > > HealthDay Reporter
> > > > > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > > > > of stem cell research into the world of viable treatments, scientists
> > > > > > have successfully fashioned adult stem cells into the kind of eye
> > > > > > cells that fall victim to the onset of age-related macular
> > > > > > degeneration, or AMD.
> > > > > > The work did not involve embryonic stem cells, which have been the
> > > > > > subject of much debate in recent years, but rather so-called "human-
> > > > > > induced pluripotent stem cells." The aim, according to the
> > > > > > researchers, was to develop a therapeutic response to the death,
> > > > > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > > > > critical to the health of the retina's vision cells.
> > > > > > But the researchers, from the Georgetown University Medical Center in
> > > > > > Washington, D.C., stress that this was a preliminary move toward that
> > > > > > goal, achieved solely in a laboratory setting. They say that numerous
> > > > > > complex obstacles must be tackled before such newly created cells
> > > > > > could be transplanted into diseased eyes.
> > > > > > "But we have shown that we are able to generate retinal cells from
> > > > > > cells originally taken from a small amount of biopsied skin, that are
> > > > > > then induced to become stem cells," noted Nady Golestaneh, an
> > > > > > assistant professor in the department of biochemistry and molecular
> > > > > > and cellular biology at Georgetown, and a co-author of a report on the
> > > > > > research, published in the March 24 issue of Stem Cells. The study was
> > > > > > funded by the U.S. National Institutes of Health.
> > > > > > "The retinal cells we have generated are really functional,"
> > > > > > Golestaneh explained. "That means they mimic the function of native
> > > > > > retinal cells that play a key role in the eye for light absorption,
> > > > > > nutrition and receptor function."
> > > > > > That's important "because, if these cells die, they can induce disease
> > > > > > in the eye, one of which is age-related macular degeneration," she
> > > > > > said. "Until now, there has not been any medication that can stop this
> > > > > > disease. So basically these people lose their central vision, which we
> > > > > > need to do daily tasks like reading, driving or anything that you need
> > > > > > to do to be independent."
> > > > > > In the United States, AMD is a leading cause of vision loss among
> > > > > > people 60 and older.
> > > > > > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > > > > > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > > > > > ophthalmology at Harvard Medical School, described the research
> > > > > > results as a "major step forward."
> > > > > > "But this is still very early work," Vavvas noted. "This has been
> > > > > > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > > > > > still a question how this will work in person because there are still
> > > > > > hurdles that need to be overcome," he added.
> > > > > > "For example, all of this work so far needs viruses to function as
> > > > > > cell
Feeed;
I wish I could agree as I used to, but I can't. I really believe those
kickers and screamers will only kick and scream louder once the
science is validated. Right now they are still in denial (to some
extent) that it will work. Once it is proven to work, then we have a
real fight on our hands. In their minds it can only lead to embryo
harvesting, women selling their eggs, the sky falling, and death
brought to all mankind. Another sign that the end is upon us. O.K. I'm
exaggerating a bit there, but not much! But, if you think the science
being validated will shut most these people up will silence them I
think you are not looking at how these people historically react. The
only thing that will change their minds is if stem cell treatment is
the only cure for THEM of some crippling affliction. Then all bets as
to how they will react are off.
On Mar 24, 12:15 pm, "Super\"feeed\"" <bottomfeeed...@yahoo.com>
wrote:
> Perception will change once the science is validated. The blind will
> not care if an unwanted embryo gave its existence of which NEVER would
> have happened anyhow to heal a 100million Blind people in the world.
> We send our Troops to die for Oil every fucking day, we allow 500,000
> Americans to die from Smoking every year, but no no no, dont touch
> those 8 cells that NOTHING can and or ever will be done to them. Dont
> use them for science. HAving this conversation is like argueing with
> an 8 yr about Bed time.
> The Grown ups will bring the zealots kicking and screaming into the
> 21st century in literally months. Those that have read the detailed
> animal studys know that the results happen fast/6 weeks. Mid May the
> Trials start, ACT may change the World by end of Q-3.
> In the interim it is important to bombard these articles with facts.
> iPSC will not work for every cell in the body this fact, they dont
> last as long, this is fact, this is and has been proven.They can not
> be controlled yet.
> feeed
> Dislcosure: Raymond Lund, Ph.D., a scientific collaborator with ACT,
> and considered one of the world’s foremost experts in retinal cell
> physiology and vision restoration, commented, “The study results of
> ACT’s RPE cells implanted in the various animal models of macular
> degeneration was phenomenal. If ACT observes even a fraction of that
> benefit in humans, it will be nothing short of a home run."
> On Mar 24, 12:08 pm, eigenman <eigenma...@gmail.com> wrote:
> > Concerning the derivation of RPE cells, it really doesn't matter
> > anymore. The one embryo that was used to make the stem cells that
> > make the RPE cells today is all that will ever be needed to make RPE
> > cells in the future. That's the benefit of immortality and unlimited
> > derivation. They won't have to touch another embryo for RPE work.
> > It's already done and will be the source for unlimited stem cells for
> > the eye in the future.
> > On Mar 24, 9:53 am, Jckrdu <jim.ku...@yahoo.com> wrote:
> > > Agree with your thoughts. I think Russo will help ACTC navigate thru
> > > these type of objections.
> > > The fact is that the embryo from which the RPE cells we are using for
> > > our TRIALS was destroyed. Lanza stated that ACTC could switch to a
> > > newer hESC line where the embryo is still intact and frozen, but
> > > making that switch will take some time. IMO, after ACTC gets the JV
> > > money and the trials are proven to be safe & effective, ACTC will make
> > > the switch to ramp-up manufacturing of RPE cells from a new line where
> > > the embryo is preserved, and those RPE cells will be used for
> > > treatments. Once this is done, ACTC will be totally clean and will be
> > > able to shout from the rooftops that our RPE therapy is embryo safe,
> > > and can physically point to the preserved embryo. Russo should be
> > > able to articulate this approach to the masses at any time.
> > > On Mar 24, 10:36 am, Toddio <toddi...@yahoo.com> wrote:
> > > > But Mr. fox would say " Were the embryos that you used, these
> > > > 'unharmed' embryos, eventually destroyed? Even if it was not in the
> > > > process of extracting the cells, they were still destroyed, is that
> > > > not the case?" And we would say, "That is correct, but the process we
> > > > use to obtain the stem cells does not harm the embryo so in the
> > > > right...." and we would be cut off and the question reiterated... "So
> > > > the the 'embryo safe' technique that was used to extract the stem
> > > > cells was not a direct cause of the demise of the embryo, but those
> > > > embryos were still eventually destroyed, correct?" and we would say
> > > > "Well, yes. But you have to understand that... "Thank you for your
> > > > time Mr. Rabin".
> > > > We need to understand that there are a lot of people who do not think
> > > > like us. We can differentiate between what seem like huge differences
> > > > to us. To others it's still just, the embryos are eventually
> > > > destroyed. (well, until you bring in the whole process of natural
> > > > conception and childbirth and miscarriage etc...). It is becoming
> > > > clear to me that the controversy is not really about how the embryo is
> > > > destroyed. It's not even about if it is destroyed. It's about an
> > > > unwillingness to accept that the old ways are just that... old. The
> > > > old order does not want to give up that power. Therapies such as the
> > > > ones ACTC are working on are game changers that we can't even
> > > > comprehend. This technology will be besieged by the far right and the
> > > > far left, those who you think are for it and those you know never will
> > > > be. It is a society changer.
> > > > That said, we just have to do what we do. Lets not get too frustrated
> > > > when we still see that most articles are still like this 5 years from
> > > > now.
> > > > Feeed has a saying; 'Only the science will save the sheeple'. He's
> > > > right.
> > > > On Mar 24, 9:16 am, John <vzvete...@yahoo.com> wrote:
> > > > > Agreed Ender. Where is our PR firm? Why aren't they lining up
> > > > > interviews with these magazines? Hey! Mr us-news, Guess what? We have
> > > > > cells that are 5xs as effective as the nearest NIH approved lines!
> > > > > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> > > > > Blastomere! And you know what else? We don't harm the embryo! If I
> > > > > had a high enough window, I would open it up and yell "We are mad as
> > > > > hell, and we are not going to take it anymore!"
> > > > > On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > > > > > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > > > > > viruses in cells causing problems, we already now iPSC are
> > > > > > "unstable"...Common you morons there is clinical trial about to be
> > > > > > started in 3 months with already differentiated RPE
> > > > > > cells...unbelieavable..
> > > > > > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > > > > > Hard to believe no mention of Advanced Cell Technology...time to
> > > > > > > barrage the site with hard facts folks...
> > > > > > > Progress Seen in Creating Eye Cells From Stem Cells
> > > > > > > Lab success may someday help people with macular degeneration,
> > > > > > > researchers say
> > > > > > > Posted: March 24, 2011
> > > > > > > By Alan Mozes
> > > > > > > HealthDay Reporter
> > > > > > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > > > > > of stem cell research into the world of viable treatments, scientists
> > > > > > > have successfully fashioned adult stem cells into the kind of eye
> > > > > > > cells that fall victim to the onset of age-related macular
> > > > > > > degeneration, or AMD.
> > > > > > > The work did not involve embryonic stem cells, which have been the
> > > > > > > subject of much debate in recent years, but rather so-called "human-
> > > > > > > induced pluripotent stem cells." The aim, according to the
> > > > > > > researchers, was to develop a therapeutic response to the death,
> > > > > > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > > > > > critical to the health of the retina's vision cells.
> > > > > > > But the researchers, from the Georgetown University Medical Center in
> > > > > > > Washington, D.C., stress that this was a preliminary move toward that
> > > > > > > goal, achieved solely in a laboratory setting. They say that numerous
> > > > > > > complex obstacles must be tackled before such newly created cells
> > > > > > > could be transplanted into diseased eyes.
> > > > > > > "But we have shown that we are able to generate retinal cells from
> > > > > > > cells originally taken from a small amount of biopsied skin, that are
> > > > > > > then induced to become stem cells," noted Nady Golestaneh, an
> > > > > > > assistant professor in the department of biochemistry and molecular
> > > > > > > and cellular biology at Georgetown, and a co-author of a report on the
> > > > > > > research, published in the March 24 issue of Stem Cells. The study was
> > > > > > > funded by the U.S. National Institutes of Health.
> > > > > > > "The retinal cells we have generated are really functional,"
> > > > > > > Golestaneh explained. "That means they mimic the function of native
> > > > > > > retinal cells that play a key role in the eye for light absorption,
> > > > > > > nutrition and receptor function."
> > > > > > > That's important "because, if these cells die, they can induce disease
> > > > > > > in the eye, one of which is age-related macular
Fortunately/unfortunately everyone has someone in their life that can use the science given the vast number of diseases it will eventually impact--yes we will always have a few that will refuse blood transfusions or organs but the lawmakers will listen to their familiy members, friends and the voters who need sight, a healthy heart, etc.JMHO
Mar 24, 2011 01:43:39 PM, advanced-cell-technology@googlegroups.com wrote:
Feeed; I wish I could agree as I used to, but I can't. I really believe those kickers and screamers will only kick and scream louder once the science is validated. Right now they are still in denial (to some extent) that it will work. Once it is proven to work, then we have a real fight on our hands. In their minds it can only lead to embryo harvesting, women selling their eggs, the sky falling, and death brought to all mankind. Another sign that the end is upon us. O.K. I'm exaggerating a bit there, but not much! But, if you think the science being validated will shut most these people up will silence them I think you are not looking at how these people historically react. The only thing that will change their minds is if stem cell treatment is the only cure for THEM of some crippling affliction. Then all bets as to how they will react are off.
On Mar 24, 12:15 pm, "Super\"feeed\"" wrote: > Perception will change once the science is validated. The blind will > not care if an unwanted embryo gave its existence of which NEVER would > have happened anyhow to heal a 100million Blind people in the world. > We send our Troops to die for Oil every fucking day, we allow 500,000 > Americans to die from Smoking every year, but no no no, dont touch > those 8 cells that NOTHING can and or ever will be done to them. Dont > use them for science. HAving this conversation is like argueing with > an 8 yr about Bed time. > The Grown ups will bring the zealots kicking and screaming into the > 21st century in literally months. Those that have read the detailed > animal studys know that the results happen fast/6 weeks. Mid May the > Trials start, ACT may change the World by end of Q-3. > In the interim it is important to bombard these articles with facts. > iPSC will not work for every cell in the body this fact, they dont > last as long, this is fact, this is and has been proven.They can not > be controlled yet. > > feeed > > Dislcosure: Raymond Lund, Ph.D., a scientific collaborator with ACT, > and considered one of the world’s foremost experts in retinal cell > physiology and vision restoration, commented, “The study results of > ACT’s RPE cells implanted in the various animal models of macular > degeneration was phenomenal. If ACT observes even a fraction of that > benefit in humans, it will be nothing short of a home run." > > http://www.advancedcell.com/news-and-media/press-releases/advanced-ce... > > On Mar 24, 12:08 pm, eigenman wrote: > > > > > Concerning the derivation of RPE cells, it really doesn't matter > > anymore. The one embryo that was used to make the stem cells that > > make the RPE cells today is all that will ever be needed to make RPE > > cells in the future. That's the benefit of immortality and unlimited > > derivation. They won't have to touch another embryo for RPE work. > > It's already done and will be the source for unlimited stem cells for > > the eye in the future. > > > On Mar 24, 9:53 am, Jckrdu wrote: > > > > Agree with your thoughts. I think Russo will help ACTC navigate thru > > > these type of objections. > > > > The fact is that the embryo from which the RPE cells we are using for > > > our TRIALS was destroyed. Lanza stated that ACTC could switch to a > > > newer hESC line where the embryo is still intact and frozen, but > > > making that switch will take some time. IMO, after ACTC gets the JV > > > money and the trials are proven to be safe & effective, ACTC will make > > > the switch to ramp-up manufacturing of RPE cells from a new line where > > > the embryo is preserved, and those RPE cells will be used for > > > treatments. Once this is done, ACTC will be totally clean and will be > > > able to shout from the rooftops that our RPE therapy is embryo safe, > > > and can physically point to the preserved embryo. Russo should be > > > able to articulate this approach to the masses at any time. > > > > On Mar 24, 10:36 am, Toddio wrote: > > > > > But Mr. fox would say " Were the embryos that you used, these > > > > 'unharmed' embryos, eventually destroyed? Even if it was not in the > > > > process of extracting the cells, they were still destroyed, is that > > > > not the case?" And we would say, "That is correct, but the process we > > > > use to obtain the stem cells does not harm the embryo so in the > > > > right...." and we would be cut off and the question reiterated... "So > > > > the the 'embryo safe' technique that was used to extract the stem > > > > cells was not a direct cause of the demise of the embryo, but those > > > > embryos were still eventually destroyed, correct?" and we would say > > > > "Well, yes. But you have to understand that... "Thank you for your > > > > time Mr. Rabin". > > > > > We need to understand that there are a lot of people who do not think > > > > like us. We can differentiate between what seem like huge differences > > > > to us. To others it's still just, the embryos are eventually > > > > destroyed. (well, until you bring in the whole process of natural > > > > conception and childbirth and miscarriage etc...). It is becoming > > > > clear to me that the controversy is not really about how the embryo is > > > > destroyed. It's not even about if it is destroyed. It's about an > > > > unwillingness to accept that the old ways are just that... old. The > > > > old order does not want to give up that power. Therapies such as the > > > > ones ACTC are working on are game changers that we can't even > > > > comprehend. This technology will be besieged by the far right and the > > > > far left, those who you think are for it and those you know never will > > > > be. It is a society changer. > > > > > That said, we just have to do what we do. Lets not get too frustrated > > > > when we still see that most articles are still like this 5 years from > > > > now. > > > > Feeed has a saying; 'Only the science will save the sheeple'. He's > > > > right. > > > > > On Mar 24, 9:16 am, John wrote: > > > > > > Agreed Ender. Where is our PR firm? Why aren't they lining up > > > > > interviews with these magazines? Hey! Mr us-news, Guess what? We have > > > > > cells that are 5xs as effective as the nearest NIH approved lines! > > > > > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called > > > > > Blastomere! And you know what else? We don't harm the embryo! If I > > > > > had a high enough window, I would open it up and yell "We are mad as > > > > > hell, and we are not going to take it anymore!" > > > > > > On Mar 24, 9:45 am, Ender wrote: > > > > > > > Isn't it great?? 3 to 5 years before they can even move to clinicals, > > > > > > viruses in cells causing problems, we already now iPSC are > > > > > > "unstable"...Common you morons there is clinical trial about to be > > > > > > started in 3 months with already differentiated RPE > > > > > > cells...unbelieavable.. > > > > > > > On Mar 24, 2:37 pm, GMAN wrote: > > > > > > > > Hard to believe no mention of Advanced Cell Technology...time to > > > > > > > barrage the site with hard facts folks... > > > > > > > >http://health.usnews.com/health-news/managing-your-healthcare/womens-... > > > > > > > > Progress Seen in Creating Eye Cells From Stem Cells > > > > > > > Lab success may someday help people with macular degeneration, > > > > > > > researchers say > > > > > > > > Posted: March 24, 2011 > > > > > > > > By Alan Mozes > > > > > > > HealthDay Reporter > > > > > > > > THURSDAY, March 24 (HealthDay News) -- To push the
I work with a lot of those kicking and screaming.folks, I've told them over and over about this company and how we have circumnavigated the moral issues that have been raised. It is like running into a brick wall head first. A good friend of mine named this behavior "The fun barrier". It will be fun when I mention that the stock that I begged them to invest in @ .17 reached $10.67 in 2012. Oh well I tried, god knows I tried!
On Thu, Mar 24, 2011 at 1:43 PM, Toddio <toddi...@yahoo.com> wrote: > Feeed; > I wish I could agree as I used to, but I can't. I really believe those > kickers and screamers will only kick and scream louder once the > science is validated. Right now they are still in denial (to some > extent) that it will work. Once it is proven to work, then we have a > real fight on our hands. In their minds it can only lead to embryo > harvesting, women selling their eggs, the sky falling, and death > brought to all mankind. Another sign that the end is upon us. O.K. I'm > exaggerating a bit there, but not much! But, if you think the science > being validated will shut most these people up will silence them I > think you are not looking at how these people historically react. The > only thing that will change their minds is if stem cell treatment is > the only cure for THEM of some crippling affliction. Then all bets as > to how they will react are off.
> On Mar 24, 12:15 pm, "Super\"feeed\"" <bottomfeeed...@yahoo.com> > wrote: > > Perception will change once the science is validated. The blind will > > not care if an unwanted embryo gave its existence of which NEVER would > > have happened anyhow to heal a 100million Blind people in the world. > > We send our Troops to die for Oil every fucking day, we allow 500,000 > > Americans to die from Smoking every year, but no no no, dont touch > > those 8 cells that NOTHING can and or ever will be done to them. Dont > > use them for science. HAving this conversation is like argueing with > > an 8 yr about Bed time. > > The Grown ups will bring the zealots kicking and screaming into the > > 21st century in literally months. Those that have read the detailed > > animal studys know that the results happen fast/6 weeks. Mid May the > > Trials start, ACT may change the World by end of Q-3. > > In the interim it is important to bombard these articles with facts. > > iPSC will not work for every cell in the body this fact, they dont > > last as long, this is fact, this is and has been proven.They can not > > be controlled yet.
> > feeed
> > Dislcosure: Raymond Lund, Ph.D., a scientific collaborator with ACT, > > and considered one of the world’s foremost experts in retinal cell > > physiology and vision restoration, commented, “The study results of > > ACT’s RPE cells implanted in the various animal models of macular > > degeneration was phenomenal. If ACT observes even a fraction of that > > benefit in humans, it will be nothing short of a home run."
> > On Mar 24, 12:08 pm, eigenman <eigenma...@gmail.com> wrote:
> > > Concerning the derivation of RPE cells, it really doesn't matter > > > anymore. The one embryo that was used to make the stem cells that > > > make the RPE cells today is all that will ever be needed to make RPE > > > cells in the future. That's the benefit of immortality and unlimited > > > derivation. They won't have to touch another embryo for RPE work. > > > It's already done and will be the source for unlimited stem cells for > > > the eye in the future.
> > > On Mar 24, 9:53 am, Jckrdu <jim.ku...@yahoo.com> wrote:
> > > > Agree with your thoughts. I think Russo will help ACTC navigate thru > > > > these type of objections.
> > > > The fact is that the embryo from which the RPE cells we are using for > > > > our TRIALS was destroyed. Lanza stated that ACTC could switch to a > > > > newer hESC line where the embryo is still intact and frozen, but > > > > making that switch will take some time. IMO, after ACTC gets the JV > > > > money and the trials are proven to be safe & effective, ACTC will > make > > > > the switch to ramp-up manufacturing of RPE cells from a new line > where > > > > the embryo is preserved, and those RPE cells will be used for > > > > treatments. Once this is done, ACTC will be totally clean and will > be > > > > able to shout from the rooftops that our RPE therapy is embryo safe, > > > > and can physically point to the preserved embryo. Russo should be > > > > able to articulate this approach to the masses at any time.
> > > > On Mar 24, 10:36 am, Toddio <toddi...@yahoo.com> wrote:
> > > > > But Mr. fox would say " Were the embryos that you used, these > > > > > 'unharmed' embryos, eventually destroyed? Even if it was not in the > > > > > process of extracting the cells, they were still destroyed, is that > > > > > not the case?" And we would say, "That is correct, but the process > we > > > > > use to obtain the stem cells does not harm the embryo so in the > > > > > right...." and we would be cut off and the question reiterated... > "So > > > > > the the 'embryo safe' technique that was used to extract the stem > > > > > cells was not a direct cause of the demise of the embryo, but those > > > > > embryos were still eventually destroyed, correct?" and we would > say > > > > > "Well, yes. But you have to understand that... "Thank you for your > > > > > time Mr. Rabin".
> > > > > We need to understand that there are a lot of people who do not > think > > > > > like us. We can differentiate between what seem like huge > differences > > > > > to us. To others it's still just, the embryos are eventually > > > > > destroyed. (well, until you bring in the whole process of natural > > > > > conception and childbirth and miscarriage etc...). It is becoming > > > > > clear to me that the controversy is not really about how the embryo > is > > > > > destroyed. It's not even about if it is destroyed. It's about an > > > > > unwillingness to accept that the old ways are just that... old. The > > > > > old order does not want to give up that power. Therapies such as > the > > > > > ones ACTC are working on are game changers that we can't even > > > > > comprehend. This technology will be besieged by the far right and > the > > > > > far left, those who you think are for it and those you know never > will > > > > > be. It is a society changer.
> > > > > That said, we just have to do what we do. Lets not get too > frustrated > > > > > when we still see that most articles are still like this 5 years > from > > > > > now. > > > > > Feeed has a saying; 'Only the science will save the sheeple'. He's > > > > > right.
> > > > > On Mar 24, 9:16 am, John <vzvete...@yahoo.com> wrote:
> > > > > > Agreed Ender. Where is our PR firm? Why aren't they lining up > > > > > > interviews with these magazines? Hey! Mr us-news, Guess what? We > have > > > > > > cells that are 5xs as effective as the nearest NIH approved > lines! > > > > > > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called > > > > > > Blastomere! And you know what else? We don't harm the embryo! If > I > > > > > > had a high enough window, I would open it up and yell "We are mad > as > > > > > > hell, and we are not going to take it anymore!"
> > > > > > On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > > > > > > Isn't it great?? 3 to 5 years before they can even move to > clinicals, > > > > > > > viruses in cells causing problems, we already now iPSC are > > > > > > > "unstable"...Common you morons there is clinical trial about to > be > > > > > > > started in 3 months with already differentiated RPE > > > > > > > cells...unbelieavable..
> > > > > > > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > > > > > > Hard to believe no mention of Advanced Cell Technology...time > to > > > > > > > > barrage the site with hard facts folks...
> > > > > > > > THURSDAY, March 24 (HealthDay News) -- To push the > theoretical promise > > > > > > > > of stem cell research into the world of viable treatments, > scientists > > > > > > > > have successfully fashioned adult stem cells into the kind of > eye > > > > > > > > cells that fall victim to the onset of age-related macular > > > > > > > > degeneration, or AMD.
> > > > > > > > The work did not involve embryonic stem cells, which have > been the > > > > > > > > subject of much debate in recent years, but rather so-called > "human- > > > > > > > > induced pluripotent stem cells." The aim, according to the > > > > > > > > researchers, was to develop a therapeutic response to the > death, > > > > > > > > caused by AMD, of retinal pigment epithelium, a cell layer > that is > > > > > > > > critical to the health of the retina's vision cells.
> > > > > > > > But the researchers, from the Georgetown University Medical > Center in > > > > > > > > Washington, D.C., stress that this was a preliminary move > toward that > > > > > > > > goal, achieved solely in a laboratory setting. They say that > numerous > > > > > > > > complex obstacles must be tackled before such newly created > cells > > > > > > > > could be transplanted into diseased eyes.
> > > > > > > > "But we have shown that we are able to generate retinal cells > from > > > > > > > > cells originally taken from a small amount of biopsied skin, > that are > > > > > > > > then induced to become stem cells," noted Nady Golestaneh, an > > > > > > > > assistant professor in the department
> Progress Seen in Creating Eye Cells From Stem Cells
> Lab success may someday help people with macular degeneration,
> researchers say
> Posted: March 24, 2011
> By Alan Mozes
> HealthDay Reporter
> THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> of stem cell research into the world of viable treatments, scientists
> have successfully fashioned adult stem cells into the kind of eye
> cells that fall victim to the onset of age-related macular
> degeneration, or AMD.
> The work did not involve embryonic stem cells, which have been the
> subject of much debate in recent years, but rather so-called "human-
> induced pluripotent stem cells." The aim, according to the
> researchers, was to develop a therapeutic response to the death,
> caused by AMD, of retinal pigment epithelium, a cell layer that is
> critical to the health of the retina's vision cells.
> But the researchers, from the Georgetown University Medical Center in
> Washington, D.C., stress that this was a preliminary move toward that
> goal, achieved solely in a laboratory setting. They say that numerous
> complex obstacles must be tackled before such newly created cells
> could be transplanted into diseased eyes.
> "But we have shown that we are able to generate retinal cells from
> cells originally taken from a small amount of biopsied skin, that are
> then induced to become stem cells," noted Nady Golestaneh, an
> assistant professor in the department of biochemistry and molecular
> and cellular biology at Georgetown, and a co-author of a report on the
> research, published in the March 24 issue of Stem Cells. The study was
> funded by the U.S. National Institutes of Health.
> "The retinal cells we have generated are really functional,"
> Golestaneh explained. "That means they mimic the function of native
> retinal cells that play a key role in the eye for light absorption,
> nutrition and receptor function."
> That's important "because, if these cells die, they can induce disease
> in the eye, one of which is age-related macular degeneration," she
> said. "Until now, there has not been any medication that can stop this
> disease. So basically these people lose their central vision, which we
> need to do daily tasks like reading, driving or anything that you need
> to do to be independent."
> In the United States, AMD is a leading cause of vision loss among
> people 60 and older.
> Dr. Demetrios Vavvas, an attending physician in the retina service of
> the Massachusetts Eye and Ear Infirmary and an assistant professor of
> ophthalmology at Harvard Medical School, described the research
> results as a "major step forward."
> "But this is still very early work," Vavvas noted. "This has been
> achieved only in-vitro. It is in-lab work with cell cultures. So it's
> still a question how this will work in person because there are still
> hurdles that need to be overcome," he added.
> "For example, all of this work so far needs viruses to function as
> cell carriers, and this creates problems," he explained. "So, people
> are now trying to see if they can replicate this kind of lab work
> without the use of viruses. That will have to happen before we can go
> to human trials. And we're not there yet," Vavvas said.
> "With the current know-how and technology, we're probably talking a
> minimum of three to five years before we can even go to clinical
> trials," he pointed out.
> The researchers used a line of adult stem cells that had been a relied-
> upon source for lab research. They said that the differentiation
> process that prodded the stem cell stock to develop into retinal cells
> equivalent to those damaged by AMD took many weeks of high-tech
> culturing, but ultimately the stem cell-generated retinal cells
> exhibited the same functional capacity and gene expression as
> naturally occurring retinal cells, the researchers reported.
> However, they cautioned that the cell line they generated also
> appeared to display DNA chromosomal damage, aspects of over-expression
> that prompted growth inhibition and some structural abnormalities.
> Though the generated cells were deemed "viable," the researchers said
> that more work would be needed to render them "safe" for treatment
> purposes.
> "But when we talk about the potential use of stem cells, we shouldn't
> only think about transplantation," Golestaneh said. "They could also
> be used as an in-vitro model to study the disease itself in the lab --
> their function, their impairment, gene mutations. That would help to
> generate targeted drugs to cure the disease."
> That makes the cells "very valuable not only for transplantation but
> also to study the mechanism of the disease and advance drug
> development," Golestaneh said.
> More information
> The U.S. National Eye Institute has more on age-related macular
> degeneration.
Well, John, I am sure there are things going on in whatever field you
move in that you don't know about. The problem is we, ACT, don't yet
have results. When we do, and if they are as great as we all expect,
it will be "Katy, bar the door". We'll have to build double walls and
a moat to protect Lanza from the ravening hordes. What we need is
patience, patience and patients. (Don't you just love the English
language. Very efficient but very confusing to non-native speakers---
There, their, and they're; here and hear, hair and hare, air and heir,
not and knot, no and know, etc.)
BD
On Mar 24, 7:29 am, John <vzvete...@yahoo.com> wrote:
> I hope so. It just seems like we can't do enough to get the attention
> that we deserve. This posted article is a prime example of media bias.
> How does this story even warrant publication? How are they even on the
> radar, on the list of must have interviews? Their approach is light
> years behind us.
> On Mar 24, 10:20 am, Ender <Radek.Ves...@logica.com> wrote:> John i hope that as we speak ACTC together with Russo working on nice
> > PR strategy to make us more visible in big media outlets. Could be
> > matched with the patient enrollment for the trials wich should be
> > starting in 2 weeks according Monday CC.
> > On Mar 24, 3:16 pm, John <vzvete...@yahoo.com> wrote:
> > > Agreed Ender. Where is our PR firm? Why aren't they lining up
> > > interviews with these magazines? Hey! Mr us-news, Guess what? We have
> > > cells that are 5xs as effective as the nearest NIH approved lines!
> > > Hey Mr Fox,CNN,NBC, ABC, Guess What? We have a technique called
> > > Blastomere! And you know what else? We don't harm the embryo! If I
> > > had a high enough window, I would open it up and yell "We are mad as
> > > hell, and we are not going to take it anymore!"
> > > On Mar 24, 9:45 am, Ender <Radek.Ves...@logica.com> wrote:
> > > > Isn't it great?? 3 to 5 years before they can even move to clinicals,
> > > > viruses in cells causing problems, we already now iPSC are
> > > > "unstable"...Common you morons there is clinical trial about to be
> > > > started in 3 months with already differentiated RPE
> > > > cells...unbelieavable..
> > > > On Mar 24, 2:37 pm, GMAN <gman7...@gmail.com> wrote:
> > > > > Hard to believe no mention of Advanced Cell Technology...time to
> > > > > barrage the site with hard facts folks...
> > > > > Progress Seen in Creating Eye Cells From Stem Cells
> > > > > Lab success may someday help people with macular degeneration,
> > > > > researchers say
> > > > > Posted: March 24, 2011
> > > > > By Alan Mozes
> > > > > HealthDay Reporter
> > > > > THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> > > > > of stem cell research into the world of viable treatments, scientists
> > > > > have successfully fashioned adult stem cells into the kind of eye
> > > > > cells that fall victim to the onset of age-related macular
> > > > > degeneration, or AMD.
> > > > > The work did not involve embryonic stem cells, which have been the
> > > > > subject of much debate in recent years, but rather so-called "human-
> > > > > induced pluripotent stem cells." The aim, according to the
> > > > > researchers, was to develop a therapeutic response to the death,
> > > > > caused by AMD, of retinal pigment epithelium, a cell layer that is
> > > > > critical to the health of the retina's vision cells.
> > > > > But the researchers, from the Georgetown University Medical Center in
> > > > > Washington, D.C., stress that this was a preliminary move toward that
> > > > > goal, achieved solely in a laboratory setting. They say that numerous
> > > > > complex obstacles must be tackled before such newly created cells
> > > > > could be transplanted into diseased eyes.
> > > > > "But we have shown that we are able to generate retinal cells from
> > > > > cells originally taken from a small amount of biopsied skin, that are
> > > > > then induced to become stem cells," noted Nady Golestaneh, an
> > > > > assistant professor in the department of biochemistry and molecular
> > > > > and cellular biology at Georgetown, and a co-author of a report on the
> > > > > research, published in the March 24 issue of Stem Cells. The study was
> > > > > funded by the U.S. National Institutes of Health.
> > > > > "The retinal cells we have generated are really functional,"
> > > > > Golestaneh explained. "That means they mimic the function of native
> > > > > retinal cells that play a key role in the eye for light absorption,
> > > > > nutrition and receptor function."
> > > > > That's important "because, if these cells die, they can induce disease
> > > > > in the eye, one of which is age-related macular degeneration," she
> > > > > said. "Until now, there has not been any medication that can stop this
> > > > > disease. So basically these people lose their central vision, which we
> > > > > need to do daily tasks like reading, driving or anything that you need
> > > > > to do to be independent."
> > > > > In the United States, AMD is a leading cause of vision loss among
> > > > > people 60 and older.
> > > > > Dr. Demetrios Vavvas, an attending physician in the retina service of
> > > > > the Massachusetts Eye and Ear Infirmary and an assistant professor of
> > > > > ophthalmology at Harvard Medical School, described the research
> > > > > results as a "major step forward."
> > > > > "But this is still very early work," Vavvas noted. "This has been
> > > > > achieved only in-vitro. It is in-lab work with cell cultures. So it's
> > > > > still a question how this will work in person because there are still
> > > > > hurdles that need to be overcome," he added.
> > > > > "For example, all of this work so far needs viruses to function as
> > > > > cell carriers, and this creates problems," he explained. "So, people
> > > > > are now trying to see if they can replicate this kind of lab work
> > > > > without the use of viruses. That will have to happen before we can go
> > > > > to human trials. And we're not there yet," Vavvas said.
> > > > > "With the current know-how and technology, we're probably talking a
> > > > > minimum of three to five years before we can even go to clinical
> > > > > trials," he pointed out.
> > > > > The researchers used a line of adult stem cells that had been a relied-
> > > > > upon source for lab research. They said that the differentiation
> > > > > process that prodded the stem cell stock to develop into retinal cells
> > > > > equivalent to those damaged by AMD took many weeks of high-tech
> > > > > culturing, but ultimately the stem cell-generated retinal cells
> > > > > exhibited the same functional capacity and gene expression as
> > > > > naturally occurring retinal cells, the researchers reported.
> > > > > However, they cautioned that the cell line they generated also
> > > > > appeared to display DNA chromosomal damage, aspects of over-expression
> > > > > that prompted growth inhibition and some structural abnormalities.
> > > > > Though the generated cells were deemed "viable," the researchers said
> > > > > that more work would be needed to render them "safe" for treatment
> > > > > purposes.
> > > > > "But when we talk about the potential use of stem cells, we shouldn't
> > > > > only think about transplantation," Golestaneh said. "They could also
> > > > > be used as an in-vitro model to study the disease itself in the lab --
> > > > > their function, their impairment, gene mutations. That would help to
> > > > > generate targeted drugs to cure the disease."
> > > > > That makes the cells "very valuable not only for transplantation but
> > > > > also to study the mechanism of the disease and advance drug
> > > > > development," Golestaneh said.
> > > > > More information
> > > > > The U.S. National Eye Institute has more on age-related macular
> > > > > degeneration.- Hide quoted text -
Here's another take on this story, more straightforward, released by
the PR Dept of Georgetown University Medical Center.
Potential Stem Cell Therapy For Age-Related Macular Degeneration
Article Date: 24 Mar 2011 - 5:00 PDT
The notion of transplanting adult stem cells to treat or even cure age-
related macular degeneration has taken a significant step toward
becoming a reality. In a study published today in Stem Cells,
Georgetown University Medical Center researchers have demonstrated,
for the first time, the ability to create retinal cells derived from
human-induced pluripotent stem cells that mimic the eye cells that die
and cause loss of sight.
Age-related macular degeneration (AMD) is a leading cause of visual
impairment and blindness in older Americans and worldwide. AMD
gradually destroys sharp, central vision needed for seeing objects
clearly and for common daily tasks such as reading and driving. AMD
progresses with death of retinal pigment epithelium (RPE), a dark
color layer of cells which nourishes the visual cells in the retina.
While some treatments can help slow its progression, there is no cure.
The discovery of human induced pluripotent stem (hiPS) cells has
opened a new avenue for the treatment of degenerative diseases, like
AMD, by using a patient's own stem cells to generate tissues and cells
for transplantation.
For transplantation to be viable in age-related macular degeneration,
researchers have to first figure out how to program the naïve hiPS
cells to function and possess the characteristics of the native
retinal pigment epithelium, RPE, the cells that die off and lead to
AMD.
The research conducted by the Georgetown scientists shows that this
critical step in regenerative medicine for AMD has greatly progressed.
"This is the first time that hiPS-RPE cells have been produced with
the characteristics and functioning of the RPE cells in the eye. That
makes these cells promising candidates for retinal regeneration
therapies in age-related macular degeneration," says the study's lead
author Nady Golestaneh, Ph.D., assistant professor in GUMC's
Department of Biochemistry and Molecular & Cellular Biology.
Using an established laboratory stem cell line, Golestaneh and her
colleagues show that RPE generated from hiPS cells under defined
conditions exhibit ion transport, membrane potential, polarized VEGF
secretion and gene expression profile similar to those of a normal
eye's RPE.
"This isn't ready for prime time though. We also identified some
issues that need to be worked out before these cells are ready for
transplantation but overall, this is a tremendous step forward in
regenerative medicine," Golestaneh adds.
She explains that the hiPS-derived RPE cells show rapid telomere
shortening, DNA chromosomal damage and increased p21 expression that
cause cell growth arrest. This might be due to the random integration
of viruses in the genome of skin fibroblasts during the reprogramming
of iPS cells. Therefore, generation of viral-free iPS cells and their
differentiation into RPE will be a necessary step towards
implementation of these cells in clinical application, Golestaneh
says.
"The next step in this research is to focus on a generation of 'safe'
as well as viable hiPS-derived somatic cells," Golestaneh concludes.
Notes:
Other authors on the paper include first author Maria Kokkinaki,
Ph.D., Department of Biochemistry and Molecular &Cellular Biology, and
Niaz Sahibzada, Ph.D., Department of Pharmacology at GUMC.
This work was funded by the National Institutes of Health. The authors
report no personal financial interests related to this study.
Source:
Karen Mallet
Georgetown University Medical Center
> Progress Seen in Creating Eye Cells From Stem Cells
> Lab success may someday help people with macular degeneration,
> researchers say
> Posted: March 24, 2011
> By Alan Mozes
> HealthDay Reporter
> THURSDAY, March 24 (HealthDay News) -- To push the theoretical promise
> of stem cell research into the world of viable treatments, scientists
> have successfully fashioned adult stem cells into the kind of eye
> cells that fall victim to the onset of age-related macular
> degeneration, or AMD.
> The work did not involve embryonic stem cells, which have been the
> subject of much debate in recent years, but rather so-called "human-
> induced pluripotent stem cells." The aim, according to the
> researchers, was to develop a therapeutic response to the death,
> caused by AMD, of retinal pigment epithelium, a cell layer that is
> critical to the health of the retina's vision cells.
> But the researchers, from the Georgetown University Medical Center in
> Washington, D.C., stress that this was a preliminary move toward that
> goal, achieved solely in a laboratory setting. They say that numerous
> complex obstacles must be tackled before such newly created cells
> could be transplanted into diseased eyes.
> "But we have shown that we are able to generate retinal cells from
> cells originally taken from a small amount of biopsied skin, that are
> then induced to become stem cells," noted Nady Golestaneh, an
> assistant professor in the department of biochemistry and molecular
> and cellular biology at Georgetown, and a co-author of a report on the
> research, published in the March 24 issue of Stem Cells. The study was
> funded by the U.S. National Institutes of Health.
> "The retinal cells we have generated are really functional,"
> Golestaneh explained. "That means they mimic the function of native
> retinal cells that play a key role in the eye for light absorption,
> nutrition and receptor function."
> That's important "because, if these cells die, they can induce disease
> in the eye, one of which is age-related macular degeneration," she
> said. "Until now, there has not been any medication that can stop this
> disease. So basically these people lose their central vision, which we
> need to do daily tasks like reading, driving or anything that you need
> to do to be independent."
> In the United States, AMD is a leading cause of vision loss among
> people 60 and older.
> Dr. Demetrios Vavvas, an attending physician in the retina service of
> the Massachusetts Eye and Ear Infirmary and an assistant professor of
> ophthalmology at Harvard Medical School, described the research
> results as a "major step forward."
> "But this is still very early work," Vavvas noted. "This has been
> achieved only in-vitro. It is in-lab work with cell cultures. So it's
> still a question how this will work in person because there are still
> hurdles that need to be overcome," he added.
> "For example, all of this work so far needs viruses to function as
> cell carriers, and this creates problems," he explained. "So, people
> are now trying to see if they can replicate this kind of lab work
> without the use of viruses. That will have to happen before we can go
> to human trials. And we're not there yet," Vavvas said.
> "With the current know-how and technology, we're probably talking a
> minimum of three to five years before we can even go to clinical
> trials," he pointed out.
> The researchers used a line of adult stem cells that had been a relied-
> upon source for lab research. They said that the differentiation
> process that prodded the stem cell stock to develop into retinal cells
> equivalent to those damaged by AMD took many weeks of high-tech
> culturing, but ultimately the stem cell-generated retinal cells
> exhibited the same functional capacity and gene expression as
> naturally occurring retinal cells, the researchers reported.
> However, they cautioned that the cell line they generated also
> appeared to display DNA chromosomal damage, aspects of over-expression
> that prompted growth inhibition and some structural abnormalities.
> Though the generated cells were deemed "viable," the researchers said
> that more work would be needed to render them "safe" for treatment
> purposes.
> "But when we talk about the potential use of stem cells, we shouldn't
> only think about transplantation," Golestaneh said. "They could also
> be used as an in-vitro model to study the disease itself in the lab --
> their function, their impairment, gene mutations. That would help to
> generate targeted drugs to cure the disease."
> That makes the cells "very valuable not only for transplantation but
> also to study the mechanism of the disease and advance drug
> development," Golestaneh said.
> More information
> The U.S. National Eye Institute has more on age-related macular
> degeneration.
