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International Behavioral Genetics Workshop Question Box
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This is the electronic question box for the
International Behavioral Genetics Workshop
hosted by the
Institute for Behavioral Genetics
in Boulder, Colorado.
Students (and faculty) can ask questions about topics covered at the Workshop.
Anonymous question can be
submitted through a web form
.
A question can be submitted using the "NEW QUESTION" button above, but this requires a Google account.
Questions can be emailed to
twin-workshop@googlegroups.com
, but your name and email address will be associated with the question.
Students can reply to questions to ask followup questions, or to provide their own answers, but this also requires a Google account.
Questions and answers from the 2017 and 2018 courses are available on the
old electronic question box forum
.
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anonymous via Institute for Behavioral Genetics
5/1/20
Двери оптом, официальный сайт компании Tradedoors в Москве
Как правильно выбрать дверную фурнитуру для входных дверей
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Двери оптом, официальный сайт компании Tradedoors в Москве
Как правильно выбрать дверную фурнитуру для входных дверей
5/1/20
anonymous via Institute for Behavioral Genetics
, …
Boomsma, D.I.
5
3/25/20
Random variability due to assigning members of twin pairs to Twin1 and Twin2
ICC will (in large samples) be identical to Pearson correlation if there are no differences in
unread,
Random variability due to assigning members of twin pairs to Twin1 and Twin2
ICC will (in large samples) be identical to Pearson correlation if there are no differences in
3/25/20
anonymous via Institute for Behavioral Genetics
, …
conor....@gmail.com
4
3/25/20
PRS for dominant genetic effects?
Just noted an error. This should me AA 2 0 0 Aa (aA) 1 2*p 1 aa 0 4*p-2 0 Check: n=10000 # plenty p=.
unread,
PRS for dominant genetic effects?
Just noted an error. This should me AA 2 0 0 Aa (aA) 1 2*p 1 aa 0 4*p-2 0 Check: n=10000 # plenty p=.
3/25/20
anonymous via Institute for Behavioral Genetics
3/15/20
Some slightly confusing elements in the univariate 5-ways scripts
There are a few slightly confusing elements in some of the univariate 5-ways scripts which look like
unread,
Some slightly confusing elements in the univariate 5-ways scripts
There are a few slightly confusing elements in some of the univariate 5-ways scripts which look like
3/15/20
jillrabin...@gmail.com
3/14/20
Q&A
question regarding creating PRS and reference panel
I am creating PRS using the traditional clumping/thresholding method with 1k genomes phase 3 as the
unread,
Q&A
question regarding creating PRS and reference panel
I am creating PRS using the traditional clumping/thresholding method with 1k genomes phase 3 as the
3/14/20
anonymous via Institute for Behavioral Genetics
, …
conor....@gmail.com
3
3/9/20
Residuals / Errors in GWAS
suppose a phenotypic score is modeled as y = b0 + b1*QTL1 + b2*QTl2... bm*QTLm + E + error QTls 1 to
unread,
Residuals / Errors in GWAS
suppose a phenotypic score is modeled as y = b0 + b1*QTL1 + b2*QTl2... bm*QTLm + E + error QTls 1 to
3/9/20
anonymous via Institute for Behavioral Genetics
,
Mike Neale
2
3/9/20
Correcting for ascertainment in spouses
I think it would be very similar to correcting for ascertainment for twins, except that it's more
unread,
Correcting for ascertainment in spouses
I think it would be very similar to correcting for ascertainment for twins, except that it's more
3/9/20
anonymous via Institute for Behavioral Genetics
, …
conor....@gmail.com
5
3/9/20
Relating all the genomic methods/models
GREML is an estimation procedures GCTA and the twin model are be related. To see how see the paper by
unread,
Relating all the genomic methods/models
GREML is an estimation procedures GCTA and the twin model are be related. To see how see the paper by
3/9/20
anonymous via Institute for Behavioral Genetics
, …
conor....@gmail.com
5
3/9/20
Can the models we've covered thus far generalize to individuals?
In this scheme of things, the statements that follow from a twin study pertain to the distribution of
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Can the models we've covered thus far generalize to individuals?
In this scheme of things, the statements that follow from a twin study pertain to the distribution of
3/9/20
anonymous via Institute for Behavioral Genetics
, …
pman...@gmail.com
7
3/9/20
Relation between scale of phrenotypic trait and GxE
Thank you very much to all for such extensive insight into my question. This is the area I am most
unread,
Relation between scale of phrenotypic trait and GxE
Thank you very much to all for such extensive insight into my question. This is the area I am most
3/9/20
anonymous via Institute for Behavioral Genetics
, …
conor....@gmail.com
3
3/9/20
Estimating power for moderation models:
here is an example. assuming the moderator is like age or ses (shared by the twins). i call is ses in
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Estimating power for moderation models:
here is an example. assuming the moderator is like age or ses (shared by the twins). i call is ses in
3/9/20
anonymous via Institute for Behavioral Genetics
, …
conor....@gmail.com
3
3/9/20
C
A may be over estimated if the "equal environment assumption" does not hold: C is greater
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C
A may be over estimated if the "equal environment assumption" does not hold: C is greater
3/9/20
anonymous via Institute for Behavioral Genetics
,
conor....@gmail.com
2
3/9/20
Why is phenotypic similarity a function of IBD?
Both IBD and IBS information can be used to obtain a measure of the genetic similarity among
unread,
Why is phenotypic similarity a function of IBD?
Both IBD and IBS information can be used to obtain a measure of the genetic similarity among
3/9/20
anonymous via Institute for Behavioral Genetics
, …
conor....@gmail.com
4
3/9/20
Common factor model
In psychometrics this is a situation in which you would fit a factor model with one common factor 1)
unread,
Common factor model
In psychometrics this is a situation in which you would fit a factor model with one common factor 1)
3/9/20
anonymous via Institute for Behavioral Genetics
, …
conor....@gmail.com
3
3/9/20
The target population of twin based heritability estimator
Good question! Not simple It depends. One necessary condition is the exisitence of a stationary
unread,
The target population of twin based heritability estimator
Good question! Not simple It depends. One necessary condition is the exisitence of a stationary
3/9/20
jillrabin...@gmail.com
,
matthew keller
2
3/8/20
Q&A
appropriate use of trans-ancestry PRS
This is a very good question. The answer depends mostly on the sizes of the African vs. trans-
unread,
Q&A
appropriate use of trans-ancestry PRS
This is a very good question. The answer depends mostly on the sizes of the African vs. trans-
3/8/20
anonymous via Institute for Behavioral Genetics
,
matthew keller
2
3/8/20
GenomicSEM question
You can't leave it blank I don't think. You can put in the UKB prevalence there, in which
unread,
GenomicSEM question
You can't leave it blank I don't think. You can put in the UKB prevalence there, in which
3/8/20
anonymous via Institute for Behavioral Genetics
,
davidm...@gmail.com
2
3/6/20
Significant relationship between SNP and Confounding in MR
I would recommend excluding the SNP! Usually this should not be the case in MR analyses with the
unread,
Significant relationship between SNP and Confounding in MR
I would recommend excluding the SNP! Usually this should not be the case in MR analyses with the
3/6/20
anonymous via Institute for Behavioral Genetics
, …
Mike Neale
4
3/6/20
silly George Box
The best student answer to the "Complete the following quote: All models are ___, some models
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silly George Box
The best student answer to the "Complete the following quote: All models are ___, some models
3/6/20
anonymous via Institute for Behavioral Genetics
,
Mike Neale
2
3/6/20
Different genetic architecture DOC
Yes you can. Well, you can at least try and see how it goes. The proportion of DZ pairs would be
unread,
Different genetic architecture DOC
Yes you can. Well, you can at least try and see how it goes. The proportion of DZ pairs would be
3/6/20
anonymous via Institute for Behavioral Genetics
, …
davidm...@gmail.com
3
3/6/20
PRS
Sorry but we will struggle to do this this year- to do it properly requires about 30minutes! We do
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PRS
Sorry but we will struggle to do this this year- to do it properly requires about 30minutes! We do
3/6/20
dabr...@colorado.edu
,
Mike Neale
2
3/6/20
Q&A
Comparison of Direction of Causality (DOC) and ACE-Beta methods
In unpublished work, I found that any three of the five possible parameters in a bivariate model (
unread,
Q&A
Comparison of Direction of Causality (DOC) and ACE-Beta methods
In unpublished work, I found that any three of the five possible parameters in a bivariate model (
3/6/20
anonymous via Institute for Behavioral Genetics
, …
robertmki...@gmail.com
5
3/6/20
Rescaling variables
I agree with Hunter on this one. There's usually no good reason to standardize your phenotypes
unread,
Rescaling variables
I agree with Hunter on this one. There's usually no good reason to standardize your phenotypes
3/6/20
anonymous via Institute for Behavioral Genetics
,
matthew keller
2
3/6/20
Databases
yes, lots and lots if you are a researcher at a university. See, eg, dbgap from NIH. UKB costs a
unread,
Databases
yes, lots and lots if you are a researcher at a university. See, eg, dbgap from NIH. UKB costs a
3/6/20
anonymous via Institute for Behavioral Genetics
, …
mid...@gmail.com
4
3/6/20
starting values
There is also a function in OpenMx call mxAutoStart(). This function will provide automatic starting
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starting values
There is also a function in OpenMx call mxAutoStart(). This function will provide automatic starting
3/6/20
anonymous via Institute for Behavioral Genetics
,
matthew keller
2
3/6/20
Quiz on Assumption slides
Answer to question 6 about assortative mating (AM) is that AM deflates CTD estimates of the
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Quiz on Assumption slides
Answer to question 6 about assortative mating (AM) is that AM deflates CTD estimates of the
3/6/20
anonymous via Institute for Behavioral Genetics
, …
mid...@gmail.com
6
3/6/20
Measurement Error
I think Conor is saying both phenotypes have measurement error, and their measurement errors will not
unread,
Measurement Error
I think Conor is saying both phenotypes have measurement error, and their measurement errors will not
3/6/20
Anna Docherty
, …
matthew keller
3
3/6/20
Q&A
Re: GenomicSEM latent factors
It's a good point. No-one I know is collecting these systematically but maybe we should! On
unread,
Q&A
Re: GenomicSEM latent factors
It's a good point. No-one I know is collecting these systematically but maybe we should! On
3/6/20
anonymous via Institute for Behavioral Genetics
,
mid...@gmail.com
2
3/6/20
genomic SEM iscore
Google led me to this: https://academic.oup.com/bioinformatics/article/36/1/112/5519113 I don't
unread,
genomic SEM iscore
Google led me to this: https://academic.oup.com/bioinformatics/article/36/1/112/5519113 I don't
3/6/20
anonymous via Institute for Behavioral Genetics
3/6/20
Twin-based SEM DOC modeling with SNPs
Who did Nathan Gillespie had a useful paper on using SNPs with twin-based SEM DOC modeling? (point 3
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Twin-based SEM DOC modeling with SNPs
Who did Nathan Gillespie had a useful paper on using SNPs with twin-based SEM DOC modeling? (point 3
3/6/20