There's no new cross domain security issue I'm aware of. One or two of my tests were cross domain, and seem to have worked fine.
Looking at my history, I now see one prerender that is also incorrectly reporting unsupported scheme, though it was https rather than http.
One possibility is that we could be noticing "chrome-extension://" requests, and then cancelling requests because of that. I believe there were fixes in the logic for cancelling in the case of non-http/https subresources and redirects in M27.
I'll experiment with the StumbleUpon extension tomorrow and see if I can reproduce this. Thanks again for the report - prerendering regressions, in particular, can very easily go unnoticed.